Ascending aortic dilatation associated with bicuspid aortic valve. Pathophysiology, molecular biology, and clinical implications

Circulation

Volumn 119, Issue 6, 2009, Pages 880-890

  Tadros, Thomas M ^a   Klein, Michael D ^a   Shapira, Oz M ^b  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Aneurysm; Aorta; Congenital; Heart defects; Valves

Indexed keywords

FIBRILLIN 1; MATRIX METALLOPROTEINASE;

AORTA DISSECTION; AORTA RUPTURE; ASCENDING AORTA; BICUSPID AORTIC VALVE; GENE MUTATION; GENETICS; HEMODYNAMICS; HUMAN; IMAGING; INHERITANCE; MOLECULAR BIOLOGY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TURNER SYNDROME; VASCULAR SMOOTH MUSCLE;

AORTA; AORTIC ANEURYSM; DILATATION, PATHOLOGIC; DISEASE MANAGEMENT; HEART DEFECTS, CONGENITAL; HUMANS; MITRAL VALVE;

EID: 61949188315     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.795401     Document Type: Review

References (124)

1. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117:e25-e146.
2. Nistri S, Basso C, Marzari C, Mormino P, Thiene G. Frequency of bicuspid aortic valve in young male conscripts by echocardiogram. Am J Cardiol. 2005;96:718-721.
3. Tutar E, Ekici F, Atalay S, Nacar N. The prevalence of bicuspid aortic valve in newborns by echocardiographic screening. Am Heart J. 2005; 150:513-515.
4. Basso C, Boschello M, Perrone C, Mecenero A, Cera A, Bicego D, Thiene G, De Dominicis E. An echocardiographic survey of primary school children for bicuspid aortic valve. Am J Cardiol. 2004;93: 661-663.
5. Kirsch EWM, Radu NC, Allaire E, Loisance DY. Pathobiology of idiopathic ascending aortic aneurysms. Asian Cardiovasc Thorac Ann. 2006;14:254-260.
6. Lilly LS. Pathophysiology of Heart Disease. 2nd ed. Baltimore, Md: Lippincott Williams & Wilkins; 1997.
7. Agmon Y, Khandheria BK, Meissner I, Schwartz GL, Sicks JD, Fought AJ, O'Fallon WM, Wiebers DO, Tajik AJ. Is aortic dilatation an atherosclerosis- related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation. J Am Coll Cardiol. 2003;42:1076-1083.
8. Nataatmadja M, West M, West J, Summers K, Walker P, Nagata M, Watanabe T. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in Marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. 2003;108:11329-11334.
9. Kappetein AP, Gittenberger-de Groot AC, Zwinderman AH, Rohmer J, Poelmann RE, Huysmans HA. The neural crest as a possible pathogenetic factor in coarctation of the aorta and bicuspid aortic valve. J Thorac Cardiovasc Surg. 1991;102:830-836.
10. Kirby ML, Waldo KL. Role of neural crest in congenital heart disease. Circulation. 1990;82:332-340.
11. Ausoni S, Sartore S. Cell lineages and tissue boundaries in cardiac arterial and venous poles: developmental patterns, animal models, and implications for congenital vascular diseases. Arterioscler Thromb Vasc Biol. 2001;21:312-320. 12. Morrison-Graham K, Schatteman GC, Bork T, Bowen-Pope DF, Weston JA. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development. 1992;115:133-142.
12. Bonderman D, Gharehbaghi-Schnell E, Wollenek G, Maurer G, Baumgartner H, Lang IM. Mechanisms underlying aortic dilatation in congenital aortic valve malformation. Circulation. 1999;99:2138-2143.
13. de Sa M, Moshkovitz Y, Butany J, David TE. Histologic abnormalities of the ascending aorta and pulmonary trunk in patients with bicuspid aortic valve disease: clinical relevance to the Ross procedure. J Thorac Cardiovasc Surg. 1999;118:588-596.
