Paraquat exposure induces nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the activation of the nitric Oxide-GAPDH-Siah cell death cascade

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 614-622

  Ortiz Ortiz, Miguel A ^a   Morán, José M ^a   Ruiz Mesa, Luz M ^a   Pedro, José M Bravo San ^a   Fuentes, José M ^a  

^a UNIVERSITY OF EXTREMADURA   (Spain)

Author keywords

GAPDH; Neurotoxicity; Nitric oxide; Nuclear translocation; Paraquat; Parkinson's disease; Siah

Indexed keywords

7 NITROINDAZOLE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NITRIC OXIDE; PARAQUAT; PROTEIN P300; PROTEIN P53; SELEGILINE; SERINE; 1 METHYL 4 PHENYLPYRIDINIUM; HERBICIDE; HISTONE ACETYLTRANSFERASE PCAF; NUCLEAR PROTEIN; SEVEN IN ABSENTIA PROTEINS; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; MESENCEPHALON; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; ACTIVE TRANSPORT; ANIMAL; CELL CULTURE; CELL NUCLEUS; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TOXICITY;

1-METHYL-4-PHENYLPYRIDINIUM; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HERBICIDES; NITRIC OXIDE; NUCLEAR PROTEINS; P300-CBP TRANSCRIPTION FACTORS; PARAQUAT; PHOSPHORYLATION; RATS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 77955064464     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq146     Document Type: Article

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