The mosaic receptor sorLA/LR11 binds components of the plasminogen- activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand

Biochemical Journal

Volumn 381, Issue 1, 2004, Pages 203-212

  Gliemann, Jørgen ^a   Hermey, Guido ^a   Nykjær, Anders ^a   Petersen, Claus M ^a   Jacobsen, Christian ^a   Andreasen, Peter A ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Endocytosis; Platelet derived growth factor BB (PDGF BB); Receptor associated protein (RAP); Type 1 plasminogen activator inhibitor (PAI 1); Urokinase type plasminogen activator (uPA); Vps10p domain receptor family

Indexed keywords

BIOCHEMISTRY; CELLS; CHEMICAL BONDS; GROWTH KINETICS; STRUCTURE (COMPOSITION); TERNARY SYSTEMS;

PLATELETS; SIGNALING EVENTS;

PROTEINS;

ALPHA 2 MACROGLOBULIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MOSAIC RECEPTOR SORLA; PLASMINOGEN ACTIVATOR; PLATELET DERIVED GROWTH FACTOR BB; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; INTERNALIZATION; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ALPHA-MACROGLOBULINS; ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; ENDOCYTOSIS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN; LDL-RECEPTOR RELATED PROTEINS; LIGANDS; MEMBRANE TRANSPORT PROTEINS; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, LDL; TRANSFECTION;

ANIMALIA;

EID: 3142680780     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040149     Document Type: Article

References (50)