14. Niwa K, Perloff JK, Bhuta SM, Laks H, Drinkwater DC, Child JS, Miner PD. Structural abnormalities of great arterial walls in congenital heart disease: light and electron microscopic analyses. Circulation. 2001;103:393-400.
15. Becker AE, Becker MJ, Edwards JE. Anomalies associated with coarctation of aorta particular reference to infancy. Circulation. 1970;41: 1067-1075.
16. Korpal-Szczyrska M, Aleszewicz-Baranowska J, Dorant B, Potaz P, Birkholz D, Kaminska H. Cardiovascular malformations in Turner syndrome [in Polish]. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2005;11:211-214.
17. Higgins CB, Wexler L. Reversal of dominance of the coronary arterial system in isolated aortic stenosis and bicuspid aortic valve. Circulation. 1975;52:292-296.
18. Hutchins GM, Nazarian IH, Bulkley BH. Association of left dominant coronary arterial system with congenital bicuspid aortic valve. Am J Cardiol. 1978;42:57-59.
19. Morimoto K, Taniguchi I, Miyasaka S, Marumoto A. Bicuspid aortic valve stenosis with single coronary artery. Ann Thorac Cardiovasc Surg. 2005;11:267-269.
20. Rashid A, Saucedo JF, Hennebry TA. Association of single coronary artery and congenital bicuspid aortic valve with review of literature. J Intervent Cardiol. 2005;18:389-391.
21. Huntingdon K, Hunter AG, Chan KL. A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. J Am Coll Cardiol. 1997;30:1809-1812.
22. Clementi M, Notari L, Borghi A, Tenconi R. Familial congenital bicuspid aortic valve: a disorder of uncertain inheritance. Am J Med Genet. 1996;62:336-338.
23. Miller MJ, Geffner ME, Lippe BM, Itami RM, Kaplan SA, DiSessa TG, Isabel-Jones JB, Friedman WF. Echocardiography reveals a high incidence of bicuspid aortic valve in Turner syndrome. J Pediatr. 1983; 102:47-50.
24. Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations. Hum Genet. 2007;121:275-284.
25. Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature. 2005;437:270-274.
26. Mohamed SA, Aherrahrou Z, Liptau H, Erasmi AW, Hagemann C, Wrobel S, Borzym K, Schunkert H, Sievers HH, Erdmann J. Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve. Biochem Biophys Res Commun. 2006;345: 1460-1465.
27. Mohamed SA, Hanke T, Schlueter C, Bullerdiek J, Sievers HH. Ubiquitin fusion degradation 1 -like gene dysregulation in bicuspid aortic valve. J Thorac Cardiovasc Surg. 2005;130:1531-1536.
28. Ben-Shachar S, Ou Z, Shaw CA, Belmont JW, Patel MS, Hummel M, Amato S, Tartaglia N, Berg J, Sutton VR, Lalani SR, Chinault AC, Cheung SW, Lupski JR, Patel A. 22q11.2 distal deletion: a recurrent genomie disorder distinct from DiGeorge syndrome and velocardiofacial syndrome. Am J Hum Genet. 2008;82:214-221.
29. Guo DC, Pannu H, Tran-Fadulu V, Papke CL, Yu RK, Avidan N, Bourgeois S, Estrera AL, Safi HJ, Sparks E, Amor D, Ades L, McConnell V, Willoughby CE, Abuelo D, Willing M, Lewis RA, Kim DH, Scherer S, Tung PP, Ahn C, Buja LM, Raman CS, Shete SS, Milewicz DM. Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections. Nat Genet. 2007;39: 1488-1493.
30. Lee TC, Zhao YD, Courtman DW, Stewart DJ. Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase. Circulation. 2000;101:2345-2348.
31. Aicher D, Urbich C, Zeiher A, Dimmeler S, Schafers HJ. Endothelial nitric oxide synthase in bicuspid aortic valve disease. Ann Thorac Surg. 2007;83:1290-1294.
32. Robinson PN, Godfrey M. The molecular genetics of Marfan syndrome and related microfibrillopathies. J Med Genet. 2000;37:9-25.
