Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 178, Issue 5, 2008, Pages 476-482

  Turato, Graziella ^a   Barbato, Angelo ^a   Baraldo, Simonetta ^a   Zanin, Maria Elena ^a   Bazzan, Erica ^a   Lokar Oliani, Kim ^a   Calabrese, Fiorella ^a   Panizzolo, Cristina ^a   Snijders, Deborah ^a   Maestrelli, Piero ^a   Zuin, Renzo ^a   Fabbri, Leonardo M ^b   Saetta, Marina ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Airway remodeling; Atopy; Inflammation; Pediatric asthma; Th2 cytokines

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 5;

ADOLESCENT; ANGIOGENESIS; ARTICLE; ASTHMA; ATOPY; BASEMENT MEMBRANE; BRONCHODILATATION; BRONCHOSCOPY; BRONCHUS BIOPSY; BRONCHUS HYPERREACTIVITY; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HISTOCHEMISTRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; LEUKOCYTE MIGRATION; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION TEST; MALE; PRIORITY JOURNAL; TISSUE SECTION; WHEEZING;

ADOLESCENT; ASTHMA; BASEMENT MEMBRANE; BRONCHI; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EOSINOPHILS; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-4; INTERLEUKIN-5; MALE; NEOVASCULARIZATION, PATHOLOGIC; RESPIRATORY MUCOSA; RESPIRATORY SOUNDS; TH2 CELLS;

EID: 51349131997     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200712-1818OC     Document Type: Article

References (41)

