메뉴 건너뛰기




Volumn 11, Issue SUPPL.1, 2013, Pages 11-23

Structure-function and regulation of ADAMTS-13 protease

Author keywords

ADAMTS13 protein; Animals; Arterial thrombosis; Autoimmune diseases; Factor VIII; Human; Thrombotic microangiopathies; Von Willebrand factor (445 733)

Indexed keywords

AUTOANTIBODY; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

EID: 84880608510     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12221     Document Type: Review
Times cited : (113)

References (148)
  • 2
    • 0035798582 scopus 로고    scopus 로고
    • Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura
    • Zheng XL, Chung D, Takayama T, Majerus E, Sadler J, Fujikawa K. Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J Biol Chem 2001; 276: 41059-63.
    • (2001) J Biol Chem , vol.276 , pp. 41059-41063
    • Zheng, X.L.1    Chung, D.2    Takayama, T.3    Majerus, E.4    Sadler, J.5    Fujikawa, K.6
  • 3
    • 0026323664 scopus 로고
    • von Willebrand factor
    • Sadler JE. von Willebrand factor. J Biol Chem 1991; 266: 22777-80.
    • (1991) J Biol Chem , vol.266 , pp. 22777-22780
    • Sadler, J.E.1
  • 4
    • 0021683006 scopus 로고
    • Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization
    • Wagner DD, Marder VJ. Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization. J Cell Biol 1984; 99: 2123-30.
    • (1984) J Cell Biol , vol.99 , pp. 2123-2130
    • Wagner, D.D.1    Marder, V.J.2
  • 7
    • 28344435221 scopus 로고    scopus 로고
    • Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions
    • Dong JF. Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions. J Thromb Haemost 2005; 3: 1710-16.
    • (2005) J Thromb Haemost , vol.3 , pp. 1710-1716
    • Dong, J.F.1
  • 11
    • 33749367421 scopus 로고    scopus 로고
    • Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts
    • Shang D, Zheng XW, Niiya M, Zheng XL. Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts. Blood 2006; 108: 2207-15.
    • (2006) Blood , vol.108 , pp. 2207-2215
    • Shang, D.1    Zheng, X.W.2    Niiya, M.3    Zheng, X.L.4
  • 13
    • 0037014999 scopus 로고    scopus 로고
    • A new name in thrombosis, ADAMTS13
    • Sadler JE. A new name in thrombosis, ADAMTS13. Proc Natl Acad Sci USA 2002; 99: 11552-4.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11552-11554
    • Sadler, J.E.1
  • 14
    • 0242266981 scopus 로고    scopus 로고
    • Shear stress and von Willebrand factor in health and disease
    • Tsai HM. Shear stress and von Willebrand factor in health and disease. Semin Thromb Hemost 2003; 29: 479-88.
    • (2003) Semin Thromb Hemost , vol.29 , pp. 479-488
    • Tsai, H.M.1
  • 17
    • 0028266474 scopus 로고
    • Shear stress enhances the proteolysis of von Willebrand factor in normal plasma
    • Tsai HM, Sussman I, Nagel RL. Shear stress enhances the proteolysis of von Willebrand factor in normal plasma. Blood 1994; 83: 2171-9.
    • (1994) Blood , vol.83 , pp. 2171-2179
    • Tsai, H.M.1    Sussman, I.2    Nagel, R.L.3
  • 18
    • 80052968358 scopus 로고    scopus 로고
    • Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis
    • Xiao J, Jin SY, Xue J, Sorvillo N, Voorberg J, Zheng XL. Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis. Arterioscler Thromb Vasc Biol 2011; 31: 2261-9.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2261-2269
    • Xiao, J.1    Jin, S.Y.2    Xue, J.3    Sorvillo, N.4    Voorberg, J.5    Zheng, X.L.6
  • 19
    • 75649138819 scopus 로고    scopus 로고
    • Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13
    • Wu T, Lin J, Cruz MA, Dong JF, Zhu C. Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. Blood 2010; 115: 370-8.
    • (2010) Blood , vol.115 , pp. 370-378
    • Wu, T.1    Lin, J.2    Cruz, M.A.3    Dong, J.F.4    Zhu, C.5
  • 20
    • 0029925856 scopus 로고    scopus 로고
    • Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis
    • Furlan M, Robles R, Lammle B. Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood 1996; 87: 4223-34.
    • (1996) Blood , vol.87 , pp. 4223-4234
    • Furlan, M.1    Robles, R.2    Lammle, B.3
  • 22
    • 0029878123 scopus 로고    scopus 로고
    • Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion
    • Tsai HM. Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion. Blood 1996; 87: 4235-44.
    • (1996) Blood , vol.87 , pp. 4235-4244
    • Tsai, H.M.1
  • 23
    • 0032569840 scopus 로고    scopus 로고
    • Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura
    • Tsai HM, Lian EC. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med 1998; 339: 1585-94.