33. Gsell O. Wandnekrosen der aorta als selbstandige Erkrankung und ihre Beziehung zur spontanruptur. Virchow Archiv. 1928;270:1-36.
34. Erdheim J. Medionecrosis aortae idiopathica. Virchows Arch. 1929;273: 454-479.
35. Bauer M, Pasic M, Meyer R, Goetze N, Bauer U, Siniawski H, Hetzer R. Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valve. Ann Thorac Surg. 2002;74:58-62.
36. Collins MJ, Dev V, Strauss BH, Fedak PW, Butany J. Variation in the histopathological features of patients with ascending aortic aneurysms: a study of 111 surgically excised cases. J Clin Pathol. 2008;61:519-523.
37. Schmid F-X, Bielenberg K, Schneider A, Haussler A, Keyser A, Birnbaum D. Ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve: involvement and clinical relevance of smooth muscle cell apoptosis and expression of cell death-initiating proteins. Eur J Cardiothorac Surg. 2003;23:537-543.
38. Tang PCY, Coady MA, Lovoulos C, Dardik A, Asian M, Elefteriades JA, Tellides G. Hyperplastic cellular remodeling of the media in ascending thoracic aortic aneurysms. Circulation. 2005;112:1098-1105.
39. Delia Corte A, Quarto C, Bancone C, Castaldo C, Di Meglio F, Nurzynska D, De Santo LS, De Feo M, Scardone M, Montagnani S, Cotrufo M. Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling. J Thorac Cardiovasc Surg. 2008;135:8-18, e11-e12.
40. Cotrufo M, Delia Corte A, De Santo LS, Quarto C, De Feo M, Romano G, Amarelli C, Scardone M, Di Meglio F, Guerra G, Scarano M, Vitale S, Castaldo C, Montagnani S. Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results. J Thorac Cardiovasc Surg. 2005;130:e501-e504.
41. Fedak PW, Verma S, David TE, Leask RL, Weisel RD, Butany J. Clinical and pathophysiological implications of a bicuspid aortic valve. Circulation. 2002;106:900-904.
42. Fedak PWM, de Sa MPL, Verma S, Nili N, Kazemian P, Butany J, Strauss BH, Weisel RD, David TE. Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. J Thorac Cardiovasc Surg. 2003;126:797-805.
43. Paes Lerne M. Molecular evaluation of the great vessels of patients with bicuspid aortic valve disease. Rev Bras Cir Cardiovasc. 2003;18: 148-156.
44. Boyum J, Fellinger EK, Schmoker JD, Trombley L, McPartland K, Ittleman FP, Howard AB. Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves. J Thorac Cardiovasc Surg. 2004;127:686-691.
45. Ikonomidis JS, Jones JA, Barbour JR, Stroud RE, Clark LL, Kaplan BS, Zeeshan A, Bavaria JE, Gorman JH III, Spinale FG, Gorman RC. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. J Thorac Cardiovasc Surg. 2007;133:1028-1036.
46. Koullias GJ, Korkolis DP, Ravichandran P, Psyrri A, Hatzaras I, Elefteriades JA. Tissue microarray detection of matrix metalloproteinases, in diseased tricuspid and bicuspid aortic valves with or without pathology of the ascending aorta. Eur J Cardiothorac Surg. 2004;26: 1098-1103.
47. LeMaire SA, Wang X, Wilks JA, Carter SA, Wen S, Won T, Leonardelli D, Anand G, Conklin LD, Wang XL, Thompson RW, Coselli JS. Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. J Surg Res. 2005;123:40-48.
48. Wilton E, Jahangiri M. Post-stenotic aortic dilatation. J Cardiothorac Surg. 2006;1:7.
49. Dollery CM, McEwan JR, Henney AM. Matrix metalloproteinases and cardiovascular disease. Circ. Res. 1995;77:863-868.
50. Jones JA, Stroud RE, Kaplan BS, Leone AM, Bavaria JE, Gorman JH III, Gorman RC, Ikonomidis JS. Differential protein kinase C isoform abundance in ascending aortic aneurysms from patients with bicuspid versus tricuspid aortic valves. Circulation. 2007;116:1144-1149.
