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Volumn 2013, Issue , 2013, Pages

Update on anticytokine treatment for asthma

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ALTRAKINCEPT; ANTIASTHMATIC AGENT; BENRALIZUMAB; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRODALUMAB; CORTICOSTEROID; CYTOKINE ANTIBODY; DUPILUMAB; ETANERCEPT; GOLIMUMAB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR ANTIBODY; INFLIXIMAB; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; INTERLEUKIN 5; LEBRIKIZUMAB; MEPOLIZUMAB; PASCOLIZUMAB; PITRAKINRA; PLACEBO; PROTEIN; RESLIZUMAB; SECUKINUMAB; TOLL LIKE RECEPTOR; TRALOKINUMAB; TRFK 5; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; CYTOKINE;

EID: 84880145696     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/104315     Document Type: Review
Times cited : (52)

References (101)
  • 2
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • 2-s2.0-52049087356 10.1016/S0140-6736(08)61452-X
    • Anderson G. P., Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. The Lancet 2008 372 9643 1107 1119 2-s2.0-52049087356 10.1016/S0140-6736(08)61452-X
    • (2008) The Lancet , vol.372 , Issue.9643 , pp. 1107-1119
    • Anderson, G.P.1
  • 3
    • 73549109887 scopus 로고    scopus 로고
    • Is the prevalence of asthma declining? Systematic review of epidemiological studies
    • 2-s2.0-73549109887 10.1111/j.1398-9995.2009.02244.x
    • Anandan C., Nurmatov U., Van Schayck O. C. P., Sheikh A., Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 2010 65 2 152 167 2-s2.0-73549109887 10.1111/j.1398-9995.2009.02244.x
    • (2010) Allergy , vol.65 , Issue.2 , pp. 152-167
    • Anandan, C.1    Nurmatov, U.2    Van Schayck, O.C.P.3    Sheikh, A.4
  • 4
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: Executive summary of the GINA dissemination committee report
    • 2-s2.0-2342590065 10.1111/j.1398-9995.2004.00526.x
    • Masoli M., Fabian D., Holt S., Beasley R., The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy 2004 59 5 469 478 2-s2.0-2342590065 10.1111/j.1398-9995.2004.00526.x
    • (2004) Allergy , vol.59 , Issue.5 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 6
    • 61849130565 scopus 로고    scopus 로고
    • Asthma
    • 2-s2.0-61849130565 10.1056/NEJMra0804579
    • Fanta C. H., Asthma. The New England Journal of Medicine 2009 360 10 1002 1014 2-s2.0-61849130565 10.1056/NEJMra0804579
    • (2009) The New England Journal of Medicine , vol.360 , Issue.10 , pp. 1002-1014
    • Fanta, C.H.1
  • 7
    • 63849312387 scopus 로고    scopus 로고
    • Influence of comorbid conditions on asthma
    • 2-s2.0-63849312387 10.1183/09031936.00121308
    • Boulet L.-P., Influence of comorbid conditions on asthma. European Respiratory Journal 2009 33 4 897 906 2-s2.0-63849312387 10.1183/09031936. 00121308
    • (2009) European Respiratory Journal , vol.33 , Issue.4 , pp. 897-906
    • Boulet, L.-P.1
  • 8
    • 0035989762 scopus 로고    scopus 로고
    • Tachykinins and airway microvascular leakage induced by HCI intra-oesophageal instillation
    • 2-s2.0-0035989762 10.1183/09031936.02.00250902
    • Daoui S., D'Agostino B., Gallelli L., Alt X. E., Rossi F., Advenier C., Tachykinins and airway microvascular leakage induced by HCI intra-oesophageal instillation. European Respiratory Journal 2002 20 2 268 273 2-s2.0-0035989762 10.1183/09031936.02.00250902
