Reconstruction of an Integrated Genome-Scale Co-Expression Network Reveals Key Modules Involved in Lung Adenocarcinoma

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Bidkhori, Gholamreza ^a   Narimani, Zahra ^a   Hosseini Ashtiani, Saman ^a   Moeini, Ali ^a   Nowzari Dalini, Abbas ^a   Masoudi Nejad, Ali ^a  

^a UNIVERSITY OF TEHRAN   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 4; BUB1 RELATED PROTEIN; CYCLIN A2; CYCLIN B2; CYCLIN DEPENDENT KINASE 5; FOCAL ADHESION KINASE 1; PROSTAGLANDIN F; PROTEIN CDC42; TRANSCRIPTION FACTOR MSX2; TRANSCRIPTION FACTOR SOX18; X LINKED INHIBITOR OF APOPTOSIS;

APPL1 GENE; ARF4 GENE; ARHGEF9 GENE; ARTICLE; ASPM GENE; ATP6V1C1 GENE; BUB1 GENE; CBX3 GENE; CDC27 GENE; CDC42 GENE; CDCA5 GENE; CDCA8 GENE; CDK1 GENE; CDK5 GENE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CLPTM1L GENE; COMPARATIVE GENOMIC HYBRIDIZATION; CYCLIN A2 GENE; CYCLIN B2 GENE; EGFR GENE; FOXP1 GENE; GENE EXPRESSION SYSTEM; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC DATABASE; GRM2 GENE; KIF15 GENE; KIF2C GENE; LPP GENE; LUNG ADENOCARCINOMA; MACF1 GENE; METASTASIS; MSX2 GENE; MYBBP1A GENE; MYO10 GENE; NEK2 GENE; NFE2L2 GENE; NUCLEOTIDE SEQUENCE; NUSAP1 GENE; PGF GENE; PIK3CA GENE; PRC1 GENE; PRKAR2A GENE; PRPF6 GENE; PTK2 GENE; RAB5A GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SMARCC1 GENE; SMC4 GENE; SOX18 GENE; SP4 GENE; SYCE2 GENE; TAF15 GENE; TBXA2R GENE; TFDP1 GENE; TRA2B GENE; TUMOR GENE; VAPB GENE; XIAP GENE; ZNF124 GENE;

ADENOCARCINOMA; CELL CYCLE; CELL GROWTH PROCESSES; CELL SURVIVAL; CLUSTER ANALYSIS; GENE REGULATORY NETWORKS; GENOME, HUMAN; HUMANS; LUNG NEOPLASMS; MUTATION; NEOPLASM METASTASIS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84880080939     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067552     Document Type: Article

References (102)

1. Jemal A, Siegel R, Xu J, Ward E, (2010) Cancer statistics, 2010. CA Cancer J Clin 60: 277-300.
2. Pore MM, Hiltermann TJ, Kruyt FA (2010) Targeting apoptosis pathways in lung cancer. Cancer Lett.
3. Ahn MJ, Won HH, Lee J, Lee ST, Sun JM, et al. (2012) The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations. Hum Genet 131: 365-372.
4. Lu TP, Lai LC, Tsai MH, Chen PC, Hsu CP, et al. (2011) Integrated analyses of copy number variations and gene expression in lung adenocarcinoma. PLoS One 6: e24829.
5. Zhao X, Weir BA, LaFramboise T, Lin M, Beroukhim R, et al. (2005) Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res 65: 5561-5570.
6. Micke P, Edlund K, Holmberg L, Kultima HG, Mansouri L, et al. (2011) Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer. J Thorac Oncol 6: 1833-1840.
7. Kao S, Shiau CK, Gu DL, Ho CM, Su WH, et al. (2012) IGDB.NSCLC: integrated genomic database of non-small cell lung cancer. Nucleic Acids Res 40: D972-977.
8. Ramos AH, Dutt A, Mermel C, Perner S, Cho J, et al. (2009) Amplification of chromosomal segment 4q12 in non-small cell lung cancer. Cancer Biol Ther 8: 2042-2050.
9. Janne PA, Li C, Zhao X, Girard L, Chen TH, et al. (2004) High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene 23: 2716-2726.
10. Ju Z, Kapoor M, Newton K, Cheon K, Ramaswamy A, et al. (2005) Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells. Mol Genet Genomics 274: 141-154.
11. Dong J, Kislinger T, Jurisica I, Wigle DA, (2009) Lung cancer: developmental networks gone awry? Cancer Biol Ther 8: 312-318.
12. Broet P, Dalmasso C, Tan EH, Alifano M, Zhang S, et al. (2011) Genomic profiles specific to patient ethnicity in lung adenocarcinoma. Clin Cancer Res 17: 3542-3550.
