Deprenyl enhances the teratogenicity of hydroxyurea in organogenesis stage mouse embryos

Toxicological Sciences

Volumn 134, Issue 2, 2013, Pages 391-399

  Schlisser, Ava E ^a   Hales, Barbara F ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

4 hydroxy 2 nonenal; Apoptosis; Caspase 3; Cell death; Glutathione; Glyceraldehyde 3 phosphate dehydrogenase; Nuclear translocation; Oxidative stress; Teratogen

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROXYUREA; SELEGILINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAUDAL MALFORMATION; CELL NUCLEUS; CONGENITAL MALFORMATION; CONTROLLED STUDY; DIGIT ANOMALY; EMBRYO; FEMALE; GLYCOLYSIS; LIMB REDUCTION; LUMBOSACRAL VERTEBRAL ABNORMALITY; MOUSE; NONHUMAN; ORGANOGENESIS; OXIDATIVE STRESS; PROTEIN LOCALIZATION; SOMITE; TAIL DEFECT; TERATOGENICITY;

4-HYDROXY-2-NONENAL; APOPTOSIS; CASPASE-3.; CELL DEATH; GLUTATHIONE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; NUCLEAR TRANSLOCATION; OXIDATIVE STRESS; TERATOGEN;

ANIMALS; DRUG SYNERGISM; EMBRYO, MAMMALIAN; FEMALE; HYDROXYUREA; MICE; MONOAMINE OXIDASE INHIBITORS; ORGANOGENESIS; PREGNANCY; PREGNANCY OUTCOME; SELEGILINE; TERATOGENS;

EID: 84880685205     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft115     Document Type: Article

References (35)