    • (1998) N Engl J Med , vol.339 , pp. 1585-1594
    • Tsai, H.M.1    Lian, E.C.2
  • 25
    • 34247109995 scopus 로고    scopus 로고
    • Structural and functional correlation of ADAMTS13
    • Dong JF. Structural and functional correlation of ADAMTS13. Curr Opin Hematol 2007; 14: 270-6.
    • (2007) Curr Opin Hematol , vol.14 , pp. 270-276
    • Dong, J.F.1
  • 27
    • 0038354777 scopus 로고    scopus 로고
    • Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases
    • Hosler GA, Cusumano AM, Hutchins GM. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases. Arch Pathol Lab Med 2003; 127: 834-9.
    • (2003) Arch Pathol Lab Med , vol.127 , pp. 834-839
    • Hosler, G.A.1    Cusumano, A.M.2    Hutchins, G.M.3
  • 28
    • 0037341346 scopus 로고    scopus 로고
    • Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura
    • Tsai HM. Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura. Arterioscler Thromb Vasc Biol 2003; 23: 388-96.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 388-396
    • Tsai, H.M.1
  • 29
    • 33845914048 scopus 로고    scopus 로고
    • ADAMTS13 and microvascular thrombosis
    • Tsai HM. ADAMTS13 and microvascular thrombosis. Expert Rev Cardiovasc Ther 2006; 4: 813-25.
    • (2006) Expert Rev Cardiovasc Ther , vol.4 , pp. 813-825
    • Tsai, H.M.1
  • 30
    • 0025999820 scopus 로고
    • Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients
    • Bell WR, Braine HG, Ness PM, Kickler TS. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. N Engl J Med 1991; 325: 398-403.
    • (1991) N Engl J Med , vol.325 , pp. 398-403
    • Bell, W.R.1    Braine, H.G.2    Ness, P.M.3    Kickler, T.S.4
  • 31
    • 78549253211 scopus 로고    scopus 로고
    • How I treat patients with thrombotic thrombocytopenic purpura: 2010
    • George JN. How I treat patients with thrombotic thrombocytopenic purpura: 2010. Blood 2010; 116: 4060-9.
    • (2010) Blood , vol.116 , pp. 4060-4069
    • George, J.N.1
  • 32
    • 0026048114 scopus 로고
    • Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group
    • Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, Spasoff RA. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 1991; 325: 393-7.
    • (1991) N Engl J Med , vol.325 , pp. 393-397
    • Rock, G.A.1    Shumak, K.H.2    Buskard, N.A.3    Blanchette, V.S.4    Kelton, J.G.5    Nair, R.C.6    Spasoff, R.A.7
  • 33
    • 2542490269 scopus 로고    scopus 로고
    • Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and non-idiopathic thrombotic thrombocytopenic purpura
    • Zheng XL, Richard KM, Goodnough LT, Sadler JE. Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and non-idiopathic thrombotic thrombocytopenic purpura. Blood 2004; 103: 4043-9.
    • (2004) Blood , vol.103 , pp. 4043-4049
    • Zheng, X.L.1    Richard, K.M.2    Goodnough, L.T.3    Sadler, J.E.4
  • 34
    • 41749101957 scopus 로고    scopus 로고
    • Pathogenesis of thrombotic microangiopathies
    • Zheng XL, Sadler JE. Pathogenesis of thrombotic microangiopathies. Annu Rev Path Mech Dis 2008; 3: 249-77.
    • (2008) Annu Rev Path Mech Dis , vol.3 , pp. 249-277
    • Zheng, X.L.1    Sadler, J.E.2
  • 35
    • 77956824177 scopus 로고    scopus 로고
    • Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura
    • Zheng XL, Wu HM, Shang D, Falls E, Skipwith CG, Cataland SR, Bennett CL, Kwaan HC. Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura. Haematologica 2010; 95: 1555-62.
    • (2010) Haematologica , vol.95 , pp. 1555-1562
    • Zheng, X.L.1    Wu, H.M.2    Shang, D.3    Falls, E.4    Skipwith, C.G.5    Cataland, S.R.6    Bennett, C.L.7    Kwaan, H.C.8
  • 37
    • 74049137935 scopus 로고    scopus 로고
    • ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura
    • Lotta LA, Garagiola I, Palla R, Cairo A, Peyvandi F. ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura. Hum Mutat 2010; 31: 11-19.
    • (2010) Hum Mutat , vol.31 , pp. 11-19
    • Lotta, L.A.1    Garagiola, I.2    Palla, R.3    Cairo, A.4    Peyvandi, F.5
  • 39
    • 78149336370 scopus 로고    scopus 로고
    • Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice
    • Huang J, Motto DG, Bundle DR, Sadler JE. Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice. Blood 2010; 116: 3653-9.
    • (2010) Blood , vol.116 , pp. 3653-3659
    • Huang, J.1    Motto, D.G.2    Bundle, D.R.3    Sadler, J.E.4
  • 43
    • 84856895477 scopus 로고    scopus 로고
    • High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women
    • Andersson HM, Siegerink B, Luken BM, Crawley JT, Algra A, Lane DA, Rosendaal FR. High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women. Blood 2012; 119: 1555-60.
