In vitro and antinociceptive profile of HON0001, an orally active NMDA receptor NR2B subunit antagonist

Pharmacology Biochemistry and Behavior

Volumn 84, Issue 1, 2006, Pages 134-141

  Suetake Koga, Sayoko ^a   Shimazaki, Toshiharu ^a   Takamori, Kazuaki ^a   Chaki, Shigeyuki ^a   Kanuma, Kosuke ^a   Sekiguchi, Yoshinori ^a   Suzuki, Tsutomu ^b   Kikuchi, Toyohiko ^b   Matsui, Yoshimitsu ^b   Honda, Toshio ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

HON0001; Inflammatory pain; Neuropathic pain; NR2B

Indexed keywords

7 HYDROXY 6 METHOXY 2 METHYL 1 [2 [4 (TRIFLUOROMETHYL)PHENYL]ETHYL] 1,2,3,4 TETRAHYDROISOQUINOLINE; CARRAGEENAN; DIZOCILPINE; DOPAMINE 1 RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; HON 0001; IFENPRODIL; ION CHANNEL; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TRITIUM; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SCREENING; HYPERALGESIA; IC 50; LATENT PERIOD; LOCOMOTION; MALE; NERVE LIGATION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; ROTAROD TEST; SCIATIC NERVE;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; AVOIDANCE LEARNING; BRAIN; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; ISOQUINOLINES; LOCOMOTION; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 33745635911     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.04.018     Document Type: Article

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