메뉴 건너뛰기




Volumn 7, Issue SUPPL 1, 2013, Pages 12-19

Fusion Oncogenes in Salivary Gland Tumors: Molecular and Clinical Consequences

Author keywords

Adenoid cystic carcinoma; Biomarker; CRTC1 MAML2; ETV6 NTRK3; Fusion oncogenes; Mucoepidermoid carcinoma; MYB NFIB; Salivary gland neoplasms; Targeted therapy

Indexed keywords

ONCOPROTEIN;

EID: 84880776065     PISSN: 1936055X     EISSN: 19360568     Source Type: Journal    
DOI: 10.1007/s12105-013-0462-z     Document Type: Article
Times cited : (165)

References (61)
  • 1
    • 33947581390 scopus 로고    scopus 로고
    • The impact of translocations and gene fusions on cancer causation
    • Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer. 2007;7: 233-45.
    • (2007) Nat Rev Cancer , vol.7 , pp. 233-245
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 3
    • 33746816237 scopus 로고    scopus 로고
    • CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas
    • Asp J, Persson F, Kost-Alimova M, Stenman G. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer. 2006;45: 820-8.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 820-828
    • Asp, J.1    Persson, F.2    Kost-Alimova, M.3    Stenman, G.4
  • 6
    • 43449125270 scopus 로고    scopus 로고
    • High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes
    • Persson F, Winnes M, Andrén Y, Wedell B, Dahlenfors R, Asp J, Mark J, Enlund F, Stenman G. High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes. Oncogene. 2008;27: 3072-80.
    • (2008) Oncogene , vol.27 , pp. 3072-3080
    • Persson, F.1    Winnes, M.2    Andrén, Y.3    Wedell, B.4    Dahlenfors, R.5    Asp, J.6    Mark, J.7    Enlund, F.8    Stenman, G.9
  • 8
    • 77956849003 scopus 로고    scopus 로고
    • New tricks from an old oncogene: gene fusions and copy number alterations of MYB in human cancer
    • Stenman G, Andersson MK, Andrén Y. New tricks from an old oncogene: gene fusions and copy number alterations of MYB in human cancer. Cell Cycle. 2010;9: 2986-95.
    • (2010) Cell Cycle , vol.9 , pp. 2986-2995
    • Stenman, G.1    Andersson, M.K.2    Andrén, Y.3
  • 11
    • 17044434576 scopus 로고    scopus 로고
    • Fusion oncogenes and tumor type specificity-insights from salivary gland tumors
    • Stenman G. Fusion oncogenes and tumor type specificity-insights from salivary gland tumors. Semin Cancer Biol. 2005;15: 224-35.
    • (2005) Semin Cancer Biol , vol.15 , pp. 224-235
    • Stenman, G.1
  • 12
    • 17044397600 scopus 로고    scopus 로고
    • Fusion oncogenes in tumor development
    • Åman P. Fusion oncogenes in tumor development. Semin Cancer Biol. 2005;15: 236-43.
    • (2005) Semin Cancer Biol , vol.15 , pp. 236-243
    • Åman, P.1
  • 13
    • 0141799898 scopus 로고    scopus 로고
    • Mechanisms of sarcoma development
    • Helman LJ, Meltzer P. Mechanisms of sarcoma development. Nat Rev Cancer. 2003;3: 685-94.
    • (2003) Nat Rev Cancer , vol.3 , pp. 685-694
    • Helman, L.J.1    Meltzer, P.2
  • 14
    • 58149398623 scopus 로고    scopus 로고
    • Translation of the Philadelphia chromosome into therapy for CML
    • Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood. 2008;112: 4808-17.
    • (2008) Blood , vol.112 , pp. 4808-4817
    • Druker, B.J.1
  • 16
    • 0028363026 scopus 로고
    • Non-random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands
    • Nordkvist A, Mark J, Gustafsson H, Bang G, Stenman G. Non-random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands. Genes Chromosomes Cancer. 1994;1994(10): 115-21.
    • (1994) Genes Chromosomes Cancer , vol.1994 , Issue.10 , pp. 115-121
    • Nordkvist, A.1    Mark, J.2    Gustafsson, H.3    Bang, G.4    Stenman, G.5
