Synthesis of phosphonate derivatives of methylenecyclopropane nucleoside analogues by alkylation-elimination method and unusual opening of cyclopropane ring

Tetrahedron

Volumn 58, Issue 30, 2002, Pages 6047-6059

  Guan, Hui Ping ^a   Qiu, Yao Ling ^a   Ksebati, Mohamad B ^b   Kern, Earl R ^c   Zemlicka, Jiri ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

Alkylation elimination; Cyclopropane ring; Methylenecyclopropane nucleoside analogues

Indexed keywords

9 [[2 (PHOSPHONOETHYL)CYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2 (PHOSPHONOETHYL)CYCLOPROPYLIDENE]METHYL]CYTOSINE; 9 [[2 (PHOSPHONOETHYL)CYCLOPROPYLIDENE]METHYL]GUANINE; 9 [[2 (PHOSPHONOMETHYL)CYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2 (PHOSPHONOMETHYL)CYCLOPROPYLIDENE]METHYL]CYTOSINE; 9 [[2 (PHOSPHONOMETHYL)CYCLOPROPYLIDENE]METHYL]GUANINE; BROMINE DERIVATIVE; CYCLOPROPANE DERIVATIVE; GUANINE DERIVATIVE; HYDROBROMIC ACID; IODIDE; MESYLIC ACID; NUCLEIC ACID BASE; NUCLEOSIDE ANALOG; PHOSPHITE; PHOSPHONIC ACID DERIVATIVE; SILANE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SYNTHESIS; HYDROLYSIS; ION EXCHANGE CHROMATOGRAPHY; ISOMER; MICHAELIS BECKER REACTION; NONHUMAN; PRIORITY JOURNAL; RING OPENING; VARICELLA ZOSTER VIRUS; VIRUS REPLICATION;

HUMAN HERPESVIRUS 3;

EID: 0037157807     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)00589-6     Document Type: Article

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