13. Wilkerson MD, Yin X, Walter V, Zhao N, Cabanski CR, et al. (2012) Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation. PLoS One 7: e36530.
14. Yoon KA, Park JH, Han J, Park S, Lee GK, et al. (2010) A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Hum Mol Genet 19: 4948-4954.
15. Galvan A, Falvella FS, Spinola M, Frullanti E, Leoni VP, et al. (2008) A polygenic model with common variants may predict lung adenocarcinoma risk in humans. Int J Cancer 123: 2327-2330.
16. Blons H, Pallier K, Le Corre D, Danel C, Tremblay-Gravel M, et al. (2008) Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma. BMC Med Genomics 1: 25.
17. Frullanti E, Galvan A, Falvella FS, Manenti G, Colombo F, et al. (2011) Multiple genetic loci modulate lung adenocarcinoma clinical staging. Clin Cancer Res 17: 2410-2416.
18. Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, et al. (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
19. Kuner R, Muley T, Meister M, Ruschhaupt M, Buness A, et al. (2009) Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes. Lung Cancer 63: 32-38.
20. Gholami AM, Fellenberg K, (2010) Cross-species common regulatory network inference without requirement for prior gene affiliation. Bioinformatics 26: 1082-1090.
21. Yu J, Smith VA, Wang PP, Hartemink AJ, Jarvis ED, (2004) Advances to Bayesian network inference for generating causal networks from observational biological data. Bioinformatics 20: 3594-3603.
22. Altay G, Emmert-Streib F, (2011) Structural influence of gene networks on their inference: analysis of C3NET. Biol Direct 6: 31.
23. Olsen C, Meyer PE, Bontempi G (2009) On the impact of entropy estimation on transcriptional regulatory network inference based on mutual information. EURASIP J Bioinform Syst Biol: 308959.
24. Margolin AA, Nemenman I, Basso K, Wiggins C, Stolovitzky G, et al. (2006) ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics 7Suppl 1: S7.
25. Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T, (2011) Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 27: 431-432.
26. Nepusz T, Yu H, Paccanaro A, (2012) Detecting overlapping protein complexes in protein-protein interaction networks. Nat Methods 9: 471-472.
27. Bader GD, Hogue CW, (2003) An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics 4: 2.
28. Yasuda H, Kobayashi S, Costa DB (2011) EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol.
29. Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, et al. (2009) Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One 4: e4576.
30. Tsakiridis T, Cutz JC, Singh G, Hirte H, Okawara G, et al. (2008) Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy. J Thorac Oncol 3: 716-722.
31. Mukohara T, Kudoh S, Yamauchi S, Kimura T, Yoshimura N, et al. (2003) Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC). Lung Cancer 41: 123-130.
32. Bidkhori G, Moeini A, Masoudi-Nejad A, (2012) Modeling of Tumor Progression in NSCLC and Intrinsic Resistance to TKI in Loss of PTEN Expression. PLoS One 7: e48004.
33. Steelman LS, Chappell WH, Abrams SL, Kempf RC, Long J, et al. (2011) Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) 3: 192-222.
34. Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, et al. (2009) A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol 16: 294-303.
35. Gupta A, Yang Q, Pandita RK, Hunt CR, Xiang T, et al. (2009) Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle 8: 2198-2210.
36. Hirsch FR, Varella-Garcia M, Bunn PA Jr, Di Maria MV, Veve R, et al. (2003) Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21: 3798-3807.
37. Chaft JE, Arcila ME, Paik PK, Lau C, Riely GJ, et al. (2012) Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling. Mol Cancer Ther 11: 485-491.
38. Spitzer JI, Ugras S, Runge S, Decarolis P, Antonescu C, et al. (2011) mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma. Genes Chromosomes Cancer 50: 338-347.
39. Dean EJ, Ward T, Pinilla C, Houghten R, Welsh K, et al. (2010) A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC. Br J Cancer 102: 97-103.
40. Liang H, Gu MN, Yang CX, Wang HB, Wen XJ, et al. (2011) Sevoflurane inhibits proliferation, induces apoptosis, and blocks cell cycle progression of lung carcinoma cells. Asian Pac J Cancer Prev 12: 3415-3420.
41. Rao M, Song W, Jiang A, Shyr Y, Lev S, et al. (2012) VAMP-Associated Protein B (VAPB) Promotes Breast Tumor Growth by Modulation of Akt Activity. PLoS One 7: e46281.
42. Tan Y, You H, Coffey FJ, Wiest DL, Testa JR, (2010) Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis 48: 531-539.
43. Tan Y, You H, Wu C, Altomare DA, Testa JR, (2010) Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem 285: 6377-6389.
44. Zhao Z, Liu XF, Wu HC, Zou SB, Wang JY, et al. (2010) Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1-related epidermal growth factor signaling pathway. Cancer Sci 101: 1454-1462.