    • (2002) European Respiratory Journal , vol.20 , Issue.2 , pp. 268-273
    • Daoui, S.1    D'Agostino, B.2    Gallelli, L.3    Alt, X.E.4    Rossi, F.5    Advenier, C.6
  • 9
    • 0037462283 scopus 로고    scopus 로고
    • Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit
    • 2-s2.0-0037462283 10.1016/S0024-3205(02)02372-X
    • Gallelli L., D'Agostino B., Marrocco G., De Rosa G., Filippelli W., Rossi F., Advenier C., Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit. Life Sciences 2003 72 10 1135 1142 2-s2.0-0037462283 10.1016/S0024-3205(02)02372-X
    • (2003) Life Sciences , vol.72 , Issue.10 , pp. 1135-1142
    • Gallelli, L.1    D'Agostino, B.2    Marrocco, G.3    De Rosa, G.4    Filippelli, W.5    Rossi, F.6    Advenier, C.7
  • 10
    • 17144408741 scopus 로고    scopus 로고
    • Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux
    • 2-s2.0-17144408741 10.1038/sj.bjp.0706066
    • D'Agostino B., Marrocco G., De Nardo M., Calò G., Guerrini R., Galleli L., Advenier C., Rossi F., Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux. British Journal of Pharmacology 2005 144 6 813 820 2-s2.0-17144408741 10.1038/sj.bjp.0706066
    • (2005) British Journal of Pharmacology , vol.144 , Issue.6 , pp. 813-820
    • D'Agostino, B.1    Marrocco, G.2    De Nardo, M.3    Calò, G.4    Guerrini, R.5    Galleli, L.6    Advenier, C.7    Rossi, F.8
  • 11
    • 9144268928 scopus 로고    scopus 로고
    • Design and baseline characteristics of the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: A large cohort of patients with severe or difficult-to-treat asthma
    • 2-s2.0-9144268928
    • Dolan C. M., Fraher K. E., Bleecker E. R., Borish L., Chipps B., Hayden M. L., Weiss S., Zheng B., Johnson C., Wenzel S., Design and baseline characteristics of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Annals of Allergy, Asthma and Immunology 2004 92 1 32 39 2-s2.0-9144268928
    • (2004) Annals of Allergy, Asthma and Immunology , vol.92 , Issue.1 , pp. 32-39
    • Dolan, C.M.1    Fraher, K.E.2    Bleecker, E.R.3    Borish, L.4    Chipps, B.5    Hayden, M.L.6    Weiss, S.7    Zheng, B.8    Johnson, C.9    Wenzel, S.10
  • 13
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • 2-s2.0-55849148482 10.1172/JCI36130
    • Barnes P. J., The cytokine network in asthma and chronic obstructive pulmonary disease. Journal of Clinical Investigation 2008 118 11 3546 3556 2-s2.0-55849148482 10.1172/JCI36130
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.11 , pp. 3546-3556
    • Barnes, P.J.1
  • 14
    • 0036230403 scopus 로고    scopus 로고
    • The involvement of sensory neuropeptides in airway hyper-responsiveness in rabbits sensitized and challenged to Parietaria judaica
    • 2-s2.0-0036230403 10.1046/j.1365-2222.2002.01328.x
    • D'Agostino B., Advenier C., De Palma R., Gallelli L., Marrocco G., Abbate G. F., Rossi F., The involvement of sensory neuropeptides in airway hyper-responsiveness in rabbits sensitized and challenged to Parietaria judaica. Clinical and Experimental Allergy 2002 32 3 472 479 2-s2.0-0036230403 10.1046/j.1365-2222.2002.01328.x
    • (2002) Clinical and Experimental Allergy , vol.32 , Issue.3 , pp. 472-479
