Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology

International Journal of Cancer

Volumn 128, Issue 9, 2011, Pages 2010-2019

  Ouyang, Yi Qin ^a,b   Zur Hausen, Axel ^a   Orlowska Volk, Marzenna ^a   Jäger, Markus ^a   Bettendorf, Herta ^a   Hirschfeld, Marc ^a   Tong, Xiao Wen ^b   Stickeler, Elmar ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b TONGJI HOSPITAL OF TONGJI UNIVERSITY   (China)

Author keywords

Endometrial carcinoma; hnRNP G; hTra2 beta1; Prognostic significance

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G; HUMAN TRANSFORMER 2 BETA1 PROTEIN; MESSENGER RNA; TRANSFORMING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; CANCER STAGING; CELL LEVEL; ENDOMETRIUM CANCER; FEMALE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; ENDOMETRIAL NEOPLASMS; FEMALE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; NEOPLASM STAGING; NERVE TISSUE PROTEINS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEINS; TISSUE ARRAY ANALYSIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 79952507525     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25544     Document Type: Article

References (37)

1. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-7. (Pubitemid 13194678)
2. Sorosky JI. Endometrial cancer. Obstet Gynecol 2008;111:436-47. (Pubitemid 351653438)
3. Enomoto T, Inoue M, Perantoni AO, Buzard GS, Miki H, Tanizawa O, Rice JM. K-ras activation in premalignant and malignant epithelial lesions of the human uterus. Cancer Res 1991;51:5308-14.
4. Witek A, Paul-Samojedny M, Stojko R, Seifert B, Mazurek U. Coexpression index of estrogen receptor alpha mRNA isoforms in simple, complex hyperplasia without atypia, complex atypical hyperplasia and adenocarcinoma. Gynecol Oncol 2007;106:407-12. (Pubitemid 47087942)
5. Shabani N, Kuhn C, Kunze S, Schulze S, Mayr D, Dian D, Gingelmaier A, Schindlbeck C, Willgeroth F, Sommer H, Jeschke U, Friese K, et al. Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer 2007;43:2434-44. (Pubitemid 350001248)
6. Fischer DC, Noack K, Runnebaum IB, Watermann DO, Kieback DG, Stamm S, Stickeler E. Expression of splicing factors in human ovarian cancer. Oncol Rep 2004;11:1085-90.
7. Matsunaga T, Shirasawa H, Hishiki T, Yoshida H, Kouchi K, Ohtsuka Y, Kawamura K, Etoh T, Ohnuma N. Enhanced expression of N-myc messenger RNA in neuroblastomas found by mass screening. Clin Cancer Res 2000;6:3199-204. (Pubitemid 30637748)
8. Stickeler E, Kittrell F, Medina D, Berget SM. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis. Oncogene 1999;18:3574-82. (Pubitemid 29322382)
9. Krecic AM, Swanson MS. hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol 1999;11:363-71.
10. Rebeca Martinez-Contreras PC, Lulzim S, Jean-Francois F, Timothee R, Benoit C. Alternative splicing in the postgenomic era, 1st edn., vol. 123-147. New York: Landes Bioscience and Springer Science+Business Media, LLC, 2007.
11. Soulard M, Della Valle V, Siomi MC, Pinol-Roma S, Codogno P, Bauvy C, Bellini M, Lacroix JC, Monod G, Dreyfuss G, et al. hnRNP G: sequence and characterization of a glycosylated RNA-binding protein. Nucleic Acids Res 1993;21:4210-7. (Pubitemid 23279008)
12. Shin KH, Kang MK, Kim RH, Christensen R, Park NH. Heterogeneous nuclear ribonucleoprotein G shows tumor suppressive effect against oral squamous cell carcinoma cells. Clin Cancer Res 2006;12:3222-8. (Pubitemid 43837373)
13. Sanford JR, Gray NK, Beckmann K, Caceres JF. A novel role for shuttling SR proteins in mRNA translation. Genes Dev 2004;18:755-68. (Pubitemid 38480888)
14. Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005;123:569-80. (Pubitemid 41608461)
15. Bedard KM, Daijogo S, Semler BL. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J 2007;26:459-67. (Pubitemid 46160946)
