Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 2, 2013, Pages

  Thatcher, Thomas H ^a,b   Hsiao, Hsi Min ^a   Pinner, Elhanan ^c   Laudon, Moshe ^c   Pollock, Stephen J ^b   Sime, Patricia J ^a,b   Phipps, Richard P ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c NEURIM PHARMACEUTICALS LTD   (Israel)

Author keywords

Anti inflammatory; Antioxidants; Chronic obstructive pulmonary disease; Cigarette smoke; Inflammation

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CIGARETTE SMOKE; DEXAMETHASONE; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MYELOPEROXIDASE; NEU 107; NEU 164; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; INFLAMMATORY CELL; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOKING; UPREGULATION;

ANTI-INFLAMMATORY; ANTIOXIDANTS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CIGARETTE SMOKE; INFLAMMATION;

ADULT; ANIMALS; ANTIOXIDANTS; CAFFEIC ACIDS; CYTOKINES; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HUMANS; INDOLES; LUNG; MEMBRANE PROTEINS; MICE; OXIDATIVE STRESS; PEROXIDASE; PNEUMONIA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; SMOKING; TOBACCO SMOKE POLLUTION; UP-REGULATION;

EID: 84880154957     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00036.2013     Document Type: Article

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