Hydroxyurea exposure triggers tissue-specific activation of p38 mitogen-activated protein kinase signaling and the DNA damage response in organogenesis-stage mouse embryos

Toxicological Sciences

Volumn 133, Issue 2, 2013, Pages 298-308

  Banh, Serena ^a   Hales, Barbara F ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

H2AX; Appendicular skeleton; Cell death; Hindlimb; MAP2K3; MEK3 6; Oxidative stress; Replication stress

Indexed keywords

HISTONE H2AX; HYDROXYUREA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CELL NUCLEUS; CONGENITAL MALFORMATION; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; EXPOSURE; FEMALE; HEART; IMMUNOREACTIVITY; MALE; MOUSE; NEURAL TUBE; NEUROEPITHELIUM; NONHUMAN; ORGANOGENESIS; SIGNAL TRANSDUCTION; SOMITE;

ΓH2AX; APPENDICULAR SKELETON; CELL DEATH; HINDLIMB.; MAP2K3; MEK3/6; OXIDATIVE STRESS; REPLICATION STRESS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CELL NUCLEUS; CYTOPLASM; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO CULTURE TECHNIQUES; EMBRYO, MAMMALIAN; FEMALE; HYDROXYUREA; MAP KINASE KINASE 3; MAP KINASE KINASE 6; MICE; MICE, INBRED STRAINS; NECROSIS; NUCLEIC ACID SYNTHESIS INHIBITORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PREGNANCY; SIGNAL TRANSDUCTION;

MUS;

EID: 84878516709     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft069     Document Type: Article

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