Cardioprotective effects of Glycyrrhiza uralensis extract against doxorubicin-induced toxicity

International Journal of Toxicology

Volumn 30, Issue 2, 2011, Pages 181-189

  Zhang, Ling ^a   Yang, Yinxin ^a   Yu, Lingyan ^a   Wang, Yi ^a   Liu, Li ^a   Fan, Xiaohui ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b NONE   (China)

Author keywords

cardiotoxicity; doxorubicin; Glycyrrhiza uralensis extract

Indexed keywords

AMIFOSTINE; CREATINE KINASE ISOENZYME; DOXORUBICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLYCYRRHIZA URALENSIS EXTRACT; LACTATE DEHYDROGENASE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLYCYRRHIZA URALENSIS; HEART; HEART PROTECTION; HISTOPATHOLOGY; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CARDIOTONIC AGENTS; CARDIOTOXINS; CREATINE KINASE, MB FORM; DOXORUBICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLYCYRRHIZA URALENSIS; L-LACTATE DEHYDROGENASE; MALE; MICE; MICE, INBRED ICR; MYOCARDIUM; PLANT EXTRACTS;

GLYCYRRHIZA URALENSIS; MUS;

EID: 79955638807     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581810393033     Document Type: Article

References (39)

1. Pacher P, Liaudet L, Bai P, et al. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation. 2003 ; 107 (6). 896-904 (Pubitemid 36241050)
2. Xu MF, Tang PL, Qian ZM, Ashraf M. Effects by doxorubicin on the myocardium are mediated by oxygen free radicals. Life Sci. 2001 ; 68 (8). 889-901 (Pubitemid 32168065)
3. Oliveira PJ, Wallace KB. Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats - relevance for mitochondrial dysfunction. Toxicology. 2006 ; 220 (2-3). 160-168 (Pubitemid 43276405)
4. Lin SP, Tsai SY, Hou YC, Chao PD. Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats. J Agric Food Chem. 2009 ; 57 (5). 1854-1859
5. Kim DC, Choi SY, Kim SH, et al. Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling. Mol Pharmacol. 2006 ; 70 (2). 493-500
6. Sheela ML, Ramakrishna MK, Salimath BP. Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. Int Immunopharmacol. 2006 ; 6 (3). 494-498 (Pubitemid 43120464)
7. Kim JY, Park SJ, Yun KJ, Cho YW, Park HJ, Lee KT. Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. Eur J Pharmacol. 2008 ; 584 (1). 175-184
8. Ji XL, Jiang YX, Ren BB, Liu K, Liu G. Effect of bismuth glycyrrhizate on experimental gastric ulcers and its mechanisms. Zhongguo Zhong Yao Za Zhi. 2007 ; 32 (14). 1429-1432
9. Agarwal R, Wang ZY, Mukhtar H. Inhibition of mouse skin tumor-initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutr Cancer. 1991 ; 15 (3-4). 187-193
10. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol. 2006 ; 46 (3). 167-192 (Pubitemid 44692903)
11. Kaur P, Kaur S, Kumar N, Singh B, Kumar S. Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L. Toxicol In Vitro. 2009 ; 23 (4). 680-686
12. Chan HT, Chan C, Ho JW. Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells. Toxicology. 2003 ; 188 (2-3). 211-217 (Pubitemid 36588901)
13. Lee CK, Park KK, Lim SS, Park JH, Chung WY. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull. 2007 ; 30 (11). 2191-2195 (Pubitemid 350097049)
14. Choi HJ, Seon MR, Lim SS, Kim JS, Chun HS, Park JH. Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. Exp Biol Med (Maywood). 2008 ; 233 (12). 1554-1560
15. Yao H, Wu B, Cheng YY, Qu HB. High throughput chemiluminescence platform for evaluating antioxidative activity of total flavonoid glycosides from plant extracts. Food Chem. 2009 ; 115 (1). 380-386
16. Chen J, Zhang W, Lu T, Li J, Zheng Y, Kong L. Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice. Life Sciences. 2006 ; 78 (23). 2742-2748
