HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas

Cancer Research

Volumn 69, Issue 5, 2009, Pages 1844-1850

  De Martino, Ivana ^a,e   Visone, Rosa ^a,e   Wierinckx, Anne ^f   Palmieri, Dario ^a,e   Ferraro, Angelo ^e   Cappabianca, Paolo ^b   Chiappetta, Gennaro ^d   Forzati, Floriana ^a,e   Lombardi, Gaetano ^c   Colao, Annamaria ^c   Trouillas, Jacqueline ^f   Fedeleind, Monica ^a,e   Fusco, Alfredo ^a,e  

^a CNR   (Italy)

^b Dipartimento di Seien ze Neurologiche   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^f INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B2; GROWTH HORMONE; HIGH MOBILITY GROUP A PROTEIN; LUCIFERASE; PROLACTIN; TRANSCRIPTION FACTOR E2F1; CCNB2 PROTEIN, HUMAN; CCNB2 PROTEIN, MOUSE; CYCLIN B; HIGH MOBILITY GROUP A1A PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENZYME ASSAY; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HMGA1 GENE; HMGA2 GENE; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; UPREGULATION; ADENOMA; ANIMAL; CELL STRAIN 3T3; GENE EXPRESSION REGULATION; GENETICS; HYPOPHYSIS TUMOR; PHYSIOLOGY; RAT;

ADENOMA; ANIMALS; CYCLIN B; GENE EXPRESSION REGULATION, NEOPLASTIC; HMGA1A PROTEIN; HMGA2 PROTEIN; HUMANS; MICE; MICE, TRANSGENIC; NIH 3T3 CELLS; PITUITARY NEOPLASMS; PROMOTER REGIONS, GENETIC; RATS; UP-REGULATION;

EID: 62449278948     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-4133     Document Type: TB

References (33)

