Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation

Free Radical Biology and Medicine

Volumn 49, Issue 5, 2010, Pages 881-893

  Hsieh, Cheng Ying ^a   Liu, Chien Liang ^b   Hsu, Ming Jen ^a   Jayakumar, Thanasekaran ^a   Chou, Duen Suey ^a   Wang, Yi Hsuan ^a,c   Hsiao, George ^a   Sheu, Joen Rong ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL CHENGCHI UNIVERSITY   (Taiwan)

Author keywords

Free radicals; Hydroxyl radical; JAK2; PLC 1; PMC; Vitamin E derivative; VSMC

Indexed keywords

6 HYDROXY 2,2,5,7,8 PENTAMETHYLCHROMAN; ALPHA TOCOPHEROL; DEFEROXAMINE; FERROUS ION; HYDROXYL RADICAL; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY INJURY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL STIMULATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FENTON REACTION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

RATTUS;

EID: 77955092406     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.06.014     Document Type: Article

References (34)

1. Hedin U., Roy J., Tran P.K. Control of smooth muscle cell proliferation in vascular disease. Curr. Opin. Lipidol. 2004, 15:559-565.
2. Ross R. Cell biology of atherosclerosis. Annu. Rev. Physiol. 1995, 57:791-804.
3. Dzau V.J., Braun-Dullaeus R.C., Sedding D.G. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat. Med. 2002, 8:1249-1256.
4. Ferns G.A., Raines E.W., Sprugel K.H., Motani A.S., Reidy M.A., Ross R. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 1991, 253:1129-1132.
5. Raines E.W. PDGF and cardiovascular disease. Cytokine Growth Factor Rev. 2004, 15:237-254.
6. Wilcox J.N., Smith K.M., Williams L.T., Schwartz S.M., Gordon D. Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J. Clin. Invest. 1988, 82:1134-1143.
7. Heldin C.H., Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 1999, 79:1283-1316.
8. Brown D.I., Griendling K.K. Nox proteins in signal transduction. Free Radic. Biol. Med. 2009, 47:1239-1253.
9. 2 for platelet-derived growth factor signal transduction. Science 1995, 270:296-299.
10. Suzuki Y.J., Packer L. Inhibition of NF-kappa B activation by vitamin E derivatives. Biochem. Biophys. Res. Commun. 1993, 193:277-283.
11. Hsiao G., Yen M.H., Lee Y.M., Sheu J.R. Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo. Br. J. Haematol. 2002, 117:699-704.
12. Hsiao G., Lee J.J., Chen Y.C., Lin J.H., Shen M.Y., Lin K.H., Chou D.S., Sheu J.R. Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. Biochem. Pharmacol. 2007, 73:682-693.
13. Pauly R.R., Bilato C., Cheng L., Monticone R., Crow M.T. Vascular smooth muscle cell cultures. Methods Cell Biol. 1997, 52:133-154.
14. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
15. Hsiao G., Lin K.H., Chang Y., Chen T.L., Tzu N.H., Chou D.S., Sheu J.R. Protective mechanisms of inosine in platelet activation and cerebral ischemic damage. Arterioscler. Thromb. Vasc. Biol. 2005, 25:1998-2004.
16. Yano K., Bauchat J.R., Liimatta M.B., Clemmons D.R., Duan C. Down-regulation of protein kinase C inhibits insulin-like growth factor I-induced vascular smooth muscle cell proliferation, migration, and gene expression. Endocrinology 1999, 140:4622-4632.
17. Chou D.S., Hsiao G., Shen M.Y., Tsai Y.J., Chen T.F., Sheu J.R. ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets. Free Radic. Biol. Med. 2005, 39:237-248.
18. Yoshida T., Azuma H., Aihara K., Fujimura M., Akaike M., Mitsui T., Matsumoto T. Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery. Atherosclerosis 2005, 178:39-47.
19. Wang Q.S., Zheng Y.M., Dong L., Ho Y.S., Guo Z., Wang Y.X. Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes. Free Radic. Biol. Med. 2007, 42:642-653.
20. Kang S.W. Two axes in platelet-derived growth factor signaling: tyrosine phosphorylation and reactive oxygen species. Cell Mol. Life Sci. 2007, 64:533-541.
21. Ingold K.U., Burton G.W., Foster D.O., Hughes L., Lindsay D.A., Webb A. Biokinetics of and discrimination between dietary RRR- and SRR-alpha-tocopherols in the male rat. Lipids 1987, 22:163-172.
22. Bjorklund M., Taipale M., Varjosalo M., Saharinen J., Lahdenpera J., Taipale J. Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature 2006, 439:1009-1013.
23. Inoue T., Node K. Molecular basis of restenosis and novel issues of drug-eluting stents. Circ. J. 2009, 73:615-621.
24. Andrae J., Gallini R., Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008, 22:1276-1312.
25. Schmitz U., Ishida M., Berk B.C. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins: characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells. Circ. Res. 1997, 81:550-557.
26. Tallquist M.D., Klinghoffer R.A., Heuchel R., Mueting-Nelsen P.F., Corrin P.D., Heldin C.H., Johnson R.J., Soriano P. Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3′-kinase and phospholipase Cgamma signaling pathways. Genes Dev. 2000, 14:3179-3190.
27. Liao H.J., de Los S.J., Carpenter G. Contrasting role of phospholipase C-γ1 in the expression of immediate early genes induced by epidermal or platelet-derived growth factors. Exp. Cell Res. 2006, 312:807-816.
28. Ha K.S., Exton J.H. Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor: a possible function for phosphatidylcholine-derived diacylglycerol. J. Biol. Chem. 1993, 268:10534-10539.
29. Jackson D.N., Foster D.A. The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival. FASEB J. 2004, 18:627-636.
30. Yeh T.C., Pellegrini S. The Janus kinase family of protein tyrosine kinases and their role in signaling. Cell Mol. Life Sci. 1999, 55:1523-1534.
31. Yellaturu C.R., Rao G.N. Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells. J. Biol. Chem. 2003, 278:9986-9992.
32. Choi M.H., Lee I.K., Kim G.W., Kim B.U., Han Y.H., Yu D.Y., Park H.S., Kim K.Y., Lee J.S., Choi C., Bae Y.S., Lee B.I., Rhee S.G., Kang S.W. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 2005, 435:347-353.
33. Simon A.R., Rai U., Fanburg B.L., Cochran B.H. Activation of the JAK-STAT pathway by reactive oxygen species. Am. J. Physiol. 1998, 275:C1640-C1652.
34. Wedgwood S., Black S.M. Combined superoxide dismutase/catalase mimetics alter fetal pulmonary arterial smooth muscle cell growth. Antioxid. Redox Signaling 2004, 6:191-197.