    • (2012) Blood , vol.119 , pp. 1555-1560
    • Andersson, H.M.1    Siegerink, B.2    Luken, B.M.3    Crawley, J.T.4    Algra, A.5    Lane, D.A.6    Rosendaal, F.R.7
  • 45
    • 33750058829 scopus 로고    scopus 로고
    • Reduced von Willebrand factor-cleaving protease (ADAMTS13) activity in acute myocardial infarction
    • Kaikita K, Soejima K, Matsukawa M, Nakagaki T, Ogawa H. Reduced von Willebrand factor-cleaving protease (ADAMTS13) activity in acute myocardial infarction. J Thromb Haemost 2006; 4: 2490-3.
    • (2006) J Thromb Haemost , vol.4 , pp. 2490-2493
    • Kaikita, K.1    Soejima, K.2    Matsukawa, M.3    Nakagaki, T.4    Ogawa, H.5
  • 55
    • 84864280369 scopus 로고    scopus 로고
    • Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model
    • Jin SY, Tohyama J, Bauer RC, Cao NN, Rader DJ, Zheng XL. Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. Arterioscler Thromb Vasc Biol 2012; 32: 1817-23.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1817-1823
    • Jin, S.Y.1    Tohyama, J.2    Bauer, R.C.3    Cao, N.N.4    Rader, D.J.5    Zheng, X.L.6
  • 56
    • 84863393759 scopus 로고    scopus 로고
    • ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice
    • Gandhi C, Khan MM, Lentz SR, Chauhan AK. ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. Blood 2011; 119: 2385-91.
    • (2011) Blood , vol.119 , pp. 2385-2391
    • Gandhi, C.1    Khan, M.M.2    Lentz, S.R.3    Chauhan, A.K.4
  • 59
    • 84871482262 scopus 로고    scopus 로고
    • ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice
    • Gandhi C, Motto DG, Jensen M, Lentz SR, Chauhan AK. ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice. Blood 2012; 120: 5224-30.
    • (2012) Blood , vol.120 , pp. 5224-5230
    • Gandhi, C.1    Motto, D.G.2    Jensen, M.3    Lentz, S.R.4    Chauhan, A.K.5
  • 65
    • 73949121978 scopus 로고    scopus 로고
    • Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage
    • Turner NA, Nolasco L, Ruggeri ZM, Moake JL. Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. Blood 2009; 114: 5102-11.
    • (2009) Blood , vol.114 , pp. 5102-5111
    • Turner, N.A.1    Nolasco, L.2    Ruggeri, Z.M.3    Moake, J.L.4
  • 66
    • 70350015029 scopus 로고    scopus 로고
    • von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size
    • Jin SY, Skipwith CG, Shang D, Zheng XL. von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size. J Thromb Haemost 2009; 7: 1749-52.
    • (2009) J Thromb Haemost , vol.7 , pp. 1749-1752
    • Jin, S.Y.1    Skipwith, C.G.2    Shang, D.3    Zheng, X.L.4
  • 67
    • 57749177100 scopus 로고    scopus 로고
    • ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals
    • Turner N, Nolasco L, Dong JF, Moake J. ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals. J Thromb Haemost 2009; 7: 229-32.
    • (2009) J Thromb Haemost , vol.7 , pp. 229-232
    • Turner, N.1    Nolasco, L.2    Dong, J.F.3    Moake, J.4
  • 68
    • 84857017558 scopus 로고    scopus 로고
    • Generation and breakdown of soluble ultralarge von Willebrand factor multimers
    • Turner N, Nolasco L, Moake J. Generation and breakdown of soluble ultralarge von Willebrand factor multimers. Semin Thromb Hemost 2012; 38: 38-46.
    • (2012) Semin Thromb Hemost , vol.38 , pp. 38-46
    • Turner, N.1    Nolasco, L.2    Moake, J.3
  • 69
    • 84864005561 scopus 로고    scopus 로고
    • ADAMTS13 promotes angiogenesis and modulates VEGF-induced angiogenesis
    • Lee M, Rodansky ES, Smith JK, Rodgers GM. ADAMTS13 promotes angiogenesis and modulates VEGF-induced angiogenesis. Microvasc Res 2012; 84: 109-15.
    • (2012) Microvasc Res , vol.84 , pp. 109-115
    • Lee, M.1    Rodansky, E.S.2    Smith, J.K.3    Rodgers, G.M.4
  • 72
    • 84880608626 scopus 로고    scopus 로고
    • Ectopic expression of ADAMTS13 in platelets as a novel therapeutic approach for arterial thrombosis
    • Abstract
    • Pickens B, Jin SY, Li D, Zheng XL. Ectopic expression of ADAMTS13 in platelets as a novel therapeutic approach for arterial thrombosis. Blood 2012; 120: 491 (Abstract).