45. Jang SY, Jang SW, Ko J, (2012) Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. Cancer Lett 314: 185-197.
46. Shigematsu H, Gazdar AF, (2006) Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 118: 257-262.
47. Sordella R, Bell DW, Haber DA, Settleman J, (2004) Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305: 1163-1167.
48. James MA, Wen W, Wang Y, Byers LA, Heymach JV, et al. (2012) Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. PLoS One 7: e36116.
49. Lister A, Nedjadi T, Kitteringham NR, Campbell F, Costello E, et al. (2011) Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer 10: 37.
50. Sasaki H, Shitara M, Yokota K, Hikosaka Y, Moriyama S, et al. (2012) Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas. Mol Med Report 6: 391-394.
51. Hu Y, Ju Y, Lin D, Wang Z, Huang Y, et al. (2012) Mutation of the Nrf2 gene in non-small cell lung cancer. Mol Biol Rep 39: 4743-4747.
52. Sankpal UT, Maliakal P, Bose D, Kayaleh O, Buchholz D, et al. (2012) Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy. Curr Med Chem 19: 3779-3786.
53. Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, et al. (2011) Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs 29: 41-51.
54. Kuramoto K, Uesaka T, Kimura A, Kobayashi M, Watanabe H, et al. (2000) ZK7, a novel zinc finger gene, is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells. Cancer Res 60: 425-430.
55. Kang JU, Koo SH, Kwon KC, Park JW, Kim JM, (2009) Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2-q29 in squamous cell carcinoma of the lung. BMC Cancer 9: 237.
56. Choi YW, Choi JS, Zheng LT, Lim YJ, Yoon HK, et al. (2007) Comparative genomic hybridization array analysis and real time PCR reveals genomic alterations in squamous cell carcinomas of the lung. Lung Cancer 55: 43-51.
57. Feng J, Zhang X, Zhu H, Wang X, Ni S, et al. (2012) High expression of FoxP1 is associated with improved survival in patients with non-small cell lung cancer. Am J Clin Pathol 138: 230-235.
58. Ijichi N, Shigekawa T, Ikeda K, Horie-Inoue K, Shimizu C, et al. (2012) Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients. Horm Cancer 3: 147-159.
59. Katoh M, Igarashi M, Fukuda H, Nakagama H (2012) Cancer genetics and genomics of human FOX family genes. Cancer Lett.
60. Young N, Hahn CN, Poh A, Dong C, Wilhelm D, et al. (2006) Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J Natl Cancer Inst 98: 1060-1067.
61. Gremel G, Ryan D, Rafferty M, Lanigan F, Hegarty S, et al. (2011) Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma. Br J Cancer 105: 565-574.
62. Heeboll S, Borre M, Ottosen PD, Andersen CL, Mansilla F, et al. (2008) SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation. Histol Histopathol 23: 1069-1076.
63. Andersen CL, Christensen LL, Thorsen K, Schepeler T, Sorensen FB, et al. (2009) Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br J Cancer 100: 511-523.
64. Ouyang YQ, zur Hausen A, Orlowska-Volk M, Jager M, Bettendorf H, et al. (2011) Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology. Int J Cancer 128: 2010-2019.
65. Takeo K, Kawai T, Nishida K, Masuda K, Teshima-Kondo S, et al. (2009) Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells. Am J Physiol Cell Physiol 297: C330-338.
66. Gabriel B, Zur Hausen A, Bouda J, Boudova L, Koprivova M, et al. (2009) Significance of nuclear hTra2-beta1 expression in cervical cancer. Acta Obstet Gynecol Scand 88: 216-221.
67. Saini V, Hose CD, Monks A, Nagashima K, Han B, et al. (2012) Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. PLoS One 7: e41401.
68. Su L, Chen D, Zhang J, Li X, Pan G, et al. (2008) The expression and bioinformatic analysis of a novel gene C20orf14 associated with lymphoma. J Huazhong Univ Sci Technolog Med Sci 28: 97-101.
69. Garcia-Garcia A, Perez-Sayans Garcia M, Rodriguez MJ, Antunez-Lopez J, Barros-Angueira F, et al. (2012) Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa. Biotech Histochem 87: 133-139.
70. Perez-Sayans M, Reboiras-Lopez MD, Somoza-Martin JM, Barros-Angueira F, Diz PG, et al. (2010) Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma. Cancer Biol Ther 9: 1057-1064.
71. Acuna Sanhueza GA, Faller L, George B, Koffler J, Misetic V, et al. (2012) Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells. BMC Cancer 12: 72.
