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Volumn 50, Issue , 2011, Pages 91-128

Acyclic and cyclic nucleoside phosphonates

Author keywords

Bioisosteres; HBV; HCV; HIV; Nucleoside phosphonates; Prodrug; Reverse transcriptase; RNA polymerase

Indexed keywords


EID: 84880604486     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527635955.ch5     Document Type: Chapter
Times cited : (3)

References (180)
  • 1
  • 2
    • 0014094091 scopus 로고
    • Nucleoside phosphonic acids. II. The synthesis of 50-deoxythymidine 50-phosphonic acid and its pyrophosphate derivatives
    • Rammler, D.H., Yengoyan, L., Paul, A.V., and Bax, P.C. (1967) Nucleoside phosphonic acids. II. The synthesis of 50-deoxythymidine 50-phosphonic acid and its pyrophosphate derivatives. Biochemistry, 6, 1828-1837.
    • (1967) Biochemistry , vol.6 , pp. 1828-1837
    • Rammler, D.H.1    Yengoyan, L.2    Paul, A.V.3    Bax, P.C.4
  • 4
    • 33747125380 scopus 로고    scopus 로고
    • Perspectives on the development of acyclic nucleotide analogs as antiviral drugs
    • Lee, W.A. and Martin, J.C. (2006) Perspectives on the development of acyclic nucleotide analogs as antiviral drugs. Antiviral Research, 71, 254-259.
    • (2006) Antiviral Research , vol.71 , pp. 254-259
    • Lee, W.A.1    Martin, J.C.2
  • 5
    • 22344455482 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens
    • Hawkins, T., Veikley, W., St Claire, R.L., 3rd, Guyer, B., Clark, N., and Kearney, B.P. (2005) Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens. Journal of Acquired Immune Deficiency Syndromes, 39, 406-411.
    • (2005) Journal of Acquired Immune Deficiency Syndromes , vol.39 , pp. 406-411
    • Hawkins, T.1    Veikley, W.2    St Claire III., R.L.3    Guyer, B.4    Clark, N.5    Kearney, B.P.6
  • 7
    • 1542690351 scopus 로고
    • Phosphonates as analogs of natural phosphates
    • Engel, R. (1977) Phosphonates as analogs of natural phosphates. Chemical Reviews, 1977, 349-367.
    • (1977) Chemical Reviews , vol.1977 , pp. 349-367
    • Engel, R.1
  • 8
    • 0014066654 scopus 로고
    • Synthesis of 50-deoxyuridine 50-phosphonic acid
    • Holÿ, A. (1967) Synthesis of 50-deoxyuridine 50-phosphonic acid. Tetrahedron Letters, 10, 881-884.
    • (1967) Tetrahedron Letters , vol.10 , pp. 881-884
    • Holÿ, A.1
  • 9
    • 27844455955 scopus 로고    scopus 로고
    • Acyclic nucleoside phosphonates: a key class of antiviral drugs
    • De Clercq, E., and Holÿ, A. (2005) Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nature Reviews Drug Discovery, 4, 928-940.
    • (2005) Nature Reviews Drug Discovery , vol.4 , pp. 928-940
    • De Clercq, E.1    Holÿ, A.2
  • 10
    • 0031036704 scopus 로고    scopus 로고
    • HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: a review of their pharmacology and clinical potential in the treatment of viral infections
    • Naesens, L., Snoeck, R., Andrei, G., Balzarini, J., Neyts, J., and De Clercq, E. (1997) HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: a review of their pharmacology and clinical potential in the treatment of viral infections. Antiviral Chemistry & Chemotherapy, 8, 1-23.
    • (1997) Antiviral Chemistry & Chemotherapy , vol.8 , pp. 1-23
    • Naesens, L.1    Snoeck, R.2    Andrei, G.3    Balzarini, J.4    Neyts, J.5    De Clercq, E.6
  • 12
    • 0028130055 scopus 로고
    • Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture
    • Heijtink, R.A., Kruining, J., de Wilde, G.A., Balzarini, J., De Clercq, E., and Schalm, S.W. (1994) Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture. Antimicrobial Agents and Chemotherapy, 38, 2180-2182.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 2180-2182
    • Heijtink, R.A.1    Kruining, J.2    de Wilde, G.A.3    Balzarini, J.4    De Clercq, E.5    Schalm, S.W.6
  • 13
    • 0027534661 scopus 로고
    • Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
    • Balzarini, J., Holÿ, A., Jindrich, J., Naesens, L., Snoeck, R., Schols, D., and De Clercq, E. (1993) Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrobial Agents and Chemotherapy, 37, 332-338.
    • (1993) Antimicrobial Agents and Chemotherapy , vol.37 , pp. 332-338
    • Balzarini, J.1    Holÿ, A.2    Jindrich, J.3    Naesens, L.4    Snoeck, R.5    Schols, D.6    De Clercq, E.7
  • 14
    • 0023763320 scopus 로고
    • (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication
    • Snoeck, R., Sakuma, T., De Clercq, E., Rosenberg, I., and Holÿ, A. (1988) (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrobial Agents and Chemotherapy, 32, 1839-1844.
    • (1988) Antimicrobial Agents and Chemotherapy , vol.32 , pp. 1839-1844
    • Snoeck, R.1    Sakuma, T.2    De Clercq, E.3    Rosenberg, I.4    Holÿ, A.5
  • 15
    • 0025026393 scopus 로고
    • Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG)
    • Neyts, J., Snoeck, R., Schols, D., Balzarini, J., and De Clercq, E. (1990) Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG). Virology, 179, 41-50.
    • (1990) Virology , vol.179 , pp. 41-50
    • Neyts, J.1    Snoeck, R.2    Schols, D.3    Balzarini, J.4    De Clercq, E.5
  • 16
    • 0029970116 scopus 로고    scopus 로고
    • Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase
    • Xiong, X., Smith, J.L., Kim, C., Huang, E.S., and Chen, M.S. (1996) Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase. Biochemical Pharmacology, 51, 1563-1567.
    • (1996) Biochemical Pharmacology , vol.51 , pp. 1563-1567
    • Xiong, X.1    Smith, J.L.2    Kim, C.3    Huang, E.S.4    Chen, M.S.5
  • 17
    • 0031020664 scopus 로고    scopus 로고
    • Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation
    • Xiong, X., Smith, J.L., and Chen, M.S. (1997) Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrobial Agents and Chemotherapy, 41, 594-599.
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , pp. 594-599
    • Xiong, X.1    Smith, J.L.2    Chen, M.S.3
  • 18
    • 2942532707 scopus 로고    scopus 로고
    • Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue
    • Bidanset, D.J., Rybak, R.J.,Hartline, C.B., and Kern, E.R. (2004) Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue. Antiviral Research, 63, 61-64.
