A closer look at Warthin tumors and the t(11;19)

Cancer Genetics and Cytogenetics

Volumn 180, Issue 2, 2008, Pages 135-139

  Fehr, André ^a   Röser, Kerstin ^b   Belge, Gazanfer ^a   Löning, Thomas ^c   Bullerdiek, Jörn ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c ALBERTINEN KRANKENHAUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSQUAMOUS CARCINOMA; ARTICLE; CHROMOSOME TRANSLOCATION 11; CRTC1 GENE; EXON; GENE EXPRESSION PROFILING; GENE FUSION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; MAML2 GENE; METAPLASIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WARTHIN TUMOR;

ADENOLYMPHOMA; CARCINOMA, MUCOEPIDERMOID; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 19; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; SALIVARY GLAND NEOPLASMS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 38149112746     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2007.10.007     Document Type: Article

References (22)

1. Marchevsky A.M. Bronchial gland tumors. In: Saldana M.J. (Ed). Pathology of pulmonary disease (1994), J.B. Lippincott, Philadelphia 597-607
2. Ellis G.L., and Auclair P.L. Tumors of the salivary glands. In: Rosai J., and Sobin L.H. (Eds). Atlas of tumor pathology, 3rd series (1996), Armed Forces Institute of Pathology, Washington, DC 155-175
3. Nordkvist A., Gustafsson H., Juberg-Ode M., and Stenman G. Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma. Cancer Genet Cytogenet 74 (1994) 77-83
4. Stenman G., Petursdottir V., Mellgren G., and Mark J. A child with a t(11;19)(q14-21;p12) in a pulmonary mucoepidermoid carcinoma. Virchows Arch 433 (1998) 579-581
5. Mitelman F, Johansson B, Mertens F, editors. Mitelman database of chromosome aberrations in cancer [Internet]. Updated May 2007. Accessed July 1, 2007. Available at: http://cgap.nci.nih.gov/Chromosomes/Mitelman.
6. Bullerdiek J., Haubrich J., Meyer K., and Bartnitzke S. Translocation t(11;19)(q21;p13.1) as the sole chromosome abnormality in a cystadenolymphoma (Warthin's tumor) of the parotid gland. Cancer Genet Cytogenet 35 (1988) 129-132
7. Eveson J.W., and Cawson R.A. Infarcted ('infected') adenolymphomas: a clinicopathological study of 20 cases. Clin Otolaryngol Allied Sci 14 (1989) 205-210
8. Warnock G.R. Papillary cystadenoma lymphomatosum (Warthin's tumor). In: Ellis G.L., Auclair P.L., and Gnepp D.R. (Eds). Surgical pathology of the salivary glands (1991), W.B. Saunders, Philadelphia 187-201
9. Simpson R.H.W., and Eveson J.W. Warthin tumour. In: Barnes L., Eveson J.W., Reichart P., and Sidransky D. (Eds). Pathology and genetics of head and neck tumoursWHO Classification of Tumours: Pathology and Genetics 9 (2005), IARC Press, Lyon 263-265
10. Di Palma S., Simpson R.H., Skalova A., and Michal M. Metaplastic (infarcted) Warthin's tumour of the parotid gland: a possible consequence of fine needle aspiration biopsy. Histopathology 35 (1999) 432-438
11. Schwerer M.J., Kraft K., Baczako K., and Maier H. Cytokeratin expression and epithelial differentiation in Warthin's tumour and its metaplastic (infarcted) variant. Histopathology 39 (2001) 347-352
12. Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., O'Neil K., Stover K., El-Naggar A., Griffin J.D., Kirsch I.R., and Kaye F.J. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. [Erratum in: Nat Genet 2003;33:430]. Nat Genet 33 (2003) 208-213
13. Enlund F., Behboudi A., Andrén Y., Öberg C., Lendahl U., Mark J., and Stenman G. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res 292 (2004) 21-28
14. Martins C., Cavaco B., Tonon G., Kaye F.J., Soares J., and Fonseca I. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. J Mol Diagn 6 (2004) 205-210
15. Conkright M.D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J.B., and Montminy M. TORCs: transducers of regulated CREB activity. Mol Cell 12 (2003) 413-423
16. Iourgenko V., Zhang W., Mickanin C., Daly I., Jiang C., Hexham J.M., Orth A.P., Miraglia L., Meltzer J., Garza D., Chirn G.W., McWhinnie E., Cohen D., Skelton J., Terry R., Yu Y., Bodian D., Buxton F.P., Zhu J., Song C., and Labow M.A. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A 100 (2003) 12147-12152
17. Wu L., Liu J., Gao P., Nakamura M., Cao Y., Shen H., and Griffin J.D. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J 24 (2005) 2391-2402
18. Rogalla P., Lemke I., Kazmierczak B., and Bullerdiek J. An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). Genes Chromosomes Cancer 29 (2000) 363-366
19. Seifert G., Brocheriou C., Cardesa A., and Eveson J.W. WHO International Histological Classification of Tumors: tentative histological classification of salivary gland tumors. Pathol Res Pract 186 (1990) 555-581
20. Behboudi A., Winnes M., Gorunova L., van den Oord J.J., Mertens F., Enlund F., and Stenman G. Clear cell hidradenoma of the skin: a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer 43 (2005) 202-205
21. Winnes M., Mölne L., Suurküla M., Andrén Y., Persson F., Enlund F., and Stenman G. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer 46 (2007) 559-563
22. Winnes M., Enlund F., Mark J., and Stenman G. The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucoepidermoid carcinoma?. J Mol Diagn 8 (2006) 394-395 author reply 395-6