메뉴 건너뛰기




Volumn 19, Issue 26, 2013, Pages 4119-4126

Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects

Author keywords

Colorectal cancer; DNA based immunomodulatory sequences; Inflammatory bowel diseases; Synthetic oligodeoxynucleotide sequences; Toll like receptor 9

Indexed keywords

CETUXIMAB; CPG OLIGODEOXYNUCLEOTIDE; DEXTRAN SULFATE; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 12; INTERLEUKIN 6; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PANITUMUMAB; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

EID: 84880102029     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i26.4119     Document Type: Review
Times cited : (36)

References (63)
  • 1
    • 0028081705 scopus 로고
    • Coley's toxins, tumor necrosis factor and cancer research: A historical perspective
    • [PMID: 7724661 DOI: 10.1016/0163-72 58(94)90023-X]
    • Wiemann B, Starnes CO. Coley's toxins, tumor necrosis factor and cancer research: a historical perspective. Pharmacol Ther 1994; 64: 529-564 [PMID: 7724661 DOI: 10.1016/0163-72 58(94)90023-X]
    • (1994) Pharmacol Ther , vol.64 , pp. 529-564
    • Wiemann, B.1    Starnes, C.O.2
  • 2
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • [PMID: 6200641]
    • Tokunaga T, Yamamoto H, Shimada S, Abe H, Fukuda T, Fujisawa Y, Furutani Y, Yano O, Kataoka T, Sudo T. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 1984; 72: 955-962 [PMID: 6200641]
    • (1984) J Natl Cancer Inst , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6    Furutani, Y.7    Yano, O.8    Kataoka, T.9    Sudo, T.10
  • 3
    • 0026464967 scopus 로고
    • DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
    • [PMID: 1281260]
    • Yamamoto S, Yamamoto T, Shimada S, Kuramoto E, Yano O, Kataoka T, Tokunaga T. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol Immunol 1992; 36: 983-997 [PMID: 1281260]
    • (1992) Microbiol Immunol , vol.36 , pp. 983-997
    • Yamamoto, S.1    Yamamoto, T.2    Shimada, S.3    Kuramoto, E.4    Yano, O.5    Kataoka, T.6    Tokunaga, T.7
  • 4
    • 0027978749 scopus 로고
    • Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro
    • [PMID: 7523351 DOI: 10.1111/j.1349-7006.1994. tb02947. x]
    • Yamamoto T, Yamamoto S, Kataoka T, Komuro K, Kohase M, Tokunaga T. Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro. Jpn J Cancer Res 1994; 85: 775-779 [PMID: 7523351 DOI: 10.1111/j.1349-7006.1994. tb02947. x]
    • (1994) Jpn J Cancer Res , vol.85 , pp. 775-779
    • Yamamoto, T.1    Yamamoto, S.2    Kataoka, T.3    Komuro, K.4    Kohase, M.5    Tokunaga, T.6
  • 6
    • 36348945135 scopus 로고    scopus 로고
    • Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation
    • [PMID: 18020622 DOI: 10.2165/00063030-200721060-00006]
    • Jurk M, Vollmer J. Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation. BioDrugs 2007; 21: 387-401 [PMID: 18020622 DOI: 10.2165/00063030-200721060-00006]
    • (2007) BioDrugs , vol.21 , pp. 387-401
    • Jurk, M.1    Vollmer, J.2
  • 7
    • 79955961130 scopus 로고    scopus 로고
    • Isolated lymphoid follicles in colon: Switch points between inflammation and colorectal cancer?