1. Johnson KR, Lehn DA, Reeves R. Alternative processing of mRNA's coding for human HMG I, HMG Y. proteins. MoI Cell Biol 1989;9:2114-2123.
2. Manfioletti G, Giancotti V, Bandiera A, et al. cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes. Nucleic Acids Res 1991.1:19:6793-797.
3. Reeves R. Molecular biology of HMGA proteins: ubs of nuclear function. Gene 2001;277:63-81.
4. Chlappetta G, Avantaggiato V, Visconti R, et al. High level expression of the HMGI (Y) gene during embryonic development. Oncogene 1996;13:2439-2446.
5. Zhou X, Benson KF, Ashar HR, Chada K. Mutation responsible for the mouse pygmy phenotype in the developmental regulated factor HMGI-C. Nature 1995; 376:771-74.
6. Fusco A, Fedele M. Roles of HMGA proteins in cancer [review]. Nat Rev Cancer 2007;12:899-910.
7. Fedele M, Beriingieri MT, Scala S, et al. Truncated and chimeric HMGI-C genes induce neoplastic transforma-tion of NIH3T3 murine fibroblasts. Oncogene 1998:17: 413-18.
8. Wood LJ, Maher JF, Bunton TE, Resar LM. The oncogenic properties of the HMG-I gene family. Cancer Res 2000;60:4256-4261.
9. Baldassarre G, Fedele M, Battista S, et al. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sd USA 2001;98:7970-975.
10. Fedele M, Battista S, Kenyon L, et al. Overexpresslon of the H.MGA2 gene in. transgenic mice leads to the onset of pituitary adenomas. Oncogene 2002;21:3190-198.
11. Fedele M, Pentimalli F, Baldassarre G, et al. Transgenic mice overexpressing the wild-type form of the HMGAl gene develop mixed growth hormone/ prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 2005;24:3427-3435.
12. Fedele M, Visone R, De Martino I, et al. HMGA2 induces pituitary tumorigenesis by enhancing E2F.1 activity. Cancer Cell 2006;9:459-71.
13. FineUi P, Pierantoni GM, Giardino D, et al. The High Mobility Group A2 gene is amplified and over-expressed in human prolactinomas. Cancer Res 2002; 62:2398-2405.
14. De Martino I, Visone R, Palmier! D, et al. The MWCd-rap gene expression is downregulated by the HMGA proteins in mouse pituitary adenomas. Endocr Relat Cancer 2007;14;875-86.
15. Mlnshull J, Blow JJ, Hunt T. Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis. Cell 1989;56:947-956.
16. Brandeis M, Rosewell I, Carrington M, et al. Cyclin B2-nuU mice develop normally and are fertile whereas cyclin Bl-null mice die in utero. Proc Natl Acad Sei USA 1998;95:4344-349
17. Wang A, Yoshimi N, Ino N, Tanaka T, Mori H. Overexpression of cyclin Bl in human colorectal cancers. J Cancer Res CUn Oncol 1997;123:124-127.
18. Soria JC, Jang SJ, Khuri FR, et al. Overexpression of cyclin Bl in early-stage non-small cell lung cancer and its clinical implication. Cancer Res 2000;60:4000-4004.
19. Sarafan-Vasseur N, Lamy A, Bourguignon. J, et al. Overexpression of B-type cyclins alters chromosomal segregation. Oncogene 2002;21:2051-2057.
20. Park. SH, Yu GR, Kim WH, Moon WS, Kim JH, Kim DG. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. Clin Cancer Res 2007;13: 858-867.
21. Turner HE, Nagy Z, Sullivan N, Esiri MM, Wass JA. Expression analysis of cyclins in pituitary adenomas and the normal pituitary gland. Clin Endocrinol (Oxf) 2000; 53:337-344.
22. Hibberts NA, Simpson. DJ, Bickne.1.1 JE, et al. Analysis of Cyclin Dl (CCNDl) allelic imbalance and over-expression, in sporadic human pituitary tumors. Clin Cancer Res 1999;5:2133-139.
23. Simpson DJ, Fryer AA, Grossman AB, et al. Cyclin. Dl (CCNDl ) genotype is associated with tumour grade in sporadic pituitary adenomas. Carcinogenesis 200.1:22: 1801-7.
24. kx A, Auger C, Devauchelle P, et al. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors Endocr Relat Cancer 2007;14:887-900.
25. Bolognese F1 Wasner M1 Lange-zu Dohna C, et al. The cyclin B2 promoter depends on NF-Y, a trimer whose CCAAT-binding activity is cell-cycle regulated. Oncogene 1999;18:1845-53.
26. MeUUo RM, Pierantoni GM, Scala S, et al. Critical role of the HMGI(Y) proteins in. adipocyte cell growth and differentiation. Mol Cell Biol 2001;21:2485-95.
27. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-AA C(T)) Method. Methods 2001;25:402-08.
28. Battista S, Fedele M, Martinez Hoyos J, et al. High MobiUty Group Al proteins downregulate RAG2 gene expression. Biochem J 2005;389:91-97.
29. Lange-zu Dohna C, Brandeis M, Berr F, Meissner J, Engeland K. A CDE/CHR tandem element regulates ceU cycle-dependent repression of cyclin B2 transcription. FEBS Lett 2000;484:77-81.
30. Epstein CB, Cross FR. CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes 1992;6: 1695-1706.
31. Fitch I, Dahmann C, Surana U, et al. Character-ization of four B-type cycUn genes of the budding yeast Saccharomyces cerevisiae. MoI Biol Cell 1992;3: 805-818
32. Chapman DL, Wolgemuth DJ. Isolation of the murine cyclin B2 cDNA and characterization of the lineage and temporal specificity of expression of the Bl and B2 cyclins during oogenesis, spermatogenesis and early embryogenesis. Development 1993;118:229-40.
33. Jackman M, Firth M, Pines J. Human cyclins Bland B2 are localized to strikingly different structures: Blto microtubules, B2 primarily to the Golgi apparatus. EMBO J 1995;14:1646-54.