메뉴 건너뛰기




Volumn 28, Issue 11, 2007, Pages 1700-1708

Dysregulation of dynorphins in Alzheimer disease

Author keywords

7B2; Alzheimer disease; Cognition; Dynorphin; Excitotoxicity; Neurodegeneration; Pro hormone convertase 2; Prodynorphin

Indexed keywords

DYNORPHIN A; DYNORPHIN B; NEUROPEPTIDE; NOCICEPTIN; PRODYNORPHIN; PROTEIN PRECURSOR;

EID: 34548595584     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.07.002     Document Type: Article
Times cited : (57)

References (74)
  • 1
    • 0035882519 scopus 로고    scopus 로고
    • Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2
    • Allen R.G., Peng B., Pellegrino M.J., Miller E.D., Grandy D.K., Lundblad J.R., et al. Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2. J Neurosci 21 (2001) 5864-5870
    • (2001) J Neurosci , vol.21 , pp. 5864-5870
    • Allen, R.G.1    Peng, B.2    Pellegrino, M.J.3    Miller, E.D.4    Grandy, D.K.5    Lundblad, J.R.6
  • 2
    • 0028981286 scopus 로고
    • [Leu5]enkephalin-encoding sequences are targets for a specific DNA-binding factor
    • Bakalkin G., Telkov M., Yakovleva T., and Terenius L. [Leu5]enkephalin-encoding sequences are targets for a specific DNA-binding factor. Proc Natl Acad Sci USA 92 (1995) 9024-9028
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9024-9028
    • Bakalkin, G.1    Telkov, M.2    Yakovleva, T.3    Terenius, L.4
  • 3
    • 0027731839 scopus 로고
    • Opioid receptor density changes in Alzheimer amygdala and putamen
    • Barg J., Belcheva M., Rowinski J., Ho A., Burke W.J., Chung H.D., et al. Opioid receptor density changes in Alzheimer amygdala and putamen. Brain Res 632 (1993) 209-215
    • (1993) Brain Res , vol.632 , pp. 209-215
    • Barg, J.1    Belcheva, M.2    Rowinski, J.3    Ho, A.4    Burke, W.J.5    Chung, H.D.6
  • 4
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 163 (2000) 495-529
    • (2000) Exp Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 5
    • 0027368472 scopus 로고
    • Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2
    • Benjannet S., Rondeau N., Paquet L., Boudreault A., Lazure C., Chretien M., et al. Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. Biochem J 294 (1993) 735-743
    • (1993) Biochem J , vol.294 , pp. 735-743
    • Benjannet, S.1    Rondeau, N.2    Paquet, L.3    Boudreault, A.4    Lazure, C.5    Chretien, M.6
  • 6
    • 0032934832 scopus 로고    scopus 로고
    • Dynorphin A processing enzyme: tissue distribution, isolation and characterization
    • Berman Y., Ageyeva L., Veksler B., Wood D., and Devi L.A. Dynorphin A processing enzyme: tissue distribution, isolation and characterization. J Biochem 125 (1999) 641-647
    • (1999) J Biochem , vol.125 , pp. 641-647
    • Berman, Y.1    Ageyeva, L.2    Veksler, B.3    Wood, D.4    Devi, L.A.5
  • 8
    • 0021797088 scopus 로고
    • A general procedure for analysis of proenkephalin B derived opioid peptides
    • Christensson-Nylander I., Nyberg F., Ragnarsson U., and Terenius L. A general procedure for analysis of proenkephalin B derived opioid peptides. Regul Pept 11 (1985) 65-76
    • (1985) Regul Pept , vol.11 , pp. 65-76
    • Christensson-Nylander, I.1    Nyberg, F.2    Ragnarsson, U.3    Terenius, L.4
  • 11
    • 0019256571 scopus 로고
    • Reduced somatostatin-like-immunoreactivity in cerebral cortex from cases of Alzheimer's disease and Alzheimer's senile dementia
    • Davies P., Katzman R., and Terry R.D. Reduced somatostatin-like-immunoreactivity in cerebral cortex from cases of Alzheimer's disease and Alzheimer's senile dementia. Nature 288 (1980) 279-280
    • (1980) Nature , vol.288 , pp. 279-280
    • Davies, P.1    Katzman, R.2    Terry, R.D.3
  • 12
    • 0024588468 scopus 로고
    • The posttranslational processing of prodynorphin in the rat anterior pituitary
    • Day R., and Akil H. The posttranslational processing of prodynorphin in the rat anterior pituitary. Endocrinology 124 (1989) 2392-2405
    • (1989) Endocrinology , vol.124 , pp. 2392-2405
    • Day, R.1    Akil, H.2
  • 13
    • 0031985151 scopus 로고    scopus 로고
    • Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
    • Day R., Lazure C., Basak A., Boudreault A., Limperis P., Dong W., et al. Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity. J Biol Chem 273 (1998) 829-836