    • [PMID: 21483625 DOI: 10.3748/wjg. v17. i13.1666]
    • Sipos F, Muzes G. Isolated lymphoid follicles in colon: switch points between inflammation and colorectal cancer? World J Gastroenterol 2011; 17: 1666-1673 [PMID: 21483625 DOI: 10.3748/wjg. v17. i13.1666]
    • (2011) World J Gastroenterol , vol.17 , pp. 1666-1673
    • Sipos, F.1    Muzes, G.2
  • 8
    • 70450222321 scopus 로고    scopus 로고
    • Transcriptional analysis of Toll-like receptors expression in M cells
    • [PMID: 19781788 DOI: 10.1016/ j. molimm.2009.09.007]
    • Cashman SB, Morgan JG. Transcriptional analysis of Toll-like receptors expression in M cells. Mol Immunol 2009; 47: 365-372 [PMID: 19781788 DOI: 10.1016/ j. molimm.2009.09.007]
    • (2009) Mol Immunol , vol.47 , pp. 365-372
    • Cashman, S.B.1    Morgan, J.G.2
  • 12
    • 79959235834 scopus 로고    scopus 로고
    • Variant Toll-like receptor4 (Asp299Gly and Thr399Ile alleles) and Toll-like receptor2 (Arg753Gln and Arg677Trp alleles) in colorectal cancer
    • [PMID: 21625017]
    • Davoodi H, Seow HF. Variant Toll-like receptor4 (Asp299Gly and Thr399Ile alleles) and Toll-like receptor2 (Arg753Gln and Arg677Trp alleles) in colorectal cancer. Iran J Allergy Asthma Immunol 2011; 10: 91-99 [PMID: 21625017]
    • (2011) Iran J Allergy Asthma Immunol , vol.10 , pp. 91-99
    • Davoodi, H.1    Seow, H.F.2
  • 13
    • 84859920121 scopus 로고    scopus 로고
    • Toll-like receptor genes and their association with colon and rectal cancer development and prognosis
    • [PMID: 21792899 DOI: 10.1002/ijc.26314]
    • Slattery ML, Herrick JS, Bondurant KL, Wolff RK. Toll-like receptor genes and their association with colon and rectal cancer development and prognosis. Int J Cancer 2012; 130: 2974-2980 [PMID: 21792899 DOI: 10.1002/ijc.26314]
    • (2012) Int J Cancer , vol.130 , pp. 2974-2980
    • Slattery, M.L.1    Herrick, J.S.2    Bondurant, K.L.3    Wolff, R.K.4
  • 14
    • 55149105005 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
    • [PMID: 19161412 DOI: 10.1111/j.1600-065X.2008.00701. x]
    • O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 2008; 226: 10-18 [PMID: 19161412 DOI: 10.1111/j.1600-065X.2008.00701. x]
    • (2008) Immunol Rev , vol.226 , pp. 10-18
    • O'Neill, L.A.1
  • 15
    • 56549093441 scopus 로고    scopus 로고
    • Toll-like receptors in autoimmunity
    • [PMID: 19076342 DOI: 10.1196/annals.1443.012]
    • Fischer M, Ehlers M. Toll-like receptors in autoimmunity. Ann N Y Acad Sci 2008; 1143: 21-34 [PMID: 19076342 DOI: 10.1196/annals.1443.012]
    • (2008) Ann N Y Acad Sci , vol.1143 , pp. 21-34
    • Fischer, M.1    Ehlers, M.2
  • 18
    • 3142697714 scopus 로고    scopus 로고
    • TLR9 is localized in the endoplasmic reticulum prior to stimulation
    • [PMID: 15240708]
    • Leifer CA, Kennedy MN, Mazzoni A, Lee C, Kruhlak MJ, Segal DM. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J Immunol 2004; 173: 1179-1183 [PMID: 15240708]
    • (2004) J Immunol , vol.173 , pp. 1179-1183
    • Leifer, C.A.1    Kennedy, M.N.2    Mazzoni, A.3    Lee, C.4    Kruhlak, M.J.5    Segal, D.M.6
  • 19
    • 10244237643 scopus 로고    scopus 로고
    • Mechanisms of TLR9 activation
    • [PMID: 15588423 DOI: 10.1179/096805104225006525]
