In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53

Biochemical and Biophysical Research Communications

Volumn 409, Issue 2, 2011, Pages 171-176

  Thangima Zannat, Mst ^a   Bhattacharjee, Rumpa B ^a   Bag, Jnanankur ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Bak; Bax; GAPDH; P53; Poly (A) binding protein; SiRNA

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; POLYADENYLIC ACID BINDING PROTEIN; PROTEIN P53; SERINE; SERINE 46; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; GLYCOLYSIS; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS;

ACETYLATION; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL NUCLEUS; CYTOPLASM; GENE KNOCKDOWN TECHNIQUES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); HELA CELLS; HUMANS; MITOCHONDRIA; PHOSPHORYLATION; POLY(A)-BINDING PROTEIN I; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SERINE; TUMOR SUPPRESSOR PROTEIN P53;

EUKARYOTA;

EID: 79957902947     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.094     Document Type: Article

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