Microstructured ternary solid dispersions to improve carbamazepine solubility

Powder Technology

Volumn 215-216, Issue , 2012, Pages 156-165

  Martins, Rodrigo M ^a   Siqueira, Silvia ^a   Tacon, Luciana A ^a   Freitas, Luis A P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dissolution test; Factorial design; Microspheres; Polymorphism; Steroyl macrogolglycerides

Indexed keywords

ANGLE OF REPOSE; AQUEOUS SOLUBILITY; CARBAMAZEPINE; COLLOIDAL SILICON DIOXIDES; CRYSTALLINITIES; DISSOLUTION RATES; DISSOLUTION TESTS; DRUG CONTENT; DRYING CONDITION; FACTORIAL DESIGN; HIGH POTENTIAL; INFRARED ANALYSIS; MICRO-PARTICLES; MICROSTRUCTURED SOLIDS; OUTLET TEMPERATURE; POLYMORPHIC MODIFICATIONS; SOLID DISPERSION; SORPTION ISOTHERMS; SPRAY DRYERS; SPRAY DRYING TECHNIQUE; STEROYL MACROGOLGLYCERIDES; THERMAL BEHAVIORS;

AMIDES; DISSOLUTION; DRUG INTERACTIONS; INFRARED SPECTROSCOPY; MICROSPHERES; MOISTURE DETERMINATION; POLYMORPHISM; SILICA; SOLUBILITY; SPRAY DRYING; X RAY DIFFRACTION;

DISPERSIONS;

AEROSIL; CARBAMAZEPINE; GELUCIRE;

ANGLE OF REPOSE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG CONTENT; DRUG SOLUBILITY; ENCAPSULATION; FACTORIAL DESIGN; INFRARED SPECTROSCOPY; MICROSTRUCTURED TERNARY SOLID DISPERSION; MOISTURE; PARTICLE SIZE; PHYSICAL PARAMETERS; PROCESS YIELD; SCANNING ELECTRON MICROSCOPY; SORPTION ISOTHERM; SPRAY DRYING; X RAY DIFFRACTION; X RAY POWDER DIFFRACTION;

EID: 84861909044     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2011.09.041     Document Type: Article

References (47)