51. Wilton E, Bland M, Thompson M, Jahangiri M. Matrix metalloproteinase expression in the ascending aorta and aortic valve. Interact Cardiovasc Thorac Surg. 2008;7:37-40.
52. Ikonomidis JS, Jones JA, Barbour JR, Stroud RE, Clark LL, Kaplan BS, Zeeshan A, Bavaria JE, Gorman JH III, Spinale FG, Gorman RC. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Circulation. 2006;114:1365-1370.
53. Lehoux S, Tedgui A. Cellular mechanics and gene expression in blood vessels. J Biomech. 2003;36:631-643.
54. Robicsek F, Thubrikar MJ, Cook JW, Fowler B. The congenitally bicuspid aortic valve: how does it function? Why does it fail? Ann Thorac Surg. 2004;77:177-185.
55. Keane MG, Wiegers SE, Plappert T, Pochettino A, Bavaria JE, Sutton MGSJ. Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions. Circulation. 2000;102: III35-III39.
56. Novaro GM, Tiong IY, Pearce GL, Grimm RA, Smedira N, Griffin BP. Features and predictors of ascending aortic dilatation in association with a congenital bicuspid aortic valve. Am J Cardiol. 2003;92:99-101.
57. Bauer M, Siniawski H, Pasic M, Schaumann B, Hetzer R, Different hemodynamic stress of the ascending aorta wall in patients with bicuspid and tricuspid aortic valve. J Card Surg. 2006;21:218-220.
58. Delia Corte A, Bancone C, Quarto C, Dialetto G, Covino FE, Scardone M, Caianiello G, Cotrufo M. Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression. Eur J Cardiothorac Surg. 2007;31:397-404.
59. Linhartova K, Beranek V, Sefrna F, Hanisova I, Sterbakova G, Peskova M. Aortic stenosis severity is not a risk factor for poststenotic dilatation of the ascending aorta. Circ J. 2007;71:84-88.
60. Feigenbaum H. Echocardiography. Philadelphia, Pa: Lea & Febiger; 1986.
61. Vasan RS, Larson MG, Levy D. Determinants of echocardiographic aortic root size: the Framingham Heart Study. Circulation. 1995;91: 734-740.
62. Clouse WD, Hallett JW Jr, Schaff HV, Gayari MM, Ilstrap DM, Melton LJ III. Improved prognosis of thoracic aortic aneurysms: a population-based study. JAMA. 1998;280:1926-1929.
63. Olsson C, Thelin S, Stahle E, Ekbom A, Granath F. Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14 000 cases from 1987 to 2002. Circulation. 2006;114:2611-2618.
64. Beroukhim RS, Kruzick TL, Taylor AL, Gao D, Yetman AT. Progression of aortic dilation in children with a functionally normal bicuspid aortic valve. Am J Cardiol. 2006;98:828-830.
65. Nistri S, Grande-Allen J, Noale M, Basso C, Siviero P, Maggi S, Crepaldi G, Thiene G. Aortic elasticity and size in bicuspid aortic valve syndrome. Eur Heart J. 2008;29:472-479.
66. Sonoda M, Takenaka K, Uno K, Ebihara A, Nagai R. A larger aortic annulus causes aortic regurgitation and a smaller aortic annulus causes aortic stenosis in bicuspid aortic valve. Echocardiography. 2008;25: 242-248.
67. Gurvitz M, Chang RK, Drant S, Allada V. Frequency of aortic root dilation in children with a bicuspid aortic valve. Am J Cardiol. 2004; 94:1337-1340.
68. Hahn RT, Roman MJ, Mogtader AH, Devereux RB. Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves. J Am Coll Cardiol. 1992;19:283-288.
69. Nistri S, Sorbo MD, Marin M, Palisi M, Scognamiglio R, Thiene G. Aortic root dilatation in young men with normally functioning bicuspid aortic valves. Heart. 1999;82:19-22.