    • (2004) Antiviral Research , vol.63 , pp. 61-64
    • Bidanset, D.J.1    Rybak R.J.Hartline, C.B.2    Kern, E.R.3
  • 19
    • 0027480153 scopus 로고
    • Evaluation of HPMPC therapy for primary and recurrent genital herpes in mice and guinea pigs
    • Bravo, F.J., Stanberry, L.R., Kier, A.B., Vogt, P.E., and Kern, E.R. (1993) Evaluation of HPMPC therapy for primary and recurrent genital herpes in mice and guinea pigs. Antiviral Research, 21, 59-72.
    • (1993) Antiviral Research , vol.21 , pp. 59-72
    • Bravo, F.J.1    Stanberry, L.R.2    Kier, A.B.3    Vogt, P.E.4    Kern, E.R.5
  • 22
    • 0030991256 scopus 로고    scopus 로고
    • High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes
    • Smith, I.L., Cherrington, J.M., Jiles, R.E., Fuller, M.D., Freeman,W.R., and Spector, S.A. (1997) High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes. The Journal of Infectious Diseases, 176, 69-77.
    • (1997) The Journal of Infectious Diseases , vol.176 , pp. 69-77
    • Smith, I.L.1    Cherrington, J.M.2    Jiles, R.E.3    Fuller, M.D.4    Freeman, W.R.5    Spector, S.A.6
  • 23
    • 0034834838 scopus 로고    scopus 로고
    • Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance
    • Palmer, S.,Margot, N., Gilbert, H., Shaw, N., Buckheit, R., Jr., and Miller, M. (2001) Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance. AIDS Research and Human Retroviruses, 17, 1167-1173.
    • (2001) AIDS Research and Human Retroviruses , vol.17 , pp. 1167-1173
    • Palmer S.Margot, N.1    Gilbert, H.2    Shaw, N.3    Buckheit, R.4    Miller, M.5
  • 26
    • 24044526915 scopus 로고    scopus 로고
    • Cross-resistance testing of nextgeneration nucleoside and nucleotide analogues against lamivudine-resistant HBV
    • Yang, H., Qi, X., Sabogal, A., Miller, M., Xiong, S., and Delaney, W.E., 4th (2005) Cross-resistance testing of nextgeneration nucleoside and nucleotide analogues against lamivudine-resistant HBV. Antiviral Therapy, 10, 625-633.
    • (2005) Antiviral Therapy , vol.10 , pp. 625-633
    • Yang, H.1    Qi, X.2    Sabogal, A.3    Miller, M.4    Xiong, S.5    Delaney, W.E.6
  • 28
    • 0029762282 scopus 로고    scopus 로고
    • Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro
    • Snoeck, R., Andrei, G., and De Clercq, E. (1996) Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro. European Journal of Clinical Microbiology & Infectious Diseases, 15, 574-579.
    • (1996) European Journal of Clinical Microbiology & Infectious Diseases , vol.15 , pp. 574-579
    • Snoeck, R.1    Andrei, G.2    De Clercq, E.3
  • 30
    • 0023633942 scopus 로고
    • Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication
    • Lin, J.C., De Clercq, E., and Pagano, J.S. (1987) Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication. Antimicrobial Agents and Chemotherapy, 31, 1431-1433.
    • (1987) Antimicrobial Agents and Chemotherapy , vol.31 , pp. 1431-1433
    • Lin, J.C.1    De Clercq, E.2    Pagano, J.S.3
  • 31
    • 0025324881 scopus 로고
    • Inhibition of herpes simplex virusDNApolymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues
    • Merta, A., Votruba, I., Rosenberg, I., Otmar, M., Hrebabeckÿ, H., Bernaerts, R., and Holÿ, A. (1990) Inhibition of herpes simplex virusDNApolymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues. Antiviral Research, 13, 209-218.
    • (1990) Antiviral Research , vol.13 , pp. 209-218
    • Merta, A.1    Votruba, I.2    Rosenberg, I.3    Otmar, M.4    Hrebabeckÿ, H.5    Bernaerts, R.6    Holÿ, A.7
  • 32
    • 0025279294 scopus 로고
    • Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase
    • Cernÿ, J., Votruba, I., Vonka, V., Rosenberg, I., Otmar, M., and Holÿ, A. (1990) Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase. Antiviral Research, 13, 253-264.
    • (1990) Antiviral Research , vol.13 , pp. 253-264
    • Cernÿ, J.1    Votruba, I.2    Vonka, V.3    Rosenberg, I.4    Otmar, M.5    Holÿ, A.6
  • 33
    • 0032235481 scopus 로고    scopus 로고
    • Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines
    • Andrei, G., Snoeck, R., Piette, J., Delvenne, P., and De Clercq, E. (1998) Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines. Oncology Research, 10, 523-531.
    • (1998) Oncology Research , vol.10 , pp. 523-531
    • Andrei, G.1    Snoeck, R.2    Piette, J.3    Delvenne, P.4    De Clercq, E.5
  • 34
    • 0032555639 scopus 로고    scopus 로고
    • Incorporation and excision of 9-(2-phosphonylmethoxyethyl)guanine (PMEG) by DNA polymerase delta and epsilon in vitro
    • Kramata, P., Downey, K.M., and Paborsky, L.R. (1998) Incorporation and excision of 9-(2-phosphonylmethoxyethyl)guanine (PMEG) by DNA polymerase delta and epsilon in vitro. The Journal of Biological Chemistry, 273, 21966-21971.
    • (1998) The Journal of Biological Chemistry , vol.273 , pp. 21966-21971
    • Kramata, P.1    Downey, K.M.2    Paborsky, L.R.3
  • 36
    • 67650003697 scopus 로고    scopus 로고
    • GS-9191. is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions
    • Wolfgang, G.H., Shibata, R., Wang, J., Ray, A.S.,Wu, S., Doerrfler, E., Reiser, H., Lee,W.A., Birkus, G., Christensen, N.D., Andrei, G., and Snoeck, R. (2009) GS-9191. is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrobial Agents and Chemotherapy, 53, 2777-2784.
    • (2009) Antimicrobial Agents and Chemotherapy , vol.53 , pp. 2777-2784
    • Wolfgang, G.H.1    Shibata, R.2    Wang, J.3    Ray A.S.Wu, S.4    Doerrfler, E.5    Reiser, H.6    Lee, W.A.7    Birkus, G.8    Christensen, N.D.9    Andrei, G.10    Snoeck, R.11
  • 38
    • 0030831418 scopus 로고    scopus 로고
    • Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses
    • Mulato, A.S. and Cherrington, J.M. (1997) Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses. Antiviral Research, 36, 91-97.
    • (1997) Antiviral Research , vol.36 , pp. 91-97
    • Mulato, A.S.1    Cherrington, J.M.2
  • 39
    • 0029989972 scopus 로고    scopus 로고
    • Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems
    • Balzarini, J., Aquaro, S., Perno, C.F., Witvrouw, M., Holÿ, A., and De Clercq, E. (1996) Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. Biochemical and Biophysical Research Communications, 219, 337-341.