    • Latz E, Visintin A, Espevik T, Golenbock DT. Mechanisms of TLR9 activation. J Endotoxin Res 2004; 10: 406-412 [PMID: 15588423 DOI: 10.1179/096805104225006525]
    • (2004) J Endotoxin Res , vol.10 , pp. 406-412
    • Latz, E.1    Visintin, A.2    Espevik, T.3    Golenbock, D.T.4
  • 20
    • 0242288476 scopus 로고    scopus 로고
    • Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs
    • [PMID: 14620151 DOI: 10.1080/00365540310016493]
    • Espevik T, Latz E, Lien E, Monks B, Golenbock DT. Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs. Scand J Infect Dis 2003; 35: 660-664 [PMID: 14620151 DOI: 10.1080/00365540310016493]
    • (2003) Scand J Infect Dis , vol.35 , pp. 660-664
    • Espevik, T.1    Latz, E.2    Lien, E.3    Monks, B.4    Golenbock, D.T.5
  • 21
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • [PMID: 12527213 DOI: 10.1016/S0165-2478(02)00228-6]
    • Akira S, Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett 2003; 85: 85-95 [PMID: 12527213 DOI: 10.1016/S0165-2478(02)00228-6]
    • (2003) Immunol Lett , vol.85 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 22
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • [PMID: 17479101 DOI: 10.1038/nm1589]
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13: 552-559 [PMID: 17479101 DOI: 10.1038/nm1589]
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 23
    • 80054707100 scopus 로고    scopus 로고
    • Lung cancer and Toll-like receptors
    • [PMID: 21789594 DOI: 10.1007/s00262-011-1057-8]
    • Pinto A, Morello S, Sorrentino R. Lung cancer and Toll-like receptors. Cancer Immunol Immunother 2011; 60: 1211-1220 [PMID: 21789594 DOI: 10.1007/s00262-011-1057-8]
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1211-1220
    • Pinto, A.1    Morello, S.2    Sorrentino, R.3
  • 24
    • 33845636049 scopus 로고    scopus 로고
    • TLR9 and the recognition of self and non-self nucleic acids
    • [PMID: 17145922 DOI: 10.1196/annals.1348.005]
    • Lamphier MS, Sirois CM, Verma A, Golenbock DT, Latz E. TLR9 and the recognition of self and non-self nucleic acids. Ann N Y Acad Sci 2006; 1082: 31-43 [PMID: 17145922 DOI: 10.1196/annals.1348.005]
    • (2006) Ann N Y Acad Sci , vol.1082 , pp. 31-43
    • Lamphier, M.S.1    Sirois, C.M.2    Verma, A.3    Golenbock, D.T.4    Latz, E.5
  • 25
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNAspecific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • [PMID: 9799232 DOI: 10.1093/emboj/17.21.6230]
    • Häcker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, Wagner H. CpG-DNAspecific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 1998; 17: 6230-6240 [PMID: 9799232 DOI: 10.1093/emboj/17.21.6230]
    • (1998) EMBO J , vol.17 , pp. 6230-6240
    • Häcker, H.1    Mischak, H.2    Miethke, T.3    Liptay, S.4    Schmid, R.5    Sparwasser, T.6    Heeg, K.7    Lipford, G.B.8    Wagner, H.9
  • 26
    • 78349255916 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways--therapeutic opportunities
    • [PMID: 20981241]
    • Zhu J, Mohan C. Toll-like receptor signaling pathways--therapeutic opportunities. Mediators Inflamm 2010; 2010: 781235 [PMID: 20981241]
    • (2010) Mediators Inflamm , vol.2010 , pp. 781235
    • Zhu, J.1    Mohan, C.2
  • 27
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • [PMID: 16763660 DOI: 10.1038/nrd2059]