    • D'Agostino, B.1    Advenier, C.2    De Palma, R.3    Gallelli, L.4    Marrocco, G.5    Abbate, G.F.6    Rossi, F.7
  • 16
    • 84870821942 scopus 로고    scopus 로고
    • The potential of biologics for the treatment of asthma
    • Pelaia G., Vatrella A., Maselli R., The potential of biologics for the treatment of asthma. Nature Reviews Drug Discovery 2012 11 12 958 972
    • (2012) Nature Reviews Drug Discovery , vol.11 , Issue.12 , pp. 958-972
    • Pelaia, G.1    Vatrella, A.2    Maselli, R.3
  • 18
    • 84873889401 scopus 로고    scopus 로고
    • Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma
    • Caruso M., Crisafulli E., Demma S., Holgate S., Polosa R., Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma. Expert Opinion on Biological Therapy 2013 13 3 393 402
    • (2013) Expert Opinion on Biological Therapy , vol.13 , Issue.3 , pp. 393-402
    • Caruso, M.1    Crisafulli, E.2    Demma, S.3    Holgate, S.4    Polosa, R.5
  • 21
    • 79955763980 scopus 로고    scopus 로고
    • Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: Operation of a lung/bone marrow axis
    • 2-s2.0-79955763980 10.1378/chest.10-2397
    • Holt P. G., Sly P. D., Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung/bone marrow axis. Chest 2011 139 5 1165 1171 2-s2.0-79955763980 10.1378/chest.10-2397
    • (2011) Chest , vol.139 , Issue.5 , pp. 1165-1171
    • Holt, P.G.1    Sly, P.D.2
  • 22
    • 77955269402 scopus 로고    scopus 로고
    • Chronic inflammation and asthma
    • 2-s2.0-77955269402 10.1016/j.mrfmmm.2009.09.005
    • Murdoch J. R., Lloyd C. M., Chronic inflammation and asthma. Mutation Research 2010 690 1-2 24 39 2-s2.0-77955269402 10.1016/j.mrfmmm.2009.09.005
    • (2010) Mutation Research , vol.690 , Issue.1-2 , pp. 24-39
    • Murdoch, J.R.1    Lloyd, C.M.2
  • 23
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    • 2-s2.0-64149087970 10.1038/nm.1946
    • Hammad H., Chieppa M., Perros F., Willart M. A., Germain R. N., Lambrecht B. N., House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nature Medicine 2009 15 4 410 416 2-s2.0-64149087970 10.1038/nm.1946
    • (2009) Nature Medicine , vol.15 , Issue.4 , pp. 410-416
    • Hammad, H.1    Chieppa, M.2    Perros, F.3    Willart, M.A.4    Germain, R.N.5    Lambrecht, B.N.6
  • 25
    • 64149099035 scopus 로고    scopus 로고
    • Dust mites' dirty dealings in the lung
    • 2-s2.0-64149099035 10.1038/nm0409-366
    • Lloyd C. M., Dust mites' dirty dealings in the lung. Nature Medicine 2009 15 4 366 367 2-s2.0-64149099035 10.1038/nm0409-366
    • (2009) Nature Medicine , vol.15 , Issue.4 , pp. 366-367
    • Lloyd, C.M.1
  • 27
    • 34250216374 scopus 로고    scopus 로고
    • T-cell co-stimulatory molecules: Their role in allergic immune reactions
    • 2-s2.0-34250216374 10.1183/09031936.00094306
    • Kallinich T., Beler K. C., Wahn U., Stock P., Hamelmann E., T-cell co-stimulatory molecules: their role in allergic immune reactions. European Respiratory Journal 2007 29 6 1246 1255 2-s2.0-34250216374 10.1183/09031936. 00094306
    • (2007) European Respiratory Journal , vol.29 , Issue.6 , pp. 1246-1255
    • Kallinich, T.1    Beler, K.C.2    Wahn, U.3    Stock, P.4    Hamelmann, E.5
  • 28
    • 38649090061 scopus 로고    scopus 로고
    • Immunological decision-making: How does the immune system decide to mount a helper T-cell response?
