Strategies to improve dissolution and oral absorption of glimepiride tablets: Solid dispersion versus micronization techniques

Drug Development and Industrial Pharmacy

Volumn 37, Issue 6, 2011, Pages 727-736

  Ning, Xiao ^a,b   Sun, Jin ^a   Han, Xiaopeng ^a   Wu, Yue ^a   Yan, Zhongtian ^a   Han, Jihong ^c   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^c KEELE UNIVERSITY   (United Kingdom)

Author keywords

glimepiride; in vitro dissolution; in vivo absorption; micronization; Solid dispersion

Indexed keywords

GLIMEPIRIDE; LACTOSE; POVIDONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DISPERSION; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; SOLID PHASE SYNTHESIS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DOGS; DRUG CARRIERS; EXCIPIENTS; HYPOGLYCEMIC AGENTS; LACTOSE; POLOXAMER; POVIDONE; SOLUBILITY; SULFONYLUREA COMPOUNDS; THERAPEUTIC EQUIVALENCY;

EID: 79955962787     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.538061     Document Type: Article

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