Impaired TNFα-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: Role of MAPkinases and histone acetylation - Effect of dexamethasone

Cell Biochemistry and Biophysics

Volumn 49, Issue 2, 2007, Pages 98-110

  Raidl, Maria ^a   Sibbing, Bernhard ^a   Strauch, Justus ^a   Müller, Katja ^a   Nemat, Andre ^a   Schneider, Paul M ^a   Hag, Haitham ^a   Erdmann, Erland ^a   Koch, Andrea ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cigarette smoking; COPD; Dexamethasone; Extracellular signal regulated protein kinases 1, 2; Histone acetylation; Human airway smooth muscle cells; p38MAPkinase; Vascular endothelial growth factor

Indexed keywords

ANTIINFLAMMATORY AGENT; BIOLOGICAL RESPONSE MODIFIER; DEXAMETHASONE; HISTONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ACETYLATION; AGED; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNIZATION; IMMUNOLOGY; LUNG; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; SMOKING; SMOOTH MUSCLE FIBER;

ACETYLATION; AGED; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL RESPONSE MODIFIERS; CHROMATIN IMMUNOPRECIPITATION; DEXAMETHASONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION; HISTONES; HUMANS; IMMUNIZATION; LUNG; MALE; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 35348927430     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-007-0043-4     Document Type: Article

References (57)