    • (1996) Biochemical and Biophysical Research Communications , vol.219 , pp. 337-341
    • Balzarini, J.1    Aquaro, S.2    Perno, C.F.3    Witvrouw, M.4    Holÿ, A.5    De Clercq, E.6
  • 40
    • 0028823560 scopus 로고
    • Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells
    • Shirasaka, T., Chokekijchai, S., Yamada, A., Gosselin, G., Imbach, J.L., and Mitsuya, H. (1995) Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells. Antimicrobial Agents and Chemotherapy, 39, 2555-2559.
    • (1995) Antimicrobial Agents and Chemotherapy , vol.39 , pp. 2555-2559
    • Shirasaka, T.1    Chokekijchai, S.2    Yamada, A.3    Gosselin, G.4    Imbach, J.L.5    Mitsuya, H.6
  • 42
    • 0036203532 scopus 로고    scopus 로고
    • Phenotypic susceptibilities to tenofovir in a large panel of clinically derived human immunodeficiency virus type 1 isolates
    • Harrigan, P.R., Miller, M.D., McKenna, P., Brumme, Z.L., and Larder, B.A. (2002) Phenotypic susceptibilities to tenofovir in a large panel of clinically derived human immunodeficiency virus type 1 isolates. Antimicrobial Agents and Chemotherapy, 46, 1067-1072.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 1067-1072
    • Harrigan, P.R.1    Miller, M.D.2    McKenna, P.3    Brumme, Z.L.4    Larder, B.A.5
  • 43
    • 0029022494 scopus 로고
    • Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and other anti-HIV active purine congeners withHIVreverse transcriptase andhumanDNApolymerasesa, b, and c
    • Cherrington, J.M., Allen, S.J.W., Bischofberger, N., and Chen, M.S. (1995) Kinetic interaction of the diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and other anti-HIV active purine congeners withHIVreverse transcriptase andhumanDNApolymerasesa, b, and c. Antiviral Chemistry & Chemotherapy, 6, 217-221.
    • (1995) Antiviral Chemistry & Chemotherapy , vol.6 , pp. 217-221
    • Cherrington, J.M.1    Allen, S.J.W.2    Bischofberger, N.3    Chen, M.S.4
  • 48
    • 0031793849 scopus 로고    scopus 로고
    • Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro
    • Xiong, X., Flores, C., Yang, H., Toole, J.J., and Gibbs, C.S. (1998) Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro. Hepatology (Baltimore, MD), 28, 1669-1673.
    • (1998) Hepatology (Baltimore, MD) , vol.28 , pp. 1669-1673
    • Xiong, X.1    Flores, C.2    Yang, H.3    Toole, J.J.4    Gibbs, C.S.5
  • 49
    • 0034852408 scopus 로고    scopus 로고
    • Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs
    • Cihlar, T., Ho, E.S., Lin, D.C., and Mulato, A.S. (2001) Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides, Nucleotides & Nucleic Acids, 20, 641-648.
    • (2001) Nucleosides, Nucleotides & Nucleic Acids , vol.20 , pp. 641-648
    • Cihlar, T.1    Ho, E.S.2    Lin, D.C.3    Mulato, A.S.4
  • 50
    • 0027183190 scopus 로고
    • Selective inhibition of cytomegaloviruses by 9-(30-ethylphosphono-10-hydroxymethyl-10-propyloxy-methyl)guanine
    • Barnard, D.L., Huffman, J.H., Sidwell, R.W., and Reist, E.J. (1993) Selective inhibition of cytomegaloviruses by 9-(30-ethylphosphono-10-hydroxymethyl-10-propyloxy-methyl)guanine. Antiviral Research, 22, 77-89.
    • (1993) Antiviral Research , vol.22 , pp. 77-89
    • Barnard, D.L.1    Huffman, J.H.2    Sidwell, R.W.3    Reist, E.J.4
  • 51
    • 0028102177 scopus 로고
    • Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice
    • Smee, D.F., Sugiyama, S.T., and Reist, E.J. (1994) Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice. Antimicrobial Agents and Chemotherapy, 38, 2165-2168.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 2165-2168
    • Smee, D.F.1    Sugiyama, S.T.2    Reist, E.J.3
  • 52
    • 0029796157 scopus 로고    scopus 로고
    • Potent anti-murine cytomegalovirus activity and reduced nephrotoxicity of ganciclovir cyclic phosphonate
    • Smee, D.F. and Reist, E.J. (1996) Potent anti-murine cytomegalovirus activity and reduced nephrotoxicity of ganciclovir cyclic phosphonate. Antimicrobial Agents and Chemotherapy, 40, 1964-1966.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 1964-1966
    • Smee, D.F.1    Reist, E.J.2
  • 53
    • 0029878448 scopus 로고    scopus 로고
    • MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection
    • Bridges, C.G., Taylor, D.L., Ahmed, P.S., Brennan, T.M., Hornsperger, J.M., Nave, J.F., Casara, P., and Tyms, A.S. (1996) MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection. Antimicrobial Agents and Chemotherapy, 40, 1072-1077.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 1072-1077
    • Bridges, C.G.1    Taylor, D.L.2    Ahmed, P.S.3    Brennan, T.M.4    Hornsperger, J.M.5    Nave, J.F.6    Casara, P.7    Tyms, A.S.8
  • 54
    • 66149096185 scopus 로고    scopus 로고
    • Pharmacokinetics of LB80331 and LB80317 following oral administration of LB80380, a new antiviral agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and mice
    • Yuen, M.F., Lee, S.H., Kang, H.M., Kim, C.R., Kim, J., Ngai,V., and Lai, C.L. (2009) Pharmacokinetics of LB80331 and LB80317 following oral administration of LB80380, a new antiviral agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and mice. Antimicrobial Agents and Chemotherapy, 53, 1779-1785.
    • (2009) Antimicrobial Agents and Chemotherapy , vol.53 , pp. 1779-1785
    • Yuen, M.F.1    Lee, S.H.2    Kang, H.M.3    Kim, C.R.4    Kim, J.5    Ngai, V.6    Lai, C.L.7
  • 55
    • 52949101763 scopus 로고    scopus 로고
    • LB80380: a promising new drug for the treatment of chronic hepatitis B
    • Fung, J., Lai, C.L., and Yuen, M.F. (2008) LB80380: a promising new drug for the treatment of chronic hepatitis B. Expert Opinion on Investigational Drugs, 17, 1581-1588.
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , pp. 1581-1588
    • Fung, J.1    Lai, C.L.2    Yuen, M.F.3
  • 58
    • 77951244983 scopus 로고    scopus 로고
    • The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization
    • Herman, B.D., Votruba, I., Holÿ, A., Sluis-Cremer, N., and Balzarini, J. (2010) The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization. The Journal of Biological Chemistry, 285, 12101-12108.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 12101-12108
    • Herman, B.D.1    Votruba, I.2    Holÿ, A.3    Sluis-Cremer, N.4    Balzarini, J.5
  • 59
    • 0242299576 scopus 로고    scopus 로고
    • 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity
    • Hockovä, D., Holÿ, A., Masojidkovä, M., Andrei, G., Snoeck, R., De Clercq, E., and Balzarini, J. (2003) 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy) ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. Journal ofMedicinal Chemistry, 46, 5064-5073.
