Optimization for glimepiride dissolution enhancement utilizing different carriers and techniques

Journal of Pharmaceutical Investigation

Volumn 43, Issue 2, 2013, Pages 115-131

  Makar, Rana R ^a   Latif, Randa ^b   Hosni, Ehab A ^a   El Gazayerly, Omaima N ^b  

^a AHRAM CANADIAN UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Dissolution enhancement; Glimepiride; Microwave solid dispersion; Solid dispersion; Triple solid dispersion; Triple solid dispersion adsorbate; Water insoluble polymers; Water soluble polymers

Indexed keywords

CARBOXYMETHYLCELLULOSE; CROSCARMELLOSE SODIUM; CROSPOVIDONE; DRUG CARRIER; GELUCIRE; GLIMEPIRIDE; MANNITOL; PREGELATINIZED STARCH; STARCH GLYCOLATE SODIUM; UNCLASSIFIED DRUG;

ARTICLE; CO GROUND MIXTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; HALF LIFE TIME; INFRARED SPECTROSCOPY; PHYSICAL MIXTURE; PRIORITY JOURNAL; SOLID DISPERSION; TERNARY SOLID DISPERSION; X RAY POWDER DIFFRACTION;

EID: 84880647126     PISSN: 20935552     EISSN: 20936214     Source Type: Journal    
DOI: 10.1007/s40005-013-0061-8     Document Type: Article

References (43)