    • (2012) Blood , vol.120 , pp. 491
    • Pickens, B.1    Jin, S.Y.2    Li, D.3    Zheng, X.L.4
  • 74
    • 45549109031 scopus 로고    scopus 로고
    • Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors
    • Gewirtz J, Thornton MA, Rauova L, Poncz M. Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors. J Thromb Haemost 2008; 6: 1160-6.
    • (2008) J Thromb Haemost , vol.6 , pp. 1160-1166
    • Gewirtz, J.1    Thornton, M.A.2    Rauova, L.3    Poncz, M.4
  • 75
    • 77955921912 scopus 로고    scopus 로고
    • Factor IX ectopically expressed in platelets can be stored in alpha-granules and corrects the phenotype of hemophilia B mice
    • Zhang G, Shi Q, Fahs SA, Kuether EL, Walsh CE, Montgomery RR. Factor IX ectopically expressed in platelets can be stored in alpha-granules and corrects the phenotype of hemophilia B mice. Blood 2010; 116: 1235-43.
    • (2010) Blood , vol.116 , pp. 1235-1243
    • Zhang, G.1    Shi, Q.2    Fahs, S.A.3    Kuether, E.L.4    Walsh, C.E.5    Montgomery, R.R.6
  • 76
    • 70450253102 scopus 로고    scopus 로고
    • A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms
    • Apte SS. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J Biol Chem 2009; 284: 31493-7.
    • (2009) J Biol Chem , vol.284 , pp. 31493-31497
    • Apte, S.S.1
  • 77
    • 0035129903 scopus 로고    scopus 로고
    • ADAMTS: a novel family of extracellular matrix proteases
    • Tang BL. ADAMTS: a novel family of extracellular matrix proteases. Int J Biochem Cell Biol 2001; 33: 33-44.
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 33-44
    • Tang, B.L.1
  • 78
    • 0344875565 scopus 로고    scopus 로고
    • Cleavage of the ADAMTS13 propeptide is not required for protease activity
    • Majerus EM, Zheng X, Tuley EA, Sadler JE. Cleavage of the ADAMTS13 propeptide is not required for protease activity. J Biol Chem 2003; 278: 46643-8.
    • (2003) J Biol Chem , vol.278 , pp. 46643-46648
    • Majerus, E.M.1    Zheng, X.2    Tuley, E.A.3    Sadler, J.E.4
  • 79
    • 60849118373 scopus 로고    scopus 로고
    • A functional calcium-binding site in the metalloprotease domain of ADAMTS13
    • Gardner MD, Chion CK, de Groot R, Shah A, Crawley JT, Lane DA. A functional calcium-binding site in the metalloprotease domain of ADAMTS13. Blood 2009; 113: 1149-57.
    • (2009) Blood , vol.113 , pp. 1149-1157
    • Gardner, M.D.1    Chion, C.K.2    de Groot, R.3    Shah, A.4    Crawley, J.T.5    Lane, D.A.6
  • 80
    • 23844465898 scopus 로고    scopus 로고
    • The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor
    • Ai J, Smith P, Wang S, Zhang P, Zheng XL. The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor. J Biol Chem 2005; 280: 29428-34.
    • (2005) J Biol Chem , vol.280 , pp. 29428-29434
    • Ai, J.1    Smith, P.2    Wang, S.3    Zhang, P.4    Zheng, X.L.5
  • 81
    • 52649182049 scopus 로고    scopus 로고
    • Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity
    • Gao W, Anderson PJ, Sadler JE. Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity. Blood 2008; 112: 1713-19.
    • (2008) Blood , vol.112 , pp. 1713-1719
    • Gao, W.1    Anderson, P.J.2    Sadler, J.E.3
  • 83
    • 0042530524 scopus 로고    scopus 로고
    • Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13
    • Zheng XL, Nishio K, Majerus EM, Sadler JE. Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13. J Biol Chem 2003; 278: 30136-41.
    • (2003) J Biol Chem , vol.278 , pp. 30136-30141
    • Zheng, X.L.1    Nishio, K.2    Majerus, E.M.3    Sadler, J.E.4
  • 84
    • 72949104661 scopus 로고    scopus 로고
    • Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
    • Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T. Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor. Proc Natl Acad Sci USA 2009; 106: 19274-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19274-19279
    • Akiyama, M.1    Takeda, S.2    Kokame, K.3    Takagi, J.4    Miyata, T.5
  • 86
    • 63649149047 scopus 로고    scopus 로고
    • Three-dimensional domain architecture of the ADAM family proteinases
    • Takeda S. Three-dimensional domain architecture of the ADAM family proteinases. Semin Cell Dev Biol 2009; 20: 146-52.
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 146-152
    • Takeda, S.1
  • 87
    • 67049114094 scopus 로고    scopus 로고
    • Essential role of the disintegrin-like domain in ADAMTS13 function
    • de Groot R, Bardhan A, Ramroop N, Lane DA, Crawley JT. Essential role of the disintegrin-like domain in ADAMTS13 function. Blood 2009; 113: 5609-16.