    • (1998) J Biol Chem , vol.273 , pp. 829-836
    • Day, R.1    Lazure, C.2    Basak, A.3    Boudreault, A.4    Limperis, P.5    Dong, W.6
  • 14
    • 0026601969 scopus 로고
    • Dynorphin increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism
    • Faden A.I. Dynorphin increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism. J Neurosci 12 (1992) 425-429
    • (1992) J Neurosci , vol.12 , pp. 425-429
    • Faden, A.I.1
  • 16
    • 0021800219 scopus 로고
    • Alzheimer's disease and senile dementia: biochemical characteristics and aspects of treatment
    • Gottfries C.G. Alzheimer's disease and senile dementia: biochemical characteristics and aspects of treatment. Psychopharmacology (Berl) 86 (1985) 245-252
    • (1985) Psychopharmacology (Berl) , vol.86 , pp. 245-252
    • Gottfries, C.G.1
  • 17
    • 0024363934 scopus 로고
    • Excitatory amino acids and Alzheimer's disease
    • Greenamyre J.T., and Young A.B. Excitatory amino acids and Alzheimer's disease. Neurobiol Aging 10 (1989) 593-602
    • (1989) Neurobiol Aging , vol.10 , pp. 593-602
    • Greenamyre, J.T.1    Young, A.B.2
  • 18
    • 0031781988 scopus 로고    scopus 로고
    • Regional distribution of neuritic plaques in non-demented elderly and cases of very mild Alzheimer's disease
    • Haroutunian V., Perl D.P., Purohit D.P., Marin D.B., Khan K., Lantz M., et al. Regional distribution of neuritic plaques in non-demented elderly and cases of very mild Alzheimer's disease. Arch Neurol 55 (1998) 1185-1191
    • (1998) Arch Neurol , vol.55 , pp. 1185-1191
    • Haroutunian, V.1    Perl, D.P.2    Purohit, D.P.3    Marin, D.B.4    Khan, K.5    Lantz, M.6
  • 20
    • 0035120270 scopus 로고    scopus 로고
    • Structure-activity analysis of dynorphin A toxicity in spinal cord neurons: intrinsic neurotoxicity of dynorphin A and its carboxyl-terminal, non-opioid metabolites
    • Hauser K.F., Knapp P.E., and Turbek C.S. Structure-activity analysis of dynorphin A toxicity in spinal cord neurons: intrinsic neurotoxicity of dynorphin A and its carboxyl-terminal, non-opioid metabolites. Exp Neurol 168 (2001) 78-87
    • (2001) Exp Neurol , vol.168 , pp. 78-87
    • Hauser, K.F.1    Knapp, P.E.2    Turbek, C.S.3
  • 21
    • 0031932526 scopus 로고    scopus 로고
    • Reversion of muscarinic autoreceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1-13), an endogenous κ-opioid receptor agonist
    • Hiramatsu M., Murasawa H., Mori H., and Kameyama T. Reversion of muscarinic autoreceptor agonist-induced acetylcholine decrease and learning impairment by dynorphin A (1-13), an endogenous κ-opioid receptor agonist. Brit J Pharmacol 123 (1998) 920-926
    • (1998) Brit J Pharmacol , vol.123 , pp. 920-926
    • Hiramatsu, M.1    Murasawa, H.2    Mori, H.3    Kameyama, T.4
  • 24
    • 0023216098 scopus 로고
    • Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: brain concentrations in controls and patients with Alzheimer's disease
    • Iguchi H., Chan J.S., Seidah N.G., and Chretien M. Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: brain concentrations in controls and patients with Alzheimer's disease. Peptides 8 (1987) 593-598
    • (1987) Peptides , vol.8 , pp. 593-598
    • Iguchi, H.1    Chan, J.S.2    Seidah, N.G.3    Chretien, M.4
  • 25
    • 0024566999 scopus 로고
    • Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task
    • Jiang H.K., Owyang V.V., Hong J.S., and Gallagher M. Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task. Proc Natl Acad Sci USA 86 (1989) 2948-2951
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2948-2951
    • Jiang, H.K.1    Owyang, V.V.2    Hong, J.S.3    Gallagher, M.4
  • 26
    • 0032575631 scopus 로고    scopus 로고
    • Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates
    • Johanning K., Juliano M.A., Juliano L., Lazure C., Lamango N.S., Steiner D.F., et al. Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates. J Biol Chem 273 (1998) 22672-22680
    • (1998) J Biol Chem , vol.273 , pp. 22672-22680
    • Johanning, K.1    Juliano, M.A.2    Juliano, L.3    Lazure, C.4    Lamango, N.S.5    Steiner, D.F.6
  • 29
    • 34548546242 scopus 로고    scopus 로고
    • Kuzmin A, Madjid N, Terenius L, Ogren SO, Bakalkin G. Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice. Neuropsychopharmacology, 2005, [Epub ahead of print].
