Type i immune response cytokine-chemokine cascade is associated with pulmonary arterial hypertension

Journal of Heart and Lung Transplantation

Volumn 31, Issue 8, 2012, Pages 865-873

  Ross, David J ^a   Strieter, Robert M ^b   Fishbein, Michael C ^c   Ardehali, Abbas ^a   Belperio, John A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b 6Novartis Institutes for BioMedical Research   (United States)

^c UCLA MEDICAL CENTER   (United States)

Author keywords

perivascular infiltrating mononuclear cells; pulmonary arterial hypertension; type 1 immune response cytokine

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR ALPHA; PLASMA PROTEIN;

ARTICLE; BLOOD VESSEL WALL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MONONUCLEAR CELL; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; WORLD HEALTH ORGANIZATION;

CASE-CONTROL STUDIES; CHEMOKINE CXCL10; CHEMOKINES; CYTOKINES; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION, PULMONARY; IMMUNITY, INNATE; INTERLEUKIN-18; LEUKOCYTES, MONONUCLEAR; MUSCLE, SMOOTH, VASCULAR; RECEPTORS, CXCR3; RECEPTORS, INTERLEUKIN-18; WORLD HEALTH ORGANIZATION;

EID: 84863306863     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.04.008     Document Type: Article

References (52)

