Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-B pathways in TNF-α-activated endothelial cells

Acta Pharmacologica Sinica

Volumn 31, Issue 5, 2010, Pages 546-553

  Chang, Ying Ling ^a   Chen, Chien Lin ^a,b   Kuo, Chao Lin ^c   Chen, Bor Chyuan ^d   You, Jyh Sheng ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d Department of Radiation Oncology   (Taiwan)

Author keywords

Glycyrrhetinic acid; Intercellular adhesion molecule 1; Mitogen activated protein kinases; Tumor necrosis factor nuclear factor B

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLYCYRRHETINIC ACID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL COUNT; CELL NUCLEUS; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GLYCYRRHIZA GLABRA; HUMAN; HUMAN CELL; MONOCYTE; PHARMACOLOGICAL BLOCKING; PLANT ROOT; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIOACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCINTILLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULITIS; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELL LINE; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCYRRHETINIC ACID; GLYCYRRHIZA; HUMANS; I-KAPPA B KINASE; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; PLANT ROOTS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 77952036094     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.34     Document Type: Article

References (33)

1. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D, et al. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 1993;171:223-9.
2. Szekanecz Z, Haines GK, Lin TR, Harlow LA, Goerdt S, Rayan G, et al. Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia. Their possible pathogenetic and clinical signifcance in rheumatoid arthritis. Arthritis Rheum 1994;37:221-31.
3. Stanciu LA, Djukanovic R. The role of ICAM-1 on T-cells in the pathogenesis of asthma. Eur Respir J 1998;11:949-57.
4. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev 1990;70:427-51.
5. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-14.
6. Kobuchi H, Roy S, Sen CK, Nguyen HG, Packer L. Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am J Physiol 1999;277(3 Pt 1): C403-11.
7. Lin SJ, Shyue SK, Hung YY, Chen YS, Ku HH, Chen JW, et al. Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-α in human endothelial cells through the JNK/p38 pathways. Arterioscler Thromb Vasc Biol 2005;25:334-40.
8. Min JK, Kim YM, Kim SW, Kwon MC, Kong YY, Hwang IK, et al. TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells. J Immunol 2005;175:531-40.
9. Hoefen RJ, Berk BC. The role of MAP kinases in endothelial activation. Vasc Pharmacol 2002;38:271-3.
10. Wong CK, Tsang CM, Ip WK, Lam CW. Molecular mechanisms for the releases of chemokines from human leukemic mast cell line (HMC) - 1 cells activated by SCF and TNF-alpha: roles of ERK, p38 MAPK, and NF-kappaB. Allergy 2006;61:289-97.
11. 2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol 2003;23:2871-82.
12. Ohuchi K, Kamada Y, Tsurufuji S. Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats. Prostaglandins Med 1981;7:457-63.
13. Lee YM, Hirota S, Jippo-Kanemoto T, Kim HR, Shin TY, Yeon Y, et al. Inhibition of histamine synthesis by glycyrrhetinic acid in mast cells cocultured with Swii 3T3 fibroblasts. Int Arch Allergy Immunol 1996;110:272-7.
14. Matsui S, Matsumoto H, Sonoda Y, Ando K, Aizu-Yokota E, Sato T, et al. Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Int Immunopharmacol 2004;4:1633-44.
15. Zakirov UB, Abdullaev AKh. The hypolipidemic and antiatherosclerotic properties of the ammonium salt of glycyrrhetic acid and of 18- dehydroglycyrrhetic acid. Eksp Klin Farmakol 1996;59:53-5.
16. Véliz LP, González FG, Duling BR, Sáez JC, Boric MP. Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo. Am J Physiol Heart Circ Physiol 2008;295: H1056-H1066.
17. Zheng QZ, Lou YJ. Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and protective effect of glycyrrhizin in vitro. Acta Pharmacol Sin 2003;24:771-7.
18. Yuan H, Ji WS, Wu KX, Jiao JX, Sun LH, Feng YT. Anti-infammatory effect of diammonium glycyrrhizinate in a rat model of ulcerative colitis. World J Gastroenterol 2006;12:4578-81.
19. Gupta B, Ghosh B. Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells. Int J Immunopharmacol 1999;21:745-57.
20. Chang YL, Shen JJ, Wung BS, Cheng JJ, Wang DL. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Mol Pharmacol 2001;60:507-13.
21. De Cesaris P, Starace D, Starace G, Filippini A, Stefanini M, Ziparo E. Activation of Jun. N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor α leads to intercellular adhesion molecule-1 expression. J Biol Chem 1999;274:28978-82.
22. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-6.
23. Gumpricht E, Dahl R, Devereaux MW, Sokol RJ. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. J Biol Chem 2005;280:10556-63.
24. Baldwin AS. The NF-κB, and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.
25. Karin M, Delhase M. JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action? Proc Natl Acad Sci USA 1998;95:9067-9.
26. Lee, FS, Hagler J, Chen ZJ, Maniatis T. Activation of the IκB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 1997;88:213-22.
27. Modur V, Zimmerman GA, Prescott SM, McIntyre TM. Endothelial cell infammatory responses to tumor necrosis factor alpha. Ceramidedependent and-independent mitogen-activated protein kinase cascades. J Biol Chem 1996;271:13094-102.
28. Fan J, Frey RS, Rahman A, Malik AB. Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-α-induced NF-κB activation and intercellular adhesion molecule-1 expression in endothelial cells. J Biol Chem 2002;277:3404-11.
29. Sasaki M, Ostanin D, Elrod JW, Oshima T, Jordan P, Itoh M, et al. TNF-alpha-induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent. Am J Physiol Cell Physiol 2003;284: C422-8.
30. Ablise M, Leininger-Muller B, Wong CD, Siest G, Loppinet V, Visvikis S. Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system. Chem Pharm Bull (Tokyo) 2004;52:1436-9.
31. Cybulsky MI, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991;251:788-91.
32. Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, et al. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J Clin Invest 1996;97:1715-22.
33. Aviram B, Volkova N, Kaplan M, Presser D, Attias J, Hayek T, et al. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifcations, reduced plasma lipid levels, and decreased systolic blood pressure. Nutrition 2002;18:268-73.