Inflammation in sputum relates to progression of disease in subjects with COPD: A prospective descriptive study

Respiratory Research

Volumn 7, Issue , 2006, Pages

  Parr, David G ^a   White, Andrew J ^b   Bayley, Darren L ^c   Guest, Peter J ^d   Stockley, Robert A ^c  

^a UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

^b Gloucester Royal Infirmary   (United Kingdom)

^c UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^d QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; INTERLEUKIN 8; LEUKOTRIENE B4; MYELOPEROXIDASE;

ADULT; AGED; ARTICLE; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; DENSITOMETRY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; LONGITUDINAL STUDY; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; PATHOGENESIS; PROSPECTIVE STUDY; RESPIRATORY TRACT INFLAMMATION; SPUTUM ANALYSIS; CHEMISTRY; COMPARATIVE STUDY; INFLAMMATION; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR; SPUTUM;

AGED; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; RISK FACTORS; SPUTUM;

EID: 33845505080     PISSN: 1465993X     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-7-136     Document Type: Article

References (31)

1. Pauwels RA, Buist AS, Ma P, Jenkins CR, Hurd SS: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. Respir Care 2001, 46:798-825.
2. Montuschi P, Collins JV, Ciabattoni G, Lazzeri N, Corradi M, Kharitonov SA, Barnes PJ: Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 2000, 162:1175-1177.
3. Gompertz S, O'Brien C, Bayley DL, Hill SL, Stockley RA: Changes in bronchial inflammation during acute exacerbations of chronic bronchitis. Eur Respir J 2001, 17:1112-1119.
4. Hill AT, Campbell EJ, Hill SL, Bayley DL, Stockley RA: Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. Am J Med 2000, 109:288-295.
5. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004, 350:2645-2653.
6. O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK: Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med 1997, 155:852-857.
7. Stanescu D, Veriter C, Sanna A: In long-term smokers and former smokers the bronchodilator response is not related to the fall in FEV. Respiration 1999, 66:501-505.
8. Cosio M, Ghezzo H, Hogg JC, Corbin R, Loveland M, Dosman J, Macklem PT: The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 1978, 298:1277-1281.
9. Snider GL, Kleinerman J, Thurlbeck WM, Bengali ZH: The Definition of Emphysema: Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases Workshop. Am Rev Resp Dis 1985, 132:182-185.
10. Gevenois PA, Zanen J, de Maertelaer V, De Vuyst P, Dumortier P, Yernault JC: Macroscopic assessment of pulmonary emphysema by image analysis. J Clin Pathol 1995, 48:318-322.
11. Gould GA, MacNee W, McLean A, Warren PM, Redpath A, Best JJ, Lamb D, Flenley DC: CT measurements of lung density in life can quantitate distal airspace enlargement - an essential defining feature of human emphysema. Am Rev Resp Dis 1988, 137:380-392.
12. Dowson LJ, Guest PJ, Stockley RA: Longitudinal changes in physiological, radiological, and health status measurements in alpha(1)-antitrypsin deficiency and factors associated with decline. Am J Respir Crit Care Med 2001, 164:1805-9.
13. Parr DG, Stoel BC, Stolk J, Stockley RA: Validation of computed tomographic lung densitometry for monitoring emphysema progression in a-1 antitrpysin deficiency. Thorax 2006, In Preeeeess:.
14. Council MR: Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. Lancet 1965, 1:775-779.
15. O'Brien C, Guest PJ, Hill SL, Stockley RA: Physiological and radiological characterisation of patients dianosed with chronic obstructive pulmonary disease in primary care. Thorax 2000, 55:635-642.
16. Fabbri LM, Hurd SS: Global Strategy for the Diagnosis, Management and Prevention of COPD: 2003 update. Eur Respir J 2003, 22:1-2.
17. Pye A, Stockley RA, Hill SL: Simple method for quantifying viable bacterial numbers in sputum. J Clin Pathol 1995, 48:719-724.
18. Stockley RA, Bayley DL: Validation of assays for inflammatory mediators in sputum. Eur Respir J 2000, 15:778-781.
19. Ogilvie CM, Forster RE, Blakemore WS, Morton JW: A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest 1954, 36:1-17.
20. Society BT: Guidelines for the measurement of respiratory function. Recommendations of the British Thoracic Society and the Association of Respiratory Technicians and Physiologists. Respir Med 1994, 88:165-94.
21. Bergin C, Müller N, Nichols DM, Lillington G, Hogg JC, Mullen B, Grymalsoki MR, Osborne S, Pare PD: The diagnosis of emphysema. A computed tomographic-pathologic correlation. Am Rev Resp Dis 1986, 133:541-546.
22. Naidich DP, McCauley DI, Khouri NF, Stitik FP, Siegelman SS: Computed tomography of bronchiectasis. J Comput Assist Tomogr 1982, 6:437-444.
23. Parr DG, Stoel BC, Stolk J, Nightingale PG, Stockley R: Influence of calibration on densitometric studies of emphysema progression using computed tomography. Am J Respir Crit Care Med 2004, 170:883-890.
24. Dirksen A, Dijkman JH, Madsen F, Stoel BC, Hutchison DC, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, Vrooman HA, Reiber JH, Hansen NC, Heckscher T, Viskum K, Stolk J: A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy. Am J Respir Crit Care Med 1999, 160:1468-1472.
25. Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA: Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002, 57:847-852.
26. Fletcher C, Peto R: The natural history of chronic airflow obstruction. Br Med J 1977, 1:1645-1648.
27. Vestbo J, Lange P: Can GOLD Stage 0 provide information of prognostic value in chronic obstructive pulmonary disease? Am J Respir Crit Care Med 2002, 166:329-332.
28. Stanescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM, Maestrelli P: Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax 1996, 51:267-271.
29. Tanino M, Betsuyaku T, Takeyabu K, Tanino Y, Yamaguchi E, Miyamoto K, Nishimura M: Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. Thorax 2002, 57:405-411.
30. de Boer WI, Sont JK, van Schadewijk A, Stolk J, van Krieken JH, Hiemstra PS: Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol 2000, 190:619-626.
31. Gompertz S, O'Brien C, Bayley D, Leung B, Hill S, Stockley R: Comparison of stable state bronchial inflammation in chronic bronchitis and previously unsuspected bronchiectasis. Eur Respir J 1999, 14:.