    • (2003) Journal ofMedicinal Chemistry , vol.46 , pp. 5064-5073
    • Hockovä, D.1    Holÿ, A.2    Masojidkovä, M.3    Andrei, G.4    Snoeck, R.5    De Clercq, E.6    Balzarini, J.7
  • 64
    • 34547734892 scopus 로고    scopus 로고
    • DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions
    • Andrei, G., Fiten, P., Froeyen, M., De Clercq, E., Opdenakker, G., and Snoeck, R. (2007) DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. Antiviral Therapy, 12, 719-732.
    • (2007) Antiviral Therapy , vol.12 , pp. 719-732
    • Andrei, G.1    Fiten, P.2    Froeyen, M.3    De Clercq, E.4    Opdenakker, G.5    Snoeck, R.6
  • 66
    • 0000248183 scopus 로고
    • Cleavage of a nucleosidic oxetane with carbanions: Synthesis of a highly promising candidate for anti-HIV agents-a phosphonate isostere of AZT 50-phosphate
    • Tanaka, H., Fukui, M., Haraguchi, K., Masaki, M., and Miyasaka, T. (1989) Cleavage of a nucleosidic oxetane with carbanions: Synthesis of a highly promising candidate for anti-HIV agents-a phosphonate isostere of AZT 50-phosphate. Tetrahedron Letters, 30, 2567-2570.
    • (1989) Tetrahedron Letters , vol.30 , pp. 2567-2570
    • Tanaka, H.1    Fukui, M.2    Haraguchi, K.3    Masaki, M.4    Miyasaka, T.5
  • 67
    • 0026784943 scopus 로고
    • 30-Azido-30,50-dideoxythymidine-50-methylphosphonic acid diphosphate: synthesis andHIV-1 reverse transcriptase inhibition
    • Freeman, G.A., Rideout, J.L., Miller, W.H., and Reardon, J.E. (1992) 30-Azido-30,50-dideoxythymidine-50-methylphosphonic acid diphosphate: synthesis andHIV-1 reverse transcriptase inhibition. Journal ofMedicinal Chemistry, 35, 3192-3196.
    • (1992) Journal ofMedicinal Chemistry , vol.35 , pp. 3192-3196
    • Freeman, G.A.1    Rideout, J.L.2    Miller, W.H.3    Reardon, J.E.4
  • 74
    • 0028006997 scopus 로고
    • Effect of anti-HIV 20-beta-fluoro-20,30-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production
    • Tsai, C.H., Doong, S.L., Johns, D.G., Driscoll, J.S., and Cheng, Y.C. (1994) Effect of anti-HIV 20-beta-fluoro-20,30-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production. Biochemical Pharmacology, 48, 1477-1481.
    • (1994) Biochemical Pharmacology , vol.48 , pp. 1477-1481
    • Tsai, C.H.1    Doong, S.L.2    Johns, D.G.3    Driscoll, J.S.4    Cheng, Y.C.5
  • 78
    • 0026661938 scopus 로고
    • Synthesis and anti-HIV activity of 9-[(2R,5R)-2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]-2,6-diaminopurine
    • Kim, C.U., Luh, B.Y., and Martin, J.C. (1992) Synthesis and anti-HIV activity of 9-[(2R,5R)-2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]-2,6-diaminopurine. Bioorganic & Medicinal Chemistry Letters, 2, 307-310.
    • (1992) Bioorganic & Medicinal Chemistry Letters , vol.2 , pp. 307-310
    • Kim, C.U.1    Luh, B.Y.2    Martin, J.C.3
  • 79
    • 0032979644 scopus 로고    scopus 로고
    • Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir
    • Bedard, J.,May, S., Lis, M., Tryphonas, L., Drach, J.,Huffman, J., Sidwell, R., Chan, L., Bowlin, T., and Rando, R. (1999) Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir. Antimicrobial Agents and Chemotherapy, 43, 557-567.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 557-567
    • Bedard J.May, S.1    Lis, M.2    Tryphonas, L.3    Drach J.Huffman, J.4    Sidwell, R.5    Chan, L.6    Bowlin, T.7    Rando, R.8
  • 80
    • 0026726122 scopus 로고
    • Synthesis and biological activity of carbocyclic derivatives of the potent antiviral agent 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG)
    • Bronson, J.J., Ferrara, L.M., Martin, J.C., and Mansuri, M.M. (1992) Synthesis and biological activity of carbocyclic derivatives of the potent antiviral agent 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG). Bioorganic and Medicinal Chemistry, 2, 685-690.
    • (1992) Bioorganic and Medicinal Chemistry , vol.2 , pp. 685-690
    • Bronson, J.J.1    Ferrara, L.M.2    Martin, J.C.3    Mansuri, M.M.4
  • 81
    • 37049083560 scopus 로고
    • The potential of carbocyclic nucleosides for the treatment of AIDS: synthesis of some diphosphorylphosphonates possessing potent activity against HIV-coded reverse transcriptase
    • Coe, D.M., Roberts, S.M., and Storer, R. (1992) The potential of carbocyclic nucleosides for the treatment of AIDS: synthesis of some diphosphorylphosphonates possessing potent activity against HIV-coded reverse transcriptase. Journal of the Chemical Society, Perkin Transactions 1, 2695-2704.
    • (1992) Journal of the Chemical Society, Perkin Transactions , vol.1 , pp. 2695-2704
    • Coe, D.M.1    Roberts, S.M.2    Storer, R.3
  • 82
    • 37049086424 scopus 로고
    • Synthesis of optically active 50-noraristeromycin: enzyme-catalysed kinetic resolution of 9-(4-hydroxycyclopent-2-enyl)purines
    • Merlo, V., Reece, F.J., Roberts, S.M., Gregson, M., and Storer, R. (1993) Synthesis of optically active 50-noraristeromycin: enzyme-catalysed kinetic resolution of 9-(4-hydroxycyclopent-2-enyl)purines. Journal of the Chemical Society, Perkin Transactions 1, 1717-1718.
    • (1993) Journal of the Chemical Society, Perkin Transactions , vol.1 , pp. 1717-1718
    • Merlo, V.1    Reece, F.J.2    Roberts, S.M.3    Gregson, M.4    Storer, R.5
  • 83
    • 0028897039 scopus 로고
    • Stereocontrolled synthesis of the four stereoisomeric diphosphorylphosphonates of carbocyclic 20,30-dideoxy-20,30-didehydro-50-noradenosine
    • Dyatkina, N.B., Theil, F., and Janta-Lipinski, M.V. (1995) Stereocontrolled synthesis of the four stereoisomeric diphosphorylphosphonates of carbocyclic 20,30-dideoxy-20,30-didehydro-50-noradenosine. Tetrahedron, 51, 761.
