Transient domoic acid excitotoxicity increases BDNF expression and activates both MEK- and PKA-dependent neurogenesis in organotypic hippocampal slices

BMC Neuroscience

Volumn 14, Issue , 2013, Pages

  Pérez Gómez, Anabel ^a   Tasker, R A ^a  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

Brain derived neurotrophic factor; H89; Hippocampus; Kainate receptor agonist; KN93; Neurogenesis; Neurotoxicity; Organotypic cultures; PD98059

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOMOIC ACID; DOUBLECORTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; CD11B ANTIGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DRUG DERIVATIVE; ENZYME INHIBITOR; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NEUROTOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN SLICE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITOTOXICITY; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MICROGLIA; MITOSIS; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SLICE CULTURE; UPREGULATION; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; DRUG INTERACTION; IN VITRO STUDY; METABOLISM; ORGAN CULTURE TECHNIQUE; SIGNAL TRANSDUCTION; TIME;

ANIMALS; ANTIGENS, CD11B; BRAIN-DERIVED NEUROTROPHIC FACTOR; CREB-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG INTERACTIONS; ENZYME INHIBITORS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; KAINIC ACID; MAP KINASE KINASE KINASES; NEUROGENESIS; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; RATS; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84880182899     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-14-72     Document Type: Article

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