The influence of drug incorporation on the structure and release properties of solid dispersions in lipid matrices

Journal of Controlled Release

Volumn 93, Issue 3, 2003, Pages 355-368

  Khan, Nurzalina ^a,c   Craig, Duncan Q M ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

Author keywords

Drug incorporation; Lipid matrices; Solid dispersions

Indexed keywords

DIFFERENTIAL SCANNING CALORIMETRY; DISPERSIONS; DISSOLUTION; DRUG PRODUCTS; EROSION; MELTING;

CAFFEINE; ENDOTHERMS;

LIPIDS;

CAFFEINE; GELUCIRE; LIPID; PARACETAMOL;

ARTICLE; COOLING; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG CONFORMATION; DRUG DISTRIBUTION; DRUG RELEASE; DRUG STRUCTURE; EROSION; LIQUID; MELTING POINT; PRIORITY JOURNAL; SOLID STATE; TEMPERATURE DEPENDENCE; WATER TRANSPORT;

EID: 0344440911     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2003.09.006     Document Type: Article

References (29)

1. Craig D.Q.M. The use of glycerides as controlled release matrices. Karsa D.R., Stephenson R.A. Excipients and Delivery Systems for Pharmaceutical Formulations. 1995;148-174 Royal Society of Chemistry, Cambridge.
2. Doelker C., Doelker E., Buri P., Waginaire L. The incorporation and in vitro release profiles of liquid, deliquescent or unstable drugs with fusible excipients in hard gelatin capsules. Drug Dev. Ind. Pharm. 12:1986;1553-1565.
3. Vial-Bernasconi A.C., Buri P., Doelker E., Beyssac E., Duchaix G., Aiache J.M. In vivo evaluation of an indomethacin monolithic, extended zero-order release hard-gelatin capsule formulation based on saturated polyglycolysed glycerides. Pharm. Acta Helv. 70:1995;307-313.
4. Koga K., Kawashima S., Murakami M. In vitro and in situ evidence for the contribution of Labrasol (R) and Gelucire 44/14 on transport of cephalexin and cefoperazone by rat intestine. Eur. J. Pharm. Biopharm. 54:2002;311-318.
5. N. Passerini, B. Perissutti, M. Moneghini, D. Voinovich, B. Albertini, C. Cavallari, and L. Rodriguez. Characterization of carbamazepine-gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds. J. Pharm. Sci. 91 699-707.
6. Itoh K., Tozuka Y., Oguchi T., Yamamoto K. Improvement of physicochemical properties of N-4472: Part I. Formulation design by using self-microemulsifying system. Int. J. Pharm. 238:2002;153-160.
7. Barker S.A., Yap S.P., Yuen K.H., McCoy C.P., Murphy J.R., Craig D.Q.M. An investigation into the structure and bioavailability of α-tocopherol dispersions in Gelucire 44/14. J. Control. Release. 91:2003;477-488.
8. Sutananta W., Craig D.Q.M., Newton J.M. An evaluation of the mechanisms of drug release from glyceride bases. J. Pharm. Pharmacol. 47:1995;182-187.
9. Dennis A.B., Farr S.J., Kellaway I.W., Taylor G., Davidson R. In vivo evaluation of rapid release and sustained release gelucire capsule formulations. Int. J. Pharm. 65:1990;85-100.
10. Green J.T., Evans B.K., Rhodes J., Thomas G.A.O., Ranshaw C., Feyerabend C., Russell M.A.H. An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics. Br. J. Clin. Pharmacol. 48:1999;485-493.
11. Bodmeier R., Paeratakul O., Chen H., Zhang W. Formulation of sustained release wax matrices within hard gelatin capsules in a fluidized bed. Drug Dev. Ind. Pharm. 16:1990;1505-1519.
12. Pinto J.F., Silverio N.P. Assessment of the extrudability of three different mixtures of saturated polyglycolysed glycerides by determination of the "specific work of extrusion" and by capillary rheometry. Pharm. Dev. Technol. 6:2001;117-128.
13. Martin L., Wilson C.G., Koosha F., Tetley L., Gray A.I., Senel S., Uchegbu I.F. The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels. J. Control. Release. 80:2002;87-100.
14. Thies C., Dos Santos I.R., Richard J., Vandevelde V., Rolland H., Benoit J.P. A supercritical fluid-based coating technology: 1. Process considerations. J. Microencapsul. 20:2003;87-96.
15. Sutananta W., Craig D.Q.M., Newton J.M. An investigation into the effect of preparation conditions on the structure and mechanical properties of pharmaceutical glyceride bases. Int. J. Pharm. 110:1994;75-91.
16. Sutananta W., Craig D.Q.M., Newton J.M. The effects of ageing on the thermal behaviour and mechanical properties of pharmaceutical glycerides. Int. J. Pharm. 111:1994;51-62.
17. Dordunoo S.K., Ford J.L., Rubinstein M.H. Solidification studies of polyethylene glycols, Gelucire 44/14 or their dispersions with triamterene or temazepam. J. Pharm. Pharmacol. 48:1996;782-789.
18. T.H. Applewhite in Bailey's industrial Oil and Fat Products, vol. 3. John Wiley and Sons, New York, 1985, pp. 203-214, 273-319.
19. Peppas N.A. Analysis of fickian and non-fickian drug release from polymers. Pharm. Acta Helv. 60:1985;110-111.
20. Beren A.R., Hopfenberg H.B. Diffusion and relaxation in glassy polymer powders: II. Separation of diffusion and relaxation parameters. Polymers. 19:1978;489.
21. Peppas N.A. Hydrogels in medicine and pharmacy. Peppas N. Properties and Application. Vol. 3:1986;109-305 CRC Press, Boca Raton.
22. Manning D., Dimick P. Crystal morphology of cocoa butter. Food Microstruct. 4:1985;249-265.
23. Chaiseri S., Dimick P. Dynamic crystallization of cocoa butter: II. Morphological, thermal and chemical characteristics during crystal growth. J. Am. Oil Chem. Soc. 72:1995;1497-1504.
24. Aronhime J.S., Sarig S., Garti N. Mechanistic considerations of polymorphic transformations of tristearin in the presence of emulsifiers. J. Am. Oil Chem. Soc. 64:1987;529-533.
25. Aronhime J.S. Application of thermal analysis (DSC) in the study of polymorphic transformations. Thermochim. Acta. 134:1988;1-14.
26. Sato K., Garti N. Crystallization and polymorphic transformation: an introduction. Crystallization and Polymorphism of Fats and Fatty Acids. 1988;3-7 Marcel Dekker, New York.
27. Garti N., Schlichter J., Sarig S. Polymorphism of even monoacid triglycerides in the presence of sorbitan monostearate, studied by the DSC. Thermochim. Acta. 93:1985;29-32.
28. Rodriguez-Hornedo N., Murphy D. Significance of controlling crystallization mechanisms and kinetics in pharmaceutical systems. J. Pharm. Sci. 88:1999;651-660.
29. Florence A.T., Attwood D. Physicochemical principles of pharmacy. 3rd ed. 1998;29 Macmillan, Hampshire.