72. Arjonen A, Kaukonen R, Ivaska J, (2011) Filopodia and adhesion in cancer cell motility. Cell Adh Migr 5: 421-430.
73. Speyer CL, Smith JS, Banda M, DeVries JA, Mekani T, et al. (2012) Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer. Breast Cancer Res Treat 132: 565-573.
74. Teh J, Chen S, (2012) mGlu Receptors and Cancerous Growth. Wiley Interdiscip Rev Membr Transp Signal 1: 211-220.
75. Arcella A, Carpinelli G, Battaglia G, D'Onofrio M, Santoro F, et al. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro Oncol 7: 236-245.
76. Watkins G, Douglas-Jones A, Mansel RE, Jiang WG, (2005) Expression of thromboxane synthase, TBXAS1 and the thromboxane A2 receptor, TBXA2R, in human breast cancer. Int Semin Surg Oncol 2: 23.
77. Skarpen E, Thoresen GH, Tasken K, Samuelsen JT, Jahnsen T, et al. (1998) Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis. Histochem Cell Biol 109: 203-209.
78. Vincent-Dejean C, Cazabat L, Groussin L, Perlemoine K, Fumey G, et al. (2008) Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity. Eur J Endocrinol 158: 829-839.
79. Cho-Chung YS, Nesterova M, Pepe S, Lee GR, Noguchi K, et al. (1999) Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment. Front Biosci 4: D898-907.
80. Bradbury AW, Carter DC, Miller WR, Cho-Chung YS, Clair T, (1994) Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa. Br J Cancer 69: 738-742.
81. Li X, Wang X, Ye H, Peng A, Chen L, (2012) Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways. Cancer Chemother Pharmacol 70: 425-437.
82. Siejka A, Barabutis N, Schally AV, (2012) GHRH antagonist inhibits focal adhesion kinase (FAK) and decreases expression of vascular endothelial growth factor (VEGF) in human lung cancer cells in vitro. Peptides 37: 63-68.
83. Zhang L, Chen J, Ke Y, Mansel RE, Jiang WG, (2005) Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance. World J Surg Oncol 3: 68.
84. Woo IS, Park MJ, Byun JH, Hong YS, Lee KS, et al. (2004) Expression of placental growth factor gene in lung cancer. Tumour Biol 25: 1-6.
85. Watanabe T, Miura T, Degawa Y, Fujita Y, Inoue M, et al. (2010) Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR. Cancer Cell Int 10: 2.
86. Whyte L, Huang YY, Torres K, Mehta RG, (2007) Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res 67: 12007-12017.
87. Wang Z, Chen J, Sun J, Cui Z, Wu H, (2012) RNA interference-mediated silencing of eukaryotic translation initiation factor 3, subunit B (EIF3B) gene expression inhibits proliferation of colon cancer cells. World J Surg Oncol 10: 119.
88. Arsic N, Bendris N, Peter M, Begon-Pescia C, Rebouissou C, et al. (2012) A novel function for Cyclin A2: control of cell invasion via RhoA signaling. J Cell Biol 196: 147-162.
89. Mo ML, Chen Z, Li J, Li HL, Sheng Q, et al. (2010) Use of serum circulating CCNB2 in cancer surveillance. Int J Biol Markers 25: 236-242.
90. Gong D, Ferrell JE Jr, (2010) The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell 21: 3149-3161.
91. Zhang N, Pati D, (2012) Sororin is a master regulator of sister chromatid cohesion and separation. Cell Cycle 11: 2073-2083.
92. Osthus RC, Karim B, Prescott JE, Smith BD, McDevitt M, et al. (2005) The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res 65: 5620-5627.
93. Chen QY, Jiao DM, Yao QH, Yan J, Song J, et al. (2012) Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines. Int J Oncol 40: 1561-1568.
94. Zhu X, Shen H, Li H, Long L, Hui L, et al. (2012) miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6. FEBS Lett.
95. Tyagarajan SK, Ghosh H, Harvey K, Fritschy JM, (2011) Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J Cell Sci 124: 2786-2796.
96. Hynes NE, Lane HA, (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354.
97. Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, et al. (2008) PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest 118: 3762-3774.
98. Mertens C, Darnell JE Jr, (2007) SnapShot: JAK-STAT signaling. Cell 131: 612.
99. Emery IF, Battelli C, Auclair PL, Carrier K, Hayes DM, (2009) Response to gefitinib and erlotinib in Non-small cell lung cancer: a restrospective study. BMC Cancer 9: 333.
100. Ganti AK, (2010) Epidermal growth factor receptor signaling in nonsmall cell lung cancer. Cancer Invest 28: 515-525.
101. Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, et al. (2005) Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res. 2005/01/25 ed. 226-235.
102. Vicent S, Lopez-Picazo JM, Toledo G, Lozano MD, Torre W, et al. (2004) ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours. Br J Cancer 90: 1047-1052.