1. 2-macroglobulin receptor-associated protein. J. Biol. Chem. 271, 31379-31383
2. Yamazaki, H., Bujo, H., Kusunoki, J., Seimiya, K., Kanaki, T., Morisaki, N., Schneider, W. J. and Saito, Y. (1996) Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J. Biol. Chem. 271, 24761-24768
3. Petersen, C. M., Nielsen, M. S., Nykjær, A., Jacobsen, L., Tommerup, N., Rasmussen, H. H., Røjgaard, H., Gliemann, J., Madsen, P. and Moestrup, S. K. (1997) Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated affinity chromatography. J. Biol. Chem. 272, 3599-3605
4. Hermey, G., Keat, S. J., Madsen, P., Jacobsen, C., Petersen, C. M. and Gliemann, J. (2003) Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. J. Biol. Chem. 278, 7390-7396
5. Herz, J. and Bock, H. H. (2002) Lipoprotein receptors in the nervous system. Annu. Rev. Biochem. 71, 405-434
6. Nykjær, A. and Willnow, T. E. (2002) The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol. 12, 273-280
7. Jacobsen, L., Madsen, P., Jacobsen, C., Nielsen, M. S., Gliemann, J. and Petersen, C. M. (2001) Activation and functional characterization of the mosaic receptor sorLA/LR11. J. Biol. Chem. 276, 22788-22796
8. Hermans-Borgmeyer, I., Hampe, W., Schinke, B., Methner, A., Nykjær, A., Susens, U., Fenger, U., Herbarth, B. and Schaller, H. C. (1998) Unique expression of a novel mosaic receptor in the developing cerebral cortex. Mech. Dev. 70, 65-76
9. Riedel, I. B., Hermans-Borgmeyer, I. and Hubner, C. A. (2002) SorLA, a member of the LDL receptor family, is expressed in the collecting duct of the murine kidney. Histochem. Cell Biol. 118, 183-191
10. Kanaki, T., Bujo, H., Hirayama, S., Ishii, I., Morisaki, N., Schneider, W. J. and Saito, Y. (1999) Expression of LR11, a mosaic LDL receptor family member, is markedly increased in atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 19, 2687-2695
11. Zhu, Y., Bujo, H., Yamazaki, H., Hirayama, S., Kanaki, T., Takahashi, K., Shibasaki, M., Schneider, W. and Saito, Y. (2002) Enhanced expression of the LDL receptor family member LR11 increases migration of smooth muscle cells in vitro. Circulation 105, 1830-1836
12. Neels, J. G., van Den Berg, B. M., Lookene, A., Olivecrona, G., Pannekoek, H. and van Zonneveld, A.-J. (1999) The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. J. Biol. Chem. 274, 31305-31311
13. Obermoeller-McCormick, L. M., Li, Y., Osaka, H., FitzGerald, D. J., Schwartz, A. L. and Bu, G. (2001) Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein. J. Cell Sci. 114, 899-908
14. 2- macroglobulin receptor/LDL receptor-related protein binds urokinase-plasminogen activator inhibitor type-1 complex. J. Biol. Chem. 267, 14543-14546
15. 2- macroglobulin receptor/low density lipoprotein receptor-related protein. J. Biol. Chem. 269, 25668-25676
16. Conese, M., Nykjær, A., Christensen, E. I., Petersen, C. M., Cremona, O., Pardi, R., Andreasen, P. A., Gliemann, J. and Blasi, F. (1995) Alpha-2 macroglobulin receptor/Ldl receptor-related protein (Lrp)-dependent internalization of the urokinase receptor. J. Cell Biol. 131, 1609-1622
17. Nykjær, A., Conese, M., Christensen, E. I., Olson, D., Cremona, O., Gliemann, J. and Blasi, F. (1997) Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J. 16, 2610-2620
18. Li, Y., Knisely, J. M., Lu, W., McCormick, L. M., Wang, J., Henkin, J., Schwartz, A. L. and Bu, G. (2002) Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. J. Biol. Chem. 277, 42366-42371
19. Blasi, F. and Carmeliet, P. (2002) uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell Biol. 3, 932-943
20. Weaver, A. M., Hussaini, I. M., Mazar, A., Henkin, J. and Gonias, S. L. (1997) Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin. J. Biol. Chem. 272, 14372-14379
21. Webb, D. J., Nguyen, D. H., Sankovic, M. and Gonias, S. L. (1999) The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro. J. Biol. Chem. 274, 7412-7420
22. Strickland, D. K., Gonias, S. L. and Argraves, W. S. (2002) Diverse roles for the LDL receptor family. Trends Endocrinol. Metab. 13, 66-74
23. Li, Y., Marzolo, M. P., van Kerkhof, P., Strous, G. J. and Bu, G. (2000) The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein-related protein. J. Biol. Chem. 275, 17187-17194
24. Boucher, P., Gotthardt, M., Li, W.-P., Anderson, R. G. W. and Herz, J. (2003) LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300, 329-332
25. Loukinova, E., Ranganathan, S., Kuznetsov, S., Gorlatova, N., Migliorin, M. M., Loukinov, D., Ulery, P. G., Mikhailenko, I., Lawrence, D. A. and Strickland, D. K. (2002) Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). J. Biol. Chem. 277, 15499-15506
26. Boucher, P., Liu, P. V., Gotthardt, M., Hiesberger, T., Anderson, R. G. W. and Herz, J. (2002) Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low density lipoprotein receptor-related protein in calveolae. J. Biol. Chem. 277, 15507-15513