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006; 5: 471-484 [PMID: 16763660 DOI: 10.1038/nrd2059]
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 28
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • [PMID: 15057783 DOI: 10.1038/nri1329]
    • Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 2004; 4: 249-258 [PMID: 15057783 DOI: 10.1038/nri1329]
    • (2004) Nat Rev Immunol , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 29
    • 79960565251 scopus 로고    scopus 로고
    • Three CpG oligodeoxynucleotide classes differentially enhance antigen-specific humoral and cellular immune responses in mice
    • [PMID: 21664398 DOI: 10.1016/ j. vaccine.2011.05.087]
    • Liu Y, Luo X, Yang C, Yu S, Xu H. Three CpG oligodeoxynucleotide classes differentially enhance antigen-specific humoral and cellular immune responses in mice. Vaccine 2011; 29: 5778-5784 [PMID: 21664398 DOI: 10.1016/ j. vaccine.2011.05.087]
    • (2011) Vaccine , vol.29 , pp. 5778-5784
    • Liu, Y.1    Luo, X.2    Yang, C.3    Yu, S.4    Xu, H.5
  • 31
    • 0034933019 scopus 로고    scopus 로고
    • Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
    • [PMID: 11449369 DOI: 10.1002/1521-4 141(200107)31]
    • Krug A, Rothenfusser S, Hornung V, Jahrsdörfer B, Blackwell S, Ballas ZK, Endres S, Krieg AM, Hartmann G. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 2001; 31: 2154-2163 [PMID: 11449369 DOI: 10.1002/1521-4 141(200107)31]
    • (2001) Eur J Immunol , vol.31 , pp. 2154-2163
    • Krug, A.1    Rothenfusser, S.2    Hornung, V.3    Jahrsdörfer, B.4    Blackwell, S.5    Ballas, Z.K.6    Endres, S.7    Krieg, A.M.8    Hartmann, G.9
  • 34
    • 33749031001 scopus 로고    scopus 로고
    • Homeostatic effects of TLR9 signaling in experimental colitis
    • [PMID: 17057215 DOI: 10.1196/annals.1326.022]
    • Lee J, Rachmilewitz D, Raz E. Homeostatic effects of TLR9 signaling in experimental colitis. Ann N Y Acad Sci 2006; 1072: 351-355 [PMID: 17057215 DOI: 10.1196/annals.1326.022]
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 351-355
    • Lee, J.1    Rachmilewitz, D.2    Raz, E.3
  • 35
    • 84860821347 scopus 로고    scopus 로고
    • Campylobacter jejuni disrupts protective Toll-like receptor 9 signaling in colonic epithelial cells and increases the severity of dextran sulfate sodium-induced colitis in mice
    • [PMID: 22311925 DOI: 10.1128/IAI.06066-11]
    • O'Hara JR, Feener TD, Fischer CD, Buret AG. Campylobacter jejuni disrupts protective Toll-like receptor 9 signaling in colonic epithelial cells and increases the severity of dextran sulfate sodium-induced colitis in mice. Infect Immun 2012; 80: 1563-1571 [PMID: 22311925 DOI: 10.1128/IAI.06066-11]
    • (2012) Infect Immun , vol.80 , pp. 1563-1571
    • O'Hara, J.R.1    Feener, T.D.2    Fischer, C.D.3    Buret, A.G.4
  • 38
    • 84863981516 scopus 로고    scopus 로고
    • Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer
    • [PMID: 22371291 DOI: 10.1007/ s10875-012-9666-3]
    • Eiró N, González L, González LO, Andicoechea A, Fernández-Díaz M, Altadill A, Vizoso FJ. Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer. J Clin Immunol 2012; 32: 848-854 [PMID: 22371291 DOI: 10.1007/ s10875-012-9666-3]
    • (2012) J Clin Immunol , vol.32 , pp. 848-854