1. Jyothi N.V.N., Prasanna P.M., Sakarkar S.N., Prabha K.S., Ramaiah P.S., Srawan G.Y. Microencapsulation techniques, factors influencing encapsulation efficiency. Journal of Microencapsulation 2010, 27:187-197.
2. Leuenberger H., Lanz M. Pharmaceutical powder technology - from art to science: the challenge of the FDA's Process Analytical Technology initiative. Advanced Powder Technology 2005, 16:3-25.
3. Passerini N., Qi S., Albertini B., Grassi M., Rodriguez L., Craig D.Q.M. Solid lipid microparticles produced by spray congealing: influence of the atomizer on microparticle characteristics and mathematical modeling of the drug release. Journal of Pharmaceutical Sciences 2010, 99:916-931.
4. Riyajan S.A., Sakdapipanich J.T. Encapsulated neem extract containing Azadiractin-A within hydrolyzed poly(vinyl acetate) for controlling its release and photodegradation stability. Chemical Engineering Journal 2009, 152:591-597.
5. Schoubben A., Blasi P., Giovagnoli S., Rossi C., Ricci M. Development of a scalable procedure for fine calcium alginate particle preparation. Chemical Engineering Journal 2010, 160:363-369.
6. Sham J.O.H., Zhang Y., Finlay W.H., Roa W.H., Lobenberg R. Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. International Journal of Pharmaceutics 2004, 269:457-467.
7. Araujo R.R., Teixeira C.C.C., Freitas L.A.P. The preparation of ternary solid dispersions of an herbal drug via spray drying of liquid feed. Drying Technology 2010, 28:412-421.
8. Sharma A., Jain C.P. Techniques to enhance solubility of poorly soluble drugs: a review. Journal of Global Pharma Technology 2010, 2:18-28.
9. Babu V.R., Areefulla S.H., Mallikarjun V. Solubility and dissolution enhancement: an overview. Journal of Pharmacy Research 2010, 3:141-145.
10. Sharma D., Soni M., Kumar S., Gupta G.D. Solubility enhancement - eminent role in poorly soluble drugs. Research Journal Of Pharmacy and Technology 2009, 2:220-224.
11. Hite M., Turner S., Federici C. Part 1: oral delivery of poorly soluble drugs. PMPS Summer 2003, 1:38-40.
12. Moneghini M., Kikic I., Voinovich D., Perissutti B., Filipovic-Grcic J. Processing of carbamazepine PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution. International Journal of Pharmaceutics 2001, 222:129-138.
13. Vippagunta S.R., Maul K.A., Tallavajhala S., Grant D.J.W. Solid-state characterization of nifedipine solid dispersions. International Journal of Pharmaceutics 2002, 236:111-123.
14. Amidon G.L., Lennernas H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification - the correlation of in-vitro drug product dissolution and in-vivo bioavailability. Pharmaceutical Research 1995, 12:413-420.
15. Chavda H.V., Patel C.N., Anand I.S. Biopharmaceutics classification system. Systematic Reviews in Pharmacy 2010, 1:62-69.
16. Hemenway J.N., Jarho P., Henri J.T., Nair S.K., Vandervelde D., Georg G.I., et al. Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine. Journal of Pharmaceutical Sciences 2010, 99:1810-1825.
17. Nair R., Gonen S., Hoag S.W. Influence of polyethylene glycol and povidone on the polymorphic transformation and solubility of carbamazepine. International Journal of Pharmaceutics 2002, 240:11-22.
18. Machiste E.O., Giunchedi P., Setti M., Conte U. Characterization of carbamazepine in systems containing a dissolution rate enhancer. International Journal of Pharmaceutics 1995, 126:65-72.
19. Ambrogi V., Perioli L., Marmottini F., Accorsi O., Pagano C., Ricci M., et al. Role of mesoporous silicates on carbamazepine dissolution rate enhancement. Microporous and Mesoporous Materials 2008, 113:445-452.
20. Leuner C., Dressman J. Improving drug solubility for oral delivery using solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics 2000, 50:47-60.
21. de Castro A.D., Silva N.P., Cury B.S.F., Evangelista R.C., Freitas L.A.P., Gremiao M.P.D. A new approach to the granulation of beta-cyclodextrin inclusion complexes. Chemical Engineering Journal 2010, 164:316-321.
22. Hu J.H., Rogers T.L., Brown J., Young T., Johnston K.P., Williams R.O. Improvement of dissolution rates of poorly water soluble APIs using novel spray freezing into liquid technology. Pharmaceutical Research 2002, 19:1278-1284.
23. Takeuchi H., Nagira S., Yamamoto H., Kawashima Y. Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method. Powder Technology 2004, 141:187-195.
24. Dhirendra K., Lewis S., Udupa N., Atin K. Solid dispersions: a review. Pakistan Journal of Pharmaceutical Sciences 2009, 22:234-246.
25. Serajuddin A.T.M. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. Journal of Pharmaceutical Sciences 1999, 88:1058-1066.
26. Yassin A.E.B., Alanazi F.K., El-Badry M., Alsarra I.A., Barakat N.S., Alanazi F.K. Preparation and characterization of spironolactone-loaded gelucire microparticles using spray-drying technique. Drug Development and Industrial Pharmacy 2009, 35:297-304.
27. Zbicinski I., Delag A., Strumillo C., Adamiec J. Advanced experimental analysis of drying kinetics in spray drying. Chemical Engineering Journal 2002, 86:207-216.
28. Chauhan B., Shimpi S., Paradkar A. Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique. European Journal of Pharmaceutical Sciences 2005, 26:219-230.
29. Gavini E., Hegge A.B., Rassu G., Sanna V., Testa C., Pirisino G., et al. Nasal administration of carbamazepine using chitosan microspheres: in vitro/in vivo studies. International Journal of Pharmaceutics 2006, 307:9-15.
30. Walton D.E., Mumford C.J. Spray dried products - characterization of particle morphology. Chemical Engineering Research and Design 1999, 77:21-38.
31. Ferreira S.L.C., Bruns R.E., Ferreira H.S., Matos G.D., David J.M., Brandao G.C., et al. Box-Behnken design: an alternative for the optimization of analytical methods. Analytica Chimica Acta 2007, 597:179-186.
32. Box M., Hunter W.G., Hunter J.S. Statistics Experimenters 1978, John Wiley & Sons, New York.
33. Damian F., Blaton N., Naesens L., Balzarini J., Kinget R., Augustijns P., et al. Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14. European Journal of Pharmaceutical Sciences 2000, 10:311-322.
34. Ameri M., Maa Y.F. Spray drying of biopharmaceuticals: stability and process considerations. Drying Technology 2006, 24:763-768.
35. Cal K., Sollohub K. Spray drying technique. I: hardware and process parameters. Journal of Pharmaceutical Sciences 2010, 99:575-586.
36. Sollohub K., Cal K. Spray drying technique: II. Current applications in pharmaceutical technology. Journal of Pharmaceutical Sciences 2010, 99:587-597.
37. Jafari S.M., Assadpoor E., He Y.H., Bhandari B. Encapsulation efficiency of food flavours and oils during spray drying. Drying Technology 2008, 26:816-835.
38. Walton D.E., Mumford C.J. The morphology of spray-dried particles - the effect of process variables upon the morphology of spray-dried particles. Chemical Engineering Research and Design 1999, 77:442-460.
39. Mooney M. The viscosity of a concentrated suspension of spherical particles. Journal of Colloid Science 1951, 6:162-170.
40. Dorman R.G. The atomization of liquid in a flat spray. British Journal of Applied Physics 1952, 3:189-192.
41. Alavi S., Caussat B. Experimental study on fluidization of micronic powders. Powder Technology 2005, 157:114-120.
42. List P.H., Schimdt P.C. Phytopharmaceutical Technology 1989, CRC Press, Boca Raton, FL.
43. Sethia S., Squillante E. Solid dispersion of carbamazepine in PVPK30 by conventional solvent evaporation and supercritical methods. International Journal of Pharmaceutics 2004, 272:1-10.
44. Passerini N., Perissutti B., Moneghini M., Voinovich D., Albertini B., Cavallari C., et al. Characterization of carbamazepine-gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds. Journal of Pharmaceutical Sciences 2002, 91:699-707.
45. Forbes R.T., Davis K.G., Hindle M., Clarke J.G., Maas J. Water vapor sorption studies on the physical stability of a series of spray-dried protein/sugar powders for inhalation. Journal of Pharmaceutical Sciences 1998, 87:1316-1321.
46. Brunauer S., Deming L.S., Deming W.E., Teller E. On a theory of the van der Waals adsorption of gases. Journal of the American Chemical Society 1940, 62:1723-1732.
47. Potluri R.H.K., Bandari S., Jukanti R., Veerareddy P.R. Solubility enhancement and physicochemical characterization of Carvedilol solid dispersion with Gelucire 50/13. Archives of Pharmacal Research 2011, 34:51-57.