    • (2009) Blood , vol.113 , pp. 5609-5616
    • de Groot, R.1    Bardhan, A.2    Ramroop, N.3    Lane, D.A.4    Crawley, J.T.5
  • 88
    • 34247845704 scopus 로고    scopus 로고
    • Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease
    • Gao W, Anderson PJ, Majerus EM, Tuley EA, Sadler JE. Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease. Proc Natl Acad Sci USA 2006; 103: 19099-104.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19099-19104
    • Gao, W.1    Anderson, P.J.2    Majerus, E.M.3    Tuley, E.A.4    Sadler, J.E.5
  • 89
    • 79960991896 scopus 로고    scopus 로고
    • Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13)
    • Xiang Y, de Groot R, Crawley JT, Lane DA. Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). Proc Natl Acad Sci USA 2011; 108: 11602-7.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11602-11607
    • Xiang, Y.1    de Groot, R.2    Crawley, J.T.3    Lane, D.A.4
  • 90
    • 28844502248 scopus 로고    scopus 로고
    • Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?
    • Zhou W, Dong L, Ginsburg D, Bouhassira EE, Tsai HM. Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? J Biol Chem 2005; 280: 39934-41.
    • (2005) J Biol Chem , vol.280 , pp. 39934-39941
    • Zhou, W.1    Dong, L.2    Ginsburg, D.3    Bouhassira, E.E.4    Tsai, H.M.5
  • 92
    • 84864531097 scopus 로고    scopus 로고
    • Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases
    • Gao W, Zhu J, Westfield LA, Tuley EA, Anderson PJ, Sadler JE. Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases. J Biol Chem 2012; 287: 26944-52.
    • (2012) J Biol Chem , vol.287 , pp. 26944-26952
    • Gao, W.1    Zhu, J.2    Westfield, L.A.3    Tuley, E.A.4    Anderson, P.J.5    Sadler, J.E.6
  • 93
    • 77950414918 scopus 로고    scopus 로고
    • Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor
    • Jin SY, Skipwith CG, Zheng XL. Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor. Blood 2010; 115: 2300-10.
    • (2010) Blood , vol.115 , pp. 2300-2310
    • Jin, S.Y.1    Skipwith, C.G.2    Zheng, X.L.3
  • 94
    • 77949882442 scopus 로고    scopus 로고
    • An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF
    • Pos W, Crawley JT, Fijnheer R, Voorberg J, Lane DA, Luken BM. An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood 2010; 115: 1640-9.
    • (2010) Blood , vol.115 , pp. 1640-1649
    • Pos, W.1    Crawley, J.T.2    Fijnheer, R.3    Voorberg, J.4    Lane, D.A.5    Luken, B.M.6
  • 96
    • 21644449866 scopus 로고    scopus 로고
    • ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis
    • Jones GC, Riley GP. ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther 2005; 7: 160-9.
    • (2005) Arthritis Res Ther , vol.7 , pp. 160-169
    • Jones, G.C.1    Riley, G.P.2
  • 99
    • 0025967115 scopus 로고
    • Cellular attachment to thrombospondin. Cooperative interactions between receptor systems
    • Asch AS, Tepler J, Silbiger S, Nachman RL. Cellular attachment to thrombospondin. Cooperative interactions between receptor systems. J Biol Chem 1991; 266: 1740-5.
    • (1991) J Biol Chem , vol.266 , pp. 1740-1745
    • Asch, A.S.1    Tepler, J.2    Silbiger, S.3    Nachman, R.L.4
  • 101
    • 71449101329 scopus 로고    scopus 로고
    • ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor
    • Vomund AN, Majerus EM. ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor. J Biol Chem 2009; 284: 30925-32.
    • (2009) J Biol Chem , vol.284 , pp. 30925-30932
    • Vomund, A.N.1    Majerus, E.M.2
  • 102
    • 22044446207 scopus 로고    scopus 로고
    • Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow
    • Tao Z, Wang Y, Choi H, Bernardo A, Nishio K, Sadler JE, Lopez JA, Dong JF. Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. Blood 2005; 106: 141-3.
    • (2005) Blood , vol.106 , pp. 141-143
    • Tao, Z.1    Wang, Y.2    Choi, H.3    Bernardo, A.4    Nishio, K.5    Sadler, J.E.6    Lopez, J.A.7    Dong, J.F.8
  • 103
    • 84880610981 scopus 로고    scopus 로고
    • Carboxyl-terminal thrombospondin-type 1 (TSP-1) repeats of ADAMTS13 inhibits platelet adhesion to collagen-coated surface under shear stress, independent of proteolytic activity
    • Abstract
    • Xiao J, Zheng XL. Carboxyl-terminal thrombospondin-type 1 (TSP-1) repeats of ADAMTS13 inhibits platelet adhesion to collagen-coated surface under shear stress, independent of proteolytic activity. Blood 2011; 118: 195 (Abstract).
