18F-labeled flavones for in vivo imaging of β-amyloid plaques in Alzheimer's brains

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 2069-2076

  Ono, Masahiro ^a,b   Watanabe, Rumi ^a   Kawashima, Hidekazu ^b   Kawai, Tomoki ^b   Watanabe, Hiroyuki ^a   Haratake, Mamoru ^a   Saji, Hideo ^b   Nakayama, Morio ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Amyloid plaque; Alzheimer's disease; Flavone; PET

Indexed keywords

AMYLOID BETA PROTEIN; CONTRAST MEDIUM; DIMETHYLAMINE; FLAVONE DERIVATIVE; FLUORINE 18; FLUOROPEGYLATED FLAVONE DERIVATIVE; UNCLASSIFIED DRUG; FLUORINE; MACROGOL DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; FEMALE; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NEUROPATHOLOGY; NONHUMAN; RADIOACTIVITY; TREATMENT OUTCOME; ANIMAL; BRAIN; CHEMISTRY; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; SENILE PLAQUE; SYNTHESIS;

MUS;

ALZHEIMER DISEASE; ANIMALS; BRAIN; FLAVONES; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MICE; MODELS, ANIMAL; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SENILE PLAQUES;

EID: 61349195322     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.025     Document Type: Article

References (22)

1. Hardy J.A., and Higgins G.A. Science 256 (1992) 184
2. Selkoe D.J. Physiol. Rev. 81 (2001) 741
3. Selkoe D.J. Nat. Biotechnol. 18 (2000) 823
4. Mathis C.A., Wang Y., and Klunk W.E. Curr. Pharm. Des. 10 (2004) 1469
5. Nordberg A. Lancet Neurol. 3 (2004) 519
6. Ono M., Wilson A., Nobrega J., Westaway D., Verhoeff P., Zhuang Z.P., Kung M.P., and Kung H.F. Nucl. Med. Biol. 30 (2003) 565
7. Verhoeff N.P., Wilson A.A., Takeshita S., Trop L., Hussey D., Singh K., Kung H.F., Kung M.P., and Houle S. Am. J. Geriatr. Psychiat. 12 (2004) 584
8. Mathis C.A., Wang Y., Holt D.P., Huang G.F., Debnath M.L., and Klunk W.E. J. Med. Chem. 46 (2003) 2740
9. Klunk W.E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D.P., Bergstrom M., Savitcheva I., Huang G.F., Estrada S., Ausen B., Debnath M.L., Barletta J., Price J.C., Sandell J., Lopresti B.J., Wall A., Koivisto P., Antoni G., Mathis C.A., and Langstrom B. Ann. Neurol. 55 (2004) 306
10. Kudo Y., Okamura N., Furumoto S., Tashiro M., Furukawa K., Maruyama M., Itoh M., Iwata R., Yanai K., and Arai H. J. Nucl. Med. 48 (2007) 553
11. Agdeppa E.D., Kepe V., Liu J., Flores-Torres S., Satyamurthy N., Petric A., Cole G.M., Small G.W., Huang S.C., and Barrio J.R. J. Neurosci. 21 (2001) RC189
12. Shoghi-Jadid K., Small G.W., Agdeppa E.D., Kepe V., Ercoli L.M., Siddarth P., Read S., Satyamurthy N., Petric A., Huang S.C., and Barrio J.R. Am. J. Geriatr. Psychiat. 10 (2002) 24
13. Rowe C.C., Ackerman U., Browne W., Mulligan R., Pike K.L., O'Keefe G., Tochon-Danguy H., Chan G., Berlangieri S.U., Jones G., Dickinson-Rowe K.L., Kung H.P., Zhang W., Kung M.P., Skovronsky D., Dyrks T., Holl G., Krause S., Friebe M., Lehman L., Lindemann S., Dinkelborg L.M., Masters C.L., and Villemagne V.L. Lancet Neurol. 7 (2008) 129
14. Ono M., Yoshida N., Ishibashi K., Haratake M., Arano Y., Mori H., and Nakayama M. J. Med. Chem. 48 (2005) 7253
15. Stephenson K.A., Chandra R., Zhuang Z.P., Hou C., Oya S., Kung M.P., and Kung H.F. Bioconjugate Chem. 18 (2007) 238
16. Ono M., Kung M.P., Hou C., and Kung H.F. Nucl. Med. Biol. 29 (2002) 633
17. Zhuang Z.P., Kung M.P., Wilson A., Lee C.W., Plossl K., Hou C., Holtzman D.M., and Kung H.F. J. Med. Chem. 46 (2003) 237
18. Cheng Y., and Prusoff W. Biochem. Pharmacol. 1973 (1973) 3099
19. Ares J.J., Outt P.E., Randall J.L., Murray P.D., Weisshaar P.S., O'Brien L.M., Ems B.L., Kakodkar S.V., Kelm G.R., Kershaw W.C., et al. J. Med. Chem. 38 (1995) 4937
20. Ono M., Haratake M., Mori H., and Nakayama M. Bioorg. Med. Chem. 15 (2007) 6802
21. Ono M., Hori M., Haratake M., Tomiyama T., Mori H., and Nakayama M. Bioorg. Med. Chem. 15 (2007) 6388
22. Zhang W., Oya S., Kung M.P., Hou C., Maier D.L., and Kung H.F. Nucl. Med. Biol. 32 (2005) 799