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Volumn 241, Issue 1, 2013, Pages 27-31

Significant increase in anxiety during aging in mGlu5 receptor knockout mice

Author keywords

Aging; Anxiety; Deletion; Depression; Genetic; MGlu5

Indexed keywords

METABOTROPIC RECEPTOR 5;

EID: 84871833960     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.11.042     Document Type: Article
Times cited : (29)

References (24)
  • 3
    • 0032853255 scopus 로고    scopus 로고
    • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
    • Gasparini F., Lingenhohl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 1999, 38:1493-1503.
    • (1999) Neuropharmacology , vol.38 , pp. 1493-1503
    • Gasparini, F.1    Lingenhohl, K.2    Stoehr, N.3    Flor, P.J.4    Heinrich, M.5    Vranesic, I.6
  • 4
    • 0035069188 scopus 로고    scopus 로고
    • Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    • Tatarczynska E., Klodzinska A., Chojnacka-Wojcik E., Palucha A., Gasparini F., Kuhn R., et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. British Journal of Pharmacology 2001, 132:1423-1430.
    • (2001) British Journal of Pharmacology , vol.132 , pp. 1423-1430
    • Tatarczynska, E.1    Klodzinska, A.2    Chojnacka-Wojcik, E.3    Palucha, A.4    Gasparini, F.5    Kuhn, R.6
  • 5
    • 33751190762 scopus 로고    scopus 로고
    • Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
    • Belozertseva I.V., Kos T., Popik P., Danysz W., Bespalov A.Y. Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests. European Neuropsychopharmacology 2007, 17:172-179.
    • (2007) European Neuropsychopharmacology , vol.17 , pp. 172-179
    • Belozertseva, I.V.1    Kos, T.2    Popik, P.3    Danysz, W.4    Bespalov, A.Y.5
  • 6
    • 33748999574 scopus 로고    scopus 로고
    • Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice
    • Li X., Need A.B., Baez M., Witkin J.M. Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice. Journal of Pharmacology and Experimental Therapeutics 2006, 319:254-259.
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.319 , pp. 254-259
    • Li, X.1    Need, A.B.2    Baez, M.3    Witkin, J.M.4
  • 7
    • 0033680311 scopus 로고    scopus 로고
    • Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents
    • Spooren W.P., Vassout A., Neijt H.C., Kuhn R., Gasparini F., Roux S., et al. Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents. Journal of Pharmacology and Experimental Therapeutics 2000, 295:1267-1275.
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.295 , pp. 1267-1275
    • Spooren, W.P.1    Vassout, A.2    Neijt, H.C.3    Kuhn, R.4    Gasparini, F.5    Roux, S.6
  • 8
    • 84857064144 scopus 로고    scopus 로고
    • The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug
    • Inta D., Filipovic D., Lima-Ojeda J.M., Dormann C., Pfeiffer N., Gasparini F., et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug. Neuropharmacology 2012, 62:2034-2039.
    • (2012) Neuropharmacology , vol.62 , pp. 2034-2039
    • Inta, D.1    Filipovic, D.2    Lima-Ojeda, J.M.3    Dormann, C.4    Pfeiffer, N.5    Gasparini, F.6
  • 9
    • 0030954048 scopus 로고    scopus 로고
    • Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    • Lu Y.M., Jia Z., Janus C., Henderson J.T., Gerlai R., Wojtowicz J.M., et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. Journal of Neuroscience 1997, 17:5196-5205.
    • (1997) Journal of Neuroscience , vol.17 , pp. 5196-5205
    • Lu, Y.M.1    Jia, Z.2    Janus, C.3    Henderson, J.T.4    Gerlai, R.5    Wojtowicz, J.M.6
  • 10
    • 0032457339 scopus 로고    scopus 로고
    • Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5
    • Jia Z., Lu Y., Henderson J., Taverna F., Romano C., Abramow-Newerly W., et al. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learning and Memory 1998, 5:331-343.
    • (1998) Learning and Memory , vol.5 , pp. 331-343
    • Jia, Z.1    Lu, Y.2    Henderson, J.3    Taverna, F.4    Romano, C.5    Abramow-Newerly, W.6
  • 11
    • 61949104116 scopus 로고    scopus 로고
    • Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation
    • Gray L., van den Buuse M., Scarr E., Dean B., Hannan A.J. Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-d-aspartic acid receptor up-regulation. International Journal of Neuropsychopharmacology 2009, 12:45-60.
    • (2009) International Journal of Neuropsychopharmacology , vol.12 , pp. 45-60
    • Gray, L.1    van den Buuse, M.2    Scarr, E.3    Dean, B.4    Hannan, A.J.5
  • 12
    • 0034745927 scopus 로고    scopus 로고
    • PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
    • Hannan A.J., Blakemore C., Katsnelson A., Vitalis T., Huber K.M., Bear M., et al. PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Nature Neuroscience 2001, 4:282-288.
    • (2001) Nature Neuroscience , vol.4 , pp. 282-288
    • Hannan, A.J.1    Blakemore, C.2    Katsnelson, A.3    Vitalis, T.4    Huber, K.M.5    Bear, M.6
  • 14
  • 16
    • 77649125812 scopus 로고    scopus 로고
    • Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis
    • Fuss J., Ben Abdallah N.M., Vogt M.A., Touma C., Pacifici P.G., Palme R., et al. Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus 2010, 20:364-376.
    • (2010) Hippocampus , vol.20 , pp. 364-376
    • Fuss, J.1    Ben Abdallah, N.M.2    Vogt, M.A.3    Touma, C.4    Pacifici, P.G.5    Palme, R.6
  • 17
    • 77958571872 scopus 로고    scopus 로고
    • Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice
    • Fuss J., Ben Abdallah N.M., Hensley F.W., Weber K.J., Hellweg R., Gass P. Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice. PLoS ONE 2010, 5:e12769.
    • (2010) PLoS ONE , vol.5
    • Fuss, J.1    Ben Abdallah, N.M.2    Hensley, F.W.3    Weber, K.J.4    Hellweg, R.5    Gass, P.6
  • 18
    • 8444223161 scopus 로고    scopus 로고
    • Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
    • Strekalova T., Spanagel R., Bartsch D., Henn F.A., Gass P. Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 2004, 29:2007-2017.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 2007-2017
    • Strekalova, T.1    Spanagel, R.2    Bartsch, D.3    Henn, F.A.4    Gass, P.5
  • 19
    • 21544434047 scopus 로고    scopus 로고
    • Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    • Ridder S., Chourbaji S., Hellweg R., Urani A., Zacher C., Schmid W., et al. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. Journal of Neuroscience 2005, 25:6243-6250.
    • (2005) Journal of Neuroscience , vol.25 , pp. 6243-6250
    • Ridder, S.1    Chourbaji, S.2    Hellweg, R.3    Urani, A.4    Zacher, C.5    Schmid, W.6
  • 21
    • 80052271739 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro
    • Zhao L., Jiao Q., Yang P., Chen X., Zhang J., Zhao B., et al. Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro. Neuroscience 2011, 192:185-194.
    • (2011) Neuroscience , vol.192 , pp. 185-194
    • Zhao, L.1    Jiao, Q.2    Yang, P.3    Chen, X.4    Zhang, J.5    Zhao, B.6
  • 22
    • 79955094725 scopus 로고    scopus 로고
    • MGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch
    • Matta J.A., Ashby M.C., Sanz-Clemente A., Roche K.W., Isaac J.T. mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. Neuron 2011, 70:339-351.
    • (2011) Neuron , vol.70 , pp. 339-351
    • Matta, J.A.1    Ashby, M.C.2    Sanz-Clemente, A.3    Roche, K.W.4    Isaac, J.T.5
  • 23
    • 40949090052 scopus 로고    scopus 로고
    • Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile×syndrome
    • Dolen G., Bear M.F. Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile×syndrome. Journal of Physiology 2008, 586:1503-1508.
    • (2008) Journal of Physiology , vol.586 , pp. 1503-1508
    • Dolen, G.1    Bear, M.F.2
  • 24
    • 84855433975 scopus 로고    scopus 로고
    • Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways
    • Menard C., Quirion R. Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways. PLoS ONE 2012, 7:e28666.
    • (2012) PLoS ONE , vol.7
    • Menard, C.1    Quirion, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.