    • (2011) Blood , vol.118 , pp. 195
    • Xiao, J.1    Zheng, X.L.2
  • 105
    • 28844490990 scopus 로고    scopus 로고
    • Role of the CUB-1 domain in docking ADAMTS-13 to unusually large von Willebrand factor in flowing blood
    • Tao Z, Peng Y, Nolasco L, Cal S, Lopez-Otin C, Li R, Moake JL, Lopez JA, Dong JF. Role of the CUB-1 domain in docking ADAMTS-13 to unusually large von Willebrand factor in flowing blood. Blood 2005; 106: 4139-45.
    • (2005) Blood , vol.106 , pp. 4139-4145
    • Tao, Z.1    Peng, Y.2    Nolasco, L.3    Cal, S.4    Lopez-Otin, C.5    Li, R.6    Moake, J.L.7    Lopez, J.A.8    Dong, J.F.9
  • 107
    • 0022389597 scopus 로고
    • Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus
    • Tans G, Govers-Riemslag JW, van Rijn JL, Rosing J. Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus. J Biol Chem 1985; 260: 9366-72.
    • (1985) J Biol Chem , vol.260 , pp. 9366-9372
    • Tans, G.1    Govers-Riemslag, J.W.2    van Rijn, J.L.3    Rosing, J.4
  • 109
    • 4143129884 scopus 로고    scopus 로고
    • ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain
    • Somerville RP, Longpre JM, Apel ED, Lewis RM, Wang LW, Sanes JR, Leduc R, Apte SS. ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem 2004; 279: 35159-75.
    • (2004) J Biol Chem , vol.279 , pp. 35159-35175
    • Somerville, R.P.1    Longpre, J.M.2    Apel, E.D.3    Lewis, R.M.4    Wang, L.W.5    Sanes, J.R.6    Leduc, R.7    Apte, S.S.8
  • 112
    • 34548834974 scopus 로고    scopus 로고
    • The cooperative activity between the carboxyl-terminal TSP-1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow
    • Zhang P, Pan W, Rux AH, Sachais BS, Zheng XL. The cooperative activity between the carboxyl-terminal TSP-1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow. Blood 2007; 110: 1887-94.
    • (2007) Blood , vol.110 , pp. 1887-1894
    • Zhang, P.1    Pan, W.2    Rux, A.H.3    Sachais, B.S.4    Zheng, X.L.5
  • 113
    • 0034641659 scopus 로고    scopus 로고
    • Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis
    • Pareti FI, Lattuada A, Bressi C, Zanobini M, Sala A, Steffan A, Ruggeri ZM. Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis. Circulation 2000; 102: 1290-5.
    • (2000) Circulation , vol.102 , pp. 1290-1295
    • Pareti, F.I.1    Lattuada, A.2    Bressi, C.3    Zanobini, M.4    Sala, A.5    Steffan, A.6    Ruggeri, Z.M.7
  • 115
    • 32644462985 scopus 로고    scopus 로고
    • Acquired von Willebrand disease type IIA in patients with aortic valve stenosis
    • Yoshida K, Tobe S, Kawata M. Acquired von Willebrand disease type IIA in patients with aortic valve stenosis. Ann Thorac Surg 2006; 81: 1114-16.
    • (2006) Ann Thorac Surg , vol.81 , pp. 1114-1116
    • Yoshida, K.1    Tobe, S.2    Kawata, M.3
  • 116
    • 38349155217 scopus 로고    scopus 로고
    • Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress
    • Shim K, Anderson PJ, Tuley EA, Wiswall E, Sadler JE. Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress. Blood 2007; 111: 651-7.
    • (2007) Blood , vol.111 , pp. 651-657
    • Shim, K.1    Anderson, P.J.2    Tuley, E.A.3    Wiswall, E.4    Sadler, J.E.5
  • 117
    • 77956514337 scopus 로고    scopus 로고
    • Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress
    • Skipwith CG, Cao W, Zheng XL. Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress. J Biol Chem 2010; 285: 28596-603.
    • (2010) J Biol Chem , vol.285 , pp. 28596-28603
    • Skipwith, C.G.1    Cao, W.2    Zheng, X.L.3
  • 119
    • 84863286346 scopus 로고    scopus 로고
    • Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood
    • Li M, Ku DN, Forest CR. Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood. Lab Chip 2012; 12: 1355-62.
    • (2012) Lab Chip , vol.12 , pp. 1355-1362
    • Li, M.1    Ku, D.N.2    Forest, C.R.3
  • 120
    • 79951556994 scopus 로고    scopus 로고
    • Analysis of morphology of platelet aggregates formed on collagen under laminar blood flow
    • Colace T, Falls E, Zheng XL, Diamond SL. Analysis of morphology of platelet aggregates formed on collagen under laminar blood flow. Ann Biomed Eng 2011; 39: 922-9.