17. Fujimura L, Matsudo Y, Kang M, Takamori Y, Tokuhisa T, Hatano M. Protective role of Nd1 in doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2004 ; 64 (2). 315-321 (Pubitemid 39361693)
18. Jang YM, Kendaiah S, Drew B, et al. Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. FEBS Lett. 2004 ; 577 (3). 483-490 (Pubitemid 39539206)
19. Pessah IN. Calcium release channel of sarcoplasmic reticulum: an important target for doxorubicin-mediated cardiotoxicity. Adv Exp Med Biol. 1992 ; 311: 409-410
20. Tokarska-Schlattner M, Zaugg M, Zuppinger C, Wallimann T, Schlattner U. New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics. J Mol Cell Cardiol. 2006 ; 41 (3). 389-405 (Pubitemid 44362995)
21. Dalloz F, Maingon P, Cottin Y, Briot F, Horiot JC, Rochette L. Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat. Free Radic Biol Med. 1999 ; 26 (7-8). 785-800 (Pubitemid 29198350)
22. Yagmurca M, Fadillioglu E, Erdogan H, Ucar M, Sogut S, Irmak MK. Erdosteine prevents doxorubicin-induced cardiotoxicity in rats. Pharmacol Res. 2003 ; 48 (4). 377-382 (Pubitemid 36945336)
23. Seo HJ, Jeong KS, Lee MK, et al. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life Sci. 2003 ; 73 (7). 933-946
24. Kelishomi RB, Ejtemaeemehr S, Tavangar SM, Rahimian R, Mobarakeh JI, Dehpour AR. Morphine is protective against doxorubicin-induced cardiotoxicity in rat. Toxicology. 2008 ; 243 (1-2). 96-104 (Pubitemid 350250961)
25. Frank L, Massaro D. Oxygen toxicity. Am J Med. 1980 ; 69 (1). 117-126 (Pubitemid 10084696)
26. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hofeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 ; 179 (73). 588-590
27. Anderson ME. Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact. 1998 ; 111-112: 1-14 (Pubitemid 28271929)
28. Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J. 1999 ; 13 (10). 1169-1183 (Pubitemid 29300363)
29. Injac R, Radic N, Govedarica B, et al. Acute doxorubicin pulmotoxicity in rats with malignant neoplasm is effectively treated with fullerenol C60(OH)24 through inhibition of oxidative stress. Pharmacol Rep. 2009 ; 61 (2). 335-342
30. Faine LA, Diniz YS, Almeida JA, Novelli EL, Ribas BO. Toxicity of ad lib. overfeeding: effects on cardiac tissue. Food Chem Toxicol. 2002 ; 40 (5). 663-668 (Pubitemid 34326433)
31. Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE. Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol. 2005 ; 131 (5). 561-578 (Pubitemid 43899624)
32. Speyer JL, Green MD, Kramer E, et al. Protective effect of the bispiperazinedione ICRF-187 against doxorubicin-induced cardiac toxicity in women with advanced breast cancer. N Engl J Med. 1988 ; 319 (12). 745-752
33. Herman EH, el-Hage A, Ferrans VJ. Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Toxicol Appl Pharmacol. 1988 ; 92 (1). 42-53 (Pubitemid 18049689)
34. Dorr RT, Lagel K, McLean S. Cardioprotection of rat heart myocytes with amifostine (Ethyol) and its free thiol, WR-1065, in vitro. Eur J Cancer. 1996 ; 32A (suppl 4). S21 - S25
35. Balanehru S, Nagarajan B. Intervention of adriamycin induced free radical damage. Biochem Int. 1992 ; 28 (4). 735-744 (Pubitemid 23027093)
36. Yamaguchi H, Noshita T, Yu T, et al. Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity. Eur J Med Chem. 2010 ; 45 (7). 2943-2948
37. Yu T, Yamaguchi H, Noshita T, Kidachi Y, Umetsu H, Ryoyama K. Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: potential involvement of H-Ras downregulation. Toxicol Lett. 2010 ; 192 (3). 425-430
38. Niwa K, Lian Z, Onogi K, et al. Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice. Oncol Rep. 2007 ; 17 (3). 617-622
39. Kim YH, Shin EK, Kim DH, Lee HH, Park JH, Kim JK. Antiangiogenic effect of licochalcone A. Biochem Pharmacol. 2010 ; 80 (8). 1152-1159