70. Nkomo VT, Enriquez-Sarano M, Ammash NM, Melton LJ HI, Bailey KR, Desjardins V, Horn RA, Tajik AJ, Bicuspid aortic valve associated with aortic dilatation: a community-based study. Arterioscler Thromb Vasc Biol. 2003;23:351-356.
71. Warren AE, Boyd ML, O'Connell C, Dodds L. Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factors. Heart. 2006;92:1496-1500.
72. Ferencik M, Pape LA. Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves. Am J Cardiol. 2003;92:43-46.
73. Holmes KW, Lehmann CU, Dalal D, Nasir K, Dietz HC, Ravekes WJ, Thompson WR, Spevak PJ. Progressive dilation of the ascending aorta in children with isolated bicuspid aortic valve. Am J Cardiol. 2007;99: 978-983.
74. Dore A, Brochu MC, Baril JF, Guertin MC, Mercier LA. Progressive dilation of the diameter of the aortic root in adults with a bicuspid aortic valve. Cardiol Young. 2003;13:526-531.
75. La Canna G, Ficarra E, Tsagalau E, Nardi M, Morandini A, Chieffo A, Maisano F, Alfieri O. Progression rate of ascending aortic dilation in patients with normally functioning bicuspid and tricuspid aortic valves. Am J Cardiol. 2006;98:249-253.
76. Novaro GM, Griffin BP. Congenital bicuspid aortic valve and rate of ascending aortic dilatation. Am J Cardiol. 2004;93:525-526.
77. Davies RR, Kaple RK, Mandapati D, Gallo A, Botta DM Jr, Elefteriades JA, Coady MA. Natural history of ascending aortic aneurysms in the setting of an unreplaced bicuspid aortic valve. Ann Thorac Surg. 2007; 83:1338-1344.
78. Pietro DA, Voelkel AG, Ray BJ, Parisi AF. Reproducibility of echocardiography: a study evaluating the variability of serial echocardiographic measurements. Chest. 1981;79:29-32.
79. Shimada I, Rooney SJ, Pagano D, Farneti PA, Davies P, Guest PJ, Bonser RS. Prediction of thoracic aortic aneurysm expansion: validation of formulae describing growth. Ann Thorac Surg. 1999;67:1968-1970.
80. Coady MA, Rizzo JA, Hammond GL, Mandapati D, Darr U, Kopf GS, Elefteriades JA. What is the appropriate size criterion for resection of thoracic aortic aneurysms? J Thorac Cardiovasc Surg. 1997;113: 476-491.
81. Yasuda H, Nakatani S, Stugaard M, Tsujita-Kuroda Y, Bando K, Kobayashi J, Yamagishi M, Kitakaze M, Kitamura S, Miyatake K. Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve. Circulation. 2003;108:II291-II294.
82. Davies RR, Goldstein LJ, Coady MA, Tittle SL, Rizzo JA, Kopf GS, Elefteriades JA. Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size. Ann Thorac Surg. 2002;73: 17-28.
83. Elefteriades JA. Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks. Ann Thorac Surg. 2002;74:S1877-S1880.
84. Svensson LG, Kim K-H, Lytle BW, Cosgrove DM. Relationship of aortic cross-sectional area to height ratio and the risk of aortic dissection in patients with bicuspid aortic valves. J Thorac Cardiovasc Surg. 2003;126:892-893.
85. Neri E, Barabesi L, Buklas D, Vricella LA, Benvenuti A, Tucci E, Sassi C, Massetti M. Limited role of aortic size in the genesis of acute type A aortic dissection. Eur J Cardiothorac Surg. 2005;28:857-863.
86. Pape LA, Tsai TT, Isselbacher EM, Oh JK, O'Gara PT, Evangelista A, Fattori R, Meinhardt G, Trimarchi S, Bossone E, Suzuki T, Cooper JV, Froehlich JB, Nienaber CA, Eagle KA. Aortic diameter >or =5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD). Circulation. 2007;116:1120-1127.