  • 17
    • 73249115584 scopus 로고    scopus 로고
    • Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
    • Persson M, Andrén Y, Mark J, Horlings HM, Persson F, Stenman G. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci USA. 2009;106: 18740-4.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18740-18744
    • Persson, M.1    Andrén, Y.2    Mark, J.3    Horlings, H.M.4    Persson, F.5    Stenman, G.6
  • 18
    • 0033551402 scopus 로고    scopus 로고
    • The myb gene family in cell growth, differentiation and apoptosis
    • Oh IH, Reddy EP. The myb gene family in cell growth, differentiation and apoptosis. Oncogene. 1999;18: 3017-33.
    • (1999) Oncogene , vol.18 , pp. 3017-3033
    • Oh, I.H.1    Reddy, E.P.2
  • 19
    • 45849137069 scopus 로고    scopus 로고
    • MYB function in normal and cancer cells
    • Ramsay RG, Gonda TJ. MYB function in normal and cancer cells. Nat Rev Cancer. 2008;8: 523-34.
    • (2008) Nat Rev Cancer , vol.8 , pp. 523-534
    • Ramsay, R.G.1    Gonda, T.J.2
  • 20
    • 77957557959 scopus 로고    scopus 로고
    • Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability, and clinicopathologic significance
    • Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM, Weber RS, Caulin C, El-Naggar AK. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability, and clinicopathologic significance. Clin Cancer Res. 2010;16: 4722-31.
    • (2010) Clin Cancer Res , vol.16 , pp. 4722-4731
    • Mitani, Y.1    Li, J.2    Rao, P.H.3    Zhao, Y.J.4    Bell, D.5    Lippman, S.M.6    Weber, R.S.7    Caulin, C.8    El-Naggar, A.K.9
  • 25
    • 79958200205 scopus 로고    scopus 로고
    • The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma
    • Fehr A, Kovács A, Löning T, Frierson H Jr, van den Oord J, Stenman G. The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. J Pathol. 2011;224: 322-7.
    • (2011) J Pathol , vol.224 , pp. 322-327
    • Fehr, A.1    Kovács, A.2    Löning, T.3    Frierson Jr., H.4    van den Oord, J.5    Stenman, G.6
  • 27
    • 42949150065 scopus 로고    scopus 로고
    • POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands
    • Möller E, Stenman G, Mandahl N, Hamberg H, Mölne L, van den Oord JJ, Brosjö O, Mertens F, Panagopoulos I. POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol. 2008;215: 78-86.
    • (2008) J Pathol , vol.215 , pp. 78-86
    • Möller, E.1    Stenman, G.2    Mandahl, N.3    Hamberg, H.4    Mölne, L.5    van den Oord, J.J.6    Brosjö, O.7    Mertens, F.8    Panagopoulos, I.9
  • 32
    • 0346725846 scopus 로고    scopus 로고
    • Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors
    • Enlund F, Behboudi A, Andren Y, Öberg C, Lendahl U, Mark J, Stenman G. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res. 2004;292: 21-8.
    • (2004) Exp Cell Res , vol.292 , pp. 21-28
    • Enlund, F.1    Behboudi, A.2    Andren, Y.3    Öberg, C.4    Lendahl, U.5    Mark, J.6    Stenman, G.7
  • 33
    • 34249081691 scopus 로고    scopus 로고
    • CRTC1/MAML2 fusion transcript in high-grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin′s tumors: implications for histogenesis and biologic behavior
    • Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. CRTC1/MAML2 fusion transcript in high-grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin′s tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer. 2007;46: 708-15.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 708-715
    • Tirado, Y.1    Williams, M.D.2    Hanna, E.Y.3    Kaye, F.J.4    Batsakis, J.G.5    El-Naggar, A.K.6
  • 36
    • 0037184924 scopus 로고    scopus 로고
    • Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling
    • Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M. Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. J Biol Chem. 2002;277: 50612-20.
    • (2002) J Biol Chem , vol.277 , pp. 50612-50620
    • Lin, S.E.1    Oyama, T.2    Nagase, T.3    Harigaya, K.4    Kitagawa, M.5
  • 37
    • 0036837899 scopus 로고    scopus 로고
    • Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
    • Wu L, Sun T, Kobayashi K, Gao P, Griffin JD. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol. 2002;22: 7688-700.
    • (2002) Mol Cell Biol , vol.22 , pp. 7688-7700
    • Wu, L.1    Sun, T.2    Kobayashi, K.3    Gao, P.4    Griffin, J.D.5
  • 38
    • 22744458562 scopus 로고    scopus 로고
    • Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation
    • Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J. 2005;24: 2391-402.
    • (2005) EMBO J , vol.24 , pp. 2391-2402
    • Wu, L.1    Liu, J.2    Gao, P.3    Nakamura, M.4    Cao, Y.5    Shen, H.6    Griffin, J.D.7
  • 41
    • 33746005602 scopus 로고    scopus 로고
    • The MECT1-MAML2 gene fusion and benign Warthin′s tumour: is the MECT1-MAML2 gene fusion specific to mucoepidermoid carcinoma?
    • Winnes M, Enlund F, Mark J, Stenman G. The MECT1-MAML2 gene fusion and benign Warthin′s tumour: is the MECT1-MAML2 gene fusion specific to mucoepidermoid carcinoma? J Mol Diagn. 2006;8: 394-5.
    • (2006) J Mol Diagn , vol.8 , pp. 394-395
    • Winnes, M.1    Enlund, F.2    Mark, J.3    Stenman, G.4
  • 50
    • 80053360695 scopus 로고    scopus 로고
    • Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion
    • Fehr A, Löning T, Stenman G. Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion. Am J Surg Pathol. 2011;35: 1600-2.
    • (2011) Am J Surg Pathol , vol.35 , pp. 1600-1602
    • Fehr, A.1    Löning, T.2    Stenman, G.3
  • 52
    • 17044431346 scopus 로고    scopus 로고
    • ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
    • Lannon CL, Sorensen PH. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol. 2005;15: 215-23.
    • (2005) Semin Cancer Biol , vol.15 , pp. 215-223
    • Lannon, C.L.1    Sorensen, P.H.2
  • 53
    • 0034677550 scopus 로고    scopus 로고
    • The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells
    • Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene. 2000;19: 906-15.
    • (2000) Oncogene , vol.19 , pp. 906-915
    • Wai, D.H.1    Knezevich, S.R.2    Lucas, T.3    Jansen, B.4    Kay, R.J.5    Sorensen, P.H.6
  • 55
    • 0031038873 scopus 로고    scopus 로고
    • Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations
    • Kas K, Voz ML, Röijer E, Åström AK, Meyen E, Stenman G, van de Ven WJ. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet. 1997;15: 170-4.
    • (1997) Nat Genet , vol.15 , pp. 170-174
    • Kas, K.1    Voz, M.L.2    Röijer, E.3    Åström, A.K.4    Meyen, E.5    Stenman, G.6    van de Ven, W.J.7
  • 60
    • 33947431322 scopus 로고    scopus 로고
    • Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    • Mayr C, Hemann MT, Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science. 2007;315: 1576-9.
    • (2007) Science , vol.315 , pp. 1576-1579
    • Mayr, C.1    Hemann, M.T.2    Bartel, D.P.3
  • 61
    • 84878020433 scopus 로고    scopus 로고
    • t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: a putative progression event
    • Jan 27, doi: 10. 1002/hed. 22926
    • Bell D, N Myers J, Rao PH, El-Naggar AK. t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: a putative progression event. Head Neck. 2012; Jan 27. doi: 10. 1002/hed. 22926.
    • (2012) Head Neck
    • Bell, D.1    Myers, J.N.2    Rao, P.H.3    El-Naggar, A.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.