Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway

FASEB Journal

Volumn 21, Issue 7, 2007, Pages 1410-1421

  Knobloch, Jürgen ^a   Shaughnessy Jr , John D ^b   Rüther, Ulrich ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Limb truncations; Microphthalmia; Programmed cell death; Teratogenic mechanism

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; DNA NUCLEOTIDYLEXOTRANSFERASE; PROCOLLAGEN; THALIDOMIDE; TRYPAN BLUE; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; EYE MALFORMATION; FIBROBLAST; GENE TARGETING; IN SITU HYBRIDIZATION; LIMB DEFORMITY; MICROPHTHALMIA; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TERATOGENICITY; UPREGULATION;

ANIMALS; APOPTOSIS; BETA CATENIN; BONE MORPHOGENETIC PROTEINS; CELL LINE; CHICK EMBRYO; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IN SITU NICK-END LABELING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIMB BUD; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TERATOGENS; THALIDOMIDE; WNT PROTEINS;

EID: 34247607671     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7603com     Document Type: Article

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