Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association

Journal of Vascular Surgery

Volumn 49, Issue 6, 2009, Pages 1525-1531

  Elmore, James R ^a   Obmann, Melissa A ^a   Kuivaniemi, Helena ^b   Tromp, Gerard ^b   Gerhard, Glenn S ^c   Franklin, David P ^a   Boddy, Amy M ^b   Carey, David J ^c  

^a GEISINGER MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEIS CENTER FOR RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTACTIN;

ABDOMINAL AORTA ANEURYSM; ARTICLE; CARDIOVASCULAR RISK; CHROMOSOME 3P; CONTROLLED STUDY; GENE FREQUENCY; GENE IDENTIFICATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AORTIC ANEURYSM, ABDOMINAL; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 3; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; ODDS RATIO; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS; SMOKING;

EID: 66149112940     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.01.041     Document Type: Article

References (19)

1. Alcorn H.G., Wolfson Jr. S.K., Sutton-Tyrrell K., and O'Leary D. Risk factors for abdominal aortic aneurysms in older adults enrolled in The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 16 (1996) 963-970
2. Reilly J.M., and Tilson M.D. Incidence and etiology of abdominal aortic aneurysms. Surg Clin North Am 69 (1989) 705-711
3. Elmore J.R., Keister B.F., Franklin D.P., Youkey J.R., and Carey D.J. Expression of matrix metalloproteinases and TIMPs in human abdominal aortic aneurysms. Ann Vasc Surg 12 (1998) 221-228
4. Kuivaniemi H., Platsoucas C.D., and Tilson III M.D. Aortic aneurysms: an immune disease with a strong genetic component. Circulation 117 (2008) 242-252
5. Lenk G.M., Tromp G., Weinsheimer S., Gatalica Z., Berguer R., and Kuivaniemi H. Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics 8 (2007) 237
6. McMillan W.D., and Pearce W.H. Inflammation and cytokine signaling in aneurysms. Ann Vasc Surg 11 (1997) 540-545
7. Thompson R.W., and Parks W.C. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann N Y Acad Sci 800 (1996) 157-174
8. Treska V., Kocova J., Boudova L., Neprasova P., Topolcan O., Pecen L., and Tonar Z. Inflammation in the wall of the abdominal aortic aneurysm and its role in the symptomatology of aneurysm. Cytokines Cell Mol Ther 7 (2002) 91-97
9. Kuivaniemi H., Boddy A.M., Lillvis J.H., Nischan J., Lenk G.M., and Tromp G. Abdominal aortic aneurysms are deep, deadly and genetic. In: Sakalihasan N., Kuivaniemi H., and Michel J.B. (Eds). Aortic aneurysms: new insights into an old problem (2008), Liege University Press, Liege, Belgium
10. Shibamura H., Olsen J.M., van Vlijmen-van Keulen C., Buxbaum S.G., Dudek D.M., Tromp G., et al. Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13. Circulation 109 (2004) 2103-2108
11. van Vlijmen-van Keulen C., Rauwerda J.A., and Pals G. Genome-wide linkage in three Dutch families maps a locus for abdominal aortic aneurysms to chromosome 19q13.3. Eur J Vasc Endovasc Surg 30 (2005) 29-35
12. Helgadottir A., Thorleifsson G., Magnusson K.P., Grétarsdottir S., Steinthorsdottir V., Manolescu A., et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 40 (2008) 217-224
13. Butcher L.M., Davis O.S., Craig I.W., and Plomin R. Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes Brain Behav 7 (2008) 435-446
14. Craig D.W., Huentelman M.J., Hu-Lince D., Zismann V.L., Kruer M.C., Lee A.M., et al. Identification of disease causing loci using an array-based genotyping approach on pooled DNA. BMC Genomics 6 (2005) 138
15. Docherty S.J., Butcher L.M., Schalkwyk L.C., and Plomin R. Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics 8 (2007) 214
16. Pearson J.V., Huentelman M.J., Halperin R.F., Tembe W.D., Melquist S., Homer N., et al. Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies. Am J Hum Genet 80 (2007) 126-139
17. Purcell S., Cherny S.S., and Sham P.C. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 (2003) 149-150
18. Yoshihara Y., Kawasaki M., Tamada A., Nagata S., Kagamiyama H., and Mori K. Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. J Neurobiol 28 (1995) 51-69
19. Boddy A.M., Lenk G.M., Lillvis J.H., Nischan J., Kyo Y., and Kuivaniemi H. Basic research studies to understand aneurysm disease. Drug News Perspect 21 (2008) 142-148