1. Ahuja N, Katare OP, Singh B (2007) Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 65: 26-38.
2. Al-Obaidi H, Ke P, Brocchini S, Buckton G (2011) Characterization and stability of ternary solid dispersions with PVP and PHPMA. Int J Pharm 419: 20-27.
3. Ammar HO, Salama HA, Ghorab M, Mahmoud AA (2006) Formulation and biological evaluation of glimepiride-cyclodextrin-polymer systems. Int J Pharm 309: 129-138.
4. Bergese P, Colombo I, Gervasoni D, Depero LE (2003) Microwave generated nanocomposites for making insoluble drugs soluble. Mater Sci Eng C23: 791-795.
5. Biswal S, Sahoo J, Murthy PN (2009) Physicochemical properties of solid dispersions of gliclazide in polyvinylpyrrolidone K90. AAPS PharmSciTech 10(2): 329-334.
6. Blagden N, de Matas M, Gavan PT, York P (2007) Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev 59: 617-630.
7. Boregowda SS, Rao BPR, Jayarama RA, Guruchar NLV (2011) Application of water-soluble/dispersible polymeric carriers in drug dissolution modulation. Asian J Pharm Sci 6(1): 26-35.
8. Branchu S, Rogueda PG, Plumb AP, Cook WG (2007) A decision-support tool for the formulation of orally active, poorly soluble compounds. Eur J Pharm Sci 32: 128-139.
9. Bühler V (2005) Polyvinylpyrrolidone excipients for pharmaceuticals. Povidone, Crospovidone and copovidone. Springer-Verlag, Berlin/Heidelberg.
10. Cilurzo F, Selmin F, Minghetti P, Gennari CGM, Demartin F, Montanari L (2008) Characterization and physical stability of fast-dissolving microparticles containing nifedipine. Eur J Pharm Biopharm 68: 579-588.
11. de Waard H, Hinrichs WLJ, Visser MR, Bologna C, Frijlink HW (2008) Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant physically mixed or incorporated. Int J Pharm 349: 66-73.
12. Dureja DH, Madan AK (2007) Solid dispersion adsorbates for enhancement of dissolution rates of drugs. PDA J Pharm Sci Technol 61(2): 97-101.
13. Frick A, Möller H, Wirbitzki E (1998) Biopharmaceutical characterization of oral immediate release drug products. In vitro/in vivo comparison of phenoxymethylpenicillin potassium, glimepiride and levofloxacin. Eur J Pharm Biopharm 46: 305-311.
14. Goddeeris C, Willems T, van den Mooter G (2008) Formulation of fast disintegrating tablets of ternary solid dispersions consisting of TPGS 1000 and HPMC 2910 or PVPVA 64 to improve the dissolution of the anti-HIV drug UC 781. Eur J Pharm Sci 34: 293-302.
15. Ilić I, Dreu R, Burjak M, Homar M, Kerč J, Srčič S (2009) Microparticle size control and glimepiride microencapsulation using spray congealing technology. Int J Pharm 381: 176-183.
16. Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S (2011) Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm 420: 1-10.
17. Kawakami K (2012) Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs. Adv Drug Deliv Rev 64: 480-495.
18. Khan N, Craig DQM (2003) The influence of drug incorporation on the structure and release properties of solid dispersions in lipid matrices. J Control Release 93: 355-368.
19. Kiran T, Shastri N, Ramakrishna S, Sadanandam M (2009) Surface solid dispersion of glimepiride for enhancement of dissolution rate. Int J PharmTech Res 1(3): 822-831.
20. Leuner C, Dressman J (2000) Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 50: 47-60.
21. Li J, Liu P, Liu J, Zhang W, Yang J, Fan Y (2012) Novel Tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: in vitro and in vivo evaluation. Eur J Pharm Biopharm 80: 426-432.
22. Martins RM, Siqueira S, Tacon LA, Freitas LAP (2012) Microstructured ternary solid dispersions to improve carbamazepine solubility. Powder Technol 215-216: 156-165.
23. Moneghini M, Bellich B, Baxa P, Princivalle F (2008) Microwave generated solid dispersions containing Ibuprofen. Int J Pharm 361: 125-130.
24. Moneghini M, Zingone G, De Zordic N (2009) Influence of the microwave technology on the physical-chemical properties of solid dispersion with Nimesulide. Powder Technol 195: 259-263.
25. Nakanishi S, Fujii M, Sugamura Y, Suzuki A, Shibata Y, Koizumi N, Watanabe Y (2011) Evaluation of the physicochemical characteristics of Crospovidone that influence solid dispersion preparation. Int J Pharm 413: 119-125.
26. Ning X, Sun J, Han X, Wu Y, Yan Z, Han J, He Z (2011) Strategies to improve dissolution and oral absorption of glimepiride tablets: solid dispersion versus micronization techniques. Drug Dev Ind Pharm 37(6): 727-736.
27. Parmar KR, Shah SR, Sheth NR (2011) Studies in dissolution enhancement of ezetimibe by solid dispersions in combination with a surface adsorbent. Dissolut Technol 8: 55-61.
28. Pouton CW (2006) Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 29: 278-287.
29. Rajpurohit VS, Rakha P, Goyal S, Dureja H, Arorac G, Nagpal M (2011) Formulation and characterization of solid dispersions of glimepiride through factorial design. Iran J Pharm Sci 7(1): 7-16.
30. Reddy MS, Fazal ul Haq SM, Apte SS (2011) Solubility enhancement of fenofibrate, a BCS class II drug by self emulsifying drug delivery systems. IRJP 2(11): 173-177.
31. Reven S, Grdadolnik J, Kristl J, Zagar E (2010) Hyperbranched poly(esteramides) as solubility enhancers for poorly water-soluble drug glimepiride. Int J Pharm 396: 119-126.
32. Roquette Pharma and Personal-Care (2012) Glycolys [on line]. Available at http://www. Roquette-pharma. com/glycolys-superdisintegrant-starch-tablets-capsules-glycolate/. Accessed on 9 Oct 2012.
33. Shah VP, Konecny JJ, Everett RL, McCullough B, Noorizadeh AC, Skelly JP (1989) In vitro dissolution profile of water-insoluble drug dosage forms in the presence of surfactants. Pharm Res 6(7): 612-618.
34. Shah J, Vasanti S, Anroop B, Vyas H (2009) Enhancement of dissolution rate of valdecoxib by solid dispersions technique with PVP K 30 & PEG 4000: preparation and in vitro evaluation. J Incl Phenom Macrocycl Chem 63: 69-75.
35. Shohin IE, Kulinich JI, Ramenskaya GV, Vasilenko GF (2011) Evaluation of in vitro equivalence for drugs containing BCS class II compound ketoprofen. Dissolut Technol 2: 26-29.
36. Singh SK, Prakash D, Srinivasan KK, Gowthamarajan K (2011) Liquisolid compacts of glimepiride: an approach to enhance the dissolution of poorly water soluble drugs. J Pharm Res 4(7): 2263-2268.
37. van den Mooter G (2012) The use of amorphous solid dispersions: a formulation strategy to overcome poor solubility and dissolution rate. Drug Discov Today 9(2): 79-85.
38. Vasconcelos T, Sarmento B, Costa P (2007) Solid dispersions as a strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today 12(23/24): 1068-1075.
39. Vidyadhara S, Babu JR, Sasidhar RLC, Ramu A, Prasad SS, Tejasree M (2011) Formulation and evaluation of glimepiride solid dispersions and their tablet formulations for enhanced bioavailability. Pharmanest 1: 15-20.
40. Vippagunta SR, Maul KA, Tallavajhala S, Grant DJW (2002) Solid-state characterization of nifedipine solid dispersions. Int J Pharm 236: 111-123.
41. Waters LJ, Bedford S, Parkes GMB (2011) Controlled microwave processing applied to the pharmaceutical formulation of ibuprofen. AAPS PharmSciTech 12(4): 1038-1043.
42. Wei H, Löbenber RL (2006) Biorelevant dissolution media as a predictive tool for glyburide a class II drug. Eur J Pharm Sci 29: 45-52.
43. Zajc N, Obreza A, Bele M, Srčič S (2005) Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method. Int J Pharm 291: 51-58.