Genetics of thoracic aortic aneurysm: At the crossroad of transforming growth factor-β signaling and vascular smooth muscle cell contractility

Circulation Research

Volumn 113, Issue 3, 2013, Pages 327-340

  Gillis, Elisabeth ^a   Van Laer, Lut ^a   Loeys, Bart L ^a,b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aortic aneurysm; Loeys Dietz syndrome; Marfan syndrome; TGF signaling; Thoracic; Vascular smooth muscle cell

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ELASTIN; FIBRILLIN 1; FIBRILLIN 2; FIBULIN; FIBULIN 4; FILAMIN A; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 10; LOSARTAN; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN KINASE; NEUTRALIZING ANTIBODY; NOTCH1 RECEPTOR; PROCOLLAGEN LYSINE 2 OXOGLUTARATE 5 DIOXYGENASE; PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; V SKI AVIAN SARCOMA VIRAL ONCOGENE HOMOLOG PROTEIN;

ADD ON THERAPY; AORTA DISSECTING ANEURYSM; ARTERIAL TORTUOSITY SYNDROME; ARTICLE; BICUSPID AORTIC VALVE; CLINICAL FEATURE; CUTIS LAXA; EHLERS DANLOS SYNDROME; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; GENE MUTATION; GENETIC DISORDER; HEMORRHAGIC TELANGIECTASIA SYNDROME; HUMAN; JUVENILE POLYPOSIS SYNDROME; LOEYS DIETZ SYNDROME; MARFAN SYNDROME; MYHRE RUVALCABA SYNDROME; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SHPRINTZEN GOLDBERG SYNDROME; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; THORACIC AORTA ANEURYSM; VASCULAR SMOOTH MUSCLE;

AORTIC ANEURYSM, THORACIC; LOEYS-DIETZ SYNDROME; MARFAN SYNDROME; TGF-Β SIGNALING; VASCULAR SMOOTH MUSCLE CELL;

ANIMALS; AORTIC ANEURYSM, THORACIC; HUMANS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; TRANSFORMING GROWTH FACTOR BETA; VASOCONSTRICTION;

EID: 84880795141     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.300675     Document Type: Article

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