    • (1995) Tetrahedron , vol.51 , pp. 761
    • Dyatkina, N.B.1    Theil, F.2    Janta-Lipinski, M.V.3
  • 85
    • 84973073873 scopus 로고
    • Synthesis and antiviral activity of some carbocyclic 5-substituted uracil derivatives
    • Popescu, A., Hornfeldt, A.-B.,Gronowitz, S., and Johansson, N.G. (1994) Synthesis and antiviral activity of some carbocyclic 5-substituted uracil derivatives. Models in Chemistry, 131, 499-511.
    • (1994) Models in Chemistry , vol.131 , pp. 499-511
    • Popescu, A.1    Hornfeldt A.-B.Gronowitz, S.2    Johansson, N.G.3
  • 90
    • 0037157807 scopus 로고    scopus 로고
    • Synthesis of phosphonates derivatives of methylenecyclopropane nucleoside analogues by alkylation-elimination method and unusual opening of cyclopropane ring
    • Guan, H.-P. Qiu, Y.-L., Ksebati, M.B., Kern, E.R., and Zemlicka, J. (2002) Synthesis of phosphonates derivatives of methylenecyclopropane nucleoside analogues by alkylation-elimination method and unusual opening of cyclopropane ring. Tetrahedron, 58, 6047-6059.
    • (2002) Tetrahedron , vol.58 , pp. 6047-6059
    • Guan, H.-P.1    Qiu, Y.-L.2    Ksebati, M.B.3    Kern, E.R.4    Zemlicka, J.5
  • 91
    • 31544458697 scopus 로고    scopus 로고
    • Synthesis of phosphonate analogues of the antiviral cyclopropane nucleoside A-5021
    • Onishi, T., Sekiyama, T., and Tsuji, T. (2005) Synthesis of phosphonate analogues of the antiviral cyclopropane nucleoside A-5021. Nucleosides, Nucleotides & Nucleic Acids, 24, 1187-1197.
    • (2005) Nucleosides, Nucleotides & Nucleic Acids , vol.24 , pp. 1187-1197
    • Onishi, T.1    Sekiyama, T.2    Tsuji, T.3
  • 93
    • 0016166780 scopus 로고
    • Synthesis and enzymatic activity of 1,2,4-triazole-3-carboxamide 60-deoxyhomoribonucleoside-60-phosphonic acid and related compounds
    • Fuertes, M., Witkowski, J.T., Streeter, D.G., and Robins, R.K. (1974) Synthesis and enzymatic activity of 1,2,4-triazole-3-carboxamide 60-deoxyhomoribonucleoside-60-phosphonic acid and related compounds. Journal of Medicinal Chemistry, 17, 642-645.
    • (1974) Journal of Medicinal Chemistry , vol.17 , pp. 642-645
    • Fuertes, M.1    Witkowski, J.T.2    Streeter, D.G.3    Robins, R.K.4
  • 98
    • 3342984321 scopus 로고
    • Synthesis of 40-(hydroxymethyl) guanosine and a phosphonate analogue of guanylic acid
    • Martin, J.C. and Verheyden, J.P.H. (1988) Synthesis of 40-(hydroxymethyl) guanosine and a phosphonate analogue of guanylic acid.Nucleosides,Nucleotides & Nucleic Acids, 7, 365-374.
    • (1988) Nucleosides,Nucleotides & Nucleic Acids , vol.7 , pp. 365-374
    • Martin, J.C.1    Verheyden, J.P.H.2
  • 99
    • 17444388557 scopus 로고    scopus 로고
    • Design, synthesis, and antiviral activity of adenosine 50-phosphonate analogues as chain terminators against hepatitis C virus
    • Koh, Y.H., Shim, J.H., Wu, J.Z., Zhong, W., Hong, Z., and Girardet, J.L. (2005) Design, synthesis, and antiviral activity of adenosine 50-phosphonate analogues as chain terminators against hepatitis C virus. Journal of Medicinal Chemistry, 48, 2867-2875.
    • (2005) Journal of Medicinal Chemistry , vol.48 , pp. 2867-2875
    • Koh, Y.H.1    Shim, J.H.2    Wu, J.Z.3    Zhong, W.4    Hong, Z.5    Girardet, J.L.6
  • 101
    • 0033039933 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of 1-[(S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl) methyl]cytosine in human immunodeficiency virus-infected patients
    • Cundy, K.C., Barditch-Crovo, P., Petty, B.G., Ruby, A., Redpath, M., Jaffe, H.S., and Lietman, P.S. (1999) Clinical pharmacokinetics of 1-[(S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl) methyl]cytosine in human immunodeficiency virus-infected patients. Antimicrobial Agents and Chemotherapy, 43, 271-277.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 271-277
    • Cundy, K.C.1    Barditch-Crovo, P.2    Petty, B.G.3    Ruby, A.4    Redpath, M.5    Jaffe, H.S.6    Lietman, P.S.7
  • 102
    • 0029991161 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects
    • Wachsman, M., Petty, B.G., Cundy, K.C., Jaffe, H.S., Fisher, P.E., Pastelak, A., and Lietman, P.S. (1996) Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects. Antiviral Research, 29, 153-161.
    • (1996) Antiviral Research , vol.29 , pp. 153-161
    • Wachsman, M.1    Petty, B.G.2    Cundy, K.C.3    Jaffe, H.S.4    Fisher, P.E.5    Pastelak, A.6    Lietman, P.S.7
  • 104
    • 19444364011 scopus 로고    scopus 로고
    • Prodrug strategies in the design of nucleoside and nucleotide antiviral therapeutics
    • Mackman, R. and Cihlar, T. (2004) Prodrug strategies in the design of nucleoside and nucleotide antiviral therapeutics. Annual Reports in Medicinal Chemistry, 39, 305-322.
    • (2004) Annual Reports in Medicinal Chemistry , vol.39 , pp. 305-322
    • Mackman, R.1    Cihlar, T.2
  • 105
    • 0343844454 scopus 로고    scopus 로고
    • Prodrugs of phosphates, phosphonates, and phosphonates
    • Krise, J.P. and Stella, V.J. (1996) Prodrugs of phosphates, phosphonates, and phosphonates. Advanced Drug Delivery Reviews, 19, 287-310.
    • (1996) Advanced Drug Delivery Reviews , vol.19 , pp. 287-310
    • Krise, J.P.1    Stella, V.J.2
  • 106
    • 0027980318 scopus 로고
    • 1-[(S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo
    • Bischofberger, N.,Hitchcock, M.J., Chen, M.S., Barkhimer, D.B., Cundy, K.C.,Kent, K.M., Lacy, S.A., Lee, W.A., Li, Z.H., Mendel, D.B. et al. (1994) 1-[(S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo. Antimicrobial Agents and Chemotherapy, 38, 2387-2391.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 2387-2391
    • Bischofberger N.Hitchcock, M.J.1    Chen, M.S.2    Barkhimer, D.B.3    Cundy K.C.Kent, K.M.4    Lacy, S.A.5    Lee, W.A.6    Li, Z.H.7    Mendel, D.B.8
  • 107
    • 0031038255 scopus 로고    scopus 로고
    • Conversion of 1-[(S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase
    • Mendel, D.B., Cihlar, T., Moon, K., and Chen, M.S. (1997) Conversion of 1-[(S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase. Antimicrobial Agents and Chemotherapy, 41, 641-646.