    • (2011) Ann Biomed Eng , vol.39 , pp. 922-929
    • Colace, T.1    Falls, E.2    Zheng, X.L.3    Diamond, S.L.4
  • 122
    • 67249086879 scopus 로고    scopus 로고
    • Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor
    • Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA. Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci USA 2009; 106: 9226-31.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9226-9231
    • Zhang, Q.1    Zhou, Y.F.2    Zhang, C.Z.3    Zhang, X.4    Lu, C.5    Springer, T.A.6
  • 123
    • 66749099068 scopus 로고    scopus 로고
    • Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor
    • Zhang X, Halvorsen K, Zhang CZ, Wong WP, Springer TA. Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science 2009; 324: 1330-4.
    • (2009) Science , vol.324 , pp. 1330-1334
    • Zhang, X.1    Halvorsen, K.2    Zhang, C.Z.3    Wong, W.P.4    Springer, T.A.5
  • 124
    • 84866538135 scopus 로고    scopus 로고
    • Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease
    • Cao W, Sabatino DE, Altynova E, Lange AM, Casina VC, Camire RM, Zheng XL. Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease. J Biol Chem 2012; 287: 32459-66.
    • (2012) J Biol Chem , vol.287 , pp. 32459-32466
    • Cao, W.1    Sabatino, D.E.2    Altynova, E.3    Lange, A.M.4    Casina, V.C.5    Camire, R.M.6    Zheng, X.L.7
  • 125
    • 84880634302 scopus 로고    scopus 로고
    • Compromised proteolytic cleavage of von Willebrand factor type 2N variants by ADAMTS13 in the presence of factor VIII (and platelets) under shear stress
    • Abstract
    • Skipwith C, Haberichter S, Cao WJ, Gehrand AL, Zheng XL. Compromised proteolytic cleavage of von Willebrand factor type 2N variants by ADAMTS13 in the presence of factor VIII (and platelets) under shear stress. Blood 2009; 114: 28 (Abstract).
    • (2009) Blood , vol.114 , pp. 28
    • Skipwith, C.1    Haberichter, S.2    Cao, W.J.3    Gehrand, A.L.4    Zheng, X.L.5
  • 126
    • 3242676770 scopus 로고    scopus 로고
    • Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13
    • Nishio K, Anderson PJ, Zheng XL, Sadler JE. Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13. Proc Natl Acad Sci USA 2004; 101: 10578-83.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10578-10583
    • Nishio, K.1    Anderson, P.J.2    Zheng, X.L.3    Sadler, J.E.4
  • 127
    • 84871874605 scopus 로고    scopus 로고
    • Simultaneous exposure of sites in von Willebrand factor for glycoprotein Ib binding and ADAMTS13 cleavage: studies with ristocetin
    • Chen J, Ling M, Fu X, Lopez JA, Chung DW. Simultaneous exposure of sites in von Willebrand factor for glycoprotein Ib binding and ADAMTS13 cleavage: studies with ristocetin. Arterioscler Thromb Vasc Biol 2012; 32: 2625-30.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2625-2630
    • Chen, J.1    Ling, M.2    Fu, X.3    Lopez, J.A.4    Chung, D.W.5
  • 128
    • 0346688700 scopus 로고    scopus 로고
    • Hydrodynamic forces applied on intercellular bonds, soluble molecules, and cell-surface receptors
    • Shankaran H, Neelamegham S. Hydrodynamic forces applied on intercellular bonds, soluble molecules, and cell-surface receptors. Biophys J 2004; 86: 576-88.
    • (2004) Biophys J , vol.86 , pp. 576-588
    • Shankaran, H.1    Neelamegham, S.2
  • 131
    • 80155138041 scopus 로고    scopus 로고
    • Novel recombinant glycosylphosphatidylinositol (GPI)-anchored ADAMTS13 and variants for assessment of anti-ADAMTS13 autoantibodies in patients with thrombotic thrombocytopenic purpura
    • Li D, Xiao J, Paessler M, Zheng XL. Novel recombinant glycosylphosphatidylinositol (GPI)-anchored ADAMTS13 and variants for assessment of anti-ADAMTS13 autoantibodies in patients with thrombotic thrombocytopenic purpura. Thromb Haemost 2011; 106: 947-58.
    • (2011) Thromb Haemost , vol.106 , pp. 947-958
    • Li, D.1    Xiao, J.2    Paessler, M.3    Zheng, X.L.4
  • 132
    • 70350006842 scopus 로고    scopus 로고
    • IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura
    • Ferrari S, Mudde GC, Rieger M, Veyradier A, Kremer Hovinga JA, Scheiflinger F. IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 2009; 7: 1703-10.
    • (2009) J Thromb Haemost , vol.7 , pp. 1703-1710
    • Ferrari, S.1    Mudde, G.C.2    Rieger, M.3    Veyradier, A.4    Kremer Hovinga, J.A.5    Scheiflinger, F.6
  • 135
    • 13844256432 scopus 로고    scopus 로고
    • The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura
    • Luken BM, Turenhout EA, Hulstein JJ, van Mourik JA, Fijnheer R, Voorberg J. The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura. Thromb Haemost 2005; 93: 267-74.