  • 30
    • 0036830947 scopus 로고    scopus 로고
    • Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
    • LaFerla F.M. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 3 (2002) 862-872
    • (2002) Nat Rev Neurosci , vol.3 , pp. 862-872
    • LaFerla, F.M.1
  • 31
    • 1542313858 scopus 로고    scopus 로고
    • Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
    • Louzada P.R., Lima A.C., Mendonca-Silva D.L., Noel F., De Mello F.G., and Ferreira S.T. Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders. FASEB J 18 (2004) 511-518
    • (2004) FASEB J , vol.18 , pp. 511-518
    • Louzada, P.R.1    Lima, A.C.2    Mendonca-Silva, D.L.3    Noel, F.4    De Mello, F.G.5    Ferreira, S.T.6
  • 32
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue L.F., Kuo Y.M., Roher A.E., Brachova L., Shen Y., Sue L., et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155 (1999) 853-862
    • (1999) Am J Pathol , vol.155 , pp. 853-862
    • Lue, L.F.1    Kuo, Y.M.2    Roher, A.E.3    Brachova, L.4    Shen, Y.5    Sue, L.6
  • 33
    • 22544461345 scopus 로고    scopus 로고
    • Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission
    • Marinova Z., Vukojevic V., Surcheva S., Yakovleva T., Cebers G., Pasikova N., et al. Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission. J Biol Chem 280 (2005) 26360-26370
    • (2005) J Biol Chem , vol.280 , pp. 26360-26370
    • Marinova, Z.1    Vukojevic, V.2    Surcheva, S.3    Yakovleva, T.4    Cebers, G.5    Pasikova, N.6
  • 35
    • 0035793936 scopus 로고    scopus 로고
    • Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients
    • Mathieu-Kia A.M., Fan L.Q., Kreek M.J., Simon E.J., and Hiller J.M. Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. Brain Res 893 (2001) 121-134
    • (2001) Brain Res , vol.893 , pp. 121-134
    • Mathieu-Kia, A.M.1    Fan, L.Q.2    Kreek, M.J.3    Simon, E.J.4    Hiller, J.M.5
  • 36
    • 0026570528 scopus 로고
    • Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., and Rydel R.E. Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12 (1992) 376-389
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 37
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean C.A., Cherny R.A., Fraser F.W., Fuller S.J., Smith M.J., Beyreuther K., et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46 (1999) 860-866
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3    Fuller, S.J.4    Smith, M.J.5    Beyreuther, K.6
  • 38
    • 33644962688 scopus 로고    scopus 로고
    • Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor
    • Merg F., Filliol D., Usynin I., Bazov I., Bark N., Hurd Y.L., et al. Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor. J. Neurochem 97 (2006) 292-301
    • (2006) J. Neurochem , vol.97 , pp. 292-301
    • Merg, F.1    Filliol, D.2    Usynin, I.3    Bazov, I.4    Bark, N.5    Hurd, Y.L.6
  • 39
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part II: standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II: standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41 (1991) 479-486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6
  • 40
    • 0027425211 scopus 로고
    • The clinical dementia rating (CDR): current version and scoring rules
    • Morris J.C. The clinical dementia rating (CDR): current version and scoring rules. Arch Neurol 43 (1993) 2412-2414
    • (1993) Arch Neurol , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 41
    • 0021988724 scopus 로고
    • Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients
    • Morrison J.H., Rogers J., Scherr S., Benoit R., and Bloom F.E. Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients. Nature 314 (1985) 90-92
    • (1985) Nature , vol.314 , pp. 90-92
    • Morrison, J.H.1    Rogers, J.2    Scherr, S.3    Benoit, R.4    Bloom, F.E.5