    • Eiró, N.1    González, L.2    González, L.O.3    Andicoechea, A.4    Fernández-Díaz, M.5    Altadill, A.6    Vizoso, F.J.7
  • 40
    • 0037109211 scopus 로고    scopus 로고
    • 'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents
    • [PMID: 12384593 DOI: 10.1093/nar/gkf582]
    • Yu D, Kandimalla ER, Bhagat L, Tang JY, Cong Y, Tang J, Agrawal S. 'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents. Nucleic Acids Res 2002; 30: 4460-4469 [PMID: 12384593 DOI: 10.1093/nar/gkf582]
    • (2002) Nucleic Acids Res , vol.30 , pp. 4460-4469
    • Yu, D.1    Kandimalla, E.R.2    Bhagat, L.3    Tang, J.Y.4    Cong, Y.5    Tang, J.6    Agrawal, S.7
  • 41
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • [PMID: 20100961 DOI: 10.1200/ JCO.2009.24.6116]
    • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28: 1254-1261 [PMID: 20100961 DOI: 10.1200/ JCO.2009.24.6116]
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 42
    • 70350359432 scopus 로고    scopus 로고
    • Toll-like receptor 9 agonist inhibits ERalpha-mediated transactivation by activating NF-kappaB in breast cancer cell lines
    • [PMID: 19724876 DOI: 10.3892/or_00000520]
    • Qiu J, Wang X, Guo X, Zhao C, Wu X, Zhang Y. Toll-like receptor 9 agonist inhibits ERalpha-mediated transactivation by activating NF-kappaB in breast cancer cell lines. Oncol Rep 2009; 22: 935-941 [PMID: 19724876 DOI: 10.3892/or_00000520]
    • (2009) Oncol Rep , vol.22 , pp. 935-941
    • Qiu, J.1    Wang, X.2    Guo, X.3    Zhao, C.4    Wu, X.5    Zhang, Y.6
  • 43
    • 84860722701 scopus 로고    scopus 로고
    • Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables
    • [PMID: 22407332]
    • Rath-Wolfson L, Purim O, Ram E, Morgenstern S, Koren R, Brenner B. Expression of estrogen receptor β1 in colorectal cancer: correlation with clinicopathological variables. Oncol Rep 2012; 27: 2017-2022 [PMID: 22407332]
    • (2012) Oncol Rep , vol.27 , pp. 2017-2022
    • Rath-Wolfson, L.1    Purim, O.2    Ram, E.3    Morgenstern, S.4    Koren, R.5    Brenner, B.6
  • 44
    • 84867076730 scopus 로고    scopus 로고
    • Estrogen receptor-β protects against colitis-associated neoplasia in mice
    • [PMID: 22488198 DOI: 10.1002/ijc.27578]
    • Saleiro D, Murillo G, Benya RV, Bissonnette M, Hart J, Mehta RG. Estrogen receptor-β protects against colitis-associated neoplasia in mice. Int J Cancer 2012; 131: 2553-2561 [PMID: 22488198 DOI: 10.1002/ijc.27578]
    • (2012) Int J Cancer , vol.131 , pp. 2553-2561
    • Saleiro, D.1    Murillo, G.2    Benya, R.V.3    Bissonnette, M.4    Hart, J.5    Mehta, R.G.6
  • 46
    • 70449127697 scopus 로고    scopus 로고
    • Safety and efficacy of PF-3512676 for the treatment of stage IV renal cell carcinoma: An open-label, multicenter phase I/II study
    • [PMID: 19815483 DOI: 10.3816/CGC.2009.n.025]
    • Thompson JA, Kuzel T, Drucker BJ, Urba WJ, Bukowski RM. Safety and efficacy of PF-3512676 for the treatment of stage IV renal cell carcinoma: an open-label, multicenter phase I/II study. Clin Genitourin Cancer 2009; 7: E58-E65 [PMID: 19815483 DOI: 10.3816/CGC.2009.n.025]
    • (2009) Clin Genitourin Cancer , vol.7
    • Thompson, J.A.1    Kuzel, T.2    Drucker, B.J.3    Urba, W.J.4    Bukowski, R.M.5
  • 47
    • 55249083982 scopus 로고    scopus 로고
    • Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma
    • [PMID: 18463532 DOI: 10.1097/CJI.0b013e318174a4df]
    • Hofmann MA, Kors C, Audring H, Walden P, Sterry W, Trefzer U. Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma. J Immunother 2008; 31: 520-527 [PMID: 18463532 DOI: 10.1097/CJI.0b013e318174a4df]
    • (2008) J Immunother , vol.31 , pp. 520-527
    • Hofmann, M.A.1    Kors, C.2    Audring, H.3    Walden, P.4    Sterry, W.5    Trefzer, U.6
  • 48
    • 71849087609 scopus 로고    scopus 로고
    • Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer
    • [PMID: 19843072 DOI: 10.1111/j.1349-7006.2009.01361. x]
    • Yamada K, Nakao M, Fukuyama C, Nokihara H, Yamamoto N, Sekine I, Kunitoh H, Ohe Y, Ohki E, Hashimoto J, Tamura T. Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer. Cancer Sci 2010; 101: 188-195 [PMID: 19843072 DOI: 10.1111/j.1349-7006.2009.01361. x]
    • (2010) Cancer Sci , vol.101 , pp. 188-195
    • Yamada, K.1    Nakao, M.2    Fukuyama, C.3    Nokihara, H.4    Yamamoto, N.5    Sekine, I.6    Kunitoh, H.7    Ohe, Y.8    Ohki, E.9    Hashimoto, J.10    Tamura, T.11
  • 50
    • 84859909667 scopus 로고    scopus 로고
    • Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma
    • [PMID: 22495394 DOI: 10.1097/ CJI.0b013e31825481fe]
    • Tarhini AA, Leng S, Moschos SJ, Yin Y, Sander C, Lin Y, Gooding WE, Kirkwood JM. Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. J Immunother 2012; 35: 359-366 [PMID: 22495394 DOI: 10.1097/ CJI.0b013e31825481fe]
    • (2012) J Immunother , vol.35 , pp. 359-366
    • Tarhini, A.A.1    Leng, S.2    Moschos, S.J.3    Yin, Y.4    Sander, C.5    Lin, Y.6    Gooding, W.E.7    Kirkwood, J.M.8
  • 52
  • 54
    • 33750463425 scopus 로고    scopus 로고
    • Experimental therapy of prostate cancer with an immunomodulatory oligonucleotide: Effects on tumor growth, apoptosis, proliferation, and potentiation of chemotherapy
    • [PMID: 16927305 DOI: 10.1002/ pros.20485]
    • Rayburn ER, Wang W, Zhang Z, Li M, Zhang R, Wang H. Experimental therapy of prostate cancer with an immunomodulatory oligonucleotide: effects on tumor growth, apoptosis, proliferation, and potentiation of chemotherapy. Prostate 2006; 66: 1653-1663 [PMID: 16927305 DOI: 10.1002/ pros.20485]
    • (2006) Prostate , vol.66 , pp. 1653-1663
    • Rayburn, E.R.1    Wang, W.2    Zhang, Z.3    Li, M.4    Zhang, R.5    Wang, H.6
  • 55
    • 35648986604 scopus 로고    scopus 로고
    • Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease
    • [PMID: 17595233 DOI: 10.1136/gut.2007.125468]
    • Henckaerts L, Pierik M, Joossens M, Ferrante M, Rutgeerts P, Vermeire S. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. Gut 2007; 56: 1536-1542 [PMID: 17595233 DOI: 10.1136/gut.2007.125468]
    • (2007) Gut , vol.56 , pp. 1536-1542
    • Henckaerts, L.1    Pierik, M.2    Joossens, M.3    Ferrante, M.4    Rutgeerts, P.5    Vermeire, S.6
  • 57
    • 84876412015 scopus 로고    scopus 로고
    • Topical treatment with the toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity
    • [DOI: 10.1002/ibd.23019]
    • Musch E, Lutfi T, von Stein P, Zargari A, Admyre C, Malek M, Löfberg R, von Stein OD. Topical treatment with the toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity. Inflamm Bowel Dis 2013; 19: 283-292 [DOI: 10.1002/ibd.23019]
