Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 50, 2006, Pages 19099-19104

  Gao, Weiqiang ^a   Anderson, Patricia J ^a   Majerus, Elaine M ^a   Tuley, Elodee A ^a   Sadler, J Evan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Enzyme kinetics; Fluid shear stress; Thrombotic thrombocytopenic purpura

Indexed keywords

METALLOPROTEINASE; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SHEAR STRESS; CELL LINE; GENETIC VARIABILITY; GENETICS; KINETICS; METABOLISM; THROMBOSIS;

CELL LINE; HUMANS; KINETICS; METALLOENDOPEPTIDASES; PROTEIN BINDING; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THROMBOSIS; VARIATION (GENETICS); VON WILLEBRAND FACTOR;

EID: 34247845704     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0607264104     Document Type: Article

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