  • 42
    • 0032605954 scopus 로고    scopus 로고
    • The cell biology of the prohormone convertases PC1 and PC2
    • Muller L., and Lindberg I. The cell biology of the prohormone convertases PC1 and PC2. Prog Nucl Acid Res Mol Biol 63 (1999) 69-108
    • (1999) Prog Nucl Acid Res Mol Biol , vol.63 , pp. 69-108
    • Muller, L.1    Lindberg, I.2
  • 43
    • 21144445957 scopus 로고    scopus 로고
    • Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance
    • Nguyen X.V., Masse J., Kumar A., Vijitruth R., Kulik C., Liu M., et al. Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance. Behav Brain Res 161 (2005) 254-262
    • (2005) Behav Brain Res , vol.161 , pp. 254-262
    • Nguyen, X.V.1    Masse, J.2    Kumar, A.3    Vijitruth, R.4    Kulik, C.5    Liu, M.6
  • 44
    • 24644441152 scopus 로고    scopus 로고
    • Prodynorphin transcripts and proteins differentially expressed and regulated in the adult human brain
    • Nikoshkov A., Hurd Y.L., Yakovleva T., Bazov I., Marinova Z., Cebers G., et al. Prodynorphin transcripts and proteins differentially expressed and regulated in the adult human brain. FASEB J 19 (2005) 1543-1545
    • (2005) FASEB J , vol.19 , pp. 1543-1545
    • Nikoshkov, A.1    Hurd, Y.L.2    Yakovleva, T.3    Bazov, I.4    Marinova, Z.5    Cebers, G.6
  • 45
    • 0028940701 scopus 로고
    • The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats
    • Nylander I., Vlaskovska M., and Terenius L. The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats. Psychopharmacology (Berl) 118 (1995) 391-400
    • (1995) Psychopharmacology (Berl) , vol.118 , pp. 391-400
    • Nylander, I.1    Vlaskovska, M.2    Terenius, L.3
  • 46
    • 0345512210 scopus 로고
    • Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease
    • Pearson R.C., Esiri M.M., Hiorns R.W., Wilcock G.K., and Powell T.P. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc. Natl Acad Sci USA 82 (1985) 4531-4534
    • (1985) Proc. Natl Acad Sci USA , vol.82 , pp. 4531-4534
    • Pearson, R.C.1    Esiri, M.M.2    Hiorns, R.W.3    Wilcock, G.K.4    Powell, T.P.5
  • 47
    • 0034665588 scopus 로고    scopus 로고
    • Basal levels and alcohol-induced changes in nociceptin/orphanin FQ, dynorphin, and enkephalin levels in C57BL/6J mice
    • Ploj K., Roman E., Gustavsson L., and Nylander I. Basal levels and alcohol-induced changes in nociceptin/orphanin FQ, dynorphin, and enkephalin levels in C57BL/6J mice. Brain Res Bull 53 (2000) 219-226
    • (2000) Brain Res Bull , vol.53 , pp. 219-226
    • Ploj, K.1    Roman, E.2    Gustavsson, L.3    Nylander, I.4
  • 49
    • 29144492108 scopus 로고    scopus 로고
    • Ancient and recent positive selection transformed opioid cis-regulation in humans
    • e387
    • Rockman M.V., Hahn M.W., Soranzo N., Zimprich F., Goldstein D.B., and Wray G.A. Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biol 3 (2005) 1-12 e387
    • (2005) PLoS Biol , vol.3 , pp. 1-12
    • Rockman, M.V.1    Hahn, M.W.2    Soranzo, N.3    Zimprich, F.4    Goldstein, D.B.5    Wray, G.A.6
  • 50
    • 17644425569 scopus 로고    scopus 로고
    • Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation
    • Saito T., Iwata N., Tsubuki S., Takaki Y., Takano J., Huang S.M., et al. Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med 11 (2005) 434-439
    • (2005) Nat Med , vol.11 , pp. 434-439
    • Saito, T.1    Iwata, N.2    Tsubuki, S.3    Takaki, Y.4    Takano, J.5    Huang, S.M.6
  • 51
    • 0031050078 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats
    • Sandin J., Georgieva J., Schott P.A., Ogren S.O., and Terenius L. Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats. Eur J Neurosci 9 (1997) 194-197
    • (1997) Eur J Neurosci , vol.9 , pp. 194-197
    • Sandin, J.1    Georgieva, J.2    Schott, P.A.3    Ogren, S.O.4    Terenius, L.5
