Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 28, 2011, Pages 11602-11607

  Xiang, Yaozu ^a   De Groot, Rens ^a   Crawley, James T B ^a   Lane, David A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Microvascular thrombosis; Thrombotic thrombocytopenia purpura

Indexed keywords

ALANINE; ASPARAGINE; DISINTEGRIN; LEUCINE; LYSINE; METALLOPROTEINASE; RECOMBINANT VON WILLEBRAND FACTOR; SERINE; THROMBOSPONDIN 1; VALINE; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; CONTROLLED STUDY; ENZYME ACTIVE SITE; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SCISSILE BOND;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYTIC DOMAIN; HEK293 CELLS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; VON WILLEBRAND FACTOR;

EID: 79960991896     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018559108     Document Type: Article

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