1. Martinez FD, Wright AL, Taussig ML, Holberg CJ, Halonen M, Morgan WJ; Group Health Medical Associates. Asthma and wheezing in the first six years of life. N Engl J Med 1995;332:133-138.
2. Stein RT, Holberg CJ, Morgan WJ, Wright AL, Lombardi E, Taussig L, Martinez FD. Peak flow variability, methacholine responsivness and atopy as markers for detecting different wheezing phenotypes in childhood. Thorax 1997;52:946-952.
3. Stein RT, Martinez FD. Asthma phenotypes in childhood: lessons from an epidemiological approach. Paediatr Respir Rev 2004;5:155-161.
4. Kurukulaaratchy RJ, Fenn M, Matthews S, Arshad SH. Characterisation of atopic and non-atopic wheeze in 10 year old children. Thorax 2004;59:563-568.
5. Illi S, von Mutius E, Lau S, Niggemann B, Grüber C, Wahn U; for the Multicentre Allergy Study (MAS) group. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 2006;368:763-770.
6. Saglani S, Bush A. The early-life origins of asthma. Curr Opin Allergy Clin Immunol 2007;7:83-90.
7. Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, Krawiec M, Larsen G, Lemanske RF, Liu A, Mauger DT, et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004;114:1282-1287.
8. Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Silva PA, Poulton R. A longitudinal, population-based cohort study of childhood asthma followed to adulthood. N Engl J Med 2003;349:1414-1422.
9. Eysink P, Bindels P, Huisman J, Bottema B, Aalberse R, Schadé B. Development of specific immunoglobulin E in coughing toddlers: a medical records review of symptoms in general practice. Pediatr Allergy Immunol 2001;12:133-141.
10. Turato G, Barbato A, Zanin ME, Baraldo S, Calabrese F, Panizzolo C, Bazzan E, Savoia F, Zuin R, Maestrelli P, et al. Airway remodelling and inflammation in non-atopic wheezing children [abstract]. Eur Respir J 2006;28:257s.
11. Turato G, Barbato A, Zanin ME, Baraldo S, Calabrese F, Maestrelli P, Rossi E, Bazzan E, Panizzolo C, Nordio B, et al. Non-atopic wheezing children have airway eosinophilia, interleukin-5 and remodelling similar to atopic wheezing children [abstract]. Am J Respir Crit Care Med 2007;175:A835.
12. Green CG, Eisenberg J, Leong A, Nathanson I, Schnapf BW, Wood RE. Flexible endoscopy of pediatric airway. Am Rev Respir Dis 1992;145:233-235.
13. Barbato A, Magarotto M, Crivellaro M, Novello A Jr, Cracco A, de Blic J, Scheinmann P, Warner JO, Zach M. Use of pediatric bronchoscope, flexible and rigid, in 51 European centres. Eur Respir J 1997;10:1761-1766.
14. Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Panizzolo C, Zanin ME, Zuin R, Maestrelli P, Fabbri LM, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006;174:975-981.
15. Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Tura M, Zuin R, Beghé B, Maestrelli P, Fabbri LM, et al. Airway inflammation in childhood asthma. Am J Respir Crit Care Med 2003;168:798-803.
16. Jeffery P, Holgate ST, Wenzel S; for the Endobronchial Biopsy Workshop Authors. Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment. Am J Respir Crit Care Med 2003;168:S1-S17.
17. Barbato A, Panizzolo C, Gheno M, Sainati L, Favero E, Faggian D, Giusti F, Pesscolderungg L, La Rosa M. Bronchoalveolar lavage in asthmatic children: evidence of neutrophil activation in mild-to-moderate persistent asthma. Pediatr Allergy Immunol 2001;12:73-77.
18. Bush A, Davies J. Rebuttal: you are wrong, Dr. Mallory. Pediatr Pulmonol 2006;41:1017-1020.
19. Di Stefano A, Turato G, Maestrelli P, Mapp CE, Ruggieri MP, Roggeri A, Boschetto P, Fabbri LM, Saetta M. Airflow limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration of the bronchial mucosa. Am J Respir Crit Care Med 1996;153:629-632.
20. Baraldo S, Turato G, Badin C, Bazzan E, Beghé B, Zuin R, Calabrese F, Casoni G, Maestrelli P, Papi A, et al. Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax 2004;59:308-312.
21. Miotto D, Ruggieri MP, Boschetto P, Cavallesco G, Papi A, Bononi I, Piola C, Murer B, Fabbri LM, Mapp CE. Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis. Eur Respir J 2003;22:602-608.
22. Aickin M, Gensler H. Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods. Am J Public Health 1996;86:726-728.
23. Sankoh AJ, Huque MF, Dubey SD. Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Stat Med 1997;16:2529-2542.
24. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316:1236-1238.
25. Spycher BD, Silverman M, Brooke AM, Minder CE, Kuehni CE. Distinguishing phenotypes of childhood wheeze and cough using latent class analysis. Eur Respir J 2008;31:974-981.
26. Stevenson EC, Turner G, Heaney LG, Schock BC, Taylor R, Gallagher T, Ennis M, Shields MD. Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy 1997;27:1027-1035.
27. Martinez FD. Heterogeneity of the association between lower respiratory illness in infancy and subsequent asthma. Proc Am Thorac Soc 2005;2:157-161.
28. Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PAB, Bartlett NW, Kebadze T, Mallia P, Stanciu LA, Parker HL, et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006;12:1023-1026.
29. Kabesch M, Tzotcheva I, Carr D, Höfler C, Weiland SK, Fritzsch C, von Mutius E, Martinez FD. A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood. J Allergy Clin Immunol 2003;112:893-898.
30. Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erikson RP, von Mutius E, Martinez FD. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 2000;105:506-513.
31. Saglani S, Malmstrom K, Pelkonen AS, Malmberg LP, Lindahl H, Kajosaari M, Turpeinen M, Rogers AV, Payne DN, Bush A, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722-727.
32. Saglani S, Payne DN, Zhu J, Wang Z, Nicholson AG, Bush A, Jeffery PK. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007;176:858-864.
33. Matzinger P. The Danger model: a renewed sense of self. Science 2002; 296:301-305.
34. Ngoc PL, Gold DR, Tzianabos AO, Weiss ST, Celedon JC. Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol 2005;5:161-166.
35. Humbert M, Durham SR, Ying S, Kimmit P, Barkans J, Assoufi B, Pfister R, Menz G, Robinson DS, Kay AB, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996;154:1497-1504.
36. Bentley AM, Menz G, Storz C, Robinson DS, Bradley B, Jeffery PK, Durham SR, Kay AB. Identification of T-lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma. Am Rev Respir Dis 1992;146:500-506.
37. Humbert M, Menz G, Ying S, Corrigan CJ, Robinson DS, Durham SR, Kay AB. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999;20:528-533.
38. Pereira MU, Sly PD, Pitrez PM, Jones MH, Escouto D, Dias ACO, Weiland SK, Stein RT. Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children. Eur Respir J 2007;29:1154-1160.
39. Guerra S. Clinical remission of asthma: what lies beyond? Thorax 2005;60:5-6.
40. Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD. Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med 2004;170:78-85.
41. van den Toorn LM, Overbeek SE, de Jongste JC, Leman K, Hoogsteden HC, Prins JB. Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med 2001;164:2107-2113.