1. Papaioannou, A. I., Kostikas, K., Kollia, P., & Gourgoulianis, K. I. (2006). Clinical implications for vascular endothelial growth factor in the lung: Friend or foe? Respiratory Research, 7, 128.
2. Ferrara, N., & Davis-Smyth, T. (1997). The biology of vascular endothelial growth factor. Endocrine Reviews, 18(1), 4-25.
3. Melter, M., Reinders, M. E., Sho, M., Pal, S., Geehan, C., Denton, M. D., Mukhopadhyay, D., & Briscoe, D. M. (2000). Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo. Blood, 96(12), 3801-3808.
4. Freeman, M. R., Schneck, F. X., Gagnon, M. L., Corless, C., Soker, S., Niknejad, K., Peoples, G. E., & Klagsbrun, M. (1995). Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis. Cancer Research, 55(18), 4140-4145.
5. Ito, Y., Betsuyaku, T., Nagai, K., Nasuhara, Y., & Nishimura, M. (2005). Expression of pulmonary VEGF family declines with age and is further down-regulated in lipopolysaccharide (LPS)-induced lung injury. Experimental Gerontology, 40(4), 315-323.
6. Acarregui, M. J., Penisten, S. T., Goss, K. L., Ramirez, K., & Snyder, J. M. (1999). Vascular endothelial growth factor gene expression in human fetal lung in vitro. American Journal of Respiratory Cell and Molecular Biology, 20(1), 14-21.
7. Thickett, D. R., Armstrong, L., Christie, S. J., & Millar, A. B. (2001). Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 164(9), 1601-1605.
8. Thickett, D. R., Armstrong, L., & Millar, A. B. (2002). A role for vascular endothelial growth factor in acute and resolving lung injury. American Journal of Respiratory and Critical Care Medicine, 166(10), 1332-1337.
9. Kanazawa, H., Eguchi, Y., Nomura, N., & Yoshikawa, J. (2005). Analysis of vascular endothelial growth factor levels in induced sputum samples from patients with cough variant asthma. Annals of Allergy Asthma & Immunology, 95(3), 266-271.
10. Kranenburg, A. R., de Boer, W. I., Alagappan, V. K., Sterk, P. J., & Sharma, H. S. (2005). Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax, 60(2), 106-113.
11. Kanazawa, H., Asai, K., Hirata, K., & Yoshikawa, J. (2003). Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. American Journal of Medicine, 114(5), 354-358.
12. Melder, R. J., Koenig, G. C., Witwer, B. P., Safabakhsh, N., Munn, L. L., & Jain, R. K. (1996). During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nature Medicine, 2(9), 992-997.
13. Kim, I., Moon, S. O., Kim, S. H., Kim, H. J., Koh, Y. S., & Koh, G. Y. (2001). Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. The Journal of Biological Chemistry, 276(10), 7614-7620.
14. Barleon, B., Sozzani, S., Zhou, D., Weich, H. A., Mantovani, A., & Marme, D. (1996). Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood, 87(8), 3336-3343.
15. Neufeld, G., Cohen, T., Gengrinovitch, S., & Poltorak, Z. (1999). Vascular endothelial growth factor (VEGF) and its receptors. The FASEB Journal, 13(1), 9-22.
16. Knox, A. J., Corbett, L., Stocks, J., Holland, E., Zhu, Y. M., & Pang, L. (2001). Human airway smooth muscle cells secrete vascular endothelial growth factor: Up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism. The FASEB Journal, 15(13), 2480-2488.
17. Nilsson, I., Shibuya, M., & Wennström, S. (2004). Differential activation of vascular genes by hypoxia in primary endothelial cells. Experimental Cell Research, 299(2), 476-485.
18. H2 cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFNγ and corticosteroids. The Journal of Allergy and Clinical Immunology, 111(6), 1307-1318.
19. Lukacs, N. W., Strieter, R. M., Chensue, S. W., Widmer, M., & Kunkel, S. L. (1995). TNFα mediates recruitment of neutrophils and eosinophils during airway inflammation. Journal of Immunology, 154(10), 5411-5417.
20. Howarth, P. H., Babu, K. S., Arshad, H. S., Lau, L., Buckley, M., McConnell, W., Beckett, P., Al Ali, M., Chauhan, A., Wilson, S. J., Reynolds, A., Davies, D. E., & Holgate, S. T. (2005). Tumour necrosis factor (TNF) alpha as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax, 60(12), 1012-1018.
21. Aaron, S. D., Angel, J. B., Lunau, M., Wright, K., Fex, C., Le Saux, N., & Dales, R. E. (2001). Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 163(2), 349-355.
22. Mura, M., dos Santos, C. C., Stewart, D., & Liu, M. (2004). Vascular endothelial growth factor related molecules in acute lung injury. Journal of Applied Physiology, 97(5), 1605-1617.
23. Ferrara, N., Gerber, H. P., & LeCouter, J. T. (2003). The biology of VEGF and its receptors. Nature Medicine, 9(6), 669-676.
24. Guo, D., Jia, Q., Song, H. Y., Warren, R. S., & Donner, D. B. (1995). Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. The Journal of Biological Chemistry, 270(12), 6729-6733.
25. Eliceiri, B. P., Paul, R., Schwartzberg, P. L., Hood, J. D., Leng, J., & Cheresh, D. A. (1999). Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Molecular Cell, 4(6), 915-924.
26. Alagappan, V. K., McKay, S., Widyastuti, A., Garrelds, I. M., Bogers, A. J., Hoogsteden, H. C., Hirst, S. J., & Sharma, H. S. (2005). Proinflammatory cytokines upregulate mRNA expression and secretion of vascular endothelial growth factor in cultured human airway smooth muscle cells. Cell Biochemistry and Biophysics, 43(1), 119-129.
27. Cano, E., & Mahadevan, L. C. (1995). Parallel signal processing among mammalian MAPKs. Trends in Biochemical Sciences, 20(3), 117-122.
28. Vanden Berghe, W., De Bosscher, K., Boone, E., Plaisance, S., & Haegeman, G. (1999). The nuclear factor-kappa B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. The Journal of Biological Chemistry, 274(45), 32091-32098.
29. Ait-Si-Ali, S., Carlisi, D., Ramirez, S., Upegui-Gonzalez, L. C., Duquet, A., Robin, P., Rudkin, B., Harel-Bellan, A., & Trouche, D. (1999). Phosphorylation by p44 MAP kinase/ERK-1 stimulates CBP histone acetyl transferase activity in vitro. Biochemical and Biophysical Research Communications, 262(1), 157-162.
30. Koch, A., Giembycz, M., Ito, K., Lim, S., Jazrawi, E., Barnes, P. J., Adcock, I., Erdmann, E., & Chung, K. F. (2004). Mitogen-activated protein kinase modulation of nuclear factor-κB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology, 30(3), 342-349.