    • 2-s2.0-38649090061 10.1111/j.1365-2567.2007.02719.x
    • Kaiko G. E., Horvat J. C., Beagley K. W., Hansbro P. M., Immunological decision-making: how does the immune system decide to mount a helper T-cell response? Immunology 2008 123 3 326 338 2-s2.0-38649090061 10.1111/j.1365-2567. 2007.02719.x
    • (2008) Immunology , vol.123 , Issue.3 , pp. 326-338
    • Kaiko, G.E.1    Horvat, J.C.2    Beagley, K.W.3    Hansbro, P.M.4
  • 29
    • 33344455022 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin: Master switch for allergic inflammation
    • 2-s2.0-33344455022 10.1084/jem.20051745
    • Liu Y.-J., Thymic stromal lymphopoietin: master switch for allergic inflammation. Journal of Experimental Medicine 2006 203 2 269 273 2-s2.0-33344455022 10.1084/jem.20051745
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.2 , pp. 269-273
    • Liu, Y.-J.1
  • 30
    • 0037338904 scopus 로고    scopus 로고
    • The role of T lymphocytes in the pathogenesis of asthma
    • 2-s2.0-0037338904 10.1067/mai.2003.169
    • Larché M., Robinson D. S., Kay A. B., The role of T lymphocytes in the pathogenesis of asthma. Journal of Allergy and Clinical Immunology 2003 111 3 450 463 2-s2.0-0037338904 10.1067/mai.2003.169
    • (2003) Journal of Allergy and Clinical Immunology , vol.111 , Issue.3 , pp. 450-463
    • Larché, M.1    Robinson, D.S.2    Kay, A.B.3
  • 31
    • 84873408369 scopus 로고    scopus 로고
    • Targeting eosinophils in allergy, inflammation and beyond
    • Fulkerson P. C., Rothenberg M. E., Targeting eosinophils in allergy, inflammation and beyond. Nature Reviews Drug Discovery 2013 12 2 117 129
    • (2013) Nature Reviews Drug Discovery , vol.12 , Issue.2 , pp. 117-129
    • Fulkerson, P.C.1    Rothenberg, M.E.2
  • 32
    • 78650804976 scopus 로고    scopus 로고
    • New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma
    • 2-s2.0-78650804976 10.1097/ACI.0b013e328342322f
    • Kaiko G. E., Foster P. S., New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma. Current Opinion in Allergy and Clinical Immunology 2011 11 1 39 45 2-s2.0-78650804976 10.1097/ACI.0b013e328342322f
    • (2011) Current Opinion in Allergy and Clinical Immunology , vol.11 , Issue.1 , pp. 39-45
    • Kaiko, G.E.1    Foster, P.S.2
  • 33
    • 79959937269 scopus 로고    scopus 로고
    • Th17 cells: New players in asthma pathogenesis
    • 2-s2.0-79959937269 10.1111/j.1398-9995.2011.02576.x
    • Cosmi L., Liotta F., Maggi E., Romagnani S., Annunziato F., Th17 cells: new players in asthma pathogenesis. Allergy 2011 66 8 989 998 2-s2.0-79959937269 10.1111/j.1398-9995.2011.02576.x
    • (2011) Allergy , vol.66 , Issue.8 , pp. 989-998
    • Cosmi, L.1    Liotta, F.2    Maggi, E.3    Romagnani, S.4    Annunziato, F.5
  • 34
    • 80054906310 scopus 로고    scopus 로고
    • T H 17 cells in asthma and inflammation
    • 2-s2.0-80054906310 10.1016/j.bbagen.2011.02.002
    • Aujla S. J., Alcorn J. F., T H 17 cells in asthma and inflammation. Biochimica et Biophysica Acta 2011 1810 11 1066 1079 2-s2.0-80054906310 10.1016/j.bbagen.2011.02.002
    • (2011) Biochimica et Biophysica Acta , vol.1810 , Issue.11 , pp. 1066-1079
    • Aujla, S.J.1    Alcorn, J.F.2
  • 36
    • 77952128925 scopus 로고    scopus 로고
    • Emerging roles of T helper subsets in the pathogenesis of asthma
    • 2-s2.0-77952128925 10.3109/08820131003615498
    • Durrant D. M., Metzger D. W., Emerging roles of T helper subsets in the pathogenesis of asthma. Immunological Investigations 2010 39 4-5 526 549 2-s2.0-77952128925 10.3109/08820131003615498
    • (2010) Immunological Investigations , vol.39 , Issue.4-5 , pp. 526-549
    • Durrant, D.M.1    Metzger, D.W.2
  • 37
    • 70350041508 scopus 로고    scopus 로고
    • Th17 immunity in patients with allergic asthma
    • 2-s2.0-70350041508 10.1159/000250438
