Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway

Oncology Reports

Volumn 30, Issue 3, 2013, Pages 1257-1264

  Lee, Hye Hyeon ^a   Jeong, Jin Woo ^b   Lee, Jun Hyuk ^c   Kim, Gi Young ^d   Cheong, Jaehun ^e   Jeong, Yong Kee ^a   Yoo, Young Hyun ^a   Choi, Yung Hyun ^f,g  

^a Dong A University   (South Korea)

^b Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

^c Korea Intellectual Property Office   (South Korea)

^d Jeju National University   (South Korea)

^e Pusan National University   (South Korea)

^f Dong Eui University   (South Korea)

^g Dong Eui University   (South Korea)

Author keywords

Apoptosis; C Jun N terminal kinase; Cordycepin; Hep3B cells; TRAIL

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BETA CATENIN; CASPASE; CORDYCEPIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL INFILTRATION; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME INACTIVATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL PROLIFERATION; DEOXYADENOSINES; FLOW CYTOMETRY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED;

EID: 84880610544     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2589     Document Type: Article

References (41)

1. Gruss HJ: Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily. Int J Clin Lab Res 26: 143-159, 1996.
2. Bonavida B, Ng CP, Jazirehi A, Schiller G and Mizutani Y: Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: The trail to non-toxic cancer therapeutics (Review). Int J Oncol 15: 793-802, 1999.
3. Koschny R, Ganten TM, Sykora J, Haas TL, Sprick MR, Kolb A, Stremmel W and Walczak H: TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 45: 649-658, 2007.
4. Secchiero P, Vaccarezza M, Gonelli A and Zauli G: TNF-related apoptosis-inducing ligand (TRAIL): a potential candidate for combined treatment of hematological malignancies. Curr Pharm Des 10: 3673-3681, 2004.
5. Bin L, Thorburn J, Thomas LR, Clark PE, Humphreys R and Thorburn A: Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J Biol Chem 282: 28189-28194, 2007.
6. Lee SH, Shin MS, Kim HS, Lee HK, Park WS, Kim SY, Lee JH, Han SY, Park JY, Oh RR, Kang CS, Kim KM, Jang JJ, Nam SW, Lee JY and Yoo NJ: Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma. Oncogene 20: 399-403, 2001.
7. Ito Y, Arita M, Adachi K, Shibata T, Sawai H and Ohno M: Chirally selective synthesis of sugar moiety of nucleosides by chemicoenzymatic approach: L- and D-riboses, showdomycin, and cordycepin. Nucleic Acids Symp Ser 10: 45-48, 1981.
8. Westhof E, Plach H, Cuno I and Lüdemann HD: Proton magnetic resonance studies of 2'-,3'-, and 5'-deoxyadenosine conformations in solution. Nucleic Acids Res 4: 939-953, 1977.
9. Horowitz B, Goldfinger BA and Marmur J: Effect of cordycepin triphosphate on the nuclear DNA-dependent RNA polymerases and poly(A) polymerase from the yeast, Saccharomyces cerevisiae. Arch Biochem Biophys 172: 143-148, 1976.
10. Müller WE, Weiler BE, Charubala R, Pfleiderer W, Leserman L, Sobol RW, Suhadolnik RJ and Schröder HC: Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry 30: 2027-2033, 1991.
11. Chen Y, Chen YC, Lin YT, Huang SH and Wang SM: Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain- caspase 7-PARP pathway. J Agric Food Chem 58: 11645-11652, 2010.
12. Lee HH, Park C, Jeong JW, Kim MJ, Seo MJ, Kang BW, Park JU, Kim GY, Choi BT, Choi YH and Jeong YK: Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species-mediated mitochondrial death pathway. Int J Oncol 42: 1036-1044, 2013.
13. Lee SJ, Moon GS, Jung KH, Kim WJ and Moon SK: c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. Food Chem Toxicol 48: 277-283, 2010.
14. Lee HJ, Burger P, Vogel M, Friese K and Brüning A: The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs 30: 1917-1925, 2012.
15. Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, Lee JD, Yoo YH and Choi YH: Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro 25: 817-824, 2011.