16. Swartz JE, Bor YC, Misawa Y, Rekosh D, Hammarskjold ML. The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. J Biol Chem 2007;282:19844-53. (Pubitemid 47100104)
17. Michlewski G, Sanford JR, Caceres JF. The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1. Mol Cell 2008;30:179-89. (Pubitemid 351626689)
18. Zhang Z, Krainer AR. Involvement of SR proteins in mRNA surveillance. Mol Cell 2004;16:597-607. (Pubitemid 39531882)
19. Sato H, Hosoda N, Maquat LE. Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell 2008;29:255-62. (Pubitemid 351172823)
20. Stoilov P, Daoud R, Nayler O, Stamm S. Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA. Hum Mol Genet 2004;13:509-24. (Pubitemid 38313210)
21. Tacke R, Tohyama M, Ogawa S, Manley JL. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 1998;93:139-48. (Pubitemid 28173559)
22. Venables JP, Bourgeois CF, Dalgliesh C, Kister L, Stevenin J, Elliott DJ. Upregulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. Hum Mol Genet 2005;14:2289-303. (Pubitemid 41417993)
23. Watermann DO, Tang Y, Zur Hausen A, Jager M, Stamm S, Stickeler E. Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene. Cancer Res 2006;66:4774-80.
24. Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. Hum Mol Genet 2000;9:685-94. (Pubitemid 30162752)
25. Nasim MT, Chernova TK, Chowdhury HM, Yue BG, Eperon IC. HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding. Hum Mol Genet 2003;12:1337-48. (Pubitemid 36722614)
26. Tavassoéli FA, Devilee, P. WHO. World Health Organization. Pathology and genetics of tumours of the breast and female genital organs: tumours of the breast and female genital organs. Lyon: IARC Press, 2003.
27. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, Lightfoot S, Menzel W, Granzow M, Ragg T. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 2006;7:3.
28. Imbeaud S, Graudens E, Boulanger V, Barlet X, Zaborski P, Eveno E, Mueller O, Schroeder A, Auffray C. Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces. Nucleic Acids Res 2005;33:e56.
29. Glare EM, Divjak M, Bailey MJ, Walters EH. beta-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels. Thorax 2002;57:765-70. (Pubitemid 34984973)
30. Eisenberg E, Levanon EY. Human housekeeping genes are compact. Trends Genet 2003;19:362-5. (Pubitemid 36794535)
31. Yamada H, Chen D, Monstein HJ, Hakanson R. Effects of fasting on the expression of gastrin, cholecystokinin, and somatostatin genes and of various housekeeping genes in the pancreas and upper digestive tract of rats. Biochem Biophys Res Commun 1997;231:835-8. (Pubitemid 27217612)
32. Goidin D, Mamessier A, Staquet MJ, Schmitt D, Berthier-Vergnes O. Ribosomal 18S RNA prevails over glyceraldehyde-3-phosphate dehydrogenase and beta-actin genes as internal standard for quantitative comparison of mRNA levels in invasive and noninvasive human melanoma cell subpopulations. Anal Biochem 2001;295:17-21. (Pubitemid 32721736)
33. Pfaffl MW. A new mathematical model for relative quantification in real-time RTPCR. Nucleic Acids Res 2001;29:e45.
34. Hirschfeld M, zur Hausen A, Bettendorf H, Jager M, Stickeler E. Alternative splicing of Cyr61 is regulated by hypoxia and significantly changed in breast cancer. Cancer Res 2009;69:2082-90.
35. van Alphen RJ, Wiemer EA, Burger H, Eskens FA. The spliceosome as target for anticancer treatment. Br J Cancer 2009;100:228-32.
36. Gabriel B, Zur Hausen A, Bouda J, Boudova L, Koprivova M, Hirschfeld M, Jager M, Stickeler E. Significance of nuclear hTra2-beta1 expression in cervical cancer. Acta Obstet Gynecol Scand 2009;88:216-21.
37. Heinrich B, Zhang Z, Raitskin O, Hiller M, Benderska N, Hartmann AM, Bracco L, Elliott D, Ben-Ari S, Soreq H, Sperling J, Sperling R, et al. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. J Biol Chem 2009;284:14303-15.