    • Zhao Y., Yang J., Gao Y.-D., Guo W., Th17 immunity in patients with allergic asthma. International Archives of Allergy and Immunology 2010 151 4 297 307 2-s2.0-70350041508 10.1159/000250438
    • (2010) International Archives of Allergy and Immunology , vol.151 , Issue.4 , pp. 297-307
    • Zhao, Y.1    Yang, J.2    Gao, Y.-D.3    Guo, W.4
  • 38
    • 0028989599 scopus 로고
    • TNF- α mediates recruitment of neutrophils and eosinophils during airway inflammation
    • 2-s2.0-0028989599
    • Lukacs N. W., Strieter R. M., Chensue S. W., Widmer M., Kunkel S. L., TNF- α mediates recruitment of neutrophils and eosinophils during airway inflammation. Journal of Immunology 1995 154 10 5411 5417 2-s2.0-0028989599
    • (1995) Journal of Immunology , vol.154 , Issue.10 , pp. 5411-5417
    • Lukacs, N.W.1    Strieter, R.M.2    Chensue, S.W.3    Widmer, M.4    Kunkel, S.L.5
  • 39
    • 0030192001 scopus 로고    scopus 로고
    • Activation of the TNF α -p55 receptor induces myocyte proliferation and modulates agonist-evoked calcium transients in cultured human tracheal smooth muscle cells
    • 2-s2.0-0030192001
    • Amrani Y., Panettieri R. A. Jr., Frossard N., Bronner C., Activation of the TNF α -p55 receptor induces myocyte proliferation and modulates agonist-evoked calcium transients in cultured human tracheal smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology 1996 15 1 55 63 2-s2.0-0030192001
    • (1996) American Journal of Respiratory Cell and Molecular Biology , vol.15 , Issue.1 , pp. 55-63
    • Amrani, Y.1    Panettieri, Jr.R.A.2    Frossard, N.3    Bronner, C.4
  • 40
    • 58849162826 scopus 로고    scopus 로고
    • Acute exacerbations of asthma: Epidemiology, biology and the exacerbation-prone phenotype
    • 2-s2.0-58849162826 10.1111/j.1365-2222.2008.03157.x
    • Dougherty R. H., Fahy J. V., Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clinical and Experimental Allergy 2009 39 2 193 202 2-s2.0-58849162826 10.1111/j.1365-2222.2008.03157.x
    • (2009) Clinical and Experimental Allergy , vol.39 , Issue.2 , pp. 193-202
    • Dougherty, R.H.1    Fahy, J.V.2
  • 44
    • 78649516124 scopus 로고    scopus 로고
    • Functions of T cells in asthma: More than just T H 2 cells
    • 2-s2.0-78649516124 10.1038/nri2870
    • Lloyd C. M., Hessel E. M., Functions of T cells in asthma: more than just T H 2 cells. Nature Reviews Immunology 2010 10 12 838 848 2-s2.0-78649516124 10.1038/nri2870
    • (2010) Nature Reviews Immunology , vol.10 , Issue.12 , pp. 838-848
    • Lloyd, C.M.1    Hessel, E.M.2
  • 45
    • 67650418178 scopus 로고    scopus 로고
    • Intrinsic asthma: Not so different from allergic asthma but driven by superantigens?
    • 2-s2.0-67650418178 10.1111/j.1365-2222.2009.03298.x
    • Barnes P. J., Intrinsic asthma: not so different from allergic asthma but driven by superantigens? Clinical and Experimental Allergy 2009 39 8 1145 1151 2-s2.0-67650418178 10.1111/j.1365-2222.2009.03298.x
    • (2009) Clinical and Experimental Allergy , vol.39 , Issue.8 , pp. 1145-1151
    • Barnes, P.J.1
  • 57
    • 47249158885 scopus 로고    scopus 로고
    • Molecular mechanisms underlying airway smooth muscle contraction and proliferation: Implications for asthma
    • 2-s2.0-47249158885 10.1016/j.rmed.2008.02.020
    • Pelaia G., Renda T., Gallelli L., Vatrella A., Busceti M. T., Agati S., Caputi M., Cazzola M., Maselli R., Marsico S. A., Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. Respiratory Medicine 2008 102 8 1173 1181 2-s2.0-47249158885 10.1016/j.rmed.2008.02.020
    • (2008) Respiratory Medicine , vol.102 , Issue.8 , pp. 1173-1181
    • Pelaia, G.1    Renda, T.2    Gallelli, L.3    Vatrella, A.4    Busceti, M.T.5    Agati, S.6    Caputi, M.7    Cazzola, M.8    Maselli, R.9    Marsico, S.A.10
  • 58
    • 80052272692 scopus 로고    scopus 로고
    • Pathophysiology of asthma: What has our current understanding taught us about new therapeutic approaches?