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , pp. 641-646
    • Mendel, D.B.1    Cihlar, T.2    Moon, K.3    Chen, M.S.4
  • 108
    • 0034008388 scopus 로고    scopus 로고
    • Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of humanrenal organic anion transporter 1
    • Ho, E.S., Lin, D.C., Mendel, D.B., and Cihlar, T. (2000) Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of humanrenal organic anion transporter 1. Journal of the American Society of Nephrology, 11, 383-393.
    • (2000) Journal of the American Society of Nephrology , vol.11 , pp. 383-393
    • Ho, E.S.1    Lin, D.C.2    Mendel, D.B.3    Cihlar, T.4
  • 109
    • 0031916651 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis (isopropyloxymethylcarbonyl) PMPA
    • Robbins, B.L., Srinivas, R.V., Kim, C., Bischofberger, N., and Fridland, A. (1998) Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis (isopropyloxymethylcarbonyl) PMPA. Antimicrobial Agents and Chemotherapy, 42, 612-617.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 612-617
    • Robbins, B.L.1    Srinivas, R.V.2    Kim, C.3    Bischofberger, N.4    Fridland, A.5
  • 110
    • 0030782524 scopus 로고    scopus 로고
    • Synthesis, in vitro biological evaluation, and oral bioavailability of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) prodrugs
    • Arimilli, M., Kim, C., and Bischofberger, N. (1997) Synthesis, in vitro biological evaluation, and oral bioavailability of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) prodrugs. Antiviral Chemistry & Chemotherapy, 8, 557-564.
    • (1997) Antiviral Chemistry & Chemotherapy , vol.8 , pp. 557-564
    • Arimilli, M.1    Kim, C.2    Bischofberger, N.3
  • 111
    • 0028306517 scopus 로고
    • Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
    • Starrett, J.E., Jr., Tortolani, D.R., Russell, J.,Hitchcock, M.J., Whiterock, V.,Martin, J.C., and Mansuri, M.M. (1994) Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Journal of Medicinal Chemistry, 37, 1857-1864.
    • (1994) Journal of Medicinal Chemistry , vol.37 , pp. 1857-1864
    • Starrett, J.E.1    Tortolani, D.R.2    Russell J.Hitchcock, M.J.3    Whiterock V.Martin, J.C.4    Mansuri, M.M.5
  • 112
    • 0030842430 scopus 로고    scopus 로고
    • Antihuman immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bispivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients
    • Barditch-Crovo, P., Toole, J., Hendrix, C.W., Cundy, K.C., Ebeling, D., Jaffe, H.S., and Lietman, P.S. (1997) Antihuman immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bispivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. The Journal of Infectious Diseases, 176, 406-413.
    • (1997) The Journal of Infectious Diseases , vol.176 , pp. 406-413
    • Barditch-Crovo, P.1    Toole, J.2    Hendrix, C.W.3    Cundy, K.C.4    Ebeling, D.5    Jaffe, H.S.6    Lietman, P.S.7
  • 114
    • 33845675035 scopus 로고    scopus 로고
    • A randomized placebo-controlled, dosefinding study of oral LB80380 in HBeAgpositive patients with chronic hepatitis B
    • Yuen, M.F., Kim, J., Kim, C.R., Ngai, V., Yuen, J.C., Min, C., Kang, H.M., Shin, B.S., Yoo, S.D., and Lai, C.L. (2006) A randomized placebo-controlled, dosefinding study of oral LB80380 in HBeAgpositive patients with chronic hepatitis B. Antiviral Therapy, 11, 977-983.
    • (2006) Antiviral Therapy , vol.11 , pp. 977-983
    • Yuen, M.F.1    Kim, J.2    Kim, C.R.3    Ngai, V.4    Yuen, J.C.5    Min, C.6    Kang, H.M.7    Shin, B.S.8    Yoo, S.D.9    Lai, C.L.10
  • 115
    • 77950606642 scopus 로고    scopus 로고
    • Antiviral activity and safety of LB80380 in hepatitis B e antigenpositive chronic hepatitis B patients with lamivudine-resistant disease
    • Yuen, M.F., Han, K.H., Um, S.H., Yoon, S.K., Kim, H.R., Kim, J., Kim, C.R., and Lai, C.L. (2010) Antiviral activity and safety of LB80380 in hepatitis B e antigenpositive chronic hepatitis B patients with lamivudine-resistant disease. Hepatology (Baltimore, MD), 51, 767-776.
    • (2010) Hepatology (Baltimore, MD) , vol.51 , pp. 767-776
    • Yuen, M.F.1    Han, K.H.2    Um, S.H.3    Yoon, S.K.4    Kim, H.R.5    Kim, J.6    Kim, C.R.7    Lai, C.L.8
  • 116
    • 0029731207 scopus 로고    scopus 로고
    • Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potentialPMEAprodrugs with improved oral bioavailability
    • Benzaria, S., Pelicano, H., Johnson, R., Maury, G., Imbach, J.L., Aubertin, A.M., Obert, G., and Gosselin, G. (1996) Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potentialPMEAprodrugs with improved oral bioavailability. Journal of Medicinal Chemistry, 39, 4958-4965.
    • (1996) Journal of Medicinal Chemistry , vol.39 , pp. 4958-4965
    • Benzaria, S.1    Pelicano, H.2    Johnson, R.3    Maury, G.4    Imbach, J.L.5    Aubertin, A.M.6    Obert, G.7    Gosselin, G.8
  • 117
    • 33748676891 scopus 로고    scopus 로고
    • Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer
    • Lin, C.C., Fang, C., Benetton, S., Xu, G.F., and Yeh, L.T. (2006) Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrobial Agents and Chemotherapy, 50, 2926-2931.
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , pp. 2926-2931
    • Lin, C.C.1    Fang, C.2    Benetton, S.3    Xu, G.F.4    Yeh, L.T.5
  • 119
    • 27244446626 scopus 로고    scopus 로고
    • Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir
    • Lin, C.C., Xu, C., Teng, A., Yeh, L.T., and Peterson, J. (2005) Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir. Journal of Clinical Pharmacology, 45, 1250-1258.
    • (2005) Journal of Clinical Pharmacology , vol.45 , pp. 1250-1258
    • Lin, C.C.1    Xu, C.2    Teng, A.3    Yeh, L.T.4    Peterson, J.5
  • 120
    • 33846503973 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of pradefovir, a livertargeting prodrug of PMEA in HBV patients
    • Lin, C., Xu, C., Yeh, L., Sullivan-Bolyai, J., and Xu, Y. (2006) Pharmacokinetics and pharmacodynamics of pradefovir, a livertargeting prodrug of PMEA in HBV patients. Journal of Hepatology, 44, S16.
