Inflammatory responses of airway smooth muscle cells and effects of endothelin receptor antagonism

American Journal of Respiratory Cell and Molecular Biology

Volumn 49, Issue 1, 2013, Pages 114-127

  Knobloch, Jürgen ^a,b   Lin, Yingfeng ^b   Konradi, Jürgen ^b   Jungck, David ^a,b   Behr, Juergen ^a,c   Strauch, Justus ^a   Stoelben, Erich ^d   Koch, Andrea ^a,b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d Lungenklinik Merheim   (Germany)

Author keywords

Airway inflammation; Endothelin receptor antagonists; Human airway smooth muscle cells; Human bronchial epithelial cells; Tissue remodeling

Indexed keywords

AMBRISENTAN; BOSENTAN; COLLAGENASE 3; CORTICOSTEROID; CYTOKINE; DEXAMETHASONE; DICKKOPF 1 PROTEIN; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 23P19; LIGAND; LIGAND 2; MACROPHAGE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MATRILYSIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 4; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AIRWAY REMODELING; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CHRONIC LUNG DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; EX VIVO STUDY; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT INFLAMMATION; RNA ISOLATION; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; UPREGULATION;

AIRWAY REMODELING; CHEMOKINES; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPERTENSION, PULMONARY; INFLAMMATION; MATRIX METALLOPROTEINASE 13; MYOCYTES, SMOOTH MUSCLE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENYLPROPIONATES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PYRIDAZINES; RECEPTORS, ENDOTHELIN; RNA STABILITY; RNA, MESSENGER; SULFONAMIDES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880439899     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0287OC     Document Type: Article

References (50)

1. Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008;118:3546-3556.
2. Agostini C, Gurrieri C. Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006;3:357-363.
3. Pullamsetti SS, Savai R, Janssen W, Dahal BK, Seeger W, Grimminger F, Ghofrani HA,Weissmann N, Schermuly RT. Inflammation, immunological reaction and role of infection in pulmonary hypertension. Clin Microbiol Infect 2011;17:7-14.
4. Barnes PJ. Glucocorticosteroids: current and future directions. Br J Pharmacol 2011;163:29-43.
5. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet 2009;373:1905-1917.
6. Tliba O, Panettieri RA Jr. Regulation of inflammation by airway smooth muscle. Curr Allergy Asthma Rep 2008;8:262-268.
7. Knobloch J, Sibbing B, Jungck D, Lin Y, Urban K, Stoelben E, Strauch J, Koch A. Resveratrol impairs the release of steroid-resistant inflammatory cytokines from human airway smooth muscle cells in chronic obstructive pulmonary disease. J Pharmacol Exp Ther 2010; 335:788-798.
8. Koziol-White CJ, Panettieri RA Jr. Airway smooth muscle and immunomodulation in acute exacerbations of airway disease. Immunol Rev 2011;242:178-185.
9. Knobloch J, Peters H, Jungck D, Müller K, Strauch J, Koch A. TNFalphainduced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism. Thorax 2009;64:1044-1052.
10. King TE Jr., Brown KK, Raghu G, du Bois RM, Lynch DA, Martinez F, Valeyre D, Leconte I, Morganti A, Roux S, et al. BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011;184:92-99.
11. Stolz D, Rasch H, Linka A, Di Valentino M, Meyer A, Brutsche M, Tamm M. A randomised, controlled trial of bosentan in severe COPD. Eur Respir J 2008;32:619-628.
12. Teder P, Noble PW. A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol 2000;23:7-10.
13. Goldie RG. Endothelin receptor subtypes: distribution and function in the lung. Pulm Pharmacol Ther 1998;11:89-95.
14. Dupuis J, Hoeper MM. Endothelin receptor antagonists in pulmonary arterial hypertension. Eur Respir J 2008;31:407-415.
15. Raidl M, Sibbing B, Strauch J, Müller K, Nemat A, Schneider PM, Hag H, Erdmann E, Koch A. Impaired TNFa-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAP kinases and histone acetylation: effect of dexamethasone. Cell Biochem Biophys 2007;49:98-110.
16. Knobloch J, Shaughnessy JD Jr., Ruther U. Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J 2007;21:1410-1421.
17. Knobloch J, Schild K, Jungck D, Urban K, Müller K, Schweda EK, Rupp J, Koch A. The T-helper cell type 1 immune response to gram-negative bacterial infections is impaired in COPD. Am J Respir Crit Care Med 2011;183:204-214.
18. Königshoff M, Eickelberg O. WNT signaling in lung disease: a failure or a regeneration signal? Am J Respir Cell Mol Biol 2010;42:21-31.
19. Shanmugam P, Valente AJ, Prabhu SD, Venkatesan B, Yoshida T, Delafontaine P, Chandrasekar B. Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. J Mol Cell Cardiol 2011; 50:928-938.
20. Kelly EA, Koziol-White CJ, Clay KJ, Liu LY, Bates ME, Bertics PJ, Jarjour NN. Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma. J Immunol 2009;182:1404-1410.
21. Besnard AG, Sabat R, Dumoutier L, Renauld JC, Willart M, Lambrecht B, Teixeira MM, Charron S, Fick L, Erard F, et al. Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am J Respir Crit Care Med 2011;183:1153-1163.
22. Imaoka H, Hoshino T, Takei S, Kinoshita T, Okamoto M, Kawayama T, Kato S, Iwasaki H, Watanabe K, Aizawa H. Interleukin-18 production and pulmonary function in COPD. Eur Respir J 2008;31:287-297.
23. Barnes PJ. Emerging pharmacotherapies for COPD. Chest 2008;134: 1278-1286.
24. Treiber A, Schneiter R, Häusler S, Stieger B. Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos 2007;35:1400-1407.
25. Clark IM, Swingler TE, Sampieri CL, Edwards DR. The regulation of matrixmetalloproteinases and their inhibitors. Int J Biochem Cell Biol 2008;40:1362-1378.
26. Tebo J, Der S, Frevel M, Khabar KS, Williams BR, Hamilton TA. Heterogeneity in control of mRNA stability by AU-rich elements. J Biol Chem 2003;278:12085-12093.
27. Armstrong J, Sargent C, Singh D. Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol 2009;158:74-83.
28. Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, Barnes PJ. Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther 2007;321:734-742.
29. Barnes PJ. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009;41:631-638.
30. Ross DJ, Strieter RM, Fishbein MC, Ardehali A, Belperio JA. Type I immune response cytokine-chemokine cascade is associated with pulmonary arterial hypertension. J Heart Lung Transplant 2012;31: 865-873.
31. Romagnani S. Cytokines and chemoattractants in allergic inflammation. Mol Immunol 2002;38:881-885.
32. Kodama N, Yamaguchi E, Hizawa N, Furuya K, Kojima J, Oguri M, Takahashi T, Kawakami Y. Expression of RANTES by bronchoalveolar lavage cells in nonsmoking patients with interstitial lung diseases. Am J Respir Cell Mol Biol 1998;18:526-531.
33. Zhang J, Patel JM. Role of the CX3CL1-CX3CR1 axis in chronic inflammatory lung diseases. Int J Clin Exp Med 2010;3:233-244.
34. Goleva E, Hauk PJ, Hall CF, Liu AH, Riches DW, Martin RJ, Leung DY. Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol 2008;122:550-559.e3.
35. Lee EJ, In KH, Kim JH, Lee SY, Shin C, Shim JJ, Kang KH, Yoo SH, Kim CH, Kim HK, et al. Proteomic analysis in lung tissue of smokers and COPD patients. Chest 2009;135:344-352.
36. Frankenberger M, Eder C, Hofer TP, Heimbeck I, Skokann K, Kassner G, Weber N, Möller W, Ziegler-Heitbrock L. Chemokine expression by small sputum macrophages in COPD. Mol Med 2011; 17:762-770.
37. Choi ES, Jakubzick C, Carpenter KJ, Kunkel SL, Evanoff H, Martinez FJ, Flaherty KR, Toews GB, Colby TV, Kazerooni EA, et al. Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Am J Respir Crit Care Med 2004;170: 508-515.
38. Traves SL, Donnelly LE. Th17 cells in airway diseases. Curr Mol Med 2008;8:416-426.
39. Ashitani J, Mukae H, Taniguchi H, Ihi T, Kadota J, Kohno S, Matsukura S. Granulocyte-colony stimulating factor levels in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis. Thorax 1999;54:1015-1020.
40. Beeh KM, Beier J, Kornmann O, Buhl R. Neutrophilic inflammation in induced sputum of patients with idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis 2003;20:138-143.
41. Meyer N, Christoph J, Makrinioti H, Indermitte P, Rhyner C, Soyka M, Eiwegger T, Chalubinski M, Wanke K, Fujita H, et al. Inhibition of angiogenesis by IL-32: possible role in asthma. J Allergy Clin Immunol 2012;129:964-973.e7.
42. Pégorier S, Arouche N,Dombret MC, AubierM, Pretolani M. Augmented epithelial endothelin-1 expression in refractory asthma. J Allergy Clin Immunol 2007;120:1301-1307.
43. Chalmers GW,Macleod KJ, Sriram S, Thomson LJ,McSharry C, Stack BH, Thomson NC. Sputum endothelin-1 is increased in cystic fibrosis and chronic obstructive pulmonary disease. Eur Respir J 1999;13:1288-1292.
44. Ross B, D'Orléans-Juste P, Giaid A. Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic. Am J Respir Cell Mol Biol 2010;42:16-20.
45. Mukhopadhyay S, Sypek J, Tavendale R, Gartner U, Winter J, LiW, Page K, Fleming M, Brady J, O'TooleM, et al. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults. J Allergy Clin Immunol 2010;126:70-76.e16.
46. Knobloch J, Jungck D, Koch A. Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis? Curr Mol Pharmacol 2011;4:26-61.
47. Laza-Stanca V, Message SD, Edwards MR, Parker HL, Zdrenghea MT, Kebadze T, Kon OM, Mallia P, Stanciu LA, Johnston SL. The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathog 2011;7:e1002114.
48. Desai B, Mattson J, Paintal H, Nathan M, Shen F, Beaumont M, Malinao MC, Li Y, Canfield J, Basham B, et al. Differential expression of monocyte/macrophage-selective markers in human idiopathic pulmonary fibrosis. Exp Lung Res 2011;37:227-238.
49. Pfaff EM, Becker S, Günther A, Königshoff M. Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis. Eur Respir J 2011;37:79-87.
50. Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P, Brightling CE. Airway smooth muscle and mast cellderived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med 2006;174:1179-1188.