    • 2-s2.0-80052272692 10.1016/j.jaci.2011.06.052
    • Holgate S. T., Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? Journal of Allergy and Clinical Immunology 2011 128 3 495 505 2-s2.0-80052272692 10.1016/j.jaci.2011. 06.052
    • (2011) Journal of Allergy and Clinical Immunology , vol.128 , Issue.3 , pp. 495-505
    • Holgate, S.T.1
  • 61
    • 84860010929 scopus 로고    scopus 로고
    • Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
    • 2-s2.0-84860010929 10.1111/j.1365-2222.2011.03854.x
    • Molfino N. A., Gossage D., Kolbeck R., Parker J. M., Geba G. P., Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clinical and Experimental Allergy 2012 42 5 712 737 2-s2.0-84860010929 10.1111/j.1365-2222.2011.03854.x
    • (2012) Clinical and Experimental Allergy , vol.42 , Issue.5 , pp. 712-737
    • Molfino, N.A.1    Gossage, D.2    Kolbeck, R.3    Parker, J.M.4    Geba, G.P.5
  • 66
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • Pavord I. D., Korn S., Howarth P., Bleecker E. R., Buhl R., Keene O. N., Ortega H., Chanez P., Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012 380 9842 651 659
    • (2012) Lancet , vol.380 , Issue.9842 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6    Ortega, H.7    Chanez, P.8
  • 69
    • 77649198441 scopus 로고    scopus 로고
    • Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
    • 2-s2.0-77649198441 10.1183/09059180.00007609
    • Oh C. K., Geba G. P., Molfino N., Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. European Respiratory Review 2010 19 115 46 54 2-s2.0-77649198441 10.1183/09059180.00007609
    • (2010) European Respiratory Review , vol.19 , Issue.115 , pp. 46-54
    • Oh, C.K.1    Geba, G.P.2    Molfino, N.3
  • 71
    • 77649203756 scopus 로고    scopus 로고
    • Effects of IL-4R α blockade on lung inflammation and airway hyperresponsiveness using Mu317RAXMu, a murine surrogate for AMG 317, in a treatment model of cockroach allergen-induced asthma in mice
    • Swart D. A., Anders-Bartholo P. M., Tocker J. E., Effects of IL-4R α blockade on lung inflammation and airway hyperresponsiveness using Mu317RAXMu, a murine surrogate for AMG 317, in a treatment model of cockroach allergen-induced asthma in mice. Journal of Allergy and Clinical Immunology 2008 121 2 S267
    • (2008) Journal of Allergy and Clinical Immunology , vol.121 , Issue.2
    • Swart, D.A.1    Anders-Bartholo, P.M.2    Tocker, J.E.3
  • 72
    • 4944239352 scopus 로고    scopus 로고
    • Anti-interleukin-4 therapy
    • 2-s2.0-4944239352 10.1016/j.iac.2004.06.008
    • Steinke J. W., Anti-interleukin-4 therapy. Immunology and Allergy Clinics of North America 2004 24 4 599 614 2-s2.0-4944239352 10.1016/j.iac.2004.06.008
    • (2004) Immunology and Allergy Clinics of North America , vol.24 , Issue.4 , pp. 599-614
    • Steinke, J.W.1
  • 73
    • 69549129344 scopus 로고    scopus 로고
    • Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma
    • 2-s2.0-69549129344 10.1177/0091270009341183
    • Burmeister Getz E., Fisher D. M., Fuller R., Human pharmacokinetics/ pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma. Journal of Clinical Pharmacology 2009 49 9 1025 1036 2-s2.0-69549129344 10.1177/0091270009341183
    • (2009) Journal of Clinical Pharmacology , vol.49 , Issue.9 , pp. 1025-1036
    • Burmeister Getz, E.1    Fisher, D.M.2    Fuller, R.3
  • 74
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
    • 2-s2.0-35348909044 10.1016/S0140-6736(07)61600-6