16. Won SY and Park EH: Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol 96: 555-561, 2005.
17. Nakamura K, Konoha K, Yoshikawa N, Yamaguchi Y, Kagota S, Shinozuka K and Kunitomo M: Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice. In Vivo 19: 137-141, 2005.
18. Yoshikawa N, Kunitomo M, Kagota S, Shinozuka K and Nakamura K: Inhibitory effect of cordycepin on hematogenic metastasis of B16-F1 mouse melanoma cells accelerated by adenosine-5'-diphosphate. Anticancer Res 29: 3857-3860, 2009.
19. Lee EJ, Kim WJ and Moon SK: Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells. Phytother Res 24: 1755-1761, 2010.
20. Tak JK, Lee JH and Park JW: Resveratrol and piperine enhance radiosensitivity of tumor cells. BMB Rep 45: 242-246, 2012.
21. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA and Herman B: The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366: 177-196, 1998.
22. Fernández-Luna JL: Apoptosis regulators as targets for cancer therapy. Clin Transl Oncol 9: 555-562, 2007.
23. Aggarwal BB, Bhardwaj U and Takada Y: Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. Vitam Horm 67: 453-483, 2004.
24. Wen X, Lin ZQ, Liu B and Wei YQ: Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer. Cell Prolif 45: 217-224, 2012.
25. Patwardhan GA and Liu YY: Sphingolipids and expression regulation of genes in cancer. Prog Lipid Res 50: 104-114, 2011.
26. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347, 1994.
27. Fukuda K: Apoptosis-associated cleavage of β-catenin in human colon cancer and rat hepatoma cells. Int J Biochem Cell Biol 31: 519-529, 1999.
28. Frese S, Pirnia F, Miescher D, Krajewski S, Borner MM, Reed JC and Schmid RA: PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2. Oncogene 22: 5427-5435, 2003.
29. Falschlehner C, Emmerich CH, Gerlach B and Walczak H: TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol 39: 1462-1475, 2007.
30. Secchiero P, Gonelli A, Carnevale E, Milani D, Pandolfi A, Zella D and Zauli G: TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways. Circulation 107: 2250-2256, 2003.
31. Seo OW, Kim JH, Lee KS, Lee KS, Kim JH, Won MH, Ha KS, Kwon YG and Kim YM: Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells. Exp Mol Med 44: 653-664, 2012.
32. Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351: 41-58, 2011.
33. Brenner D and Mak TW: Mitochondrial cell death effectors. Curr Opin Cell Biol 21: 871-877, 2009.
34. Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, Pandey SK, Nwokorie C, Onwudiwe N and Srivastava RK: Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. J Biol Chem 276: 38361-38369, 2001.
35. Tran SE, Holmstrom TH, Ahonen M, Kahari VM and Eriksson JE: MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors. J Biol Chem 276: 16484-16490, 2001.
36. Söderström TS, Poukkula M, Holmström TH, Heiskanen KM and Eriksson JE: Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. J Immunol 169: 2851-2860, 2002.
37. Jurewicz A, Matysiak M, Andrzejak S and Selmaj K: TRAIL-induced death of human adult oligodendrocytes is mediated by JNK pathway. Glia 53: 158-166, 2006.
38. Mühlenbeck F, Haas E, Schwenzer R, Schubert G, Grell M, Smith C, Scheurich P and Wajant H: TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways. J Biol Chem 273: 33091-33098, 1998.
39. Qu J, Zhao M, Teng Y, Zhang Y, Hou K, Jiang Y, Yang X, Shang H, Qu X and Liu Y: Interferon-α sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway. Cancer Biol Ther 12: 494-502, 2011.
40. Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M and Aggarwal BB: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. J Biol Chem 286: 1134-1146, 2011.
41. Phipps LE, Hino S and Muschel RJ: Targeting cell spreading: a method of sensitizing metastatic tumor cells to TRAIL-induced apoptosis. Mol Cancer Res 9: 249-258, 2011. Forestry Korea