Formulation and characterization of solid dispersions of glimepiride through factorial design

Iranian Journal of Pharmaceutical Sciences

Volumn 7, Issue 1, 2011, Pages 7-16

  Rajpurohit, Veerendra S ^a   Rakha, Pankaj ^a   Goyal, Surender ^a   Dureja, Harish ^b   Arorac, Gitika ^d   Nagpal, Manju ^c  

^a Rajendra Institute of Technology and Sciences   (India)

^b MAHARSHI DAYANAND UNIVERSITY   (India)

^c CHITKARA UNIVERSITY   (India)

^d NONE

Author keywords

Factorial design; Glimepiride; PEG 6000; PVP K25; Solid dispersion

Indexed keywords

GLIMEPIRIDE;

ARTICLE; DISPERSION; DRUG RELEASE; DRUG SOLUBILITY; FACTORIAL DESIGN; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; WETTABILITY; X RAY DIFFRACTION;

EID: 84857564190     PISSN: 17352444     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Youn YS, Stera K. Improved intestinal delivery of salmon calcitonin by Lys18amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy. J Control Rel 2006; 114: 334-2.
2. Sugawara M. The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlledrelease formulations. Eur J Pharm Sci 2005; 26: 1-8.
3. Drooge DJ. Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. Int J Pharm 2006; 310: 220-9.
4. Vippagunta SR. Factors affecting the formation of eutectic solid dispersions and their dissolution behavior. J Pharm Sci 2006; 96: 294-304.
5. Streubel A. Drug delivery to the upper small intestine window using gastroretentive technologies. Curr Opin Pharmacol 2006; 6: 501-8.
6. Tanaka N. Development of novel sustainedrelease system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): in vivo evaluation. J Control Rel 2006; 112: 51-6.
7. Patro S, Himasankar K, Choudhary AA, Rao ME. Effect of some hydrophilic polymers on dissolution rate of roxitromycin. Indian J Pharm Sci 2005; 67: 334-1.
8. Vasconcalos T, Sarmento B, Costa P. Solid dispersion as strategy to improve oral bioavailability of poof water soluble drugs. Drug Discovery Today 2007; 12: 1068-75.
9. Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J Pharm Sci 1971; 60: 1281-302.
10. Deepti, Dureja H, Madan AK. Solid dispersion adsorbates for enhancement of dissolution rate of drugs. PDA J Pharm Sci Technol 2007; 61: 1-5.
11. Kiran T, Shastri N, Ramakrishna S, Sadanandam M. Surface solid dispersion of glimepiride for enhancement of dissolution rate. Int J Pharm Tech Res 2009; 1: 822-31.
12. Mehta A, Vasanti S, Tyagi R, Shukla A. Formulation and evaluation of solid dispersion of an antidiabetic drug. Curr Trends Biotech Pharm 2009; 3: 76-84.
13. Amidon GL, Lennernas H, Shah VP, Crisen JR. A theoretical basis for a biopharmaceutics drug classification: the correlation of in vitro drug products dissolution and in vivo bioavailability. Pharm Res 1995; 12: 413-24.