    • Wenzel S., Wilbraham D., Fuller R., Getz E. B., Longphre M., Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007 370 9596 1422 1431 2-s2.0-35348909044 10.1016/S0140-6736(07)61600-6
    • (2007) Lancet , vol.370 , Issue.9596 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 75
    • 84864445917 scopus 로고    scopus 로고
    • IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist
    • 2-s2.0-84860124436 10.1016/j.jaci.2012.03.030
    • Slager R. E., Otulana B. A., Hawkins G. A., Yen Y. P., Peters S. P., Wenzel S. E., Meyers D. A., Bleecker E. R., IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist. Journal of Allergy and Clinical Immunology 2012 130 2 516 522 2-s2.0-84860124436 10.1016/j.jaci.2012.03.030
    • (2012) Journal of Allergy and Clinical Immunology , vol.130 , Issue.2 , pp. 516-522
    • Slager, R.E.1    Otulana, B.A.2    Hawkins, G.A.3    Yen, Y.P.4    Peters, S.P.5    Wenzel, S.E.6    Meyers, D.A.7    Bleecker, E.R.8
  • 79
    • 77952022559 scopus 로고    scopus 로고
    • An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males
    • 2-s2.0-77952022559 10.1111/j.1365-2125.2010.03647.x
    • Oh C. K., Faggioni R., Jin F., Roskos L. K., Wang B., Birrell C., Wilson R., Molfino N. A., An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males. British Journal of Clinical Pharmacology 2010 69 6 645 655 2-s2.0-77952022559 10.1111/j.1365-2125.2010.03647.x
    • (2010) British Journal of Clinical Pharmacology , vol.69 , Issue.6 , pp. 645-655
    • Oh, C.K.1    Faggioni, R.2    Jin, F.3    Roskos, L.K.4    Wang, B.5    Birrell, C.6    Wilson, R.7    Molfino, N.A.8
  • 81
    • 79958219647 scopus 로고    scopus 로고
    • Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma
    • 2-s2.0-79958219647
    • Oh C. K., Raible D., Geba G. P., Molfino N. A., Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma. Inflammation and Allergy 2011 10 3 180 186 2-s2.0-79958219647
    • (2011) Inflammation and Allergy , vol.10 , Issue.3 , pp. 180-186
    • Oh, C.K.1    Raible, D.2    Geba, G.P.3    Molfino, N.A.4
  • 83
    • 79952049626 scopus 로고    scopus 로고
    • Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma
    • article 14 2-s2.0-79952049626 10.1186/1471-2466-11-14
    • Parker J. M., Oh C. K., LaForce C., Miller S. D., Pearlman D. S., Le C., Robbie G. J., White W. I., White B., Molfino N. A., Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulmonary Medicine 2011 11 article 14 2-s2.0-79952049626 10.1186/1471-2466-11-14
    • (2011) BMC Pulmonary Medicine , vol.11
    • Parker, J.M.1    Oh, C.K.2    Laforce, C.3    Miller, S.D.4    Pearlman, D.S.5    Le, C.6    Robbie, G.J.7    White, W.I.8    White, B.9    Molfino, N.A.10
  • 84
    • 0036826485 scopus 로고    scopus 로고
    • Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF)
    • 2-s2.0-0036826485 10.1016/S0008-8749(02)00565-8
    • Yamashita N., Tashimo H., Ishida H., Kaneko F., Nakano J., Kato H., Hirai K., Horiuchi T., Ohta K., Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF). Cellular Immunology 2002 219 2 92 97 2-s2.0-0036826485 10.1016/S0008-8749(02)00565-8
    • (2002) Cellular Immunology , vol.219 , Issue.2 , pp. 92-97
    • Yamashita, N.1    Tashimo, H.2    Ishida, H.3    Kaneko, F.4    Nakano, J.5    Kato, H.6    Hirai, K.7    Horiuchi, T.8    Ohta, K.9
  • 86
    • 38149091442 scopus 로고    scopus 로고
    • Targeting TNF- α: A novel therapeutic approach for asthma
    • 2-s2.0-38149091442 10.1016/j.jaci.2007.10.028
    • Brightling C., Berry M., Amrani Y., Targeting TNF- α: a novel therapeutic approach for asthma. Journal of Allergy and Clinical Immunology 2008 121 1 5 10 2-s2.0-38149091442 10.1016/j.jaci.2007.10.028