  • 52
    • 0032495806 scopus 로고    scopus 로고
    • Hippocampal dynorphin B injections impair spatial learning in rats: a κ-opioid receptor-mediated effect
    • Sandin J., Nylander I., Georgieva J., Schott P.A., Ogren S.O., and Terenius L. Hippocampal dynorphin B injections impair spatial learning in rats: a κ-opioid receptor-mediated effect. Neuroscience 85 (1998) 375-382
    • (1998) Neuroscience , vol.85 , pp. 375-382
    • Sandin, J.1    Nylander, I.2    Georgieva, J.3    Schott, P.A.4    Ogren, S.O.5    Terenius, L.6
  • 53
    • 0346725080 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ modulates spatial learning via ORL-1 receptors in the dorsal hippocampus of the rat
    • Sandin J., Ogren S.O., and Terenius L. Nociceptin/orphanin FQ modulates spatial learning via ORL-1 receptors in the dorsal hippocampus of the rat. Brain Res 997 (2004) 222-233
    • (2004) Brain Res , vol.997 , pp. 222-233
    • Sandin, J.1    Ogren, S.O.2    Terenius, L.3
  • 54
    • 0030724785 scopus 로고    scopus 로고
    • Differential metabolism of dynorphins in substantia nigra, striatum, and hippocampus
    • Sandin J., Tan-No K., Kasakov L., Nylander I., Winter A., Silberring J., et al. Differential metabolism of dynorphins in substantia nigra, striatum, and hippocampus. Peptides 18 (1997) 949-956
    • (1997) Peptides , vol.18 , pp. 949-956
    • Sandin, J.1    Tan-No, K.2    Kasakov, L.3    Nylander, I.4    Winter, A.5    Silberring, J.6
  • 55
    • 0028080298 scopus 로고
    • Non-opioid effects of dynorphins: possible role of the NMDA receptor
    • Shukla V.K., and Lemaire S. Non-opioid effects of dynorphins: possible role of the NMDA receptor. Trends Pharmacol Sci 15 (1994) 420-424
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 420-424
    • Shukla, V.K.1    Lemaire, S.2
  • 56
    • 0026785317 scopus 로고
    • Characterization of dynorphin A-converting enzyme in human spinal cord
    • Silberring J., Castello M.E., and Nyberg F. Characterization of dynorphin A-converting enzyme in human spinal cord. J Biol Chem 267 (1992) 21324-21328
    • (1992) J Biol Chem , vol.267 , pp. 21324-21328
    • Silberring, J.1    Castello, M.E.2    Nyberg, F.3
  • 57
    • 0024410213 scopus 로고
    • A novel bovine spinal cord endoprotease with high specificity for dynorphin B
    • Silberring J., and Nyberg F. A novel bovine spinal cord endoprotease with high specificity for dynorphin B. J Biol Chem 264 (1989) 11082-11086
    • (1989) J Biol Chem , vol.264 , pp. 11082-11086
    • Silberring, J.1    Nyberg, F.2
  • 58
    • 10744229214 scopus 로고    scopus 로고
    • Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation
    • Singh I.N., Goody R.J., Goebel S.M., Martin K.M., Knapp P.E., Marinova Z., et al. Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation. Neuroscience 122 (2003) 1013-1023
    • (2003) Neuroscience , vol.122 , pp. 1013-1023
    • Singh, I.N.1    Goody, R.J.2    Goebel, S.M.3    Martin, K.M.4    Knapp, P.E.5    Marinova, Z.6
  • 60
    • 0026605218 scopus 로고
    • Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity
    • Skilling S.R., Sun X., Kurtz H.J., and Larson A.A. Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity. Brain Res 575 (1992) 272-278
    • (1992) Brain Res , vol.575 , pp. 272-278
    • Skilling, S.R.1    Sun, X.2    Kurtz, H.J.3    Larson, A.A.4
  • 61
    • 0034128003 scopus 로고    scopus 로고
    • Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism
    • Tang Q., Lynch R.M., Porreca F., and Lai J. Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism. J Neurophysiol 83 (2000) 2610-2615
    • (2000) J Neurophysiol , vol.83 , pp. 2610-2615
    • Tang, Q.1    Lynch, R.M.2    Porreca, F.3    Lai, J.4
  • 63
    • 23044468691 scopus 로고    scopus 로고
    • The synaptic Aβ hypothesis of alzheimer disease