    • (2006) Journal of Hepatology , vol.44 , pp. S16
    • Lin, C.1    Xu, C.2    Yeh, L.3    Sullivan-Bolyai, J.4    Xu, Y.5
  • 122
    • 0035991969 scopus 로고    scopus 로고
    • Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus
    • Ono-Nita, S.K., Kato, N., Shiratori, Y., Carrilho, F.J., and Omata, M. (2002) Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrobial Agents and Chemotherapy, 46, 2602-2605.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 2602-2605
    • Ono-Nita, S.K.1    Kato, N.2    Shiratori, Y.3    Carrilho, F.J.4    Omata, M.5
  • 123
    • 0037019284 scopus 로고    scopus 로고
    • 2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents
    • Sekiya, K., Takashima, H., Ueda, N., Kamiya, N., Yuasa, S., Fujimura, Y., and Ubasawa, M. (2002) 2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents. Journal of Medicinal Chemistry, 45, 3138-3142.
    • (2002) Journal of Medicinal Chemistry , vol.45 , pp. 3138-3142
    • Sekiya, K.1    Takashima, H.2    Ueda, N.3    Kamiya, N.4    Yuasa, S.5    Fujimura, Y.6    Ubasawa, M.7
  • 124
    • 85017450010 scopus 로고    scopus 로고
    • A Safety and pharmacodynamic dose ranging study of LY582563 (MCC-478), a novel nucleotide analogue prodrug, in chronic hepatitis B patients
    • (Abs T1360)
    • Wise, S., Soon, K., Lowe, S., Teng, C., Pan, A., and McGill, J. (2002) A Safety and pharmacodynamic dose ranging study of LY582563 (MCC-478), a novel nucleotide analogue prodrug, in chronic hepatitis B patients. Gastroenterology, 122, 452 (Abs T1360).
    • (2002) Gastroenterology , vol.122 , pp. 452
    • Wise, S.1    Soon, K.2    Lowe, S.3    Teng, C.4    Pan, A.5    McGill, J.6
  • 125
    • 67349157073 scopus 로고    scopus 로고
    • Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art
    • Hostetler, K.Y. (2009) Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art. Antiviral Research, 82, A84-A88.
    • (2009) Antiviral Research , vol.82 , pp. A84-A88
    • Hostetler, K.Y.1
  • 126
    • 0042632872 scopus 로고    scopus 로고
    • Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney
    • Ciesla, S.L., Trahan, J.,Wan,W.B., Beadle, J.R., Aldern, K.A., Painter, G.R., and Hostetler, K.Y. (2003) Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney. Antiviral Research, 59, 163-171.
    • (2003) Antiviral Research , vol.59 , pp. 163-171
    • Ciesla, S.L.1    Trahan J.Wan, W.B.2    Beadle, J.R.3    Aldern, K.A.4    Painter, G.R.5    Hostetler, K.Y.6
  • 127
    • 43649092617 scopus 로고    scopus 로고
    • Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models
    • Quenelle, D.C., Collins, D.J., Pettway, L.R., Hartline, C.B., Beadle, J.R., Wan, W.B., Hostetler, K.Y., and Kern, E.R. (2008) Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models. Antiviral Research, 79, 133-135.
    • (2008) Antiviral Research , vol.79 , pp. 133-135
    • Quenelle, D.C.1    Collins, D.J.2    Pettway, L.R.3    Hartline, C.B.4    Beadle, J.R.5    Wan, W.B.6    Hostetler, K.Y.7    Kern, E.R.8
  • 132
    • 67049086876 scopus 로고    scopus 로고
    • The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitisCvirus replication in genotype 1A, 1B, and 2A replicons
    • Wyles, D.L., Kaihara, K.A., Korba, B.E., Schooley, R.T., Beadle, J.R., and Hostetler, K.Y. (2009) The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitisCvirus replication in genotype 1A, 1B, and 2A replicons. Antimicrobial Agents and Chemotherapy, 53, 2660-2662.
    • (2009) Antimicrobial Agents and Chemotherapy , vol.53 , pp. 2660-2662
    • Wyles, D.L.1    Kaihara, K.A.2    Korba, B.E.3    Schooley, R.T.4    Beadle, J.R.5    Hostetler, K.Y.6
  • 134
    • 84911396917 scopus 로고    scopus 로고
    • Amidate prodrugs of nucleoside phosphonates: from design to in vivo proof of concept
    • Cihlar, T. (2008) Amidate prodrugs of nucleoside phosphonates: from design to in vivo proof of concept. Colletion Symposium Series, 10, 45-53.
    • (2008) Colletion Symposium Series , vol.10 , pp. 45-53
    • Cihlar, T.1
  • 137
    • 18244398917 scopus 로고    scopus 로고
    • Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue
    • Lee, W.A., He, G.-X., Eisenberg, E., Cihlar, T., Swaminathan, S., Mulato, A., and Cundy, K.C. (2005) Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrobial Agents and Chemotherapy, 49, 1898-1906.
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , pp. 1898-1906
    • Lee, W.A.1    He, G.-X.2    Eisenberg, E.3    Cihlar, T.4    Swaminathan, S.5    Mulato, A.6    Cundy, K.C.7
  • 139
    • 45749091322 scopus 로고    scopus 로고
    • Activation of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl] adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases
    • Birkus, G.,Kutty, N.,He, G.X.,Mulato, A., Lee, W., McDermott, M., and Cihlar, T. (2008) Activation of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl] adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases. Molecular Pharmacology, 74, 92-100.
    • (2008) Molecular Pharmacology , vol.74 , pp. 92-100
    • Birkus, G.1    Kutty, N.2    He, G.X.3    Mulato, A.4    Lee, W.5    McDermott, M.6    Cihlar, T.7
  • 140
    • 34247380394 scopus 로고    scopus 로고
    • Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins
    • Chou, T.F., Baraniak, J., Kaczmarek, R., Zhou, X., Cheng, J., Ghosh, B., and Wagner, C.R. (2007) Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins. Molecular Pharmacology, 4, 208-217.
    • (2007) Molecular Pharmacology , vol.4 , pp. 208-217
    • Chou, T.F.1    Baraniak, J.2    Kaczmarek, R.3    Zhou, X.4    Cheng, J.5    Ghosh, B.6    Wagner, C.R.7
  • 141
    • 0038312076 scopus 로고    scopus 로고
    • Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication
    • Keith, K.A., Hitchcock, M.J., Lee, W.A., Holÿ, A., and Kern, E.R. (2003) Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrobial Agents and Chemotherapy, 47, 2193-2198.
