Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells

British Journal of Nutrition

Volumn 110, Issue 3, 2013, Pages 391-400

  Kim, Hyo Jung ^a   Cha, Byung Yoon ^b   Park, In Sil ^a   Lim, Ji Sun ^a   Woo, Je Tae ^b   Kim, Jong Sang ^a  

^a Kyungpook National University   (South Korea)

^b CHUBU UNIVERSITY   (Japan)

Author keywords

Dehydroglyasperin C; Migration; Platelet derived growth factor signalling pathway; Platelet derived growth factor BB; Proliferation; Vascular smooth muscle cells

Indexed keywords

ANTIOXIDANT; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; DEHYDROGLYASPERIN C; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA1; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; AORTA MEDIA; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CELL CYCLE CHECKPOINT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; GLYCYRRHIZA; HUMAN; HUMAN CELL; MALE; NEOINTIMA; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER;

ACTIN CYTOSKELETON; ANIMALS; ANTIOXIDANTS; AORTA; BENZOPYRANS; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CYCLINS; DNA; DOWN-REGULATION; GLYCYRRHIZA; HUMANS; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLAQUE, ATHEROSCLEROTIC; PLATELET-DERIVED GROWTH FACTOR; RATS;

EID: 84880850428     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512005399     Document Type: Article

References (59)

1. Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809.
2. Raines EW (2004) PDGF and cardiovascular disease. Cytokine Growth Factor Rev 15, 237-254.
3. Jiang B, Yamamura S, Nelson PR, et al. (1996) Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. Surgery 120, 427-431.
4. Koyama N, Hart CE & Clowes AW (1994) Different functions of the platelet-derived growth factor-alpha and-beta receptors for the migration and proliferation of cultured baboon smooth muscle cells. Circ Res 75, 682-691.
5. Sirois MG, Simons M & Edelman ER (1997) Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening. Circulation 95, 669-676.
6. Jawien A, Bowen-Pope DF, Lindner V, et al. (1992) Plateletderived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest 89, 507-511.
7. Banai S, Wolf Y, Golomb G, et al. (1998) PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation 97, 1960-1969.
8. Bornfeldt KE, Raines EW, Nakano T, et al. (1994) Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest 93, 1266-1274.
9. Bornfeldt KE, Raines EW, Graves LM, et al. (1995) Plateletderived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Ann N Y Acad Sci 766, 416-430.
10. Venkatesan B, Ghosh-Choudhury N, Das F, et al. (2008) Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J 22, 3469-3482.
11. Kim HJ, Cha BY, Choi B, et al. (2012) Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration. Br J Nutr 107, 24-35.
12. Mae T, Kishida H, Nishiyama T, et al. (2003) A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. J Nutr 133, 3369-3677.
13. Fukai T, Marumo A, Kaitou K, et al. (2002) Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci 71, 1449-1463.
14. Shin YW, Bae EA, Lee B, et al. (2007) In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. Planta Med 73, 257-261.
15. Gupta VK, Fatima A, Faridi U, et al. (2008) Antimicrobial potential of Glycyrrhiza glabra roots. J Ethnopharmacol 116, 377-380.
16. Chin YW, Jung HA, Liu Y, et al. (2007) Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Agric Food Chem 55, 4691-4697.
17. Zhang L, Yang Y, Yu L, et al. (2011) Cardioprotective effects of Glycyrrhiza uralensis extract against doxorubicin-induced toxicity. Int J Toxicol 30, 181-189.
18. Eu CH, Lim WY, Ton SH, et al. (2010) Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids Health Dis 9, 81.
19. Chang YL, Chen CL, Kuo CL, et al. (2010) Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells. Acta Pharmacol Sin 31, 546-553.
20. Lim WY, Chia YY, Liong SY, et al. (2009) Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats. Lipids Health Dis 8, 31.
21. Haraguchi H, Ishikawa H, Mizutani K, et al. (1998) Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorg Med Chem 6, 339-347.
22. Shibata S (2000) A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 120, 849-862.
23. Kondo K, Shiba M, Yamaji H, et al. (2007) Species identification of licorice using nrDNA and cpDNA genetic markers. Biol Pharm Bull 30, 1497-1502.
24. Kuroda M, Mimaki Y, Sashida Y, et al. (2003) Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice. Bioorg Med Chem Lett 13, 4267-4272.
25. Hatano T, Shintani Y, Aga Y, et al. (2000) Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull (Tokyo) 48, 1286-1292.
26. Li J, Lim SS, Lee ES, et al. (2011) Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. Exp Biol Med (Maywood) 236, 435-444.
27. Seon MR, Park SY, Kwon SJ, et al. (2012) Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. J Nutr Biochem 23, 85-92.
28. Seon MR, Lim SS, Choi HJ, et al. (2010) Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. Mol Nutr Food Res 54, 1329-1339.
29. Seo JY, Park J, Kim HJ, et al. (2009) Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes. J Med Food 12, 1038-1045.
30. Cha BY, Shi WL, Yonezawa T, et al. (2009) An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells. J Pharmacol Sci 110, 105-110.
31. Erl W, Weber C & Hansson GK (2000) Pyrrolidine dithiocarbamate- induced apoptosis depends on cell type, density, and the presence of Cu(2 \+ ) and Zn(2 \+ ). Am J Physiol Cell Physiol 278, 1116-1125.
32. Clowes AW, Reidy MA & ClowesMM(1983) Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 49, 327-333.
33. Sherr CJ & Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13, 1501-1512.
34. dos Remedios CG, Chhabra D, Kekic M, et al. (2003) Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol Rev 83, 433-473.
35. Xiong Y, Hannon GJ, Zhang H, et al. (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704.
36. Ferns GA, Raines EW, Sprugel KH, et al. (1991) Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 253, 1129-1132.
37. Newby AC & Zaltsman AB (2000) Molecular mechanisms in intimal hyperplasia. J Pathol 190, 300-309.
38. Park JH, Lim HJ, Lee KS, et al. (2008) Anti-proliferative effect of licochalcone A on vascular smooth muscle cells. Biol Pharm Bull 31, 1996-2000.
39. Braun-Dullaeus RC, Mann MJ, Sedding DG, et al. (2004) Cell cycle-dependent regulation of smooth muscle cell activation. Arterioscler Thromb Vasc Biol 24, 845-850.
40. Sherr CJ (1996) Cancer cell cycles. Science 274, 1672-1677.
41. Jirawatnotai S, Aziyu A, Osmundson EC, et al. (2004) Cdk4 is indispensable for postnatal proliferation of the anterior pituitary. J Biol Chem 279, 51100-51106.
42. Martin A, Odajima J, Hunt SL, et al. (2005) Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell 7, 591-598.
43. Guevara NV, Chen KH & Chan L (2001) Apoptosis in atherosclerosis: pathological and pharmacological implications. Pharmacol Res 44, 59-71.
44. Wilcox JN, Smith KM, Williams LT, et al. (1998) Plateletderived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J Clin Invest 82, 1134-1143.
45. Sundaresan M, Yu ZX, Ferrans VJ, et al. (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270, 296-299.
46. Brown DI & Griendling KK (2009) Nox proteins in signal transduction. Free Radic Biol Med 47, 1239-1253.
47. Choi MH, Lee IK, Kim GW, et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435, 347-353.
48. Heldin CH & Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79, 1283-1316.
49. Lee YS, Kim SH, Kim JK, et al. (2010) Rapid identification and preparative isolation of antioxidant components in licorice. J Sep Sci 33, 664-671.
50. Hsieh CY, Liu CL, Hsu MJ, et al. (2010) Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation. Free Radic Biol Med 49, 881-893.
51. Sosroseno W, Bird PS & Seymour GJ (2003) Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW 264.7 cells). J Microbiol Immunol Infect 36, 229-235.
52. Pan W, Ikeda K, Takebe M, et al. (2001) Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr 131, 1154-1158.
53. Kim HJ, Suh HJ, Kim JH, et al. (2010) Estrogenic activity of glyceollins isolated from soybean elicited with Aspergillus sojae. J Med Food 13, 382-390.
54. Wei GL, Krasinski K, Kearney M, et al. (1997) Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty. Circ Res 80, 418-426.
55. Lavoie JN, L'Allemain G, Brunet A, et al. (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271, 20608-20616.
56. Castro C, Diez-Juan A, Cortes MJ, et al. (2003) Distinct regulation of mitogen-activated protein kinases and p27Kip1 in smooth muscle cells from different vascular beds. A potential role in establishing regional phenotypic variance. J Biol Chem 278, 4482-4490.
57. Yang Z, Madinova A, Kozai T, et al. (2002) Felodipine inhibits nuclear translocation of p42/44 mitogen-activated protein kinase and human smooth muscle cell growth. Cardiovasc Res 53, 227-231.
58. Adam RM, Borer JG, Williams J, et al. (1999) Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. Endocrinology 140, 5866-5875.
59. Jalvy S, Renault MA, Leen LL, et al. (2007) Autocrine expression of osteopontin contributes to PDGF-mediated arterial smooth muscle cell migration. Cardiovasc Res 75, 738-747.