87. Edwards WD, Leaf DS, Edwards JE. Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. Circulation. 1978;57: 1022-1025.
88. Gore I. Dissecting aneurysms of the aorta in persons under forty years of age. AMA Arch Pathol. 1953;55:1-13.
89. Erbel R, Eggebrecht H. Aortic dimensions and the risk of dissection. Heart. 2006;92:137-142.
90. Yazdani Sabet H, Edwards WD, Tazelaar HD, Daly RC. Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases. Mayo Clin Proc. 1999;74:14-26.
91. Hartnell GG. Imaging of aortic aneurysms and dissection: CT and MRI. J Thorac Imaging. 2001;16:35-46.
92. Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O'Gara PT, O'Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Page RL, Riegel B. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol. 2006;48:e1-e148.
93. Cooney JR, Ho VB. Answer to last month's radiology case and image: bicuspid aortic valve. Military Med. 2006;171:iv-v.
94. Woodard PK, Bhalla S, Javidan-Nejad C, Gutierrez FR. Non-coronary cardiac CT imaging. Semin Ultrasound CT MR. 2006;27:56-75.
95. Khalil A, Helmy T, Porembka DT. Aortic pathology: aortic trauma, debris, dissection, and aneurysm. Crit Care Med. 2007;35:S392-S400.
96. Tamborini G, Galli CA, Maltagliati A, Andreini D, Pontone G, Quaglia C, Ballerini G, Pepi M. Comparison of feasibility and accuracy of transthoracic echocardiography versus computed tomography in patients with known ascending aortic aneurysm. Am J Cardiol. 2006;98: 966-969.
97. Meijboom LJ, Groenink M, van der Wall EE, Romkes H, Stoker J, Mulder BJ. Aortic root asymmetry in Marfan patients: evaluation by magnetic resonance imaging and comparison with standard echocardiography. Int J Cardiac Imaging. 2000;16:161-168.
98. Yetman AT. Cardiovascular pharmacotherapy in patients with Marfan syndrome. Am J Cardiovasc Drugs. 2007;7:117-126.
99. Shores J, Berger KR, Murphy EA, Pyeritz RE. Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marian's syndrome. N Engl J Med. 1994;330:1335-1341.
100. Gersony DR, McClaughlin MA, Jin Z, Gersony WM. The effect of beta-blocker therapy on clinical outcome in patients with Marfan's syndrome: a meta-analysis. Int J Cardiol. 2007;114:303-308.
101. Nagashima H, Sakomura Y, Aoka Y, Uto K, Kameyama K, Ogawa M, Aomi S, Koyanagi H, Ishizuka N, Naruse M, Kawana M, Kasanuki H. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis in cystic medial degeneration associated with Marfan's syndrome. Circulation. 2001;104:I282-I287.
102. Yetman AT, Bornemeier RA, McCrindle BW. Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome. Am J Cardiol. 2005;95:1125-1127.
103. Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B, Dietz HC III. Angiotensin II blockade and aortic-root dilation in Marfan's syndrome. N Engl J Med. 2008;358:2787-2795.
104. Verma S, Szmitko PE, Fedak PW, Errett L, Latter DA, David TE. Can statin therapy alter the natural history of bicuspid aortic valves? Am J Physiol. 2005;288:H2547-H2549.
105. Nagashima H, Aoka Y, Sakomura Y, Sakuta A, Aomi S, Ishizuka N, Hagiwara N, Kawana M, Kasanuki H. A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. J Vasc Surg. 2002;36:158-163.
106. Rossebo AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, Gerdts E, Gohlke-Barwolf C, Holme I, Kesaniemi YA, Malbecq W, Nienaber CA, Ray S, Skjaerpe T, Wachteil K, Willenheimer R. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359:1343-1356.
107. Isselbacher EM. Thoracic and abdominal aortic aneurysms. Circulation. 2005;111:816-828.
108. Galloway AC, Colvin SB, LaMendola CL, Hurwitz JB, Baumann FG, Harris LJ, Culliford AT, Grossi EA, Spencer FC. Ten-year operative experience with 165 aneurysms of the ascending aorta and aortic arch. Circulation. 1989;80:I249-I256.