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 283-292
    • Musch, E.1    Lutfi, T.2    von Stein, P.3    Zargari, A.4    Admyre, C.5    Malek, M.6    Löfberg, R.7    von Stein, O.D.8
  • 58
    • 83555161584 scopus 로고    scopus 로고
    • A safety study of a B-class CpG ODN in Sprague-Dawley rats
    • [PMID: 21538408 DOI: 10.1002/ jat.1683]
    • Liu L, Shen L, Liu X, Yu Y, Li Y, Wang L, He C, Sun J, Li B. A safety study of a B-class CpG ODN in Sprague-Dawley rats. J Appl Toxicol 2012; 32: 60-71 [PMID: 21538408 DOI: 10.1002/ jat.1683]
    • (2012) J Appl Toxicol , vol.32 , pp. 60-71
    • Liu, L.1    Shen, L.2    Liu, X.3    Yu, Y.4    Li, Y.5    Wang, L.6    He, C.7    Sun, J.8    Li, B.9
  • 59
    • 33144460185 scopus 로고    scopus 로고
    • Dynamic regulation of pro-and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    • [PMID: 16461893 DOI: 10.1073/pnas.0510965103]
    • Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA. Dynamic regulation of pro-and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 2006; 103: 2274-2279 [PMID: 16461893 DOI: 10.1073/pnas.0510965103]
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2274-2279
    • Chi, H.1    Barry, S.P.2    Roth, R.J.3    Wu, J.J.4    Jones, E.A.5    Bennett, A.M.6    Flavell, R.A.7
  • 60
    • 84857625202 scopus 로고    scopus 로고
    • Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity
    • [PMID: 22086297 DOI: 10.1007/s11882-011-0233-4]
    • Matesic D, Lenert A, Lenert P. Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity. Curr Allergy Asthma Rep 2012; 12: 8-17 [PMID: 22086297 DOI: 10.1007/s11882-011-0233-4]
    • (2012) Curr Allergy Asthma Rep , vol.12 , pp. 8-17
    • Matesic, D.1    Lenert, A.2    Lenert, P.3
  • 61
    • 2342604970 scopus 로고    scopus 로고
    • Of men, mice and pigs: Looking at their plasmacytoid dendritic cells [corrected]
    • [PMID: 15096180 DOI: 10.1111/ j.1365-2567.2004.01878. x]
    • Hochrein H, Wagner H. Of men, mice and pigs: looking at their plasmacytoid dendritic cells [corrected]. Immunology 2004; 112: 26-27 [PMID: 15096180 DOI: 10.1111/ j.1365-2567.2004.01878. x]
    • (2004) Immunology , vol.112 , pp. 26-27
    • Hochrein, H.1    Wagner, H.2
  • 62
    • 0038717560 scopus 로고    scopus 로고
    • CpG motifs: The active ingredient in bacterial extracts?
    • [PMID: 12835699 DOI: 10.1038/nm0703-831]
    • Krieg AM. CpG motifs: the active ingredient in bacterial extracts? Nat Med 2003; 9: 831-835 [PMID: 12835699 DOI: 10.1038/nm0703-831]
    • (2003) Nat Med , vol.9 , pp. 831-835
    • Krieg, A.M.1
  • 63
    • 2342497250 scopus 로고    scopus 로고
    • Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete interferon-alpha, tumour necrosis factor-alpha and interleukin-12
    • [PMID: 15096181 DOI: 10.1111/ j.1365-2567.2004.01856. x]
    • Guzylack-Piriou L, Balmelli C, McCullough KC, Summerfield A. Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete interferon-alpha, tumour necrosis factor-alpha and interleukin-12. Immunology 2004; 112: 28-37 [PMID: 15096181 DOI: 10.1111/ j.1365-2567.2004.01856. x]
    • (2004) Immunology , vol.112 , pp. 28-37
    • Guzylack-Piriou, L.1    Balmelli, C.2    McCullough, K.C.3    Summerfield, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.