31. Fabbri, L., Pauwels, R. A., & Hurd, S. S. (2004). Gold Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary updated 2003. COPD, 1, 105-141.
32. Pauwels, R. A., Buist, A. S., Calverley, P. M., Jenkins, C. R., & Hurd, S. S. (2001). GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. American Journal of Respiratory and Critical Care Medicine, 163(5), 1256-1276.
33. American Thoracic Society. (1995). Standardization of spirometry, 1994 update. American Journal of Respiratory and Critical Care Medicine, 152(3), 1107-1136.
34. Goldman, H. I., & Becklake, M. R. (1959). Respiratory function tests; normal values at median altitudes and the prediction of normal results. American Review of Tuberculosis, 79(4), 457-467.
35. Oltmanns, U., Issa, R., Sukkar, M. B., John, M., & Chung, K. F. (2003). Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. British Journal of Pharmacology, 139(6), 1228-1234.
36. Ito, K., Ito, M., Elliott, W. M., Cosio, B., Caramori, G., Kon, O. M., Barczyk, A., Hayashi, S., Adcock, I. M., Hogg, J. C., & Barnes, P. J. (2005). Decreased histone deacetylase activity in chronic obstructive pulmonary disease. The New England Journal of Medicine, 352(19), 1967-1976.
37. Nagai, K., Betsuyaku, T., Ito, Y., Nasuhara, Y., & Nishimura, M. (2005). Decrease of vascular endothelial growth factor in macrophages from long-term smokers. The European Respiratory Journal, 25(4), 626-633.
38. Marwick, J. A., Stevenson, C. S., Giddings, J., MacNee, W., Butler, K., Rahman, I., & Kirkham, P. A. (2006). Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: Morphological impact of VEGFR-2 inhibition. American Journal of Physiolgy. Lung Cell and Molecular Physiology, 290(5), L897-L908.
39. Christou, H., Yoshida, A., Arthur, V., Morita, T., & Kourembanas, S. (1998). Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology, 18(6), 768-776.
40. Takagi, H., King, G. L., Ferrara, N., & Aiello, L. P. (1996). Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Investigative Ophtalmology & Visual Science, 37(7), 1311-1321.
41. Elias, J. A., Kang, M. J., Crouthers, K., Homer, R., & Lee, C. G. (2006). Mechanistic heterogeneity in chronic obstructive pulmonary disease: Insights from transgenic mice. Proceedings of the American Thoracic Society, 3(6), 494-498.
42. Calabrese, C., Bocchino, V., Vatrella, A., Marzo, C., Guarino, C., Mascitti, S., Tranfa, C. M., Cazzola, M., Micheli, P., Caputi, M., & Marsico, S. A. (2006). Evidence of angiogenesis in bronchial biopsies of smokers with and without airway obstruction. Respiratory Medicine, 100(8), 1415-1422.
43. Kasahara, Y., Tuder, R. M., Taraseviciene-Stewart, L., Le Cras, T. D., Abman, S., Hirth, P. K., Waltenberger, J., & Voelkel, N. F. (2000). Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. The Journal of Clinical Investigation, 106(11), 1311-1319.
44. Tang, J. R., Markham, N. E., Lin, Y. J., McMurtry, I. F., Maxey, A., Kinsella, J. P., & Abman, S. H. (2004). Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. American Journal of Physiolgy. Lung Cell and Molecular Physiology, 287(2), L344-L351.
45. Lee, K. S., Min, K. H., Kim, S. R., Park, S. J., Park, H. S., Jin, G. Y., & Lee, Y. C. (2006). Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), 161-170.
46. Ito, K., Lim, S., Caramori, G., Chung, K. F., Barnes, P. J., & Adcock, I. M. (2001). Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. The FASEB Journal, 15(6), 1110-1112.
47. Malo, M. S., Biswas, S., Abedrapo, M. A., Yeh, L., Chen, A., & Hodin, R. A. (2006). The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression. DNA Cell Biology, 25(12), 684-695.
48. Lee, J. Y., Kim, N. A., Sanford, A., & Sullivan, K. E. (2003). Histone acetylation and chromatin conformation are regulated separately at the TNFα promoter in monocytes and macrophages. Journal of Leukocyte Biology, 73(6), 862-871.
49. Sakao, S., Tatsumi, K., Hashimoto, T., Igari, H., Shino, Y., Shirasawa, H., & Kuriyama, T. (2003). Vascular endothelial growth factor and the risk of smoking-related COPD. Chest, 124(1), 323-327.
50. Keatings, V. M., Collins, P. D., Scott, D. M., & Barnes, P. J. (1996). Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. American Journal of Respiratory and Critical Care Medicine, 153(2), 530-534.
51. Mal, H. (2007). Prevalence and diagnosis of severe pulmonary hypertension in patients with chronic obstructive pulmonary disease. Current Opinion in Pulmonary Medicine, 13(2), 114-119.
52. Duyndam, M. C., Hulscher, S. T., van der Wall, E., Pinedo, H. M., & Boven, E. (2003). Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. The Journal of Biological Chemistry, 278(9), 6885-6895.
53. Sauer, H., Bekhite, M. M., Hescheler, J., & Wartenberg, M. (2005). Redox control of angiogenic factors and CD31-positive vessel-like structures in mouse embryonic stem cells after direct current electrical field stimulation. Experimental Cell Research, 304(2), 380-390.
54. Wang, F. S., Wang, C. J., Chen, Y. J., Chang, P. R., Huang, Y. T., Sun, Y. C., Huang, H. C., Yang, Y. J., & Yang, K. D. (2004). Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1α and VEGF-A expression in shock wave-stimulated osteoblasts. The Journal of Biological Chemistry, 279(11), 10331-10337.
55. Wang, M., Crisostomo, P. R., Herring, C., Meldrum, K. K., & Meldrum, D. R. (2006). Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism. American Journal of Physiology. Regulatory, Integrative and Comparitive Physiology, 291(4), R880-R884.
56. Demirjian, L., Abboud, R. T., Li, H., & Duronio, V. (2006). Acute effect of cigarette smoke on TNFα release by macrophages mediated through the ERK-1/-2 pathway. Biochimica et Biophysica Acta, 1762(6), 592-597.
57. Tran, T., Fernandes, D. J., Schuliga, M., Harris, T., Landells, L., & Stewart, A. G. (2005). Stimulus-dependent glucocorticoid-resistance of GM-CSF production in human cultured airway smooth muscle. British Journal of Pharmacology, 145, 123-131.