    • (2008) Journal of Allergy and Clinical Immunology , vol.121 , Issue.1 , pp. 5-10
    • Brightling, C.1    Berry, M.2    Amrani, Y.3
  • 93
    • 77956671917 scopus 로고    scopus 로고
    • Interleukin-17 regulation: An attractive therapeutic approach for asthma
    • article 78 2-s2.0-77956671917 10.1186/1465-9921-11-78
    • Park S. J., Lee Y. C., Interleukin-17 regulation: an attractive therapeutic approach for asthma. Respiratory Research 2010 11 article 78 2-s2.0-77956671917 10.1186/1465-9921-11-78
    • (2010) Respiratory Research , vol.11
    • Park, S.J.1    Lee, Y.C.2
  • 95
    • 65549152797 scopus 로고    scopus 로고
    • Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway
    • 2-s2.0-65549152797 10.1164/rccm.200805-666OC
    • Kearley J., Buckland K. F., Mathie S. A., Lloyd C. M., Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. American Journal of Respiratory and Critical Care Medicine 2009 179 9 772 781 2-s2.0-65549152797 10.1164/rccm.200805-666OC
    • (2009) American Journal of Respiratory and Critical Care Medicine , vol.179 , Issue.9 , pp. 772-781
    • Kearley, J.1    Buckland, K.F.2    Mathie, S.A.3    Lloyd, C.M.4
  • 97
    • 53749105022 scopus 로고    scopus 로고
    • Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells
    • 2-s2.0-53749105022 10.1016/j.clim.2008.07.015
    • Shi L., Leu S.-W., Xu F., Zhou X., Yin H., Cai L., Zhang L., Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. Clinical Immunology 2008 129 2 202 210 2-s2.0-53749105022 10.1016/j.clim.2008.07.015
    • (2008) Clinical Immunology , vol.129 , Issue.2 , pp. 202-210
    • Shi, L.1    Leu, S.-W.2    Xu, F.3    Zhou, X.4    Yin, H.5    Cai, L.6    Zhang, L.7
  • 98
    • 77958117957 scopus 로고    scopus 로고
    • IL-27/IFN- γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    • 2-s2.0-77958117957 10.4049/jimmunol.1001039
    • Li J. J., Wang W., Baines K. J., Bowden N. A., Hansbro P. M., Gibson P. G., Kumar R. K., Foster P. S., Yang M., IL-27/IFN- γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Journal of Immunology 2010 185 7 4401 4409 2-s2.0-77958117957 10.4049/jimmunol.1001039
    • (2010) Journal of Immunology , vol.185 , Issue.7 , pp. 4401-4409
    • Li, J.J.1    Wang, W.2    Baines, K.J.3    Bowden, N.A.4    Hansbro, P.M.5    Gibson, P.G.6    Kumar, R.K.7    Foster, P.S.8    Yang, M.9
  • 99
    • 84868608435 scopus 로고    scopus 로고
    • The expanding role(s) of eosinophils in health and disease
    • Jacobsen E. A., Helmers R. A., Lee J. J., Lee N. A., The expanding role(s) of eosinophils in health and disease. Blood 2012 120 19 3882 3890
    • (2012) Blood , vol.120 , Issue.19 , pp. 3882-3890
    • Jacobsen, E.A.1    Helmers, R.A.2    Lee, J.J.3    Lee, N.A.4
  • 101
    • 84855384507 scopus 로고    scopus 로고
    • Eosinophils preserve parasitic nematode larvae by regulating local immunity
    • 2-s2.0-84855384507 10.4049/jimmunol.1101980
    • Gebreselassie N. G., Moorhead A. R., Fabre V., Gagliardo L. F., Lee N. A., Lee J. J., Appleton J. A., Eosinophils preserve parasitic nematode larvae by regulating local immunity. Journal of Immunology 2012 188 1 417 425 2-s2.0-84855384507 10.4049/jimmunol.1101980
    • (2012) Journal of Immunology , vol.188 , Issue.1 , pp. 417-425
    • Gebreselassie, N.G.1    Moorhead, A.R.2    Fabre, V.3    Gagliardo, L.F.4    Lee, N.A.5    Lee, J.J.6    Appleton, J.A.7


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