Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging

Journal of Neuroscience

Volumn 33, Issue 31, 2013, Pages 12792-12804

  Ménard, Caroline ^a   Tse, Yiu Chung ^a   Cavanagh, Chelsea ^a   Chabot, Jean Guy ^a   Herzog, Herbert ^b   Schwarzer, Christoph ^c   Wong, Tak Pan ^a   Quirion, Rémi ^a  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL) PYRIDINE; DYNORPHIN; METABOTROPIC RECEPTOR; NORBINALTORPHIMINE; PRODYNORPHIN; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; ELECTROPHYSIOLOGY; GENE; GENE SILENCING; GENOTYPE; GENOTYPING TECHNIQUE; HIPPOCAMPUS; HYPOTHERMIA; IMMUNOCYTOCHEMISTRY; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PRODYNORPHIN GENE; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; SPATIAL MEMORY; WESTERN BLOTTING;

AGING; ANIMALS; ANXIETY; BENZAMIDES; BENZPHETAMINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBRAL CORTEX; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENKEPHALINS; EXCITATORY AMINO ACID ANTAGONISTS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; HIPPOCAMPUS; LONG-TERM SYNAPTIC DEPRESSION; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN PRECURSORS; PYRAZOLES; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RECOGNITION (PSYCHOLOGY);

EID: 84880817069     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0290-13.2013     Document Type: Article

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