109. Cohn LH, Rizzo RJ, Adams DH, Aranki SF, Couper GS, Beckel N, Collins JJ Jr. Reduced mortality and morbidity for ascending aortic aneurysm resection regardless of cause. Ann Thorac Surg, 1996;62: 463-468.
110. Milewicz DM, Dietz HC, Miller DC. Treatment of aortic disease in patients with Marfan syndrome. Circulation. 2005;111:e150-e157.
111. Isselbacher E. Diseases of the aorta. In: Libby P, Bonow RO, Zipes DP, Mann DL, ed. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa: WB Saunders; 2007.
112. Guyatt GH, Oxman AD, Kunz R, Falck-Ytter Y, Vist GE, Liberati A, Schunemann HJ; GRADE Working Group. Going from evidence to recommendations. BMJ. 2008;336:1049-1051.
113. Oliver JM, Gallego P, Gonzalez A, Aroca A, Bret M, Mesa JM. Risk factors for aortic complications in adults with coarctation of the aorta. J Am Coll Cardiol. 2004;44:1641-1647.
114. Rosenthal E. Coarctation of the aorta from fetus to adult: curable condition or life long disease process? Heart. 2005;91:1495-1502.
115. Cambria RA, Gloviczki P, Stanson AW, Cherry KJ Jr, Bower TC, Hallett JW Jr, Pairolero PC. Outcome and expansion rate of 57 thoracoabdominal aortic aneurysms managed nonoperatively. Am J Surg. 1995;170:213-217.
116. Muluk SC, Gertler JP, Brewster DC, Cambria RP, LaMuraglia GM, Moncure AC, Darling RC, Abbott WM. Presentation and patterns of aortic aneurysms in young patients. J Vasc Surg. 1994;20:880-886.
117. Davies RR, Gallo A, Coady MA, Tellides G, Botta DM, Burke B, Coe MP, Kopf GS, Elefteriades JA. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann Thorac Surg. 2006;81:169-177.
118. Svensson LG, Khitin L. Aortic cross-sectional area/height ratio timing of aortic surgery in asymptomatic patients with Marfan syndrome. J Thorac Cardiovasc Surg. 2002;123:360-361.
119. Dake MD, Miller DC, Semba CP, Mitchell RS, Walker PJ, Liddell RP. Transluminal placement of endovascular stent-grafts for the treatment of descending thoracic aortic aneurysms. N Engl J Med. 1994;331: 1729-1734.
120. Patel HJ, Williams DM, Upchurch GR Jr, Shillingford MS, Dasika NL, Proctor MC, Deeb GM. Long-term results from a 12-year experience with endovascular therapy for thoracic aortic disease. Ann Thorac Surg. 2006;82:2147-2153.
121. Bavaria JE, Appoo JJ, Makaroun MS, Verier J, Yu ZF, Mitchell RS. Endovascular stem grafting versus open surgical repair of descending thoracic aortic aneurysms in low-risk patients: a multicenter comparative trial. J Thorac Cardiovasc Surg. 2007;133:369-377.
122. Baril DT, Carroccio A, Palchik E, Ellozy SH, Jacobs TS, Teodorescu V, Marin ML. Endovascular treatment of complicated aortic aneurysms in patients with underlying arteriopathies. Ann Vasc Surg. 2006;20: 464-471.
123. LeMaire SA, Carter SA, Volguina IV, Laux AT, Milewicz DM, Borsato GW, Cheung CK, Bozinovski J, Markesino JM, Vaughn WK, Coselli JS. Spectrum of aortic operations in 300 patients with confirmed or suspected Marfan syndrome. Ann Thorac Surg. 2006;81:2063-2078.
124. Geisbusch P, Kotelis D, von Tengg-Kobligk H, Hyhlik-Durr A, Allenberg JR, Bockler D. Thoracic aortic endografting in patients with connective tissue diseases. J Endovasc Ther. 2008;15:144-149.