Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells

Toxicology in Vitro

Volumn 25, Issue 4, 2011, Pages 817-824

  Jeong, Jin Woo ^a,b   Jin, Cheng Yun ^c   Park, Cheol ^c   Hong, Su Hyun ^a   Kim, Gi Young ^d   Jeong, Yong Kee ^e   Lee, Jae Dong ^b   Yoo, Young Hyun ^f   Choi, Yung Hyun ^a,c  

^a Dong Eui University   (South Korea)

^b Pusan National University   (South Korea)

^c Dong Eui University   (South Korea)

^d Jeju National University   (South Korea)

^e Dong A University   (South Korea)

^f Dong A University College of Medicine   (South Korea)

Author keywords

Apoptosis; Caspase; Cordycepin; ROS

Indexed keywords

CASPASE; CORDYCEPIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CORDYCEPS; DEOXYADENOSINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKEMIA; MEDICINE, CHINESE TRADITIONAL; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; U937 CELLS;

BACTERIA (MICROORGANISMS); CORDYCEPS MILITARIS;

EID: 79955472992     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.02.001     Document Type: Article

References (31)

1. Ahn Y.J., Park S.J., Lee S.G., Shin S.C., Choi D.H. Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. J. Agric. Food Chem. 2000, 48:2744-2748.
2. Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science 1998, 281:1305-1308.
3. Boatright K.M., Salvesen G.S. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 2003, 15:725-731.
4. Chakraborti T., Das S., Mondal M., Roychoudhury S., Chakraborti S. Oxidant, mitochondria and calcium: an overview. Cell Signal. 1999, 11:77-85.
5. Choi W.Y., Kim G.Y., Lee W.H., Choi Y.H. Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway. Chemotherapy 2008, 54:279-287.
6. Crack P.J., Taylor J.M. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 2005, 38:1433-1444.
7. Cunningham K.G., Manson W., Spring F.S., Hutchinson S.A. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris. Nature 1950, 166:949.
8. De Laurenzi V., Melino G. Apoptosis. The little devil of death. Nature 2000, 406:135-136.
9. Dlugosz P.J., Billen L.P., Annis M.G., Zhu W., Zhang Z., Lin J., Leber B., Andrews D.W. Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J. 2006, 25:2287-2296.
10. Fiers W., Beyaert R., Declercq W., Vandenabeele P. More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 1999, 18:7719-7730.
11. Fleury C., Mignotte B., Vayssière J.L. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002, 84:131-141.
12. Gao Z., Tian Y., Wang J., Yin Q., Wu H., Li Y.M., Jiang X. A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo. J. Biol. Chem. 2007, 282:30718-30727.
13. Horowitz B., Goldfinger B.A., Marmur J. Effect of cordycepin triphosphate on the nuclear DNA-dependent RNA polymerases and poly(A) polymerase from the yeast, Saccharomyces cerevisiae. Arch. Biochem. Biophys. 1976, 172:143-148.
14. Jang K.J., Han M.H., Lee B.H., Kim B.W., Kim C.H., Yoon H.M., Choi Y.H. Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. J. Acupunct. Meridian. Stud. 2010, 3:24-31.
15. Jin Z., el-Deiry W.S. Overview of cell death signaling pathways. Cancer Biol. Ther. 2005, 4:139-163.
16. Jung E.J., Kim C.W., Kim D.R. Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp. Mol. Med. 2008, 40:276-285.
17. Kim H.G., Shrestha B., Lim S.Y., Yoon D.H., Chang W.C., Shin D.J., Han S.K., Park S.M., Park J.H., Park H.I., Sung J.M., Jang Y., Chung N., Hwang K.C., Kim T.W. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur. J. Pharmacol. 2006, 545:192-199.
18. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 2000, 6:513-519.
19. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371:346-347.
20. Lee K.B., Lee J.S., Park J.W., Huh T.L., Lee Y.M. Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases. Exp. Mol. Med. 2008, 40:118-129.
21. Mohamad N., Gutiérrez A., Núñez M., Cocca C., Martín G., Cricco G., Medina V., Rivera E., Bergoc R. Mitochondrial apoptotic pathways. Biocell 2005, 29:149-161.
22. Muller W.E., Seibert G., Beyer R., Breter H.J., Maidhof A., Zahn R.K. Effect of cordycepin on nucleic acid metabolism in L5178Y cells and on nucleic acid-synthesizing enzyme systems. Cancer Res. 1977, 37:3824-3833.
23. Nakamura K., Yoshikawa N., Yamaguchi Y., Kagota S., Shinozuka K., Kunitomo M. Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res. 2006, 26:43-47.
24. Nechushtan A., Smith C.L., Lamensdorf I., Yoon S.H., Youle R.J. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J. Cell Biol. 2001, 153:1265-1276.
25. Okada H., Mak T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat. Rev. Cancer 2004, 4:592-603.
26. Park C., Jin C.Y., Kwon H.J., Hwang H.J., Kim G.Y., Choi I.W., Kwon T.K., Kim B.W., Kim W.J., Choi Y.H. Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. Toxicol. in Vitro 2010, 24:486-494.
27. Paterson R.R. Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory?. Phytochemistry 2008, 69:1469-1495.
28. Shin D.Y., Kim G.Y., Li W., Choi B.T., Kim N.D., Kang H.S., Choi Y.H. Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells. Biomed. Phamacother. 2009, 63:86-94.
29. Sugar A.M., McCaffrey R.P. Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob. Agents Chemother. 1998, 42:1424-1427.
30. Yang J., Liu K., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng P.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997, 275:1129-1132.
31. Yin X.M. Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res. 2000, 10:161-167.