    • Tanzi R.E. The synaptic Aβ hypothesis of alzheimer disease. Nat Neurosci 8 (2005) 977-979
    • (2005) Nat Neurosci , vol.8 , pp. 977-979
    • Tanzi, R.E.1
  • 64
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30 (1991) 572-580
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6
  • 65
    • 0031081066 scopus 로고    scopus 로고
    • Effects of the κ-opioid dynorphin A(1-13) on learning and memory in mice
    • Ukai M., Itoh J., Kobayashi T., Shinkai N., and Kameyama T. Effects of the κ-opioid dynorphin A(1-13) on learning and memory in mice. Behav Brain Res 83 (1997) 169-172
    • (1997) Behav Brain Res , vol.83 , pp. 169-172
    • Ukai, M.1    Itoh, J.2    Kobayashi, T.3    Shinkai, N.4    Kameyama, T.5
  • 66
    • 17344385566 scopus 로고    scopus 로고
    • Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone
    • Vanderah T.W., Laughlin T., Lashbrook J.M., Nichols M.L., Wilcox G.L., Ossipov M.H., et al. Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain 68 (1996) 275-281
    • (1996) Pain , vol.68 , pp. 275-281
    • Vanderah, T.W.1    Laughlin, T.2    Lashbrook, J.M.3    Nichols, M.L.4    Wilcox, G.L.5    Ossipov, M.H.6
  • 68
    • 0034028488 scopus 로고    scopus 로고
    • Concurrent modulation of anxiety and memory
    • Wall P.M., and Messier C. Concurrent modulation of anxiety and memory. Behav Brain Res 109 (2000) 229-241
    • (2000) Behav Brain Res , vol.109 , pp. 229-241
    • Wall, P.M.1    Messier, C.2
  • 69
    • 0032837741 scopus 로고    scopus 로고
    • The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging
    • Wang J., Dickson D.W., Trojanowski J.Q., and Lee V.M. The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging. Exp Neurol 158 (1999) 328-337
    • (1999) Exp Neurol , vol.158 , pp. 328-337
    • Wang, J.1    Dickson, D.W.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 70
    • 0344398367 scopus 로고
    • Immunohistochemical distribution of α-neo-endorphin/dynorphin neuronal systems in rat brain: evidence for colocalization
    • Weber E., Roth K.A., and Barchas J.D. Immunohistochemical distribution of α-neo-endorphin/dynorphin neuronal systems in rat brain: evidence for colocalization. Proc Natl Acad Sci USA 79 (1982) 3062-3066
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 3062-3066
    • Weber, E.1    Roth, K.A.2    Barchas, J.D.3
  • 71
    • 0033525771 scopus 로고    scopus 로고
    • The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
    • Westphal C.H., Muller L., Zhou A., Zhu X., Bonner-Weir S., Schambelan M., et al. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell 96 (1999) 689-700
    • (1999) Cell , vol.96 , pp. 689-700
    • Westphal, C.H.1    Muller, L.2    Zhou, A.3    Zhu, X.4    Bonner-Weir, S.5    Schambelan, M.6
  • 72
    • 10744221721 scopus 로고    scopus 로고
    • The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease
    • Winsky-Sommerer R., Grouselle D., Rougeot C., Laurent V., David J.P., Delacourte A., et al. The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease. Neuroscience 122 (2003) 437-447
    • (2003) Neuroscience , vol.122 , pp. 437-447
    • Winsky-Sommerer, R.1    Grouselle, D.2    Rougeot, C.3    Laurent, V.4    David, J.P.5    Delacourte, A.6
  • 73
    • 34548576736 scopus 로고    scopus 로고
    • Yakovleva T, Bazov I, Cebers G, Marinova Z, Hara Y, Ahmed A, et al. Prodynorphin storage and processing in axon terminals and dendrites. FASEB J, in press.
  • 74
    • 0029075455 scopus 로고
    • 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity
    • Zhu X., and Lindberg I. 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. J Cell Biol 129 (1995) 1641-1650
    • (1995) J Cell Biol , vol.129 , pp. 1641-1650
    • Zhu, X.1    Lindberg, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.