Structural basis of filamin A functions

Journal of Cell Biology

Volumn 179, Issue 5, 2007, Pages 1011-1025

  Nakamura, Fumihiko ^a   Osborn, Teresia M ^a,b   Hartemink, Christopher A ^a   Hartwig, John H ^a   Stossel, Thomas P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

F ACTIN; FILAMIN A; IMMUNOGLOBULIN;

ARTICLE; BINDING AFFINITY; CROSS LINKING; DIMERIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ACTINS; BINDING SITES; CELL LINE, TUMOR; CONTRACTILE PROTEINS; CROSS-LINKING REAGENTS; CYTOSKELETON; DIMERIZATION; GTPASE-ACTIVATING PROTEINS; HUMANS; MICROFILAMENT PROTEINS; MICROFILAMENTS; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 36849063186     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200707073     Document Type: Article

References (49)

1. Amann, K.J., B.A. Renley, and J.M. Ervasti. 1998. A cluster of basic repeats in the dystrophin rod domain binds F-actin through an electrostatic interaction. J. Biol. Chem. 273:28419-28423.
2. Cukier, I.H., Y. Li, and J.M. Lee. 2007. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. FEBS Lett. 581:1661-1672.
3. DiDonna, B.A., and A.J. Levine. 2007. Unfolding cross-linkers as rheology regulators in F-actin networks. Phys. R ev. E. Stat. Nonlin. Soft Matter Phys. 75:041909.
4. Discher, D.E., P. Janmey, and Y.L. Wang. 2005. Tissue cells feel and respond to the stiffness of their substrate. Science. 310:1139-1143.
5. Feng, Y., and C.A. Walsh. 2004. The many faces of filamin: a versatile molecular scaffold for cell motility and signalling. Nat. Cell Biol. 6:1034-1038.
6. Feng, Y., M.H. Chen, I.P. Moskowitz, A.M. Mendonza, L. Vidali, F. Nakamura, D.J. Kwiatkowski, and C.A. Walsh. 2006. Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc. Natl. Acad. Sci. USA. 103:19836-19841.
7. Ferland, R.J., J.N. Gaitanis, K. Apse, U. Tantravahi, C.A. Walsh, and V.L. Sheen. 2006. Periventricular nodular heterotopia and Williams syndrome. Am. J. Med. Genet. A. 140:1305-1311.
8. Flanagan, L.A., J. Chou, H. Falet, R. Neujahr, J.H. Hartwig, and T.P. Stossel. 2001. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J. Cell Biol. 155:511-517.
9. Fucini, P., C. Renner, C. Herberhold, A.A. Noegel, and T.A. Holak. 1997. The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold. Nat. Struct. Biol. 4:223-230.
10. Gardel, M.L., F. Nakamura, J.H. Hartwig, J.C. Crocker, T.P. Stossel, and D.A. Weitz. 2006. Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc. Natl. Acad. Sci. USA. 103:1762-1767.
11. Goldmann, W.H., and G. Isenberg. 1993. Analysis of filamin and alpha-actinin binding to actin by the stopped flow method. FEBS Lett. 336:408-410.
12. Gorlin, J.B., R. Yamin, S. Egan, M. Stewart, T.P. Stossel, D.J. Kwiatkowski, and J.H. Hartwig. 1990. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J. Cell Biol. 111:1089-1105.
13. Hart, A.W., J.E. Morgan, J. Schneider, K. West, L. McKie, S. Bhattacharya, I.J. Jackson, and S.H. Cross. 2006. Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum. Mol. Genet. 15:2457-2467.
14. Hartwig, J.H. 1995. Actin-binding proteins. 1: Spectrin super family. Protein Profile. 2:703-800.
15. Hartwig, J.H., and P. Shevlin. 1986. The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages. J. Cell Biol. 103:1007-1020.
16. Hartwig, J.H., and T.P. Stossel. 1981. Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments. J. Mol. Biol. 145:563-581.
17. Hartwig, J.H., J. Tyler, and T.P. Stossel. 1980. Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments. J. Cell Biol. 87:841-848.
18. Kainulainen, T., A. Pender, M. D'Addario, Y. Feng, P. Lekic, and C.A. McCulloch. 2002. Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces. J. Biol. Chem. 277:21998-22009.
19. Kiema, T., Y. Lad, P. Jiang, C.L. Oxley, M. Baldassarre, K.L. Wegener, I.D. Campbell, J. Ylanne, and D.A. Calderwood. 2006. The molecular basis of filamin binding to integrins and competition with talin. Mol. Cell. 21:337-347.
20. Klotz, I.M., and D.L. Hunston. 1971. Properties of graphical representations of multiple classes of binding sites. Biochemistry. 10:3065-3069.
21. Kovacsovics, T.J., and J.H. Hartwig. 1996. Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood. 87:618-629.
22. Kyndt, F., J.P. Gueffet, V. Probst, P. Jaafar, A. Legendre, F. Le Bouffant, C. Toquet, E. Roy, L. McGregor, S.A. Lynch, et al. 2007. Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy. Circulation. 115:40-49.
