Design, synthesis, and antiviral activity of adenosine 5′-phosphonate analogues as chain terminators against hepatitis C virus

Journal of Medicinal Chemistry

Volumn 48, Issue 8, 2005, Pages 2867-2875

  Koh, Yung Hyo ^a   Shim, Jae Hoon ^a   Wu, Jim Zhen ^a   Zhong, Weidong ^a   Hong, Zhi ^a   Girardet, Jean Luc ^a  

^a Drug Discovery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 [2,3 DIHYDROXY 4 (PHOSPHONOMETHOXY)CYCLOPENT 1 YL]ADENINE; 9 [2,3 DIHYDROXY 4 [(HYDROXYPYROPHOSPHOROXY)PHOSPHONOMETHOXY]CYCLOPENT 1 YL]ADENINE; 9 [5' DEOXY 5' [(HYDROXYPYROPHOSPHOROXY)PHOSPHINYL]BETA RIBOFURANOSYL]ADENINE; 9 [5',6' DIDEOXY 6' (HYDROXYPHOSPHINYL) BETA RIBOHEXOFURANOSYL]ADENINE; 9 [5',6' DIDEOXY 6' (HYDROXYPYROPHOSPHOROXY)PHOSPHINYL] BETA RIBOHEXOFURANOSYL]ADENINE; 9 [5',6' DIDEOXY 6' [(HYDROXYPYROPHOSPHOROXY)PHOSPHINYL] 2' C METHYL BETA RIBOHEXOFURANOSYL]ADENINE; 9 [TETRAHYDRO 3,4 DIHYDROXY 5 [(HYDROXYLPYROPHOSPHOROXY)PHOSPHONOMETHOXY] 2 FURANYL]ADENINE; ADEFOVIR; ADENOSINE KINASE; ADENOSINE TRIPHOSPHATE; CIDOFOVIR; NUCLEOSIDE MONOPHOSPHATE KINASE; PHOSPHONIC ACID DERIVATIVE; PRODRUG; PYROPHOSPHATE; RNA DIRECTED RNA POLYMERASE; TENOFOVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG SYNTHESIS; HEPATITIS C VIRUS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL LINE; DEOXYADENOSINES; DNA, VIRAL; DRUG DESIGN; HEPACIVIRUS; HUMANS; PHOSPHONIC ACIDS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 17444388557     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049029u     Document Type: Article

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