    • (2003) Antimicrobial Agents and Chemotherapy , vol.47 , pp. 2193-2198
    • Keith, K.A.1    Hitchcock, M.J.2    Lee, W.A.3    Holÿ, A.4    Kern, E.R.5
  • 142
    • 59749106127 scopus 로고    scopus 로고
    • Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation
    • Cihlar, T., Laflamme, G., Fisher, R.,Carey, A.C., Vela, J.E., Mackman, R., and Ray, A.S. (2009) Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrobial Agents and Chemotherapy, 53, 150-156.
    • (2009) Antimicrobial Agents and Chemotherapy , vol.53 , pp. 150-156
    • Cihlar, T.1    Laflamme, G.2    Fisher R.Carey, A.C.3    Vela, J.E.4    Mackman, R.5    Ray, A.S.6
  • 146
    • 0031775862 scopus 로고    scopus 로고
    • Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments
    • Cihlar, T., Fuller, M.D., and Cherrington, J.M. (1998) Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. Journal of Virology, 72, 5927-5936.
    • (1998) Journal of Virology , vol.72 , pp. 5927-5936
    • Cihlar, T.1    Fuller, M.D.2    Cherrington, J.M.3
  • 155
    • 0031710248 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults
    • Deeks, S.G., Barditch-Crovo, P., Lietman, P.S.,Hwang, F., Cundy, K.C.,Rooney, J.F., Hellmann, N.S., Safrin, S., and Kahn, J.O. (1998) Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults. Antimicrobial Agents and Chemotherapy, 42, 2380-2384.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 2380-2384
    • Deeks, S.G.1    Barditch-Crovo, P.2    Lietman P.S.Hwang, F.3    Cundy K.C.Rooney, J.F.4    Hellmann, N.S.5    Safrin, S.6    Kahn, J.O.7
  • 164
    • 73549119700 scopus 로고    scopus 로고
    • The evolution of HIV treatment guidelines: current state-ofthe-art of ART
    • Zolopa, A.R. (2010) The evolution of HIV treatment guidelines: current state-ofthe-art of ART. Antiviral Research, 85, 241-244.
    • (2010) Antiviral Research , vol.85 , pp. 241-244
    • Zolopa, A.R.1
  • 166
    • 14944352535 scopus 로고    scopus 로고
    • Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation
    • Weber, J., Chakraborty, B., Weberova, J., Miller, M.D., and Quinones-Mateu, M.E. (2005) Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation. Journal of Clinical Microbiology, 43, 1395-1400.
    • (2005) Journal of Clinical Microbiology , vol.43 , pp. 1395-1400
    • Weber, J.1    Chakraborty, B.2    Weberova, J.3    Miller, M.D.4    Quinones-Mateu, M.E.5
  • 167
    • 2342661255 scopus 로고    scopus 로고
    • K65R, TAMs and tenofovir
    • Miller, M.D. (2004) K65R, TAMs and tenofovir. AIDS Reviews, 6, 22-33.
    • (2004) AIDS Reviews , vol.6 , pp. 22-33
    • Miller, M.D.1
  • 168
    • 55449087831 scopus 로고    scopus 로고
    • Renal dysfunction and tenofovir toxicity in HIV-infected patients
    • Szczech, L.A. (2008) Renal dysfunction and tenofovir toxicity in HIV-infected patients. Topics in HIV Medicine, 16, 122-126.
    • (2008) Topics in HIV Medicine , vol.16 , pp. 122-126
    • Szczech, L.A.1
  • 169
    • 17144422152 scopus 로고    scopus 로고
    • Long-term renal safety of tenofovir disoproxil fumarate in antiretroviralnaive HIV-1-infected patients: data from a double-blind randomized activecontrolled multicentre study
    • Izzedine, H., Hulot, J.S., Vittecoq, D., Gallant, J.E., Staszewski, S., Launay-Vacher, V., Cheng, A., and Deray, G. (2005) Long-term renal safety of tenofovir disoproxil fumarate in antiretroviralnaive HIV-1-infected patients: data from a double-blind randomized activecontrolled multicentre study. Nephrology, Dialysis, Transplantation, 20, 743-746.
    • (2005) Nephrology, Dialysis, Transplantation , vol.20 , pp. 743-746
    • Izzedine, H.1    Hulot, J.S.2    Vittecoq, D.3    Gallant, J.E.4    Staszewski, S.5    Launay-Vacher, V.6    Cheng, A.7    Deray, G.8
  • 170
    • 16844370820 scopus 로고    scopus 로고
    • Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment
    • Gallant, J.E., Parish, M.A., Keruly, J.C., and Moore, R.D. (2005) Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment. Clinical Infectious Diseases, 40, 1194-1198.
    • (2005) Clinical Infectious Diseases , vol.40 , pp. 1194-1198
    • Gallant, J.E.1    Parish, M.A.2    Keruly, J.C.3    Moore, R.D.4
  • 174
    • 73849128498 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for the prevention of HIV infection: future implementation challenges
    • Karim, S. and Baxter, C. (2009) Antiretroviral prophylaxis for the prevention of HIV infection: future implementation challenges. HIV Therapy, 3, 3-6.
    • (2009) HIV Therapy , vol.3 , pp. 3-6
    • Karim, S.1    Baxter, C.2
  • 175
    • 0036324405 scopus 로고    scopus 로고
    • Tenofovir treatment in patients with lamivudine-resistant hepatitis B mutants strongly affects viral replication
    • van Bommel, F., Wunsche, T., Schurmann, D., and Berg, T. (2002) Tenofovir treatment in patients with lamivudine-resistant hepatitis B mutants strongly affects viral replication. Hepatology (Baltimore, MD), 36, 507-508.
    • (2002) Hepatology (Baltimore, MD) , vol.36 , pp. 507-508
    • van Bommel, F.1    Wunsche, T.2    Schurmann, D.3    Berg, T.4
  • 176
    • 0037426728 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate in patients with HIV and lamivudineresistant hepatitis B virus
    • Benhamou, Y., Tubiana, R., and Thibault, V. (2003) Tenofovir disoproxil fumarate in patients with HIV and lamivudineresistant hepatitis B virus. The New England Journal of Medicine, 348, 177-178.
    • (2003) The New England Journal of Medicine , vol.348 , pp. 177-178
    • Benhamou, Y.1    Tubiana, R.2    Thibault, V.3
  • 177
    • 0037159877 scopus 로고    scopus 로고
    • Activity of tenofovir on hepatitis B virus replication in HIV-co-infected patients failing or partially responding to lamivudine
    • Nunez, M., Perez-Olmeda, M., Diaz, B., Rios, P., Gonzalez-Lahoz, J., and Soriano, V. (2002) Activity of tenofovir on hepatitis B virus replication in HIV-co-infected patients failing or partially responding to lamivudine. AIDS (London, England), 16, 2352-2354.
    • (2002) AIDS (London, England) , vol.16 , pp. 2352-2354
    • Nunez, M.1    Perez-Olmeda, M.2    Diaz, B.3    Rios, P.4    Gonzalez-Lahoz, J.5    Soriano, V.6


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