    • (2005) Thromb Haemost , vol.93 , pp. 267-274
    • Luken, B.M.1    Turenhout, E.A.2    Hulstein, J.J.3    van Mourik, J.A.4    Fijnheer, R.5    Voorberg, J.6
  • 136
    • 33750069427 scopus 로고    scopus 로고
    • Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura
    • Luken BM, Kaijen PH, Turenhout EA, Kremer Hovinga JA, van Mourik JA, Fijnheer R, Voorberg J. Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 2006; 4: 2355-64.
    • (2006) J Thromb Haemost , vol.4 , pp. 2355-2364
    • Luken, B.M.1    Kaijen, P.H.2    Turenhout, E.A.3    Kremer Hovinga, J.A.4    van Mourik, J.A.5    Fijnheer, R.6    Voorberg, J.7
  • 137
    • 33748597666 scopus 로고    scopus 로고
    • Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP
    • Luken BM, Turenhout EA, Kaijen PH, Greuter MJ, Pos W, van Mourik JA, Fijnheer R, Voorberg J. Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP. Thromb Haemost 2006; 96: 295-301.
    • (2006) Thromb Haemost , vol.96 , pp. 295-301
    • Luken, B.M.1    Turenhout, E.A.2    Kaijen, P.H.3    Greuter, M.J.4    Pos, W.5    van Mourik, J.A.6    Fijnheer, R.7    Voorberg, J.8
  • 138
    • 80052964635 scopus 로고    scopus 로고
    • Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain
    • Pos W, Sorvillo N, Fijnheer R, Feys HB, Kaijen PH, Vidarsson G, Voorberg J. Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain. Haematologica 2011; 96: 1670-7.
    • (2011) Haematologica , vol.96 , pp. 1670-1677
    • Pos, W.1    Sorvillo, N.2    Fijnheer, R.3    Feys, H.B.4    Kaijen, P.H.5    Vidarsson, G.6    Voorberg, J.7
  • 139
    • 79960425069 scopus 로고    scopus 로고
    • Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
    • Yamaguchi Y, Moriki T, Igari A, Nakagawa T, Wada H, Matsumoto M, Fujimura Y, Murata M. Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. Thromb Res 2011; 128: 169-73.
    • (2011) Thromb Res , vol.128 , pp. 169-173
    • Yamaguchi, Y.1    Moriki, T.2    Igari, A.3    Nakagawa, T.4    Wada, H.5    Matsumoto, M.6    Fujimura, Y.7    Murata, M.8
  • 141
    • 74649087411 scopus 로고    scopus 로고
    • Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link
    • Scully M, Brown J, Patel R, McDonald V, Brown CJ, Machin S. Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link. J Thromb Haemost 2010; 8: 257-62.
    • (2010) J Thromb Haemost , vol.8 , pp. 257-262
    • Scully, M.1    Brown, J.2    Patel, R.3    McDonald, V.4    Brown, C.J.5    Machin, S.6
  • 143
    • 84860333489 scopus 로고    scopus 로고
    • ADAMTS13 meets MR, then what?
    • Zheng XL. ADAMTS13 meets MR, then what? Blood 2012; 119: 3652-4.
    • (2012) Blood , vol.119 , pp. 3652-3654
    • Zheng, X.L.1
  • 145
    • 74549138555 scopus 로고    scopus 로고
    • Registry of 919 patients with thrombotic microangiopathies across Japan: database of Nara Medical University during 1998-2008
    • Fujimura Y, Matsumoto M. Registry of 919 patients with thrombotic microangiopathies across Japan: database of Nara Medical University during 1998-2008. Intern Med 2010; 49: 7-15.
    • (2010) Intern Med , vol.49 , pp. 7-15
    • Fujimura, Y.1    Matsumoto, M.2
  • 146
    • 0034566798 scopus 로고    scopus 로고
    • Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome
    • von Furlan M. Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome. Adv Nephrol Necker Hosp 2000; 30: 71-81.
    • (2000) Adv Nephrol Necker Hosp , vol.30 , pp. 71-81
    • von Furlan, M.1
  • 147
    • 79959849239 scopus 로고    scopus 로고
    • Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura
    • Pos W, Luken BM, Sorvillo N, Hovinga JA, Voorberg J. Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 2011; 9: 1285-91.
    • (2011) J Thromb Haemost , vol.9 , pp. 1285-1291
    • Pos, W.1    Luken, B.M.2    Sorvillo, N.3    Hovinga, J.A.4    Voorberg, J.5
  • 148
    • 84860316787 scopus 로고    scopus 로고
    • Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
    • Jian C, Xiao J, Gong L, Skipwith CG, Jin SY, Kwaan HC, Zheng XL. Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. Blood 2012; 119: 3836-43.
    • (2012) Blood , vol.119 , pp. 3836-3843
    • Jian, C.1    Xiao, J.2    Gong, L.3    Skipwith, C.G.4    Jin, S.Y.5    Kwaan, H.C.6    Zheng, X.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.