1. K.M. Chin, L.J. Rubin Pulmonary arterial hypertension J Am Coll Cardiol 51 2008 1527 1538
2. N. Galie, W. Seeger, R. Naeije, G. Simonneau, L.J. Rubin Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension J Am Coll Cardiol 43 12 Suppl S 2004 81 88S
3. J.R. Runo, J.E. Loyd Primary pulmonary hypertension Lancet 361 2003 1533 1544
4. G. Simonneau, N. Galie, L.J. Rubin Clinical classification of pulmonary hypertension J Am Coll Cardiol 43 12 Suppl S 2004 5 12S
5. V.V. McLaughlin, A. Shillington, S. Rich Survival in primary pulmonary hypertension: the impact of epoprostenol therapy Circulation 106 2002 1477 1482
6. O. Sitbon, M. Humbert, H. Nunes Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival J Am Coll Cardiol 40 2002 780 788
7. E.D. Austin, M.T. Rock, C.A. Mosse T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension Respir Med 104 2010 454 462
8. D. Heath, M. Yacoub Lung mast cells in plexogenic pulmonary arteriopathy J Clin Pathol 44 1991 1003 1006
9. F. Perros, P. Dorfmuller, R. Souza Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension Eur Respir J 29 2007 462 468
10. R.F. Pinto, L. Higuchi Mde, V.D. Aiello Decreased numbers of T-lymphocytes and predominance of recently recruited macrophages in the walls of peripheral pulmonary arteries from 26 patients with pulmonary hypertension secondary to congenital cardiac shunts Cardiovasc Pathol 13 2004 268 275
11. R.M. Tuder, B. Groves, D.B. Badesch, N.F. Voelkel Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension Am J Pathol 144 1994 275 285
12. S. Ulrich, L. Taraseviciene-Stewart, L.C. Huber, R. Speich, N. Voelkel Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study Respir Res 9 2008 20
13. W. Wang, H. Yan, W. Zhu, Y. Cui, J. Chen, X. Wang, S. Li, J. Zhu Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension J Clin Immunol 29 2009 705 713
14. M. Fujita, R.J. Mason, C. Cool, J.M. Shannon, N. Hara, K.A. Fagan Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression J Appl Physiol 93 2002 2162 2170
15. M.K. Steiner, O.L. Syrkina, N. Kolliputi, E.J. Mark, C.A. Hales, A.B. Waxman Interleukin-6 overexpression induces pulmonary hypertension Circ Res 104 2009 236 244
16. N.F. Voelkel, R.M. Tuder, J. Bridges, W.P. Arend Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline Am J Respir Cell Mol Biol 11 1994 664 675
17. K. Akita, T. Ohtsuki, Y. Nukada Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells J Biol Chem 272 1997 26595 26603
18. T. Ghayur, S. Banerjee, M. Hugunin Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production Nature 386 1997 619 623
19. Z. Kato, J. Jee, H. Shikano The structure and binding mode of interleukin-18 Nat Struct Biol 10 2003 966 971
20. K. Torigoe, S. Ushio, T. Okura Purification and characterization of the human interleukin-18 receptor J Biol Chem 272 1997 25737 25742
21. W.P. Arend, G. Palmer, C. Gabay IL-1, IL-18, and IL-33 families of cytokines Immunol Rev 223 2008 20 38
22. J.A. Belperio, M.P. Keane, D.A. Arenberg CXC chemokines in angiogenesis J Leukoc Biol 68 2000 1 8
23. M.P. Keane, R.M. Strieter The role of CXC chemokines in the regulation of angiogenesis Chem Immunol 72 1999 86 101
24. M. Loetscher, B. Gerber, P. Loetscher Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes J Exp Med 184 1996 963 969
25. K. Balabanian, A. Foussat, P. Dorfmuller CX(3)C chemokine fractalkine in pulmonary arterial hypertension Am J Respir Crit Care Med 165 2002 1419 1425
26. P. Dorfmuller, V. Zarka, I. Durand-Gasselin Chemokine RANTES in severe pulmonary arterial hypertension Am J Respir Crit Care Med 165 2002 534 539
27. M. Humbert, G. Monti, F. Brenot Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension Am J Respir Crit Care Med 151 1995 1628 1631
28. T. Itoh, N. Nagaya, H. Ishibashi-Ueda Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension Respirology 11 2006 158 163
29. F. Perros, P. Dorfmuller, R. Souza Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension Eur Respir J 29 2007 937 943
30. O. Sanchez, E. Marcos, F. Perros Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 176 2007 1041 1047
31. N. Galie, M.M. Hoeper, M. Humbert Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) Eur Heart J 30 2009 2493 2537
32. A. Busuttil, S.S. Weigt, M.P. Keane CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis Eur Respir J 34 2009 676 686
33. Z. Mallat, C. Heymes, A. Corbaz Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure FASEB J 18 2004 1752 1754
34. Z. Mallat, P. Henry, R. Fressonnet Increased plasma concentrations of interleukin-18 in acute coronary syndromes Heart 88 2002 467 469
35. Y. Seta, T. Kanda, T. Tanaka Interleukin 18 in acute myocardial infarction Heart 84 2000 668
36. L. Tiret, T. Godefroy, E. Lubos Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease Circulation 112 2005 643 650
37. S. Blankenberg, T. Godefroy, O. Poirier Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk Circ Res 99 2006 102 108
38. C. Kaya, R. Pabuccu, B. Berker, H. Satiroglu Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors Fertil Steril 93 2010 1200 1207
39. H. Yamagami, K. Kitagawa, T. Hoshi Associations of serum IL-18 levels with carotid intima-media thickness Arterioscler Thromb Vasc Biol 25 2005 1458 1462
40. V.S. Reddy, S.D. Prabhu, S. Mummidi Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation Am J Physiol Heart Circ Physiol 299 2010 H1242 H1254
41. B. Venkatesan, A.J. Valente, V.S. Reddy, D.A. Siwik, B. Chandrasekar Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration Am J Physiol Heart Circ Physiol 297 2009 H874 H886
42. N. Gerdes, G.K. Sukhova, P. Libby, R.S. Reynolds, J.L. Young, U. Schonbeck Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis J Exp Med 195 2002 245 257
43. C.R. Mackay Homing of naive, memory and effector lymphocytes Curr Opin Immunol 5 1993 423 427
44. R.L. Rabin, M.K. Park, F. Liao, R. Swofford, D. Stephany, J.M. Farber Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling J Immunol 162 1999 3840 3850
45. D.D. Taub, A.R. Lloyd, K. Conlon Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells J Exp Med 177 1993 1809 1814
46. C. Herder, J. Baumert, B. Thorand Chemokines and incident coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002 Arterioscler Thromb Vasc Biol 26 2006 2147 2152
47. P. Libby, U. Schoenbeck, F. Mach, A.P. Selwyn, P. Ganz Current concepts in cardiovascular pathology: the role of LDL cholesterol in plaque rupture and stabilization Am J Med 104 1998 14 18S
48. C. Cheng, D. Tempel, R. van Haperen Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines J Clin Invest 117 2007 616 626
49. J.A. Belperio, M.P. Keane, M.D. Burdick Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome J Immunol 169 2002 1037 1049
50. M. Melter, A. Exeni, M.E. Reinders Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection Circulation 104 2001 2558 2564
51. W.W. Hancock, W. Gao, V. Csizmadia, K.L. Faia, N. Shemmeri, A.D. Luster Donor-derived IP-10 initiates development of acute allograft rejection J Exp Med 193 2001 975 980
52. M. Wang, T.A. Markel, D.R. Meldrum Interleukin 18 in the heart Shock 30 2008 3 10