Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

European Journal of Pharmacology

Volumn 639, Issue 1-3, 2010, Pages 40-46

  Rosenbrock, Holger ^a   Kramer, Gert ^a   Hobson, Scott ^a   Koros, Eliza ^a   Grundl, Marc ^a   Grauert, Matthias ^a   Reymann, Klaus G ^b   Schröder, Ulrich H ^b  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

Author keywords

ADX 47273; Long term potentiation; Metabotropic glutamate receptor 5; MGlu5 receptor; NMDA(N methyl D aspartate) receptor; Positive allosteric modulator

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; [(4 FLUORO PHENYL) [3 (3 8FLUOROPHENYL) [1,2,4] OXADIAZOL 5 YL]PIPERIDIN 1 YL]METHANONE; ADX 47273; CALCIUM ION; KETAMINE; METABOTROPIC RECEPTOR 5; UNCLASSIFIED DRUG; 3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; AMINO ACID RECEPTOR STIMULATING AGENT; CALCIUM; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXADIAZOLE DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE; S-(4-FLUOROPHENYL)-(3-(3-(4-FLUOROPHENYL)-(1,2,4)-OXADIAZOL-5-YL)PIPERIDIN-1-YL)METHANONE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; DRUG POTENTIATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LOCOMOTION; LONG TERM POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; COGNITION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; WISTAR RAT;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MALE; METHOXYHYDROXYPHENYLGLYCOL; NEURONS; OXADIAZOLES; PHOSPHORYLATION; PIPERIDINES; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SRC-FAMILY KINASES; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 77953618742     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.02.057     Document Type: Article

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