23. Lad, Y., T. Kiema, P. Jiang, O.T. Pentikainen, C.H. Coles, I.D. Campbell, D.A. Calderwood, and J. Ylanne. 2007. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 26:3993-4004.
24. Liu, G., L. Thomas, R.A. Warren, C.A. Enns, C.C. Cunningham, J.H. Hartwig, and G. Thomas. 1997. Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J. Cell Biol. 139:1719-1733.
25. Matsudaira, P. 1994. Actin crosslinking proteins at the leading edge. Semin. Cell Biol. 5:165-174.
26. Morris, R.J. 1995. Antigen-antibody interactions: how affinity and kinetics affect assay design and selection procedures. In Monoclonal Antibodies. M.A. Ritter and H.M. Ladyman, editors. Cambridge University Press, Cambridge. 34-57.
27. Nakamura, F., E. Osborn, P.A. Janmey, and T.P. Stossel. 2002. Comparison of filamin A-induced cross-linking and Arp2/3 complex-mediated branching on the mechanics of actin filaments. J. Biol. Chem. 277:9148-9154.
28. Nakamura, F., J.H. Hartwig, T.P. Stossel, and P.T. Szymanski. 2005. Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J. Biol. Chem. 280:32426-32433.
29. Nakamura, F., R. Pudas, O. Heikkinen, P. Permi, I. Kilpelainen, A.D. Munday, J.H. Hartwig, T.P. Stossel, and J. Ylanne. 2006. The structure of the GPIb-filamin A complex. Blood. 107:1925-1932.
30. Niederman, R., P.C. Amrein, and J. Hartwig. 1983. Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein. J. Cell Biol. 96:1400-1413.
31. Nomura, M., K. Yoshikawa, T. Tanaka, K. Sobue, and K. Maruyama. 1987. The role of tropomyosin in the interactions of F-actin with caldesmon and actin-binding protein (or filamin). Eur. J. Biochem. 163:467-471.
32. Ohta, Y., J.H. Hartwig, and T.P. Stossel. 2006. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat. Cell Biol. 8:803-814.
33. Pfaff, M., S. Liu, D.J. Erle, and M.H. Ginsberg. 1998. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. J. Biol. Chem. 273:6104-6109.
34. Podolski, J.L., and T.L. Steck. 1990. Length distribution of F-actin in Dictyostelium discoideum. J. Biol. Chem. 265:1312-1318.
35. Popowicz, G.M., R. Muller, A.A. Noegel, M. Schleicher, R. Huber, and T.A. Holak. 2004. Molecular structure of the rod domain of Dictyostelium filamin. J. Mol. Biol. 342:1637-1646.
36. Popowicz, G.M., M. Schleicher, A.A. Noegel, and T.A. Holak. 2006. Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem. Sci. 31:411-419.
37. Pudas, R., T.R. Kiema, P.J. Butler, M. Stewart, and J. Ylanne. 2005. Structural basis for vertebrate filamin dimerization. Structure. 13:111-119.
38. Robertson, S.P. 2005. Filamin A: phenotypic diversity. Curr. Opin. Genet. Dev. 15:301-307.
39. Robertson, S.P., S.R. Twigg, A.J. Sutherland-Smith, V. Biancalana, R.J. Gorlin, D. Horn, S.J. Kenwrick, C.A. Kim, E. Morava, R. Newbury-Ecob, et al. 2003. Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. Nat. Genet. 33:487-491.
40. Schliwa, M., J. van Blerkom, and K.R. Porter. 1981. Stabilization and the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. Proc. Natl. Acad. Sci. USA. 78:4329-4333.
41. Sharma, C.P., R.M. Ezzell, and M.A. Arnaout. 1995. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J. Immunol. 154:3461-3470.
42. Sjekloca, L., R. Pudas, B. Sjoblom, P. Konarev, O. Carugo, V. Rybin, T.R. Kiema, D. Svergun, J. Ylanne, and K.D. Carugo. 2007. Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer. J. Mol. Biol. 368:1011-1023.
43. Stossel, T.P., J. Condeelis, L. Cooley, J.H. Hartwig, A. Noegel, M. Schleicher, and S.S. Shapiro. 2001. Filamins as integrators of cell mechanics and signalling. Nat. Rev. Mol. Cell Biol. 2:138-145.
44. Tavano, R., R.L. Contento, S.J. Baranda, M. Soligo, L. Tuosto, S. Manes, and A. Viola. 2006. CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse. Nat. Cell Biol. 8:1270-1276.
45. Thelin, W.R., Y. Chen, M. Gentzsch, S.M. Kreda, J.L. Sallee, C.O. Scarlett, C.H. Borchers, K. Jacobson, M.J. Stutts, and S.L. Milgram. 2007. Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J. Clin. Invest. 117:364-374.
46. Tigges, U., B. Koch, J. Wissing, B.M. Jockusch, and W.H. Ziegler. 2003. The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha. J. Biol. Chem. 278:23561-23569.
47. Tyler, J.M., J.M. Anderson, and D. Branton. 1980. Structural comparison of several actin-binding macromolecules. J. Cell. Biol. 85:489-495.
48. Wilkinson, K.D. 2004. Quantitative analysis of protein-protein interactions. Methods Mol. Biol. 261:15-32.
49. Yin, H.L., J.H. Hartwig, K. Maruyama, and T.P. Stossel. 1981. Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization. J. Biol. Chem. 256:9693-9697.