27. Swertfeger, D. K., Bu, G. and Hui, D. Y. (2002) Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration. J. Biol. Chem. 277, 4141-4146
28. Gonias, S. L., Carmichael, A., Mettenburg, J. M., Roadcap, D. W., Irvin, W. P. and Webb, D. J. (2000) Identical or overlapping sequences in the primary structure of human alpha (2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor- and transforming growth factor-beta. J. Biol. Chem. 275, 5826-5831
29. Egelund, R., Petersen, T. E. and Andreasen, P. A. (2001) A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism. Eur. J. Biochem. 268, 673-685
30. Grebenschikov, N., Sweep, F., Geurts, A., Andreasen, P., De Witte, H., Schousboe, S., Heuvel, J. and Benraad, T. (1999) ELISA for complexes of urokinase-type and tissue-type plasminogen activators with their type-1 inhibitor (uPA-PAI-1 and tPA-PAI-1). Int. J. Cancer 81, 598-606
31. 2-macroglobulin receptor (low density lipoprotein receptor-related protein). J. Biol. Chem. 266, 14011-14017
32. FitzGerald, D. J., Fryling, C. M., Zdanovsky, A., Saelinger, C. B., Kounnas, M. Z., Winkles, J. A., Strickland, D. and Leppla, S. (1995) Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein. J. Cell Biol. 129, 1533-1541
33. Petersen, C. M., Nielsen, M. S., Jacobsen, C., Tauris, J., Jacobsen, L., Gliemann, J., Moestrup, S. K. and Madsen, P. (1999) Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J. 18, 595-604
34. Zhu, Y., Bujo, H., Yamazaki, H., Ohwaki, K., Jiang, M., Hirayama, S., Kanaki, T., Shibasaki, M., Takahashi, K., Schneider, W. J. and Saito, Y. (2004) LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration. Circ. Res. 92, 752-758
35. Li, Y., Lu, W., Marzolo, M. P. and Bu, G. (2001) Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J. Biol. Chem. 276, 18000-18006
36. Heegaard, C. W., Simonsen, A. C., Oka, K., Kjøller, L., Christensen, A., Madsen, B., Ellgaard, L., Chan, L. and Andreasen, P. A. (1995) Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator inhibitor complex. J. Biol. Chem. 270, 20855-20861
37. Fowler, B., Mackman, N., Parmer, R. J. and Miles, L. A. (1998) Binding of human single chain urokinase to Chinese hamster ovary cells and cloning of hamster u-PAR. Thromb. Haemostasis 80, 148-154
38. Nielsen, M. S., Madsen, P., Christensen, E. I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R. and Petersen, C. M. (2001) The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J. 20, 2180-2190
39. Nielsen, M. S., Jacobsen, C., Olivecrona, G., Gliemann, J. and Petersen, C. M. (1999) Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem. 274, 8832-8836
40. Zhang, J. C., Sakthivel, R., Kniss, D., Graham, C. H., Strickland, D. K. and McCrae, K. R. (1998) The low density lipoprotein receptor-related protein/alpha2 macroglobulin receptor regulates cell surface plasminogen activator activity on human trophoblast cells. J. Biol. Chem. 273, 32273-32280
41. Webb, D. J., Nguyen, D. H. D. and Gonias, S. L. (2000) Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration in Matrigel invasion. J. Cell Sci. 113, 121-134
42. Andersen, O. M., Petersen, H. H., Jacobsen, C., Moestrup, S. K., Etzerodt, M., Andreasen, P. A. and Thøgersen, H. C. (2001) Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein. Biochem. J. 357, 289-296
43. Rodenburg, K. W., Kjøller, L., Petersen, H. H. and Andreasen, P. A. (1998) Binding of urokinase-type plasminogen activator-plasminogen activator-inhibitor-1 complex to the endocytosis receptors alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor. Biochem. J. 329, 55-63
44. Horn, I. R., van den Berg, B. M., Moestrup, S. K., Pannekoek, H. and van Zonneveld, A. J. (1998) Plasminogen activator inhibitor 1 contains a cryptic high affinity receptor binding site that is exposed upon complex formation with tissue-type plasminogen activator. Thromb. Haemostasis 80, 822-828
45. Stefansson, S., Muhammad, S., Cheng, X. F., Battey, F. D., Strickland, D. K. and Lawrence, D. A. (1998) Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein. J. Biol. Chem. 273, 6358-6366
46. Zhuo, M., Holtzman, D. M., Li, Y., Osaka, H., DeMaro, J., Jacquin, M. and Bu, G. (2000) Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. J. Neurosci. 20, 542-549
47. 2- macroglobulin by the low density lipoprotein receptor-related protein requires the cooperation of two ligand binding cluster regions. J. Biol. Chem. 276, 39484-39491
48. Liu, C.-X., Li, Y., Obermoeller-McCormick, L. M., Schwartz, A. L. and Bu, G. (2001) The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J. Biol. Chem. 276, 28889-28896
49. Ma, Z., Thomas, K. S., Webb, D. J., Moravec, R., Salicioni, A. M., Mars, W. M. and Gonias, S. L. (2002) Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J. Cell Biol. 159, 1061-1070
50. Jo, M., Thomas, K. S., O'Donnell, D. M. and Gonias, S. L. (2003) Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J. Biol. Chem. 278, 1642-1646