1. Azam, S., Jouvet, N., Jilani, A., Vongsamphanh, R., Yang, X., Yang, S., and Ramotar, D. (2008). Human glyceraldehyde-3-phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme APE1. J. Biol. Chem. 283, 30632-30641.
2. Banh, S., and Hales, B. F. (2013). Hydroxyurea exposure triggers tissue-specific activation of p38 mitogen-activated protein kinase signaling and the DNA damage response in organogenesis-stage mouse embryos. Toxicol. Sci. 133, 298-308.
3. Carlile, G. W., Chalmers-Redman, R. M., Tatton, N. A., Pong, A., Borden, K. E., and Tatton, W. G. (2000). Reduced apoptosis after nerve growth factor and serum withdrawal: Conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer. Mol. Pharmacol. 57, 2-12.
4. Carujo, S., Estanyol, J. M., Ejarque, A., Agell, N., Bachs, O., and Pujol, M. J. (2006). Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity. Oncogene 25, 4033-4042.
5. DeSesso, J. M., Jacobson, C. F., Scialli, A. R., and Goeringer, G. C. (2000). Hydroxylamine moiety of developmental toxicants is associated with early cell death: A structure-activity analysis. Teratology 62, 346-355.
6. DeSesso, J. M., Scialli, A. R., and Goeringer, G. C. (1994). D-mannitol, a specific hydroxyl free radical scavenger, reduces the developmental toxicity of hydroxyurea in rabbits. Teratology 49, 248-259.
7. Diez, J. A., and Maderdrut, J. L. (1977). Development of multiple forms of mouse brain monoamine oxidase in vivo and in vitro. Brain Res. 128, 187-192.
8. Esterbauer, H., Schaur, R. J., and Zollner, H. (1991). Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11, 81-128.
9. Hara, M. R., and Snyder, S. H. (2006). Nitric oxide-GAPDH-Siah: A novel cell death cascade. Cell. Mol. Neurobiol. 26, 527-538.
10. Hara, M. R., Thomas, B., Cascio, M. B., Bae, B. I., Hester, L. D., Dawson, V. L., Dawson, T. M., Sawa, A., and Snyder, S. H. (2006). Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc. Natl. Acad. Sci. U.S.A. 103, 3887-3889.
11. Huang, J., Yakubu, M., Kim-Shapiro, D. B., and King, S. B. (2006). Rat livermediated metabolism of hydroxyurea to nitric oxide. Free Radic. Biol. Med. 40, 1675-1681.
12. Human prescription drug label; Eldepryl (selegiline hydrochloride) capsule. Somerset Pharmaceuticals Inc. 2009.
13. Jiang, Z. L., Fletcher, N. M., Diamond, M. P., Abu-Soud, H. M., and Saed, G. M. (2009). S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosis. Wound Repair Regen. 17, 224-229.
14. Kornberg, M. D., Sen, N., Hara, M. R., Juluri, K. R., Nguyen, J. V., Snowman, A. M., Law, L., Hester, L. D., and Snyder, S. H. (2010). GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12, 1094-1100.
15. Kovacic, P. (2011). Hydroxyurea (therapeutics and mechanism): Metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med. Hypotheses 76, 24-31.
16. Kusner, L. L., Sarthy, V. P., and Mohr, S. (2004). Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase: A role in high glucose-induced apoptosis in retinal Müller cells. Invest. Ophthalmol. Vis. Sci. 45, 1553-1561.
17. Le, W., Jankovic, J., Xie, W., Kong, R., and Appel, S. H. (1997). (-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition. Neurosci. Lett. 224, 197-200.
18. Magyar, K., and Szende, B. (2004). (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology 25, 233-242.
19. Meyer-Siegler, K., Mauro, D. J., Seal, G., Wurzer, J., deRiel, J. K., and Sirover, M. A. (1991). A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. Proc. Natl. Acad. Sci. U.S.A. 88, 8460-8464.
20. Nicotra, A., Pierucci, F., Parvez, H., and Senatori, O. (2004). Monoamine oxidase expression during development and aging. Neurotoxicology 25, 155-165.
21. Olanow, C. W. (1993). A rationale for monoamine oxidase inhibition as neuroprotective therapy for Parkinson's disease. Mov. Disord. 8(Suppl. 1), S1-S7.
22. Ornoy, A. (2007). Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod. Toxicol. 24, 31-41.
23. Ortiz-Ortiz, M. A., Morán, J. M., Ruiz-Mesa, L. M., Bravo-San Pedro, J. M., and Fuentes, J. M. (2010). Paraquat exposure induces nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the activation of the nitric oxide-GAPDH-Siah cell death cascade. Toxicol. Sci. 116, 614-622.
24. Sen, N., Hara, M. R., Kornberg, M. D., Cascio, M. B., Bae, B. I., Shahani, N., Thomas, B., Dawson, T. M., Dawson, V. L., Snyder, S. H., et al. (2008). Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat. Cell Biol. 10, 866-873.
25. Schardein, J. L. (2000). Chemically Induced Birth Defects, 3rd ed., pp. 566- 574. Marcel Dekker, Inc, New York, NY.
26. Schlisser, A. E., Yan, J., and Hales, B. F. (2010). Teratogen-induced oxidative stress targets glyceraldehyde-3-phosphate dehydrogenase in the organogenesis stage mouse embryo. Toxicol. Sci. 118, 686-695.
27. Szende, B., Bökönyi, G., Bocsi, J., Kéri, G., Timár, F., and Magyar, K. (2001). Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites. J. Neural Transm. 108, 25-33.
28. Tatton, W. G., Wadia, J. S., Ju, W. Y., Chalmers-Redman, R. M., and Tatton, N. A. (1996). (-)-Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase. J. Neural Transm. Suppl. 48, 45-59.
29. Thangima Zannat, M., Bhattacharjee, R. B., and Bag, J. (2011). In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53. Biochem. Biophys. Res. Commun. 409, 171-176.
30. Tristan, C., Shahani, N., Sedlak, T. W., and Sawa, A. (2011). The diverse functions of GAPDH: Views from different subcellular compartments. Cell. Signal. 23, 317-323.
31. Wells, P. G., Bhuller, Y., Chen, C. S., Jeng, W., Kasapinovic, S., Kennedy, J. C., Kim, P. M., Laposa, R. R., McCallum, G. P., Nicol, C. J., et al. (2005). Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species. Toxicol. Appl. Pharmacol. 207(2 Suppl), 354-366.
32. Xiao, H., Lv, F., Xu, W., Zhang, L., Jing, P., and Cao, X. (2011). Deprenyl prevents MPP(+)-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk. Toxicology 290, 286-294.
33. Yan, J., and Hales, B. F. (2005). Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos. Toxicol. Sci. 85, 1013-1023.
34. Yan, J., and Hales, B. F. (2006). Depletion of glutathione induces 4-hydroxynonenal protein adducts and hydroxyurea teratogenicity in the organogenesis stage mouse embryo. J. Pharmacol. Exp. Ther. 319, 613-621.
35. Zheng, L., Roeder, R. G., and Luo, Y. (2003). S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 114, 255-266.