Depletion of glutathione induces 4-hydroxynonenal protein adducts and hydroxyurea teratogenicity in the organogenesis stage mouse embryo

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 2, 2006, Pages 613-621

  Yan, Jin ^a   Hales, Barbara F ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; BUTHIONINE SULFOXIMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROXYUREA; PROTEIN C FOS; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; EMBRYO; EMBRYOTOXICITY; EXENCEPHALY; FEMALE; FETUS MORTALITY; FETUS WEIGHT; GASTROSCHISIS; HOMEOSTASIS; HYDROCEPHALUS; IMMUNOREACTIVITY; LIMB MALFORMATION; LIPID PEROXIDATION; MOUSE; NEURAL TUBE; NONHUMAN; ORGANOGENESIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SKELETON MALFORMATION; SOMITE; SPINA BIFIDA; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ALDEHYDES; ANIMALS; BUTHIONINE SULFOXIMINE; DNA; EMBRYO; FEMALE; GLUTATHIONE; HYDROXYUREA; MICE; OXIDATIVE STRESS; PREGNANCY; PROTO-ONCOGENE PROTEINS C-FOS; TRANSCRIPTION FACTOR AP-1;

EID: 33751197937     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.109850     Document Type: Article

References (36)

1. Abate C, Patel L, Rauscher FJ III, and Curran T (1990) Redox regulation of fos and jun DNA-binding activity in vitro. Science (Wash DC) 249:1157-1161.
2. Angel P and Karin M (1991) The role of Jun, Fos and the AP-1 complex in cellproliferation and transformation. Biochim Biophys Acta 1072:129-157.
3. Awasthi YC, Ansari GA, and Awasthi S (2005) Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol 401:379-407.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Carbone DL, Doorm JA, Kiebler Z, Ickes BR, and Petersen DR (2005) Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. J Pharmacol Exp Ther 315:8-15.
6. Cederberg J, Siman CM, and Eriksson UJ (2001) Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatr Res 49:755-762.
7. Chen CS and Wells PG (2006) Enhanced tumorigenesis in p53 knockout mice exposed in utero to high dose vitamin E. Carcinogenesis 27:1358-1368.
8. DeSesso JM (1979) Cell death and free radicals: a mechanism for hydroxyurea teratogenesis. Med Hypotheses 5:937-951.
9. DeSesso JM (1981) Amelioration of teratogenesis. I. Modification of hydroxyurea-induced teratogenesis by the antioxidant propyl gallate. Teratology 24:19-35.
10. DeSesso JM, Scialli AR, and Goeringer GC (1994) D-Mannitol, a specific hydroxyl free radical scavenger, reduces the developmental toxicity of hydroxyurea in rabbits. Teratology 49:248-259.
11. Griffith OW and Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 254:7558-7560.
12. Hales BF and Brown H (1991) The effect of in vivo glutathione depletion with buthionine sulfoximine on rat embryo development. Teratology 44:251-257.
13. Hansen JM, Harris KK, Philbert MA, and Harris C (2002) Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb. J. Pharmacol. Exp Ther 300:768-776.
14. Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, and Yodoi J (1997) AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci USA 94:3633-3638.
15. Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, et al. (2006) Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 12:446-451.
16. Jochum W, Passegue E, and Wagner EF (2001) AP-1 in mouse development and tumorigenesis. Oncogene 20:2401-2412.
17. Kakishita H and Hattori Y (2001) Vascular smooth muscle cell activation and growth by 4-hydroxynonenal. Life Sci 69:689-697.
18. Kapphahn RJ, Giwa BM, Berg KM, Roehrich H, Feng X, Olsen TW, and Ferrington DA (2006) Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets. Exp Eye Res 83:165-175.
19. Kawakami Y, Rodriguez-Leon J, Koth CM, Buscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, et al. (2003) MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat Cell Biol 5:513-519.
20. Leonarduzzi G, Robbesyn F, and Poli G (2004) Signaling kinases modulated by 4-hydroxynonenal. Free Radic Biol Med 37:1694-1702.
21. Li Y, Cao Z, Zhu H, and Trush MA (2005) Differential roles of 3H-1,2-dithiole-3-thione-induced glutathione, glutathione S-transferase and aldose reductase in protecting against 4-hydroxy-2-nonenal toxicity in cultured cardiomyocytes. Arch Biochem Biophys 439:80-90.
22. Longo L, Vanegas OC, Patel M, Rosti V, Li H, Waka J, Merghoub T, Pandolfi PP, Notaro R, Manova K, et al. (2002) Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO (Eur Mol Biol Organ) J 21:4229-4239.
23. Naya M, Mataki Y, Takahira H, Deguchi T, and Yasuda M (1990) Effects of phorone and/or buthionine sulfoximine on teratogenicity of 5-fluorouracil in mice. Teratology 41:275-280.
24. Nicol CJ, Zielenski J, Tsui L-C, and Wells PG (2000) An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis. FASEB J 14:111-127.
25. Ozolins TR, Harrouk W, Doerksen T, Trasler JM, and Hales BF (2002) Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activation. Teratology 66:192-200.
26. Schaur RJ (2003) Basic aspects of the biochemical reactivity of 4-hydroxynonenal. Mol Aspects Med 24:149-159.
27. Shi ZZ, Osei-Frimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, and Lieberman MW (2000) Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci USA 97:5101-5106.
28. Slott VL and Hales BF (1987a) Effect of glutathione depletion by buthionine sulfoximine on rat embryonic development in vitro. Biochem Pharmacol 36:683-688.
29. Slott VL and Hales BF (1987b) Protection of rat embryos in culture against the embryotoxicity of acrolein using exogenous glutathione. Biochem Pharmacol 36:2187-2194.
30. Wells PG, Kim PM, Laposa RR, Nicol CJ, Parman T, and Winn LM (1997) Oxidative damage in chemical teratogenesis. Mutat Res 396:65-78.
31. Wells PG, Bhuller Y, Chen CS, Jeng W, Kasapinovic S, Kennedy JC, Kim PM, Laposa RR, McCallum GB, Nicol CJ, et al. (2005) Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species. Toxicol Appl Pharmacol 207:S354-S366.
32. Wisdom R (1999) AP-1: one switch for many signals. Exp Cell Res 253:180-185.
33. Wong M, Helston LM, and Wells PG (1989) Enhancement of murine phenytoin teratogenicity by the γ-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate. Teratology 40:127-141.
34. Yan J and Hales BF (2005) Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos. Toxicol Sci 85:1013-1023.
35. Zucker RM, Hunter ES III, and Rogers JM (1999) Apoptosis and morphology in mouse embryos by confocal laser scanning microscopy. Methods 18:473-480.
36. Zuzarte-Luis V, Montero JA, Rodriguez-Leon J, Merino R, Rodriguez-Rey JC, and Hurle JM (2004) A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol 272:39-52.