EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland

Genes Chromosomes and Cancer

Volumn 50, Issue 7, 2011, Pages 559-570

  Antonescu, Cristina R ^a   Katabi, Nora ^a   Zhang, Lei ^a   Sung, Yun Shao ^a   Seethala, Raja R ^b   Jordan, Richard C ^c   Perez Ordoñez, Bayardo ^d,e   Have, Cherry ^d,e   Asa, Sylvia L ^d,e   Leong, Iona T ^f,g   Bradley, Grace ^g   Klieb, Hagen ^h   Weinreb, Ilan ^d,e  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f MOUNT SINAI HOSPITAL   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

^h SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 1; NUCLEIC ACID BINDING PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN EWSR1; PROTEIN FUS; PROTEIN MAML2; PROTEIN ZNF444; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; HYALINIZING CLEAR CELL CARCINOMA; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND CARCINOMA;

ACTIVATING TRANSCRIPTION FACTOR 1; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CALMODULIN-BINDING PROTEINS; CARCINOMA; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; RNA-BINDING PROTEINS; SALIVARY GLAND NEOPLASMS; SOFT TISSUE NEOPLASMS;

EID: 79955669241     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20881     Document Type: Article

References (32)

1. Agaram NP, Laquaglia MP, Ustun B, Guo T, Wong GC, Socci ND, Maki RG, DeMatteo RP, Besmer P, Antonescu CR. 2008. Molecular characterization of pediatric gastrointestinal stromal tumors. Clin Cancer Res 14: 3204-3215.
2. Antonescu CR, Tschernyavsky SJ, Woodruff JM, Jungbluth AA, Brennan MF, Ladanyi M. 2002. Molecular diagnosis of clear cell sarcoma: Detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases. J Mol Diagn 4: 44-52.
3. Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. 2006. EWS-CREB1: A recurrent variant fusion in clear cell sarcoma-Association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res 12: 5356-5362.
4. Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M. 2007. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 46: 1051-1060.
5. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD. 2010. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer 49: 1114-1124.
6. Behboudi A, Enlund F, Winnes M, Andren Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Makitie A, Grenman R, Mark J, Stenman G. 2006. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer 45: 470-481.
7. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, Lumerman H, Mills SE. 2001. Mucoepidermoid carcinoma: A clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 25: 835-845.
8. Clark MA, Johnson MB, Thway K, Fisher C, Thomas JM, Hayes AJ. 2008. Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience. Eur J Surg Oncol 34: 800-804.
9. Dardick I, Leong I. 2009. Clear cell carcinoma: Review of its histomorphogenesis and classification as a squamous cell lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108: 399-405.
10. do Prado RF, Lima CF, Pontes HA, Almeida JD, Cabral LA, Carvalho YR. 2007. Calcifications in a clear cell mucoepidermoid carcinoma: A case report with histological and immunohistochemical findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104: e40-e44.
11. Fanburg-Smith JC, Miettinen M. 1999. Angiomatoid "malignant" fibrous histiocytoma: A clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol 30: 1336-1343.
12. Goode RK, El-Naggar AK. 2005. Mucoepidermoid carcinoma. In: Barnes EL, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press, pp. 219-220.
13. Kapur R, Sugar J, Edward DP. 2005. Conjunctival mucoepidermoid carcinoma: Clear cell variant. Arch Ophthalmol 123: 1265-1268.
14. Kosemehmetoglu K, Folpe AL. 2010. Clear cell sarcoma of tendons and aponeuroses, and osteoclast-rich tumour of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: A review and update. J Clin Pathol 63: 416-423.
15. Martins C, Cavaco B, Tonon G, Kaye FJ, Soares J, Fonseca I. 2004. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. J Mol Diagn 6: 205-210.
16. Michal M, Skalova A, Simpson RH, Rychterova V, Leivo I. 1996. Clear cell malignant myoepithelioma of the salivary glands. Histopathology 28: 309-315.
17. Milchgrub S, Gnepp DR, Vuitch F, Delgado R, Albores-Saavedra J. 1994. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol 18: 74-82.
18. Moller E, Stenman G, Mandahl N, Hamberg H, Molne L, van den Oord JJ, Brosjo O, Mertens F, Panagopoulos I. 2008. POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol 215: 78-86.
19. Nakayama T, Miyabe S, Okabe M, Sakuma H, Ijichi K, Hasegawa Y, Nagatsuka H, Shimozato K, Inagaki H. 2009. Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma. Mod Pathol 22: 1575-1581.
20. O'Regan E, Shandilya M, Gnepp DR, Timon C, Toner M. 2004. Hyalinizing clear cell carcinoma of salivary gland: An aggressive variant. Oral Oncol 40: 348-352.
21. O'sullivan-Mejia ED, Massey HD, Faquin WC, Powers CN. 2009. Hyalinizing clear cell carcinoma: Report of eight cases and a review of literature. Head Neck Pathol 3: 179-185.
22. Peison B, Benisch B, Schwartz IS, Gordon RE. 1988. Clear-cell mucoepidermoid carcinoma arising in the nasal cavity: Case report with ultrastructural observations. Mt Sinai J Med 55: 417-420.
23. Pires FR, Azevedo RS, Ficarra G, Cardoso AS, Carlos R, Kowalski LP, de Almeida OP. 2010. Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: Comparative clinicopathologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109: e22-27.
24. Seethala RR. 2009. An update on grading of salivary gland carcinomas. Head Neck Pathol 3: 69-77.
25. Seethala RR, Barnes EL, Hunt JL. 2007. Epithelial-myoepithelial carcinoma: A review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol 31: 44-57.
26. Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. 2010. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol 34: 1106-1121.
27. Seo IS, Tomich CE, Warfel KA, Hull MT. 1980. Clear cell carcinoma of the larynx A variant of mucoepidermoid carcinoma. Ann Otol Rhinol Laryngol 89: 168-172.
28. Solar AA, Schmidt BL, Jordan RC. 2009. Hyalinizing clear cell carcinoma: Case series and comprehensive review of the literature. Cancer 115: 75-83.
29. Terada T, Ikeuchi S, Inomoto C, Shimamura K. 2004. Mucoepidermoid carcinoma of the palate composed exclusively of clear cells (clear cell variant). Virchows Arch 445: 541-543.
30. Wang WL, Mayordomo E, Zhang W, Hernandez VS, Tuvin D, Garcia L, Lev DC, Lazar AJ, López-Terrada D. 2009. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts). Mod Pathol 22: 1201-1209.
31. Yang S, Chen X. 2010. Calcifications in clear cell mucoepidermoid carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109: 274-275.
32. Yang S, Zhang J, Chen X, Wang L, Xie F. 2008. Clear cell carcinoma, not otherwise specified, of salivary glands: A clinicopathologic study of 4 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106: 712-720.