The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma

Journal of Pathology

Volumn 224, Issue 3, 2011, Pages 322-327

  Fehr, A ^a   Kovacs A ^b   Loning T ^c   Frierson Jr , H F ^d   Van Den Oord, J J ^e   Stenman, G ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c Albertinen Pathologie   (Germany)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

adenoid cystic carcinoma; chromosome translocation; dermal cylindroma; fusion gene; MYB NFIB

Indexed keywords

ADENOID CYSTIC CARCINOMA; ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; CLINICAL ARTICLE; CYLINDROMA; FEMALE; GENE ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE FUSION; GENETIC LINKAGE; HUMAN; MALE; NFIB GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; ONCOGENE MYB; PRIORITY JOURNAL; SALIVARY GLAND TUMOR; SEQUENCE ANALYSIS;

AGED; AGED, 80 AND OVER; CARCINOMA, ADENOID CYSTIC; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 9; FEMALE; HUMANS; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-MYB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALIVARY GLAND NEOPLASMS; SKIN NEOPLASMS; TRANSLOCATION, GENETIC;

EID: 79958200205     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2909     Document Type: Article

References (27)

1. Persson M, Andren Y, Mark J, et al., Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci USA 2009; 106: 18740-18744.
2. Stenman G, Andersson MK, Andren Y,. New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer. Cell Cycle 2010; 9: 2986-2995.
3. Ramsay RG, Gonda TJ,. MYB function in normal and cancer cells. Nat Rev Cancer 2008; 8: 523-534. (Pubitemid 351881853)
4. Oh IH, Reddy EP,. The myb gene family in cell growth, differentiation and apoptosis. Oncogene 1999; 18: 3017-3033. (Pubitemid 29276541)
5. Clappier E, Cuccuini W, Kalota A, et al., The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 2007; 110: 1251-1261. (Pubitemid 47281423)
6. Lahortiga I, De Keersmaecker K, Van Vlierberghe P, et al., Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat Genet 2007; 39: 593-595. (Pubitemid 46676109)
7. Wohlfahrt C, Ternesten A, Sahlin P, et al., Cytogenetic and fluorescence in situ hybridization analyses of a microcystic adnexal carcinoma with del(6)(q23q25). Cancer Genet Cytogenet 1997; 98: 106-110. (Pubitemid 27431126)
8. Behboudi A, Winnes M, Gorunova L, et al., Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer 2005; 43: 202-205. (Pubitemid 40570740)
9. Möller E, Stenman G, Mandahl N, et al., POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol 2008; 215: 78-86. (Pubitemid 351619878)
10. Winnes M, Molne L, Suurkula M, et al., Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer 2007; 46: 559-563. (Pubitemid 46649570)
11. McNiff J, T.H. M, Requena L, et al., Benign tumours with apocrine and eccrine differentiation. In World Health Organization Classification of Tumors Pathology and Genetics of Skin Tumours, LeBoit PE, Burg G, Weedon D, et al (eds). IARC Press: Lyon, France, 2006; 139-148.
12. Weedon D,. Skin Pathology, 2nd edn. Churchill-Livingstone: London, 2002; 890-891.
13. Bignell GR, Warren W, Seal S, et al., Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet 2000; 25: 160-165. (Pubitemid 30394985)
14. Klein W, Chan E, Seykora JT,. Tumors of the epidermal appendages. In Lever's Histopathology of Skin, 9th edn, Elder DE, Elenitsas R, Johnson BL, et al (eds). Lippincott Williams & Wilkins: Philadelphia, PA, 2005; 897-898.
15. Massoumi R, Chmielarska K, Hennecke K, et al., Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-κB signaling. Cell 2006; 125: 665-677.
16. Massoumi R, Paus R,. Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. Bioessays 2007; 29: 1203-1214. (Pubitemid 350221789)
17. Nordkvist A, Mark J, Gustafsson H, et al., Non-random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands. Genes Chromosomes Cancer 1994; 10: 115-121. (Pubitemid 24155981)
18. Mitani Y, Li J, Rao PH, et al., Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability and clinicopathological significance. Clin Cancer Res 2010; 16: 4722-4731.
19. West RB, Kong C, Clarke N, et al., MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol 2011; 35: 92-99.
20. Behboudi A, Enlund F, Winnes M, et al., Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer 2006; 45: 470-481.
21. Tonon G, Modi S, Wu L, et al., t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 2003; 33: 208-213. (Pubitemid 36177076)
22. Larsen WJ,. Human Embryology, 3rd edn. Churchill Livingstone: Philadelphia, PA, 2001; 351-378, 465-480.
23. Naylor E, Sarkar P, Perlis CS, et al., Primary cutaneous adenoid cystic carcinoma. J Am Acad Dermatol 2008; 58: 636-641. (Pubitemid 351375048)
24. Leonard N, Chaggar R, Jones C, et al., Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours. J Clin Pathol 2001; 54: 689-692. (Pubitemid 32835416)
25. Biggs PJ, Chapman P, Lakhani SR, et al., The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas. Oncogene 1996; 12: 1375-1377. (Pubitemid 26127270)
26. Fukuda M, Hiroi M, Suzuki S, et al., Loss of CYLD might be associated with development of salivary gland tumors. Oncol Rep 2008; 19: 1421-1427.
27. Reiley W, Zhang M, Sun SC,. Negative regulation of JNK signaling by the tumor suppressor CYLD. J Biol Chem 2004; 279: 55161-55167. (Pubitemid 40066510)